B G Pollock

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi request reprint Evaluation of platelet activation in depressed patients with ischemic heart disease after paroxetine or nortriptyline treatment
    B G Pollock
    Department of Psychiatry, University of Pittsburgh School of Medicine, University of Pittsburgh Medical Center, Pennsylvania, USA
    J Clin Psychopharmacol 20:137-40. 2000
  2. ncbi request reprint The pharmacokinetic imperative in late-life depression
    Bruce G Pollock
    Academic Division of Geriatrics and Neuropsychiatry, University of Pittsburgh, Thomas Detre Hall E 1234, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    J Clin Psychopharmacol 25:S19-23. 2005
  3. ncbi request reprint Comparison of citalopram, perphenazine, and placebo for the acute treatment of psychosis and behavioral disturbances in hospitalized, demented patients
    Bruce G Pollock
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
    Am J Psychiatry 159:460-5. 2002
  4. ncbi request reprint Citalopram: a comprehensive review
    B G Pollock
    University of Pittsburgh Medical Center, 3811 O Hara Street, Pittsburgh, PA 15213 2593, USA
    Expert Opin Pharmacother 2:681-98. 2001
  5. ncbi request reprint Serum anticholinergicity in elderly depressed patients treated with paroxetine or nortriptyline
    B G Pollock
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
    Am J Psychiatry 155:1110-2. 1998
  6. ncbi request reprint A double-blind randomized comparison of nortriptyline plus perphenazine versus nortriptyline plus placebo in the treatment of psychotic depression in late life
    B H Mulsant
    Intervention Research Center for the Study of Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
    J Clin Psychiatry 62:597-604. 2001
  7. ncbi request reprint The 5-HTTPR polymorphism confers liability to a combined phenotype of psychotic and aggressive behavior in Alzheimer disease
    R A Sweet
    Department of Psychiatry, School of Medicine, University of Pittsburgh, Pennsylvania, USA
    Int Psychogeriatr 13:401-9. 2001
  8. ncbi request reprint Influence of serotonin-transporter-linked promoter region polymorphism on platelet activation in geriatric depression
    E M Whyte
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
    Am J Psychiatry 158:2074-6. 2001
  9. ncbi request reprint Nortriptyline and interpersonal psychotherapy as maintenance therapies for recurrent major depression: a randomized controlled trial in patients older than 59 years
    C F Reynolds
    The Mental Health Clinical Research Centers for Late and Mid Life Mood Disorders, Department of Psychiatry, University of Pittsburgh Medical Center, PA 15213, USA
    JAMA 281:39-45. 1999
  10. ncbi request reprint A twelve-week, double-blind, randomized comparison of nortriptyline and paroxetine in older depressed inpatients and outpatients
    B H Mulsant
    Intervention Research Center for the Study of Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Am J Geriatr Psychiatry 9:406-14. 2001

Collaborators

Detail Information

Publications93

  1. ncbi request reprint Evaluation of platelet activation in depressed patients with ischemic heart disease after paroxetine or nortriptyline treatment
    B G Pollock
    Department of Psychiatry, University of Pittsburgh School of Medicine, University of Pittsburgh Medical Center, Pennsylvania, USA
    J Clin Psychopharmacol 20:137-40. 2000
    ..The effect of paroxetine on PF4 and BTG plasma levels suggests that it may reduce platelet aggregation in vivo and may positively impact IHD-related mortality in this population...
  2. ncbi request reprint The pharmacokinetic imperative in late-life depression
    Bruce G Pollock
    Academic Division of Geriatrics and Neuropsychiatry, University of Pittsburgh, Thomas Detre Hall E 1234, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    J Clin Psychopharmacol 25:S19-23. 2005
    ..Population pharmacokinetics provides a means for assessing antidepressant drug exposure with relative ease and precision in clinical trials...
  3. ncbi request reprint Comparison of citalopram, perphenazine, and placebo for the acute treatment of psychosis and behavioral disturbances in hospitalized, demented patients
    Bruce G Pollock
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
    Am J Psychiatry 159:460-5. 2002
    ....
  4. ncbi request reprint Citalopram: a comprehensive review
    B G Pollock
    University of Pittsburgh Medical Center, 3811 O Hara Street, Pittsburgh, PA 15213 2593, USA
    Expert Opin Pharmacother 2:681-98. 2001
    ..This paper reviews the full spectrum of citalopram's clinical efficacy, as well as its safety and tolerability, in a range of patients...
  5. ncbi request reprint Serum anticholinergicity in elderly depressed patients treated with paroxetine or nortriptyline
    B G Pollock
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
    Am J Psychiatry 155:1110-2. 1998
    ..The authors' goal was to compare serum anticholinergicity of 61 elderly depressed patients randomly assigned to double-blind treatment with paroxetine (N=31) or nortriptyline (N=30)...
