Toni I Pollin

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. pmc PedHunter 2.0 and its usage to characterize the founder structure of the Old Order Amish of Lancaster County
    Woei Jyh Lee
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland 20894, USA
    BMC Med Genet 11:68. 2010
  2. pmc Investigations of the Y chromosome, male founder structure and YSTR mutation rates in the Old Order Amish
    Toni I Pollin
    Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA
    Hum Hered 65:91-104. 2008
  3. ncbi request reprint Linkage of plasma adiponectin levels to 3q27 explained by association with variation in the APM1 gene
    Toni I Pollin
    Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, 660 W Redwood St, Rm 478, Baltimore, MD 21201, USA
    Diabetes 54:268-74. 2005
  4. pmc A null mutation in human APOC3 confers a favorable plasma lipid profile and apparent cardioprotection
    Toni I Pollin
    Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Science 322:1702-5. 2008
  5. ncbi request reprint Polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in the Amish: replication and evidence for a role in both insulin secretion and insulin resistance
    Coleen M Damcott
    Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Diabetes 55:2654-9. 2006
  6. ncbi request reprint Genetic variation in adiponectin receptor 1 and adiponectin receptor 2 is associated with type 2 diabetes in the Old Order Amish
    Coleen M Damcott
    Division of Endocrinology, Diabetesand Nutrition, University of Maryland School of Medicine, 660 West Redwood St, Room 494, Baltimore, MD 21201, USA
    Diabetes 54:2245-50. 2005
  7. ncbi request reprint Variation in the lamin A/C gene: associations with metabolic syndrome
    Nanette I Steinle
    Department of Medicine, University of Maryland School of Medicine, Baltimore 21201, USA
    Arterioscler Thromb Vasc Biol 24:1708-13. 2004
  8. pmc Genetic variation in PEAR1 is associated with platelet aggregation and cardiovascular outcomes
    Joshua P Lewis
    Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Circ Cardiovasc Genet 6:184-92. 2013
  9. pmc Genome-wide association scan identifies variants near Matrix Metalloproteinase (MMP) genes on chromosome 11q21-22 strongly associated with serum MMP-1 levels
    Yu Ching Cheng
    Division of Endocrinology, Diabetes and Nutrition, School of Medicine, University of Maryland, Baltimore, MD, USA
    Circ Cardiovasc Genet 2:329-37. 2009
  10. ncbi request reprint A genome-wide linkage scan of insulin level derived traits: the Amish Family Diabetes Study
    Wen Chi Hsueh
    Department of Medicine, School of Medicine, University of California, San Francisco, California, USA
    Diabetes 56:2643-8. 2007

Detail Information

Publications56

  1. pmc PedHunter 2.0 and its usage to characterize the founder structure of the Old Order Amish of Lancaster County
    Woei Jyh Lee
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland 20894, USA
    BMC Med Genet 11:68. 2010
    ..In addition, we developed PedHunter, a suite of query software that can solve pedigree-related problems automatically and systematically...
  2. pmc Investigations of the Y chromosome, male founder structure and YSTR mutation rates in the Old Order Amish
    Toni I Pollin
    Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA
    Hum Hered 65:91-104. 2008
    ..Using Y chromosome short tandem repeat (YSTR) genotypes, (1) evaluate the accuracy and completeness of the Lancaster County Old Order Amish (OOA) genealogical records and (2) estimate YSTR mutation rates...
  3. ncbi request reprint Linkage of plasma adiponectin levels to 3q27 explained by association with variation in the APM1 gene
    Toni I Pollin
    Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, 660 W Redwood St, Rm 478, Baltimore, MD 21201, USA
    Diabetes 54:268-74. 2005
    ..51 LOD units (to 0.71). These findings, combined with a two-point LOD score of 2.35 for SNP +2019, provide evidence that variation in APM1 is responsible for linkage of adiponectin levels to 3q27 in the Old Order Amish...
