Ian F Pollack

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. pmc A phase II study of gefitinib and irradiation in children with newly diagnosed brainstem gliomas: a report from the Pediatric Brain Tumor Consortium
    Ian F Pollack
    Department of Neurosurgery, Children s Hospital of Pittsburgh, 4401 Penn Avenue, Pittsburgh, PA 15224, USA
    Neuro Oncol 13:290-7. 2011
  2. pmc Identification of ATP citrate lyase as a positive regulator of glycolytic function in glioblastomas
    Marie E Beckner
    Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA
    Int J Cancer 126:2282-95. 2010
  3. pmc Bortezomib-induced sensitization of malignant human glioma cells to vorinostat-induced apoptosis depends on reactive oxygen species production, mitochondrial dysfunction, Noxa upregulation, Mcl-1 cleavage, and DNA damage
    Daniel R Premkumar
    Department of Neurosurgery, Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15223, USA
    Mol Carcinog 52:118-33. 2013
  4. ncbi Rarity of PTEN deletions and EGFR amplification in malignant gliomas of childhood: results from the Children's Cancer Group 945 cohort
    Ian F Pollack
    Departments of Neurosurgery, University of Pittsburgh Medical Center, Children s Hospital of Pittsburgh, Pennsylvania 15213, USA
    J Neurosurg 105:418-24. 2006
  5. pmc Identification of survival genes in human glioblastoma cells by small interfering RNA screening
    Nikhil G Thaker
    Department of Pharmacology and Chemical Biology, Biomedical Science Tower 3, 3501 Fifth Avenue, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Mol Pharmacol 76:1246-55. 2009
  6. ncbi Coadministration of sorafenib with rottlerin potently inhibits cell proliferation and migration in human malignant glioma cells
    Esther P Jane
    Department of Neurosurgery, University of Pittsburgh School of Medicine, University of Pittsburgh Cancer Institute Brain Tumor Center, Pennsylvania, USA
    J Pharmacol Exp Ther 319:1070-80. 2006
  7. pmc EphA2 as a glioma-associated antigen: a novel target for glioma vaccines
    Manabu Hatano
    Department of Neurological Surgery, University of Pittsburgh School of Medicine and University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA
    Neoplasia 7:717-22. 2005
  8. pmc Tumor cells from ultrasonic aspirations of glioblastomas migrate and form spheres with radial outgrowth
    Marie E Beckner
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Cancer Lett 255:135-44. 2007
  9. doi Outcome of children with metastatic medulloblastoma treated with carboplatin during craniospinal radiotherapy: a Children's Oncology Group Phase I/II study
    Regina I Jakacki
    Children s Hospital of Pittsburgh, 4401 Penn Ave, Pittsburgh, PA 15224, USA
    J Clin Oncol 30:2648-53. 2012
  10. ncbi Association between chromosome 1p and 19q loss and outcome in pediatric malignant gliomas: results from the CCG-945 cohort
    Ian F Pollack
    Department of Neurosurgery, University of Pittsburgh Medical Center and the Children s Hospital of Pittsburgh, Pittsburgh, PA, USA
    Pediatr Neurosurg 39:114-21. 2003