  6. ncbi request reprint A double-blind randomized comparison of nortriptyline plus perphenazine versus nortriptyline plus placebo in the treatment of psychotic depression in late life
    B H Mulsant
    Intervention Research Center for the Study of Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
    J Clin Psychiatry 62:597-604. 2001
    ..To conduct the first randomized study comparing the efficacy of an antidepressant alone versus an antidepressant plus a neuroleptic in the treatment of late-life psychotic depression...
  7. ncbi request reprint The 5-HTTPR polymorphism confers liability to a combined phenotype of psychotic and aggressive behavior in Alzheimer disease
    R A Sweet
    Department of Psychiatry, School of Medicine, University of Pittsburgh, Pennsylvania, USA
    Int Psychogeriatr 13:401-9. 2001
    ..We recently found that AD subjects homozygous for long alleles (l) of an insertion/deletion polymorphism in the promoter region of the serotonin transporter (5-HTTPR) had elevated rates of aggressive behavior...
  8. ncbi request reprint Influence of serotonin-transporter-linked promoter region polymorphism on platelet activation in geriatric depression
    E M Whyte
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
    Am J Psychiatry 158:2074-6. 2001
    ..Variations in the serotonin-transporter-linked promoter region (5-HTTLPR) polymorphism may influence the degree of activation. The authors examined the association among depression, platelet activation, and 5-HTTLPR genotype...
  9. ncbi request reprint Nortriptyline and interpersonal psychotherapy as maintenance therapies for recurrent major depression: a randomized controlled trial in patients older than 59 years
    C F Reynolds
    The Mental Health Clinical Research Centers for Late and Mid Life Mood Disorders, Department of Psychiatry, University of Pittsburgh Medical Center, PA 15213, USA
    JAMA 281:39-45. 1999
    ..Elderly patients with major depression are at high risk for recurrence, increased mortality, and chronic disability...
  10. ncbi request reprint A twelve-week, double-blind, randomized comparison of nortriptyline and paroxetine in older depressed inpatients and outpatients
    B H Mulsant
    Intervention Research Center for the Study of Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Am J Geriatr Psychiatry 9:406-14. 2001
    ....
  11. ncbi request reprint Comparison of paroxetine and nortriptyline in depressed patients with ischemic heart disease
    S P Roose
    Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    JAMA 279:287-91. 1998
    ..Patients with heart disease need a safe and effective treatment for depression...
  12. ncbi request reprint Dual-task performance in depressed geriatric patients
    R D Nebes
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Psychiatry Res 102:139-51. 2001
    ....
  13. ncbi request reprint Paroxetine versus nortriptyline in the continuation and maintenance treatment of depression in the elderly
    G M Bump
    Intervention Research Center for Late-Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Depress Anxiety 13:38-44. 2001
    ..Paroxetine and nortriptyline demonstrated similar efficacy in relapse and recurrence prevention in elderly depressed patients over an 18-month period...
  14. ncbi request reprint Pharmacologic profile of perphenazine's metabolites
    R A Sweet
    Geriatric Psychopharmacology, Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania, USA
    J Clin Psychopharmacol 20:181-7. 2000
    ..Further exploration of atypical properties of DAPZ should include de novo administration of this metabolite in animal models...
  15. ncbi request reprint The 5-HTTPR*S/*L polymorphism and aggressive behavior in Alzheimer disease
    D L Sukonick
    Division of Geriatrics and Neuropsychiatry, Department of Psychiatry, University of Pittsburgh, PA, USA
    Arch Neurol 58:1425-8. 2001
    ....
  16. ncbi request reprint Catechol-O-methyltransferase haplotypes are associated with psychosis in Alzheimer disease
    R A Sweet
    Division of Geriatrics and Neuropsychiatry, Department of Psychiatry, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Mol Psychiatry 10:1026-36. 2005
    ..Examination of variation at ERE6 in subjects with schizophrenia, and further examination of the independent and additive effects of variations in COMT on gene expression, is warranted...
  17. ncbi request reprint Three-year outcomes of maintenance nortriptyline treatment in late-life depression: a study of two fixed plasma levels
    C F Reynolds
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA 15213, USA
    Am J Psychiatry 156:1177-81. 1999
    ..This study compared the long-term efficacy of two fixed plasma levels of nortriptyline in preventing or delaying recurrence of major depression in elderly patients and in minimizing residual depressive symptoms and somatic complaints...
  18. ncbi request reprint The effects of perphenazine on the concentration of nortriptyline and its hydroxymetabolites in older patients
    B H Mulsant
    Geriatric Psychopharmacology Program, Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
    J Clin Psychopharmacol 17:318-21. 1997
    ....
  19. ncbi request reprint Methodological issues in characterizing treatment response in demented patients with behavioral disturbances
    B H Mulsant
    Department of Psychiatry, University of Pittsburgh, PA, USA
    Int J Geriatr Psychiatry 12:537-47. 1997
    ....