  4. pmc A null mutation in human APOC3 confers a favorable plasma lipid profile and apparent cardioprotection
    Toni I Pollin
    Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Science 322:1702-5. 2008
    ..Subclinical atherosclerosis, as measured by coronary artery calcification, was less common in carriers than noncarriers, which suggests that lifelong deficiency of apoC-III has a cardioprotective effect...
  5. ncbi request reprint Polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in the Amish: replication and evidence for a role in both insulin secretion and insulin resistance
    Coleen M Damcott
    Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Diabetes 55:2654-9. 2006
    ..04 and P = 0.007, respectively). These data provide replicating evidence that variants in TCF7L2 increase the risk for type 2 diabetes and novel evidence that the variants likely influence both insulin secretion and insulin sensitivity...
  6. ncbi request reprint Genetic variation in adiponectin receptor 1 and adiponectin receptor 2 is associated with type 2 diabetes in the Old Order Amish
    Coleen M Damcott
    Division of Endocrinology, Diabetesand Nutrition, University of Maryland School of Medicine, 660 West Redwood St, Room 494, Baltimore, MD 21201, USA
    Diabetes 54:2245-50. 2005
    ..001; OR 1.64-1.71). To our knowledge, these data provide the first evidence for association between variation in the adiponectin receptors and type 2 diabetes...
  7. ncbi request reprint Variation in the lamin A/C gene: associations with metabolic syndrome
    Nanette I Steinle
    Department of Medicine, University of Maryland School of Medicine, Baltimore 21201, USA
    Arterioscler Thromb Vasc Biol 24:1708-13. 2004
    ..To determine whether polymorphisms in LMNA influence susceptibility to metabolic syndrome and its constituent components...
  8. pmc Genetic variation in PEAR1 is associated with platelet aggregation and cardiovascular outcomes
    Joshua P Lewis
    Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Circ Cardiovasc Genet 6:184-92. 2013
    ..Clinical Trial Registration- URL: http://www.clinicaltrials.gov. Unique identifiers: NCT00799396 and NCT00370045...
  9. pmc Genome-wide association scan identifies variants near Matrix Metalloproteinase (MMP) genes on chromosome 11q21-22 strongly associated with serum MMP-1 levels
    Yu Ching Cheng
    Division of Endocrinology, Diabetes and Nutrition, School of Medicine, University of Maryland, Baltimore, MD, USA
    Circ Cardiovasc Genet 2:329-37. 2009
    ..Matrix metalloproteinase (MMP)-1 may play a role in cardiovascular disease susceptibility by influencing plaque rupture via its ability to degrade extracellular collagens...
  10. ncbi request reprint A genome-wide linkage scan of insulin level derived traits: the Amish Family Diabetes Study
    Wen Chi Hsueh
    Department of Medicine, School of Medicine, University of California, San Francisco, California, USA
    Diabetes 56:2643-8. 2007
    ..The goal of our study was to identify chromosomal regions that are likely to harbor genetic determinants of these traits...
  11. pmc Triglyceride response to an intensive lifestyle intervention is enhanced in carriers of the GCKR Pro446Leu polymorphism
    Toni I Pollin
    Division of Endocrinology, Diabetes, and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland21201, USA
    J Clin Endocrinol Metab 96:E1142-7. 2011
    ..OBJECTIVE, SETTING, AND PATIENTS: We sought to replicate these associations and evaluate interactions with lifestyle and metformin interventions in the multiethnic Diabetes Prevention Program (DPP)...
  12. ncbi request reprint Polymorphisms in both promoters of hepatocyte nuclear factor 4-alpha are associated with type 2 diabetes in the Amish
    Coleen M Damcott
    Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Diabetes 53:3337-41. 2004
    ..022; dominant model, P = 0.010). The results of this study provide evidence that variants in both the P1 and P2 promoters of HNF4A increase risk for typical type 2 diabetes...
  13. pmc Glucokinase regulatory protein gene polymorphism affects postprandial lipemic response in a dietary intervention study
    Haiqing Shen
    Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, 660 West Redwood Street, Rm 494, Baltimore, MD 21201, USA
    Hum Genet 126:567-74. 2009
    ..03). Our data indicate that the rs1260326 T allele of GCKR is associated with both higher fasting levels of TG as well as the postprandial TG response, which may result in higher atherogenic risk...
