D Pomp

Summary

Affiliation: University of Nebraska
Country: USA

Publications

  1. ncbi Characterization of QTL with major effects on fatness and growth on mouse chromosome 2
    Nancy C Jerez-Timaure
    Animal Science, University of Nebraska, Lincoln, NE 68583 0908, USA
    Obes Res 12:1408-20. 2004
  2. ncbi Applying functional genomics research to the study of pig reproduction
    D Pomp
    Department of Animal Science, University of Nebraska, Lincoln, NE 68583 0908, USA
    Reprod Suppl 58:277-92. 2001
  3. pmc Identification of quantitative trait loci influencing traits related to energy balance in selection and inbred lines of mice
    D E Moody
    Department of Animal Science, University of Nebraska, Lincoln, Nebraska 68583, USA
    Genetics 152:699-711. 1999
  4. pmc Quantitative genetics of transgenic mice: components of phenotypic variation in body weights and weight gains
    A C Clutter
    Department of Animal Science, Oklahoma State University, Stillwater 74078 0425, USA
    Genetics 143:1753-60. 1996
  5. ncbi Evaluation of gene expression in pigs selected for enhanced reproduction using differential display PCR and human microarrays: I. Ovarian follicles
    C D Gladney
    Department of Animal Science, University of Nebraska, Lincoln 68583 0908, USA
    J Anim Sci 82:17-31. 2004
  6. ncbi Evaluation of gene expression in pigs selected for enhanced reproduction using differential display PCR: II. Anterior pituitary
    G R Bertani
    Department of Animal Science, University of Nebraska, Lincoln 68583 0908, USA
    J Anim Sci 82:32-40. 2004
  7. ncbi Mapping of the melatonin receptor 1a (MTNR1A) gene in pigs, sheep, and cattle
    L A Messer
    Department of Animal Science, Iowa State University, Ames, Iowa 50011 3150, USA
    Mamm Genome 8:368-70. 1997
  8. ncbi Identification of quantitative trait loci affecting reproduction in pigs
    J P Cassady
    Animal Science Department, University of Nebraska, Lincoln 68583 0908, USA
    J Anim Sci 79:623-33. 2001
  9. ncbi Candidate gene analysis for loci affecting litter size and ovulation rate in swine
    R C Linville
    Department of Animal Science, University of Nebraska, Lincoln 68583-0908, USA
    J Anim Sci 79:60-7. 2001
  10. ncbi Physical mapping of genes in the porcine ovarian transcriptome
    A R Caetano
    Department of Animal Science, University of Nebraska, Lincoln, NE 68583 0908, USA
    Anim Genet 36:322-30. 2005

Detail Information

Publications57

  1. ncbi Characterization of QTL with major effects on fatness and growth on mouse chromosome 2
    Nancy C Jerez-Timaure
    Animal Science, University of Nebraska, Lincoln, NE 68583 0908, USA
    Obes Res 12:1408-20. 2004
    ..To isolate and characterize a region on mouse chromosome 2 harboring quantitative trait loci with large influences on growth and fatness...
  2. ncbi Applying functional genomics research to the study of pig reproduction
    D Pomp
    Department of Animal Science, University of Nebraska, Lincoln, NE 68583 0908, USA
    Reprod Suppl 58:277-92. 2001
    ....
  3. pmc Identification of quantitative trait loci influencing traits related to energy balance in selection and inbred lines of mice
    D E Moody
    Department of Animal Science, University of Nebraska, Lincoln, Nebraska 68583, USA
    Genetics 152:699-711. 1999
    ..The presence of a QTL influencing 6-wk weight was also confirmed. Suggestive evidence for additional QTL influencing heat loss, percentage subcutaneous fat, and percentage heart was found for chromosome 1...