  20. ncbi request reprint Polymorphism of the serotonin transporter: implications for the use of selective serotonin reuptake inhibitors
    F E Lotrich
    Department of Psychiatry, Western Psychiatric Institute and Clinics, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    Am J Pharmacogenomics 1:153-64. 2001
    ..Findings both supporting and inconsistent with these conclusions are reviewed. The clinical effects of the polymorphisms may be associated with effects on platelets, neural 5-HTT levels, and indices of serotonergic function...
  21. ncbi request reprint Allelic variation in the serotonin transporter promoter affects onset of paroxetine treatment response in late-life depression
    B G Pollock
    Intervention Research Center for Late Life Mood Disorders and the Geriatric Psychopharmacology Program, Graduate School of Public Health, Pittsburgh, PA 15213, USA
    Neuropsychopharmacology 23:587-90. 2000
    ..Onset of response to nortriptyline was not affected. Allelic variation of 5-HTTLPR may contribute to the variable initial response of patients treated with a selective serotonin reuptake inhibitor...
  22. ncbi request reprint Anticholinergic differences among patients receiving standard clinical doses of olanzapine or clozapine
    K N Chengappa
    Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pennsylvania 15213 2593, USA
    J Clin Psychopharmacol 20:311-6. 2000
    ..However, none of the patients in either group expressed any desire to discontinue these medications as a result of the anticholinergic side effects...
  23. ncbi request reprint Alterations of striatal dopamine receptor binding in Alzheimer disease are associated with Lewy body pathology and antemortem psychosis
    R A Sweet
    University of Pittsburgh, Division of Geriatrics and Neuropsychiatry, Western Psychiatric Institute and Clinic, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Arch Neurol 58:466-72. 2001
    ..Lewy bodies (LB) are present in at least 20% to 30% of persons with Alzheimer disease (AD) and contribute to the risk of psychosis and to excess cognitive burden...
  24. ncbi request reprint Selective serotonin reuptake inhibitors for late-life depression: a comparative review
    L K Solai
    University of Pittsburgh School of Medicine, Pennsylvania, USA
    Drugs Aging 18:355-68. 2001
    ....
  25. ncbi request reprint Treatment of nortriptyline's side effects in elderly patients: a double-blind study of bethanechol
    J Rosen
    Department of Psychiatry, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213
    Am J Psychiatry 150:1249-51. 1993
    ..The potential use of bethanechol in older patients to reduce morbidity and improve compliance with medication regimens is discussed...
  26. ncbi request reprint Endogenous concentrations of DHEA and DHEA-S decrease with remission of depression in older adults
    T J Fabian
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pennsylvania 15261, USA
    Biol Psychiatry 50:767-74. 2001
    ..CONCLUSIONS: Our data suggest that the decrease in DHEA and DHEA-S in remitters is related to remission of depression rather than to a direct drug effect on steroids, as nonremitters had no change in hormone concentrations...
  27. ncbi request reprint Nortriptyline in the hospitalized elderly: tolerance and side effect reduction
    J Rosen
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, PA 15213
    Psychopharmacol Bull 29:327-31. 1993
    ..Patients receiving bethanechol had reduced subjective complaints of anticholinergic side effects and showed improvement on an objective measure of salivary flow...
  28. ncbi request reprint Antipsychotics in older patients. A safety perspective
    B G Pollock
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pennsylvania, USA
    Drugs Aging 6:312-23. 1995
    ..Prospective and frequent assessments for adverse effects are also essential...
  29. ncbi request reprint Reduced binding of [18F]altanserin to serotonin type 2A receptors in aging: persistence of effect after partial volume correction
    C C Meltzer
    Department of Radiology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Brain Res 813:167-71. 1998
    ..This finding, which is consistent with prior postmortem and in vivo studies, has both etiological and potential therapeutic implications for behavioral changes commonly observed in the elderly, including geriatric depression...
  30. ncbi request reprint Cognitive and psychomotor effects of paroxetine and sertraline on healthy elderly volunteers
    P M Furlan
    Department of Psychiatry, University of Pennsylvania, 3600 Market St, Philadelphia, PA 19104, USA
    Am J Geriatr Psychiatry 9:429-38. 2001
    ..Plasma sertraline levels were associated with mild and transient behavioral changes, as well as early termination in several subjects...
  31. ncbi request reprint Antipsychotic radioreceptor assay: a modification identifying selective receptor effects
    R A Sweet
    Geriatric Psychopharmacology Program, Division of Geriatrics and Neuropsychiatry, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Ther Drug Monit 23:421-6. 2001
    ..Valid receptor-selective antipsychotic assays can be established and may have utility for dissecting the in vivo activity of atypical antipsychotics in relation to specific outcomes in clinical trials...