  14. ncbi request reprint Polymorphism in the calsequestrin 1 (CASQ1) gene on chromosome 1q21 is associated with type 2 diabetes in the old order Amish
    Mao Fu
    Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Diabetes 53:3292-9. 2004
    ..These findings, coupled with similar findings in Utah Caucasians, suggest that sequence variation in CASQ1 may influence risk of type 2 diabetes...
  15. pmc Physical activity and the association of common FTO gene variants with body mass index and obesity
    Evadnie Rampersaud
    Department of Medicine, University of Maryland, Baltimore, USA
    Arch Intern Med 168:1791-7. 2008
    ..The role of lifestyle factors (such as physical activity) in those with an underlying FTO genetic predisposition is unknown...
  16. ncbi request reprint Variants in the ghrelin gene are associated with metabolic syndrome in the Old Order Amish
    Nanette I Steinle
    Department of Medicine, University of Maryland, Baltimore, Maryland 21201, USA
    J Clin Endocrinol Metab 90:6672-7. 2005
    ..Its gene, GHRL, is located on chromosome 3 in a region where we have shown linkage to eating behavior, percentage body fat, and total and low-density lipoprotein cholesterol levels in subjects of the Amish Family Diabetes Study...
  17. pmc Extension of type 2 diabetes genome-wide association scan results in the diabetes prevention program
    Allan F Moore
    Center for Human Genetic Research, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA
    Diabetes 57:2503-10. 2008
    ....
  18. ncbi request reprint Does having children extend life span? A genealogical study of parity and longevity in the Amish
    Patrick F McArdle
    Department of Epidemiology and Preventive Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Gerontol A Biol Sci Med Sci 61:190-5. 2006
    ..We evaluated this issue by using genealogical data from an Old Order Amish community in Lancaster, Pennsylvania, a population characterized by large nuclear families, homogeneous lifestyle, and extensive genealogical records...
  19. ncbi request reprint Exploring the genetics of longevity in the Old Order Amish
    John Sorkin
    Department of Medicine, University of Maryland, School of Medicine, Baltimore, MD 21201, USA
    Mech Ageing Dev 126:347-50. 2005
    ..In this article, we describe our strategy for identifying variants in genes that influence longevity in the Amish and present the results of our studies to date...
  20. pmc Living the good life? Mortality and hospital utilization patterns in the Old Order Amish
    Braxton D Mitchell
    Department of Medicine, Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, USA
    PLoS ONE 7:e51560. 2012
    ....
  21. ncbi request reprint Quantitative trait loci for BMD identified by autosome-wide linkage scan to chromosomes 7q and 21q in men from the Amish Family Osteoporosis Study
    Elizabeth A Streeten
    Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Bone Miner Res 21:1433-42. 2006
    ..Using autosome-wide linkage analysis in 964 Amish, strong evidence was found for the presence of genes affecting hip and spine BMD in men on chromosomes 7q31 and 21q22 (LOD = 4.15 and 3.36, respectively)...
  22. pmc Genetic effects on postprandial variations of inflammatory markers in healthy individuals
    Yu Ching Cheng
    Department of Medicine, Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Obesity (Silver Spring) 18:1417-22. 2010
    ..Genetic factors appear to play a significant role influencing basal inflammatory levels but to have minimal influence on post-fat intake inflammatory changes...
  23. ncbi request reprint The relationship between parity and bone mineral density in women characterized by a homogeneous lifestyle and high parity
    Elizabeth A Streeten
    Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Room N3W130, 22 South Greene Street, Baltimore, Maryland 21201, USA
    J Clin Endocrinol Metab 90:4536-41. 2005
    ..We reported previously that Old Order Amish (OOA) women have fewer hip fractures and higher bone mineral density (BMD) than non-Amish Caucasian women...
  24. ncbi request reprint The exon 1 Cys7Gly polymorphism within the betacellulin gene is associated with type 2 diabetes in African Americans
    Kristi Silver
    Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Diabetes 54:1179-84. 2005
    ..Further studies will be needed to understand the different roles that betacellulin polymorphisms play in susceptibility to type 2 diabetes in Caucasians and African Americans...