  4. pmc Quantitative genetics of transgenic mice: components of phenotypic variation in body weights and weight gains
    A C Clutter
    Department of Animal Science, Oklahoma State University, Stillwater 74078 0425, USA
    Genetics 143:1753-60. 1996
    ..Additive genetic correlations between wild-type and transgenic expression of body weights tended to decline with age, indicating that a partially different array of genes may have begun to affect body weight in the transgenic group...
  5. ncbi Evaluation of gene expression in pigs selected for enhanced reproduction using differential display PCR and human microarrays: I. Ovarian follicles
    C D Gladney
    Department of Animal Science, University of Nebraska, Lincoln 68583 0908, USA
    J Anim Sci 82:17-31. 2004
    ..This work represents one of the first applications of gene expression analysis to evaluate long-term selection response in livestock populations...
  6. ncbi Evaluation of gene expression in pigs selected for enhanced reproduction using differential display PCR: II. Anterior pituitary
    G R Bertani
    Department of Animal Science, University of Nebraska, Lincoln 68583 0908, USA
    J Anim Sci 82:32-40. 2004
    ..Our findings indicate that long-term selection to increase ovulation rate and decrease embryo mortality has altered transcriptional patterns in the anterior pituitary, most likely as correlated responses...
  7. ncbi Mapping of the melatonin receptor 1a (MTNR1A) gene in pigs, sheep, and cattle
    L A Messer
    Department of Animal Science, Iowa State University, Ames, Iowa 50011 3150, USA
    Mamm Genome 8:368-70. 1997
  8. ncbi Identification of quantitative trait loci affecting reproduction in pigs
    J P Cassady
    Animal Science Department, University of Nebraska, Lincoln 68583 0908, USA
    J Anim Sci 79:623-33. 2001
    ..Ovulation rate and age at puberty are laborious to measure, and thus marker-assisted selection may provide a practical and efficient method of selection...
  9. ncbi Candidate gene analysis for loci affecting litter size and ovulation rate in swine
    R C Linville
    Department of Animal Science, University of Nebraska, Lincoln 68583-0908, USA
    J Anim Sci 79:60-7. 2001
    ..We were not able to find significant associations between the polymorphic markers and phenotypes studied; however, we cannot rule out that other genetic variation within these candidate genes has an effect on the traits studied...
  10. ncbi Physical mapping of genes in the porcine ovarian transcriptome
    A R Caetano
    Department of Animal Science, University of Nebraska, Lincoln, NE 68583 0908, USA
    Anim Genet 36:322-30. 2005
    ..A total of 12 differentially expressed genes were mapped to regions previously reported to contain quantitative trait loci affecting swine ovulation rate...
  11. ncbi Polymerase chain reaction-based polymorphisms in the porcine cholecystokinin (CCK) gene and assignment to chromosome 13
    A C Clutter
    Department of Animal Science, Oklahoma State University, Stillwater 74078 0435, USA
    Anim Genet 27:369-70. 1996
    ..Linkage analysis revealed that the CCK gene is located on porcine chromosome 13...
  12. ncbi Body composition of inactivated growth hormone (oMt1a-oGH) transgenic mice: generation of an obese phenotype
    A M Oberbauer
    Department of Animal Science, University of California, Davis, USA
    Growth Dev Aging 61:169-79. 1997
    ..The oMt1a-oGH mouse provides a novel model of induced obesity in response to inactivation of a GH-transgene by the withdrawal of the transgene stimulus...
  13. ncbi Genetic dissection of obesity in polygenic animal models
    D Pomp
    Department of Animal Science, University of Nebraska, Lincoln 68583, USA
    Behav Genet 27:285-306. 1997
    ..This review describes the design and strategies of such studies and summarizes the results and their implications toward understanding the complex nature of obesity in humans...
  14. ncbi Ontogeny of elongation and gene expression in the early developing porcine conceptus
    J V Yelich
    Department of Animal Science, Oklahoma State University, Stillwater 74078, USA
    Biol Reprod 57:1256-65. 1997
    ..LIFR expression is highly associated with steroidogenic enzyme production with an initial peak preceding rapid trophoblastic elongation, suggesting that LIF may be involved in early conceptus development in the pig...