  32. ncbi request reprint Serum anticholinergic activity, white matter hyperintensities, and cognitive performance
    R D Nebes
    Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Neurology 65:1487-9. 2005
    ....
  33. ncbi request reprint Prevalence and risk of thrombocytopenia with valproic acid: experience at a psychiatric teaching hospital
    E L Conley
    School of Pharmacy, University of Pittsburgh, PA 16261, USA
    Pharmacotherapy 21:1325-30. 2001
    ..001) were identified as significant risk factors for developing thrombocytopenia. CONCLUSION: The estimated prevalence of thrombocytopenia is 12% in the general psychiatric population receiving VPA, with the elderly at greatest risk...
  34. ncbi request reprint Correlates of anticholinergic activity in patients with dementia and psychosis treated with risperidone or olanzapine
    Benoit H Mulsant
    Western Psychiatric Institute and Clinic, Department of Psychiatry, Division of Geriatric Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Clin Psychiatry 65:1708-14. 2004
    ..Older individuals with dementia are highly sensitive to the effects of muscarinic receptor blockade...
  35. ncbi request reprint Development of a short form of the Severe Impairment Battery
    Judith Saxton
    Univ of Pittsburgh, Pittsburgh, PA, USA
    Am J Geriatr Psychiatry 13:999-1005. 2005
    ..The authors sought to develop a short form of the Severe Impairment Battery (SIB)...
  36. ncbi request reprint Aging and clinical pharmacology: implications for antidepressants
    Francis E Lotrich
    Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    J Clin Pharmacol 45:1106-22. 2005
    ..The authors review these age-associated differences and discuss their implications for antidepressant use in older adults...
  37. ncbi request reprint Population pharmacokinetics as a method to detect variable risperidone exposure in patients suffering from dementia with behavioral disturbances
    Robert R Bies
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Am J Geriatr Pharmacother 3:87-91. 2005
    ..This study was intended to compare the consistency of risperidone exposure in patients who have dementia and behavioral disturbances treated in a psychiatric hospital versus a community care setting...
  38. ncbi request reprint Comorbid anxiety disorder in late life depression: association with memory decline over four years
    Alison K DeLuca
    The Intervention Research Center for Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Int J Geriatr Psychiatry 20:848-54. 2005
    ..The purpose of this study was to determine whether comorbid GAD or PD was associated with poorer long-term outcomes of late-life MDD, in terms of symptoms, functional disability, and cognitive status...
  39. ncbi request reprint Dextromethorphan-induced delirium and possible methadone interaction
    Francis E Lotrich
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    Am J Geriatr Pharmacother 3:17-20. 2005
    ..It is metabolized primarily by the cytochrome P450 (CYP) 2D6 isozyme. Methadone has been found to inhibit CYP2D6, indicating a potential for interaction with dextromethorphan...
  40. ncbi request reprint The metabolic syndrome is associated with reduced central serotonergic responsivity in healthy community volunteers
    Matthew F Muldoon
    Division of Clinical Pharmacology, Departments of Medicine and Epidemiology, University of Pittsburgh, 4015 O Hara Street, Pittsburgh, PA 15260, USA
    J Clin Endocrinol Metab 91:718-21. 2006
    ..The pathobiology of the metabolic syndrome remains unclear. The central nervous system is likely to be involved via regulation of eating, physical activity, blood pressure, and metabolism...
  41. ncbi request reprint Late-onset major depression: clinical and treatment-response variability
    Henry C Driscoll
    Intervention Research Center for Late Life Mood Disorders, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Int J Geriatr Psychiatry 20:661-7. 2005
    ..To explore clinical and treatment-response variability in late-onset vs early-onset non-bipolar, non-psychotic major depression...
  42. ncbi request reprint Association of the serotonin transporter gene-linked polymorphic region (5-HTTLPR) genotype with depression in elderly persons after hip fracture
    Eric J Lenze
    Intervention Research Center for the Study of Late Life Mood Disorders, Department of Psychiatry, University of Pittsburg School of Medicine, Pittsburgh, PA, USA
    Am J Geriatr Psychiatry 13:428-32. 2005
    ..The authors examined the serotonin transporter gene-linked polymorphic region (5-HTTLPR) as a predictor of major depressive disorder and depressive symptoms after hip fracture, a common stressful medical event...
  43. ncbi request reprint Accelerating symptom-reduction in late-life depression: a double-blind, randomized, placebo-controlled trial of sleep deprivation
    Charles F Reynolds
    Intervention Research Center for Late Life Mood Disorders IRC LLMD, Univ of Pittsburgh School of Medicine, 3811 O Hara Street, E 113521, Pittsburgh, PA 15213, USA
    Am J Geriatr Psychiatry 13:353-8. 2005
    ..Authors tested the hypothesis that one night of total sleep deprivation (TSD) would accelerate antidepressant response to paroxetine, as compared with TSD+placebo (PBO) and paroxetine-alone, in late-life major depression...