  25. ncbi request reprint Reduced incidence of hip fracture in the Old Order Amish
    Elizabeth A Streeten
    Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Bone Miner Res 19:308-13. 2004
    ..The incidence of hip fracture was estimated in a community of Old Order Amish and compared with available data from non-Amish whites. Hip fracture rates were 40% lower in the Amish, and the Amish also experienced higher BMD...
  26. pmc Familial defective apolipoprotein B-100 and increased low-density lipoprotein cholesterol and coronary artery calcification in the old order amish
    Haiqing Shen
    Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Arch Intern Med 170:1850-5. 2010
    ..Elevated low-density lipoprotein cholesterol (LDL-C) levels are a major cardiovascular disease risk factor. Genetic factors are an important determinant of LDL-C levels...
  27. pmc The genetic response to short-term interventions affecting cardiovascular function: rationale and design of the Heredity and Phenotype Intervention (HAPI) Heart Study
    Braxton D Mitchell
    Division of Endocrinology, Department of Medicine, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Am Heart J 155:823-8. 2008
    ..Efforts to identify genes influencing CVD risk have met with limited success to date, likely because of the small effect sizes of common CVD risk alleles and the presence of gene by gene and gene by environment interactions...
  28. pmc Genetic modulation of lipid profiles following lifestyle modification or metformin treatment: the Diabetes Prevention Program
    Toni I Pollin
    Division of Endocrinology, Diabetes, and Nutrition, Department of Medicine, and Program in Genetics and Genomic Medicine, University of Maryland School of Medicine, Baltimore, Maryland, United States of America
    PLoS Genet 8:e1002895. 2012
    ..Our findings suggest that a high genetic burden confers an adverse lipid profile and predicts attenuated response in LDL-C levels and small LDL particle number to dietary and physical activity interventions aimed at weight loss...
  29. ncbi request reprint A genome-wide scan of serum lipid levels in the Old Order Amish
    Toni I Pollin
    Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, 660 W Redwood Street, Room 492, Baltimore, MD 21201, USA
    Atherosclerosis 173:89-96. 2004
    ....
  30. pmc Association of cytochrome P450 2C19 genotype with the antiplatelet effect and clinical efficacy of clopidogrel therapy
    Alan R Shuldiner
    Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, 660 W Redwood St, Room 494, Baltimore, MD 21201, USA
    JAMA 302:849-57. 2009
    ..However, nonresponsiveness is widely recognized and is related to recurrent ischemic events...
  31. ncbi request reprint Evidence that Rho guanine nucleotide exchange factor 11 (ARHGEF11) on 1q21 is a type 2 diabetes susceptibility gene in the Old Order Amish
    Mao Fu
    Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Diabetes 56:1363-8. 2007
    ..These results, coupled with similar findings in Pima Indians, suggest that sequence variation in ARHGEF11 may influence risk of type 2 diabetes...
  32. pmc Osteoporosis-pseudoglioma syndrome: description of 9 new cases and beneficial response to bisphosphonates
    Elizabeth A Streeten
    Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, USA
    Bone 43:584-90. 2008
    ....
  33. ncbi request reprint Eating behavior in the Old Order Amish: heritability analysis and a genome-wide linkage analysis
    Nanette I Steinle
    University of Maryland School of Medicine, Baltimore 21201, USA
    Am J Clin Nutr 75:1098-106. 2002
    ..Eating behavior and thus dietary intake affect the development of obesity-related diseases such as diabetes, hypertension, and hyperlipidemia...
  34. pmc Investigating parent of origin effects in studies of type 2 diabetes and obesity
    Evadnie Rampersaud
    Division of Endocrinology, Diabetes and Nutrition, University of Maryland, Baltimore, MD, USA
    Curr Diabetes Rev 4:329-39. 2008
    ..Through this paper, we hope emphasizes the potentially significant importance of POE in the etiology of T2DM and obesity...