  15. ncbi Rapid communication: Mapping of the pro-opiomelanocortin (POMC) gene to pig chromosome by linkage analysis using a PCR-RFLP
    L A Messer
    Department of Animal Science, University of Nebraska, Lincoln 68583 0908, USA
    J Anim Sci 79:2241-2. 2001
  16. ncbi Quantitative genomics: exploring the genetic architecture of complex trait predisposition
    D Pomp
    Department of Animal Science, University of Nebraska, Lincoln 68583 0908, USA
    J Anim Sci 82:E300-312. 2004
    ....
  17. ncbi Mapping of porcine ESTs obtained from the anterior pituitary
    G R Bertani
    Department of Animal Science, University of Nebraska, Lincoln, NE, USA
    Anim Genet 34:132-4. 2003
    ....
  18. ncbi Predictors of marker-informativeness for an outbred F2 design
    J L Rocha
    Department of Animal Science, University of Nebraska-Lincoln, Lincoln, NE 68583-0908, USA
    Anim Genet 32:365-70. 2001
    ..07-0.09 MI units). The degree of relative advantage conferred by the F2 generalization of the PIC index over the traditional index was found to be of minor significance...
  19. ncbi Linkage mapping of the retinoic acid receptor-gamma gene to porcine chromosome 5
    L Messer
    Department of Animal Science, Iowa State University, Ames 50011 3150, USA
    Anim Genet 27:175-7. 1996
    ..This augments the homology of pig chromosome 5 and human chromosome 12 established by previous comparative mapping...
  20. ncbi A genome scan for quantitative trait loci and imprinted regions affecting reproduction in pigs
    J W Holl
    Department of Animal Science, University of Nebraska, Lincoln 68581 0908, USA
    J Anim Sci 82:3421-9. 2004
    ..10), NN (P < 0.10), and MUM (P < 0.10) were detected. No QTL were detected with half-sib analyses. Multiple QTL models with imprinting effects are more appropriate for analyzing F2 data than single Mendelian QTL line-cross models...
  21. ncbi Detection of transcripts for retinoic acid receptors, retinol-binding protein, and transforming growth factors during rapid trophoblastic elongation in the porcine conceptus
    J V Yelich
    Department of Animal Science, Oklahoma State University, Stillwater 74078, USA
    Biol Reprod 57:286-94. 1997
    ....
  22. ncbi Quantitative genetics of energy balance--lessons from animal models
    D Pomp
    Department of Animal Science, University of Nebraska, Lincoln 68585 0908, USA
    Obes Res 7:106-10. 1999
    ..Applications of this information toward understanding and treatment of human obesity are explored...
  23. ncbi The M16 mouse: an outbred animal model of early onset polygenic obesity and diabesity
    Mark F Allan
    Department of Animal Science, University of Nebraska, Lincoln, NE 68583 0908, USA
    Obes Res 12:1397-407. 2004
    ..To characterize the phenotypic consequences of long-term selective breeding for rapid weight gain, with an emphasis on obesity and obesity-induced diabetes (diabesity)...
  24. ncbi Assignment of the porcine obese (leptin) gene to chromosome 18 by linkage analysis of a new PCR-based polymorphism
    S Sasaki
    Department of Animal Science, Oklahoma State University, Stilwater, Oklahoma 74078 0425, USA
    Mamm Genome 7:471-2. 1996
  25. ncbi Comparative mapping of RPL3, a gene overexpressed in multiple obesity models
    M F Allan
    Animal Science Department, University of Nebraska, Lincoln 68583 0908, USA
    Anim Biotechnol 12:167-71. 2001
    ..Comparative mapping implicates a previously mapped copy of RPL3 on HSA22 as the functional copy of human RPL3, while predictive mapping places the porcine homologue on SSC5...