  44. ncbi request reprint Does education moderate neuropsychological impairment in late-life depression?
    Rishi K Bhalla
    Intervention Research Center for the Study of Late Life Mood Disorders, Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, PA 15213, USA
    Int J Geriatr Psychiatry 20:413-7. 2005
    ..This study examined whether educational level influences the degree of neuropsychological impairment associated with late-life depression...
  45. ncbi request reprint Serum anticholinergic activity and cognition in patients with moderate-to-severe dementia
    Marci L Chew
    Western Psychiatric Institute and Clinic, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Am J Geriatr Psychiatry 13:535-8. 2005
    ..The authors investigated the association between serum anticholinergic activity (SAA) and cognitive performance in a group of patients with moderate-to-severe dementia...
  46. ncbi request reprint What is the optimal duration of a short-term antidepressant trial when treating geriatric depression?
    Benoit H Mulsant
    Advanced Center in Intervention and Services Research for Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Clin Psychopharmacol 26:113-20. 2006
    ..To determine the optimal duration of an antidepressant trial in elderly patients, the authors examined the probability of eventually responding to treatment based on early improvement...
  47. ncbi request reprint CYP2D6 genotype and venlafaxine-XR concentrations in depressed elderly
    Ellen M Whyte
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, USA
    Int J Geriatr Psychiatry 21:542-9. 2006
    ....
  48. ncbi request reprint A double-blind comparison of citalopram and risperidone for the treatment of behavioral and psychotic symptoms associated with dementia
    Bruce G Pollock
    Rotman Research Institute at Baycrest, Toronto, Ontario, Canada
    Am J Geriatr Psychiatry 15:942-52. 2007
    ..To compare citalopram and risperidone for the treatment of psychotic symptoms and agitation associated with dementia, with a priori hypotheses that risperidone would be more efficacious for psychosis and citalopram for agitation...
  49. ncbi request reprint Maintenance treatment for old-age depression preserves health-related quality of life: a randomized, controlled trial of paroxetine and interpersonal psychotherapy
    Alexandre Y Dombrovski
    Western Psychiatric Institute and Clinic, Department of Psychiatry, School of Medicine, University of Pittsburgh, Pennsylvania, USA
    J Am Geriatr Soc 55:1325-32. 2007
    ..To determine whether maintenance antidepressant pharmacotherapy and interpersonal psychotherapy sustain gains in health-related quality of life (HR-QOL) achieved during short-term treatment in older patients with depression...
  50. pmc Depression following pegylated interferon-alpha: characteristics and vulnerability
    Francis E Lotrich
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    J Psychosom Res 63:131-5. 2007
    ..The first objective was to further characterize this depression and, secondly, to examine whether pre-treatment temperament was correlated with subsequent vulnerability to IFN-alpha...
  51. ncbi request reprint Recovery from major depression in older adults receiving augmentation of antidepressant pharmacotherapy
    Mary Amanda Dew
    Department of Psychiatry, University of Pittsburgh School of Medicine and Western Psychiatric Institute and Clinic, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Am J Psychiatry 164:892-9. 2007
    ..The authors examined likelihood, speed, and predictors of recovery in older adults receiving augmentation pharmacotherapy after inadequate response to standardized treatment with paroxetine plus interpersonal psychotherapy...
  52. ncbi request reprint Effect of comorbid anxiety on treatment response and relapse risk in late-life depression: controlled study
    Carmen Andreescu
    Western Psychiatric Institute and Clinic, 3811 O Hara Street, Room E 823, Pittsburgh, PA15213, USA
    Br J Psychiatry 190:344-9. 2007
    ..Comorbid anxiety is common in depressive disorders in both middle and late life, and it affects response to antidepressant treatment...
  53. ncbi request reprint Serum anticholinergic activity and motor performance in elderly persons
    Robert D Nebes
    Department of Psychiatry, University of Pittsburgh Medical Center, Pennsylvania, USA
    J Gerontol A Biol Sci Med Sci 62:83-5. 2007
    ..Medications prescribed to elderly persons often have an anticholinergic effect, as do many commonly used over-the-counter drugs. Anticholinergic medications are known to produce psychomotor slowing, especially in older persons...
  54. ncbi request reprint Paroxetine treatment of primary insomnia in older adults
    Charles F Reynolds
    Advanced Center for Interventions and Services Research for Late Life Mood Disorders ACISR LLMD and the John A Hartford Center of Excellence in Geriatric Psychiatry, Western Psychiatric Institute and Clinic, Pittsburgh, PA, USA
    Am J Geriatr Psychiatry 14:803-7. 2006
    ..The goal of this study was to test the efficacy of paroxetine for primary insomnia in older adults...