  35. ncbi request reprint Adiponectin levels and genotype: a potential regulator of life span in humans
    Gil Atzmon
    Institute for Aging Research, Diabetes Research and Training Center, Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, NY 10461, USA
    J Gerontol A Biol Sci Med Sci 63:447-53. 2008
    ....
  36. ncbi request reprint Omentin plasma levels and gene expression are decreased in obesity
    Celia M de Souza Batista
    Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Diabetes 56:1655-61. 2007
    ..In summary, decreased omentin levels are associated with increasing obesity and insulin resistance. Therefore, omentin levels may be predictive of the metabolic consequences or co-morbidities associated with obesity...
  37. ncbi request reprint Genome-wide linkage and association analyses to identify genes influencing adiponectin levels: the GEMS Study
    Hua Ling
    Department of Epidemiology and Preventive Medicine, University of Maryland, Baltimore, Maryland, USA
    Obesity (Silver Spring) 17:737-44. 2009
    ..We additionally identified a second gene (CDH13) possibly influencing variation in adiponectin levels. The impact of these SNPs on health and disease has yet to be determined...
  38. ncbi request reprint Association of TLR4 polymorphisms with symptomatic respiratory syncytial virus infection in high-risk infants and young children
    Agnes A Awomoyi
    Department of Microbiology and Immunology, University of Maryland Baltimore, 660 W Redwood Street, Baltimore, MD 21201, USA
    J Immunol 179:3171-7. 2007
    ....
  39. ncbi request reprint A genome-wide scan for autoimmune thyroiditis in the Old Order Amish: replication of genetic linkage on chromosome 5q11.2-q14.3
    Elsie M Allen
    Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Clin Endocrinol Metab 88:1292-6. 2003
    ..01) to autoimmune thyroiditis and/or AITD-hypothyroidism was also detected in five other regions. We conclude that a gene on chromosome 5q11.2-q14.3 is likely to contribute to susceptibility to AITD in the Amish...
  40. pmc Primordial linkage of β2-microglobulin to the MHC
    Yuko Ohta
    Department of Microbiology and Immunology, University of Maryland, Baltimore, MD 21201, USA
    J Immunol 186:3563-71. 2011
    ....
  41. ncbi request reprint Familial aggregation of tobacco use behaviors among amish men
    Katie L Nugent
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD
    Nicotine Tob Res 16:923-30. 2014
    ..Tobacco use in the Old Order Amish community is almost exclusively confined to males...
  42. pmc Single nucleotide polymorphism in toll-like receptor 6 is associated with a decreased risk for ureaplasma respiratory tract colonization and bronchopulmonary dysplasia in preterm infants
    Alexandra H Winters
    Department of Medicine, University of Maryland, Baltimore School of Medicine, Baltimore, MD, USA
    Pediatr Infect Dis J 32:898-904. 2013
    ..We hypothesized that variants in genes regulating the innate immune response are associated with altered risk for Ureaplasma spp. respiratory colonization and BPD in preterm infants...
  43. pmc Seasonality of mood and behavior in the Old Order Amish
    Uttam K Raheja
    Mood and Anxiety Program, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA
    J Affect Disord 147:112-7. 2013
    ..We examined seasonality and winter seasonal affective disorder (SAD) in the Old Order Amish of Lancaster County, Pennsylvania, a unique population that prohibits use of network electric light in their homes...
  44. pmc Menopause and risk of diabetes in the Diabetes Prevention Program
    Catherine Kim
    Department of Medicine, University of Michigan, Ann Arbor, MI, USA
    Menopause 18:857-68. 2011
    ..The study objectives were to examine the association between menopause status and diabetes risk among women with glucose intolerance and to determine if menopause status modifies response to diabetes prevention interventions...
  45. pmc Acute-phase serum amyloid A: an inflammatory adipokine and potential link between obesity and its metabolic complications
    Rong Ze Yang
    Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland, USA
    PLoS Med 3:e287. 2006
    ..However, the molecular and cellular mechanisms that link obesity to chronic inflammation and CVD are poorly understood...