  26. pmc Individuality in gut microbiota composition is a complex polygenic trait shaped by multiple environmental and host genetic factors
    Andrew K Benson
    Department of Food Science and Technology and Core for Applied Genomics and Ecology, University of Nebraska, Lincoln, NE 68583 0919, USA
    Proc Natl Acad Sci U S A 107:18933-8. 2010
    ....
  27. ncbi Localization of a recessive juvenile cataract mutation to proximal chromosome 7 in mice
    E J Cargill
    Department of Animal Science, University of Nebraska, Lincoln, Nebr 68583 0908, USA
    Hum Hered 52:77-82. 2001
    ..To localize the chromosomal position of a novel cataract mutation (juvenile recessive cataract; jrc) in mice...
  28. ncbi Fine mapping of a QTL region with large effects on growth and fatness on mouse chromosome 2
    Nancy C Jerez-Timaure
    Department of Animal Science, University of Nebraska, Lincoln, Nebraska 68583 0908, USA
    Physiol Genomics 21:411-22. 2005
    ....
  29. ncbi A large-sample QTL study in mice: II. Body composition
    Joao L Rocha
    Department of Animal Science, University of Nebraska, Lincoln, Nebraska 68583 0908, USA
    Mamm Genome 15:100-13. 2004
    ..In this study, growth and body weight are interpreted in terms of organ subcomponents underlying the macro aggregate traits, and anchored on the corresponding genomic locations...
  30. ncbi A large-sample QTL study in mice: I. Growth
    Joao L Rocha
    Department of Animal Science, University of Nebraska, Lincoln, Nebraska 68583 0908, USA
    Mamm Genome 15:83-99. 2004
    ..Only a few epistatic interactions among detected QTL, little statistical support for gender-specific QTL, and significant age effects on genetic architecture were other primary observations from this study...
  31. ncbi Linkage mapping of the retinol-binding protein 4 (RBP4) gene to porcine chromosome 14
    L A Messer
    Department of Animal Science, Iowa State University, Ames, Iowa 50011 3150, USA
    Mamm Genome 7:396. 1996
  32. pmc Genomic mapping of direct and correlated responses to long-term selection for rapid growth rate in mice
    Mark F Allan
    Department of Animal Science, University of Nebraska, Lincoln, Nebraska 68583, USA
    Genetics 170:1863-77. 2005
    ..Several QTL demonstrating differential regulation of regional adipose deposition and age-dependent regulation of growth and energy consumption were identified...
  33. ncbi Linkage mapping of the bovine insulin-like growth factor-1 receptor gene
    D E Moody
    Department of Animal Science, Oklahoma State University, Stillwater 74078, USA
    Mamm Genome 7:168-9. 1996
  34. ncbi Evaluation of hypothalamic gene expression in mice divergently selected for heat loss
    Stephanie R Wesolowski
    Department of Animal Science, University of Nebraska, Lincoln, Nebraska 68583 0908, USA
    Physiol Genomics 13:129-37. 2003
    ..These results provide information on correlated responses in the transcriptome of mice selected for high and low energy expenditure and reveal new information regarding genetic regulation of energy balance...
  35. ncbi Differential expression of NAT1 translational repressor during development of bovine intramuscular adipocytes
    Kirby D Childs
    Department of Animal Science, Oklahoma Agriculture Experiment Station, Oklahoma State University, Stillwater, Oklahoma 74078, USA
    Physiol Genomics 10:49-56. 2002
    ..NAT1 mRNA was quantified in individual animals to confirm differential expression among treatment groups. Results indicate that NAT1 message is more abundant (P < 0.05) in intramuscular adipocytes of younger/leaner animals...