  55. ncbi request reprint Cardiovascular changes associated with venlafaxine in the treatment of late-life depression
    Ellyn M Johnson
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Am J Geriatr Psychiatry 14:796-802. 2006
    ..Potential cardiovascular side effects from venlafaxine-XR must be considered when prescribing this medication, especially in geriatric patients, who often present with comorbid medical conditions...
  56. ncbi request reprint Emergence, persistence, and resolution of suicidal ideation during treatment of depression in old age
    Katalin Szanto
    University of Pittsburgh School of Medicine, Department of Psychiatry, Pittsburgh, Pennsylvania 15213, United States
    J Affect Disord 98:153-61. 2007
    ..To determine the rate and clinical correlates of emergent, persistent, and resolved suicidal ideation during treatment of major depression in the elderly...
  57. ncbi request reprint A model of anticholinergic activity of atypical antipsychotic medications
    Marci L Chew
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Schizophr Res 88:63-72. 2006
    ..However, it is difficult with the available data to predict the likelihood of anticholinergic effects occurring with various doses of an atypical antipsychotic...
  58. ncbi request reprint Persistence of neuropsychologic deficits in the remitted state of late-life depression
    Rishi K Bhalla
    Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Am J Geriatr Psychiatry 14:419-27. 2006
    ..Cognitive impairment in late-life depression (LLD) is prevalent, disabling, and persists despite the remission of depressive symptoms. This article characterizes neuropsychologic functioning during remission in LLD...
  59. pmc Paroxetine: population pharmacokinetic analysis in late-life depression using sparse concentration sampling
    Yan Feng
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, PA 15261, USA, and Rotman Research Institute, Baycrest Hospital, University of Toronto, Canada
    Br J Clin Pharmacol 61:558-69. 2006
    ..To develop a population pharmacokinetic (PK) model using sparse sampling of long-term treatment with paroxetine in elderly depressed subjects, incorporating CYP2D6 genotype as well as other covariates...
  60. ncbi request reprint Outcomes of late-life anxiety disorders during 32 weeks of citalopram treatment
    Stephen Blank
    Intervention Research Center for Late Life Mood Disorders, The Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Clin Psychiatry 67:468-72. 2006
    ..Anxiety disorders are common in later life, but little is known about the long-term benefits and risks of pharmacotherapy...
  61. doi request reprint Sex, race, and smoking impact olanzapine exposure
    Kristin L Bigos
    Department of Pharmaceutical Sciences, University of Pittsburgh, School of Pharmacy, 805 Salk Hall, 3501 Terrace St, Pittsburgh, PA 15261, USA
    J Clin Pharmacol 48:157-65. 2008
    ..0001). Differences in olanzapine exposure due to sex, race, and smoking may account for some of the variability in response to olanzapine...
  62. ncbi request reprint Efficacy and tolerability of citalopram in the treatment of late-life anxiety disorders: results from an 8-week randomized, placebo-controlled trial
    Eric J Lenze
    Intervention Research Center for Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine and VA Healthcare System, PA, USA
    Am J Psychiatry 162:146-50. 2005
    ..Anxiety disorders are highly prevalent in elderly persons. However, to date, the efficacy of selective serotonin reuptake inhibitors (SSRIs) for the treatment of anxiety disorders in this age group has not been established...
  63. ncbi request reprint Estimating treatment effects from longitudinal clinical trial data with missing values: comparative analyses using different methods
    Patricia R Houck
    Department of Psychiatry, University of Pittsburgh, Western Psychiatric Institute and Clinic, UPMC Health System, Thomas Detre Hall, 3811 O Hara Street, Pittsburgh, PA 15213 2593, USA
    Psychiatry Res 129:209-15. 2004
    ..No significant treatment differences were found. We conclude that attention to the missing-data mechanism should be an integral part in analysis of clinical trial data...
  64. ncbi request reprint Paroxetine-induced hyponatremia in the elderly due to the syndrome of inappropriate secretion of antidiuretic hormone (SIADH)
    Tanya J Fabian
    Intervention Research Center for Late Life Mood Disorders, USA
    J Geriatr Psychiatry Neurol 16:160-4. 2003
    ..Data suggest hyponatremia is a common adverse event in elderly patients prescribed paroxetine and implicates inappropriate secretion of ADH as the potential mechanism...
  65. ncbi request reprint Depression and Bipolar Support Alliance consensus statement on the unmet needs in diagnosis and treatment of mood disorders in late life
    Dennis S Charney
    National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
    Arch Gen Psychiatry 60:664-72. 2003
    ..To review progress made during the past decade in late-life mood disorders and to identify areas of unmet need in health care delivery and research...