  46. ncbi request reprint Association between a novel variant of the human type 2 deiodinase gene Thr92Ala and insulin resistance: evidence of interaction with the Trp64Arg variant of the beta-3-adrenergic receptor
    Daniela Mentuccia
    Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland, Baltimore, Maryland 21201, USA
    Diabetes 51:880-3. 2002
    ..This variant strongly associates with insulin resistance and, in subjects with the Trp64Arg ADRB3 variant, an increased BMI, suggesting an interaction between these two common gene variants...
  47. pmc Scavenger receptor class B type I protein as an independent predictor of high-density lipoprotein cholesterol levels in subjects with hyperalphalipoproteinemia
    Michael West
    Department of Medicine, Division of Endocrinology and Metabolism, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    J Clin Endocrinol Metab 94:1451-7. 2009
    ..In mice, scavenger receptor class B, type I (SR-BI) receptor protein deficiency is associated with elevated high-density lipoprotein (HDL)-cholesterol (HDL-C) levels...
  48. doi request reprint Direct-to-Consumer genetic testing: what are we talking about?
    Meredith Weaver
    Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD, USA
    J Genet Couns 21:361-6. 2012
    ..It is our hope that genetic counselors in practice will continue to critically evaluate claims made about emerging new tests, including those marketed DTC, in order to provide the best possible services to our patients...
  49. pmc Genomic imprinting in diabetes
    Braxton D Mitchell
    Division of Endocrinology, Diabetes and Nutrition, University of Maryland, 6601 West Redwood Street, Baltimore, MD 21201, USA
    Genome Med 2:55. 2010
    ..We summarize current views on the role of imprinting in diabetes and in particular chromosome 6q24-related transient neonatal diabetes mellitus, the best known example of an imprinted genetic disorder that leads to diabetes...
  50. ncbi request reprint Meta-analysis of genome-wide linkage studies of quantitative lipid traits in families ascertained for type 2 diabetes
    Alka Malhotra
    Diabetes and Obesity Research Unit, Genetic Basis of Human Disease, Translational Genomics Research Institute, 445 N 5th Street, Phoenix, AZ 85004, USA
    Diabetes 56:890-6. 2007
    ....
  51. ncbi request reprint Genome-wide and fine-mapping linkage studies of type 2 diabetes and glucose traits in the Old Order Amish: evidence for a new diabetes locus on chromosome 14q11 and confirmation of a locus on chromosome 1q21-q24
    Wen Chi Hsueh
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas, USA
    Diabetes 52:550-7. 2003
    ..07, P = 0.000085 for HbA(1c) and LOD = 1.50 for glucose 0). In conclusion, our findings provide evidence that type 2 diabetes susceptibility genes reside on chromosomes 1, 14, and 18...
  52. pmc Meta-analysis of 23 type 2 diabetes linkage studies from the International Type 2 Diabetes Linkage Analysis Consortium
    Weihua Guan
    Department of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, Michigan 48109 2029, USA
    Hum Hered 66:35-49. 2008
    ..The International Type 2 Diabetes Linkage Analysis Consortium was formed to localize type 2 diabetes predisposing variants based on 23 autosomal linkage scans...
  53. pmc TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program
    Jose C Florez
    Diabetes Prevention Program Outcomes Study Coordinating Center, George Washington University, Rockville, MD 20852, USA
    N Engl J Med 355:241-50. 2006
    ....
  54. ncbi request reprint Variation within the gene encoding the upstream stimulatory factor 1 does not influence susceptibility to type 2 diabetes in samples from populations with replicated evidence of linkage to chromosome 1q
    Eleftheria Zeggini
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK
    Diabetes 55:2541-8. 2006
    ..These data exclude USF1 as a major contributor to type 2 diabetes susceptibility and the basis for the chromosome 1q linkage. They reveal only limited evidence for replication of USF1 effects on continuous metabolic traits...
  55. ncbi request reprint Hepatic lipase genotype, diabetes risk, and implications for preventative medicine
    Alan R Shuldiner
    J Clin Endocrinol Metab 89:2015-8. 2004