  36. ncbi QTL analysis in livestock
    Joao L Rocha
    Department of Animal Science, University of Nebraska Lincoln, Lincoln, NE, USA
    Methods Mol Biol 195:311-46. 2002
  37. ncbi A large-sample QTL study in mice: III. Reproduction
    Joao L Rocha
    Department of Animal Science, University of Nebraska, Lincoln, Nebraska 68583 0908, USA
    Mamm Genome 15:878-86. 2004
    ..This is unfortunate as traits with low heritability are among those that could most benefit from QTL-complemented breeding and selection strategies in food animal production...
  38. ncbi Sex identification in mammals with polymerase chain reaction and its use to examine sex effects on diameter of day-10 or -11 pig embryos
    D Pomp
    Department of Animal Science, Oklahoma State University, Stillwater 74078, USA
    J Anim Sci 73:1408-15. 1995
    ....
  39. pmc Fine mapping of "mini-muscle," a recessive mutation causing reduced hindlimb muscle mass in mice
    John Hartmann
    Department of Nutrition, University of North Carolina, Chapel Hill, NC 27599, USA
    J Hered 99:679-87. 2008
    ..Identification of the genetic variation that underlies MM could potentially be very important in understanding both normal muscle function and disregulation of muscle physiology leading to disease...
  40. pmc Genetic variance and covariance patterns for body weight and energy balance characters in an advanced intercross population of mice
    Larry J Leamy
    Department of Biology, University of North Carolina at Charlotte, 28223, USA
    Genet Sel Evol 37:151-73. 2005
    ..The independence of body weight and adiposity suggests that this advanced intercross population is ideal for a comprehensive discovery of genes controlling regulation of mammalian adiposity that are distinct from those for body weight...
  41. ncbi Phenotypic effects of the "mini-muscle" allele in a large HR x C57BL/6J mouse backcross
    Robert M Hannon
    Department of Biology, University of California, Riverside, CA 92521, USA
    J Hered 99:349-54. 2008
    ....
  42. ncbi High-resolution comparative mapping of pig Chromosome 4, emphasizing the FAT1 region
    Maria Moller
    Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Box 597, 75124, Uppsala, Sweden
    Mamm Genome 15:717-31. 2004
    ..This refined SSC4 map and the comparative analysis will be a great aid in the search for the genes underlying the FAT1 locus...
  43. ncbi Pleiotropy of quantitative trait loci for organ weights and limb bone lengths in mice
    Larry J Leamy
    Department of Biology, University of North Carolina at Charlotte, Charlotte, North Carolina 28223, USA
    Physiol Genomics 10:21-9. 2002
    ..The direction of the effect of these QTLs was almost always consistent within and between characters, with little evidence for antagonistic pleiotropy...
  44. pmc An epistatic genetic basis for physical activity traits in mice
    Larry J Leamy
    Department of Biology, University of North Carolina at Charlotte, Charlotte, NC 28223, USA
    J Hered 99:639-46. 2008
    ....
  45. pmc Complex genetics of obesity in mouse models
    Daniel Pomp
    Department of Nutrition, Carolina Center for Genome Science, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Annu Rev Nutr 28:331-45. 2008
    ..And third, we explore the effects of recent findings indicating increasing levels of complexity in the nature of variation underlying, and the heritability of, complex traits such as obesity...
  46. pmc The nature and identification of quantitative trait loci: a community's view
    Oduola Abiola
    Nat Rev Genet 4:911-6. 2003
    ..Quantitative trait loci (QTLs) can be identified in several ways, but is there a definitive test of whether a candidate locus actually corresponds to a specific QTL?..
  47. doi Genotype X diet interactions in mice predisposed to mammary cancer: II. Tumors and metastasis
    Ryan R Gordon
    Department of Nutrition, University of North Carolina, Chapel Hill, NC 27599, USA
    Mamm Genome 19:179-89. 2008
    ..These findings highlight the importance of accurately modeling not only the human cancer characteristics in mice but also the environmental exposures of human populations...