  66. ncbi request reprint Persistence of cognitive impairment in geriatric patients following antidepressant treatment: a randomized, double-blind clinical trial with nortriptyline and paroxetine
    Robert D Nebes
    Intervention Research Center for the Study of Late Life Mood Disorders, Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    J Psychiatr Res 37:99-108. 2003
    ..The present results suggest that cognitive dysfunction persists in older depressed patients even after their mood disorder has responded to antidepressant medications...
  67. ncbi request reprint Apathy and executive function in depressed elderly
    Robert S Marin
    The Intervention Research Center for the Study of Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania, USA
    J Geriatr Psychiatry Neurol 16:112-6. 2003
    ..Correlations may have been reduced by low variance for the variables of interest and by psychometric limitations of the ApHRSD...
  68. ncbi request reprint Serotonin transporter promoter polymorphism in African Americans : allele frequencies and implications for treatment
    Francis E Lotrich
    Department of Psychiatry, Western Psychiatric Institute and Clinics, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    Am J Pharmacogenomics 3:145-7. 2003
    ....
  69. ncbi request reprint Serum anticholinergic activity in a community-based sample of older adults: relationship with cognitive performance
    Benoit H Mulsant
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
    Arch Gen Psychiatry 60:198-203. 2003
    ..To our knowledge, there has not yet been any systematic study of the prevalence of SAA and its effect on cognition in a community-based population...
  70. ncbi request reprint Influence of DHEA administration on 24-hour cortisol concentrations
    Patricia D Kroboth
    Pharmacodynamic Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Clin Psychopharmacol 23:96-9. 2003
    ..0001) and on Day 15 in men (p = 0.002). The mechanism by which DHEA lowers plasma cortisol concentrations merits further investigation...
  71. ncbi request reprint Risk factors for falls during treatment of late-life depression
    Jin H Joo
    Intervention Research Center for Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
    J Clin Psychiatry 63:936-41. 2002
    ..This study evaluated the time course and potential risk factors for falls in a treatment protocol for late-life depression to identify specific at-risk periods and risk factors for falls in this population...
  72. ncbi request reprint Response speed and rate of remission in primary and specialty care of elderly patients with depression
    Leslie Thomas
    Intervention Research Center for Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Am J Geriatr Psychiatry 10:583-91. 2002
    ....
  73. ncbi request reprint Glucose metabolic response to total sleep deprivation, recovery sleep, and acute antidepressant treatment as functional neuroanatomic correlates of treatment outcome in geriatric depression
    Gwenn S Smith
    Department of Psychiatry Research, Hillside Hospital of the North Shore Long Island Jewish Health System, 75 59 263rd Street, Glen Oaks, NY 11004, USA
    Am J Geriatr Psychiatry 10:561-7. 2002
    ....
  74. ncbi request reprint Serotonin modulation of cerebral glucose metabolism measured with positron emission tomography (PET) in human subjects
    Gwenn S Smith
    Department of Psychiatry Research, Hillside Hospital, Neuroscience Institute of the North Shore Long Island Jewish Health System, Glen Oaks, New York 11004, USA
    Synapse 45:105-12. 2002
    ..Future studies will evaluate how the acute metabolic response to citalopram relates to the metabolic response after chronic treatment in patients with geriatric depression...
  75. ncbi request reprint Course and rate of antidepressant response in the very old
    Ariel G Gildengers
    The Intervention Research Centers for Late Life and Mid Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Affect Disord 69:177-84. 2002
    ..The authors examined elderly patients with major depression to determine the relationship of current age to treatment response course and success rate...
  76. ncbi request reprint Risperidone and 9-hydroxyrisperidone concentrations are not dependent on age or creatinine clearance among elderly subjects
    Rae Ann Maxwell
    Pharmacy Department, Western Psychiatric Institute and Clinic, VA Pittsburgh Health System, Pennsylvania, USA
    J Geriatr Psychiatry Neurol 15:77-81. 2002
    ..These results were unchanged when concentrations were corrected for total daily risperidone dose. Among elderly subjects, risperidone and 9-OH clearance do not decline with increasing age or declining CrCl...
  77. ncbi request reprint Gender differences in the pharmacokinetics and pharmacodynamics of antidepressants
    Robert R Bies
    Department of Pharmaceutical Sciences, 805 Salk Hall, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Gend Specif Med 6:12-20. 2003
    ..Given the evidence of distinct gender-specific differences, it is critical that these differences be addressed more widely in research evaluating the administration of antidepressants in women...
  78. ncbi request reprint Good treatment outcomes in late-life depression with comorbid anxiety
    Eric J Lenze
    The Intervention Research Center in Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Affect Disord 77:247-54. 2003
    ..This study evaluated the impact of comorbid anxiety on response, dropouts, and side effects, in elderly subjects treated for depression...
