Research Topics
| Daniel A PollardSummaryAffiliation: University of California Country: USA Publications
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Detail Information
Publications
Detecting the limits of regulatory element conservation and divergence estimation using pairwise and multiple alignmentsDaniel A Pollard
Graduate Group in Biophysics, University of California, Berkeley, CA 94720, USA
BMC Bioinformatics 7:376. 2006..Yet how multiple alignment accuracy varies across sequence types, tree topologies, divergences and tools, and further how this variation impacts specific inferences, remains unclear...
Large-scale turnover of functional transcription factor binding sites in DrosophilaAlan M Moses
Graduate Group in Biophysics, University of California Berkeley, Berkeley, California, United States of America
PLoS Comput Biol 2:e130. 2006..Finally, we show that binding-site gains and losses are asymmetrically distributed with respect to D. melanogaster, consistent with lineage-specific acquisition and loss of Zeste-responsive regulatory elements...
MONKEY: identifying conserved transcription-factor binding sites in multiple alignments using a binding site-specific evolutionary modelAlan M Moses
Graduate Group in Biophysics, University of California, Berkeley, CA 94720, USA
Genome Biol 5:R98. 2004..Using genomes from the genus Saccharomyces, we illustrate how the significance of real sites increases with evolutionary distance and explore the relationship between conservation and function...
Widespread discordance of gene trees with species tree in Drosophila: evidence for incomplete lineage sortingDaniel A Pollard
Graduate Group in Biophysics, University of California Berkeley, Berkeley, California, USA
PLoS Genet 2:e173. 2006..Methods to infer the correct species tree, the history of every base in the genome, and comparative methods that control for and/or utilize this information will be valuable advancements for the field of comparative genomics...
Benchmarking tools for the alignment of functional noncoding DNADaniel A Pollard
Biophysics Graduate Group, University of California, Berkeley, CA 94720, USA
BMC Bioinformatics 5:6. 2004..For noncoding sequences, where such independent validation is lacking, simulation provides an effective means to generate "correct" alignments with which to benchmark alignment tools...
Evolution of genes and genomes on the Drosophila phylogenyAndrew G Clark
Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA
Nature 450:203-18. 2007..These may prove to underlie differences in the ecology and behaviour of these diverse species...
Transcription factors bind thousands of active and inactive regions in the Drosophila blastodermXiao Yong Li
Genomics Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America
PLoS Biol 6:e27. 2008....