  48. doi Genotype X diet interactions in mice predisposed to mammary cancer. I. Body weight and fat
    Ryan R Gordon
    Department of Nutrition, University of North Carolina, Chapel Hill, NC 27599, USA
    Mamm Genome 19:163-78. 2008
    ..QTL x diet and/or gender interactions were present at 15 of these QTL, indicating that such interactions play a significant role in defining the genetic architecture of complex traits such as body weight and obesity...
  49. pmc Bayesian model selection for genome-wide epistatic quantitative trait loci analysis
    Nengjun Yi
    Department of Biostatistics, University of Alabama, Birmingham 35294, USA
    Genetics 170:1333-44. 2005
    ..We illustrate the proposed method by detecting new epistatic QTL for obesity in a backcross of CAST/Ei mice onto M16i...
  50. ncbi Fine mapping of mouse QTLs for fatness using SNP data
    Armin O Schmitt
    Institute for Animal Sciences, Humboldt Universitat zu Berlin, Berlin, Germany
    OMICS 11:341-50. 2007
    ..Viewing the genomic region of fatness-related QTLs under several different aspects is appropriate to assess the many thousands of genes that reside in such QTLs and to produce lists of more robust candidate genes...
  51. pmc Bayesian mapping of genomewide interacting quantitative trait loci for ordinal traits
    Nengjun Yi
    Section on Statistical Genetics, Department of Biostatistics, University of Alabama, Birmingham, Alabama 35294 0022, USA
    Genetics 176:1855-64. 2007
    ....
  52. pmc An efficient Bayesian model selection approach for interacting quantitative trait loci models with many effects
    Nengjun Yi
    Department of Biostatistics, Section on Statistical Genetics, University of Alabama, Birmingham, Alabama 35294 0022, USA
    Genetics 176:1865-77. 2007
    ..Our method has been implemented in the freely available package R/qtlbim (http://www.qtlbim.org) to facilitate the general usage of the Bayesian methodology for genomewide interacting QTL analysis...
  53. ncbi Collateral density, remodeling, and VEGF-A expression differ widely between mouse strains
    Dan Chalothorn
    Department of Cell and Molecular Physiology, University of North Carolina, Chapel Hill, North Carolina 27599 7545, USA
    Physiol Genomics 30:179-91. 2007
    ..These findings suggest these strains offer a model to investigate genetic determinants of collateral formation and growth in ischemia...
  54. ncbi The contribution of epistatic pleiotropy to the genetic architecture of covariation among polygenic traits in mice
    Jason B Wolf
    Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK
    Evol Dev 8:468-76. 2006
    ..Thus, although epistatic pleiotropy made a smaller contribution than single-locus pleiotropy, it clearly made a significant contribution to the genetic architecture of variation/covariation...
  55. ncbi Bayesian analyses of multiple epistatic QTL models for body weight and body composition in mice
    Nengjun Yi
    Department of Biostatistics, Section on Statistical Genetics, University of Alabama, Birmingham, AL 35294, USA
    Genet Res 87:45-60. 2006
    ..Several main and epistatic effects were shared by the body composition and body weight traits, suggesting that pleiotropy plays an important role in growth and obesity...
  56. ncbi EST-based gene discovery in pig: virtual expression patterns and comparative mapping to human
    Christopher K Tuggle
    Center for Integrated Animal Genomics and Department of Animal Science, Iowa State University, 2255 Kildee Hall, Ames, Iowa 50011, USA
    Mamm Genome 14:565-79. 2003
    ..We demonstrate the utility of this software for comparative mapping by localizing 61 genes on the porcine physical map for Chromosomes (Chrs) 5, 10, and 14...
  57. pmc Quantitative trait loci for physical activity traits in mice
    J Timothy Lightfoot
    Department of Kinesiology, University of North Carolina, Charlotte, NC 28223, USA
    Physiol Genomics 32:401-8. 2008
    ..1, DIST13.1, SPD13.1, and SPD9.1 were subsequently replicated by haplotype association mapping. The results of this study suggest a genetic basis of voluntary activity in mice and provide a foundation for future candidate gene studies...