  79. ncbi request reprint alpha1-acid glycoprotein in late-life depression: relationship to medical burden and genetics
    Opeolu M Adeoye
    Department of Emergency Medicine, University of Cincinnati, Cincinnati, Ohio, USA
    J Geriatr Psychiatry Neurol 16:235-9. 2003
    ..Frequency differences in ORM1 allelic variants apparently did not influence increased AAG concentrations in depressed patients...
  80. ncbi request reprint Antidepressant pharmacotherapy in the treatment of depression in the very old: a randomized, placebo-controlled trial
    Steven P Roose
    New York State Psychiatric Institute, 1051 Riverside Drive, New York, NY 10032, USA
    Am J Psychiatry 161:2050-9. 2004
    ..This study determined the efficacy of antidepressant medication for the treatment of depression in the "old-old."..
  81. ncbi request reprint Neuroendocrine response to intravenous citalopram in healthy control subjects: pharmacokinetic influences
    Francis E Lotrich
    Department of Psychiatry, Western Psychiatric Institute and Clinic, Pittsburgh, PA, USA
    Psychopharmacology (Berl) 178:268-75. 2005
    ..The neuroendocrine response to intravenous citalopram may provide an acute, functional, in vivo measure of the neural serotonin (5-HT) system...
  82. ncbi request reprint Neuropathologic correlates of late-onset major depression
    Robert A Sweet
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Neuropsychopharmacology 29:2242-50. 2004
    ..These preliminary findings suggest that AD is the predominant neuropathologic condition in LLMD subjects with dementia. Further assessment of the role of comorbid cerebrovascular disease and comorbid DLB is needed...
  83. ncbi request reprint Effects of serotonin transporter promoter polymorphisms on serotonin function
    Gwenn S Smith
    Department of Psychiatry, The Zucker Hillside Hospital, Glen Oaks, NY 11004, USA
    Neuropsychopharmacology 29:2226-34. 2004
    ....
  84. ncbi request reprint Meta-analysis of serotonin transporter polymorphisms and affective disorders
    Francis E Lotrich
    Department of Psychiatry, University of Pittsburgh Medical Center, Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania, USA
    Psychiatr Genet 14:121-9. 2004
    ..These factors should Influence the interpretation of the association found in this analysis...
  85. ncbi request reprint Executive functioning, illness course, and relapse/recurrence in continuation and maintenance treatment of late-life depression: is there a relationship?
    Meryl A Butters
    Intervention Research Center for Late Life Mood Disorders, Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh Medical Center, USA
    Am J Geriatr Psychiatry 12:387-94. 2004
    ..The authors tested the hypothesis that impaired executive functioning leads to high rates of relapse and recurrence in late-life depression...
  86. ncbi request reprint The nature and determinants of neuropsychological functioning in late-life depression
    Meryl A Butters
    Department of Psychiatry, University of Pittsburgh Medical Center, PA, USA
    Arch Gen Psychiatry 61:587-95. 2004
    ..Cognitive impairment in late-life depression (LLD) is highly prevalent, disabling, poorly understood, and likely related to long-term outcome...
  87. ncbi request reprint Achieving long-term optimal outcomes in geriatric depression and anxiety
    Benoit H Mulsant
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    CNS Spectr 8:27-34. 2003
    ....
  88. ncbi request reprint Treatment considerations for anxiety in the elderly
    Eric J Lenze
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    CNS Spectr 8:6-13. 2003
    ..Overall, the research in late-life anxiety has not caught up to the literature in late-life depression and, for the most part, treatment recommendations must be extrapolated from studies in young adults...
  89. ncbi request reprint Paroxetine-induced hyponatremia in older adults: a 12-week prospective study
    Tanya J Fabian
    Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Arch Intern Med 164:327-32. 2004
    ....
  90. ncbi request reprint Serotonin modulation of cerebral glucose metabolism in normal aging
    Sara Goldberg
    Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, 75 59 263rd Street, Glen Oaks, NY 11004, USA
    Neurobiol Aging 25:167-74. 2004
    ..These results suggest different compensatory processes in anterior compared to posterior brain regions secondary to the age-related loss of serotonin innervation...
  91. ncbi request reprint Plasma levels of citalopram in depressed patients with hepatitis C
    Ondria C Gleason
    Department of Psychiatry, University of Oklahoma College of Medicine Tulsa, 74135 2512, USA
    Psychosomatics 45:29-33. 2004
    ....
  92. ncbi request reprint APOE is associated with age-of-onset, but not cognitive functioning, in late-life depression
    Meryl A Butters
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Int J Geriatr Psychiatry 18:1075-81. 2003
    ..We also predicted that APOE4 allele frequency would be increased among subjects with LLD...
  93. ncbi request reprint Effects of nortriptyline and paroxetine on postural sway in depressed elderly patients
    David C Mamo
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
    Am J Geriatr Psychiatry 10:199-205. 2002
    ..Further studies with other SSRIs are needed...