Detail Information

Publications80

  1. pmc A phase II study of gefitinib and irradiation in children with newly diagnosed brainstem gliomas: a report from the Pediatric Brain Tumor Consortium
    Ian F Pollack
    Department of Neurosurgery, Children s Hospital of Pittsburgh, 4401 Penn Avenue, Pittsburgh, PA 15224, USA
    Neuro Oncol 13:290-7. 2011
    ....
  2. pmc Identification of ATP citrate lyase as a positive regulator of glycolytic function in glioblastomas
    Marie E Beckner
    Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA
    Int J Cancer 126:2282-95. 2010
    ..In summary, gene expression data, proteomics and functional assays support ACLY as a positive regulator of glycolysis in glioblastomas...
  3. pmc Bortezomib-induced sensitization of malignant human glioma cells to vorinostat-induced apoptosis depends on reactive oxygen species production, mitochondrial dysfunction, Noxa upregulation, Mcl-1 cleavage, and DNA damage
    Daniel R Premkumar
    Department of Neurosurgery, Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15223, USA
    Mol Carcinog 52:118-33. 2013
    ..The significantly enhanced antitumor activity that results from the combination of bortezomib and HDACIs offers promise as a novel treatment for glioma patients...
  4. ncbi Rarity of PTEN deletions and EGFR amplification in malignant gliomas of childhood: results from the Children's Cancer Group 945 cohort
    Ian F Pollack
    Departments of Neurosurgery, University of Pittsburgh Medical Center, Children s Hospital of Pittsburgh, Pennsylvania 15213, USA
    J Neurosurg 105:418-24. 2006
    ..To address this issue, we examined tumor samples from the Children's Cancer Group 945 study, a large randomized trial of treatment for childhood malignant gliomas...
  5. pmc Identification of survival genes in human glioblastoma cells by small interfering RNA screening
    Nikhil G Thaker
    Department of Pharmacology and Chemical Biology, Biomedical Science Tower 3, 3501 Fifth Avenue, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Mol Pharmacol 76:1246-55. 2009
    ....
  6. ncbi Coadministration of sorafenib with rottlerin potently inhibits cell proliferation and migration in human malignant glioma cells
    Esther P Jane
    Department of Neurosurgery, University of Pittsburgh School of Medicine, University of Pittsburgh Cancer Institute Brain Tumor Center, Pennsylvania, USA
    J Pharmacol Exp Ther 319:1070-80. 2006
    ....
  7. pmc EphA2 as a glioma-associated antigen: a novel target for glioma vaccines
    Manabu Hatano
    Department of Neurological Surgery, University of Pittsburgh School of Medicine and University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA
    Neoplasia 7:717-22. 2005
    ..Taken together, these data suggest that EphA2883-891 may be an attractive antigen epitope for molecularly targeted glioma vaccines...
  8. pmc Tumor cells from ultrasonic aspirations of glioblastomas migrate and form spheres with radial outgrowth
    Marie E Beckner
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Cancer Lett 255:135-44. 2007
    ..Cultures were maintained for more than six weeks without fibroblastic overgrowth. Our observations show that ultrasonically aspirated specimens contain cells useful for studies of tumor migration and growth of tumorspheres...
  9. doi Outcome of children with metastatic medulloblastoma treated with carboplatin during craniospinal radiotherapy: a Children's Oncology Group Phase I/II study
    Regina I Jakacki
    Children s Hospital of Pittsburgh, 4401 Penn Ave, Pittsburgh, PA 15224, USA
    J Clin Oncol 30:2648-53. 2012
    ....
  10. ncbi Association between chromosome 1p and 19q loss and outcome in pediatric malignant gliomas: results from the CCG-945 cohort
    Ian F Pollack
    Department of Neurosurgery, University of Pittsburgh Medical Center and the Children s Hospital of Pittsburgh, Pittsburgh, PA, USA
    Pediatr Neurosurg 39:114-21. 2003
    ....
  11. pmc IDH1 mutations are common in malignant gliomas arising in adolescents: a report from the Children's Oncology Group
    Ian F Pollack
    Department of Neurosurgery, Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, 4401 Penn Avenue, Pittsburgh, PA 15224, USA
    Childs Nerv Syst 27:87-94. 2011
    ..Because pediatric malignant gliomas share some molecular features with adult secondary gliomas, we questioned whether a subset of these tumors also exhibited IDH mutations...
  12. ncbi Co-administration of NVP-AEW541 and dasatinib induces mitochondrial-mediated apoptosis through Bax activation in malignant human glioma cell lines
    Daniel R Premkumar
    Department of Neurosurgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15201, USA
    Int J Oncol 37:633-43. 2010
    ....
  13. pmc ABT-737 synergizes with bortezomib to induce apoptosis, mediated by Bid cleavage, Bax activation, and mitochondrial dysfunction in an Akt-dependent context in malignant human glioma cell lines
    Daniel R Premkumar
    Department of Neurosurgery, Children s Hospital of Pittsburgh, 4401 Penn Avenue, Pittsburgh, PA 15224, USA
    J Pharmacol Exp Ther 341:859-72. 2012
    ....
  14. ncbi O6-methylguanine-DNA methyltransferase expression strongly correlates with outcome in childhood malignant gliomas: results from the CCG-945 Cohort
    Ian F Pollack
    Department of Neurosurgery, University of Pittsburgh Cancer Institute, University of Pittsburgh Medical Center and the Children s Hospital of Pittsburgh, Pittsburgh, PA 15213, USA
    J Clin Oncol 24:3431-7. 2006
    ..Epigenetic silencing of MGMT has been associated with prolonged survival in adults with malignant gliomas, although the association between MGMT expression status and outcome in pediatric malignant gliomas has not been defined...
  15. ncbi Cooperative inhibitory effect of ZD1839 (Iressa) in combination with 17-AAG on glioma cell growth
    Daniel R Premkumar
    Department of Neurosurgery, University of Pittsburgh School of Medicine, University of Pittsburgh Cancer Institute Brain Tumor Center, Pittsburgh, Pennsylvania 15213, USA
    Mol Carcinog 45:288-301. 2006
    ....
  16. doi Catalyst-dependent drug loading of LDI-glycerol polyurethane foams leads to differing controlled release profiles
    Wesley N Sivak
    Department of Bioengineering, School of Engineering, University of Pittsburgh, Pittsburgh, PA, USA
    Acta Biomater 4:1263-74. 2008
    ..0x10(-8)). These results clearly demonstrate the long-term, catalyst-dependent release of DB-67 from LDI-glycerol polyurethane foams, indicating their potential for use in implantable drug-delivery devices...
  17. pmc Identification of chemosensitivity nodes for vinblastine through small interfering RNA high-throughput screens
    Carolyn A Kitchens
    Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Pharmacol Exp Ther 339:851-8. 2011
    ..These results illustrate the usefulness of unbiased siRNA screens as a method for identifying potential novel anticancer therapeutic combinations...
  18. ncbi Impact of proliferation index on outcome in childhood malignant gliomas: results in a multi-institutional cohort
    Ian F Pollack
    Departments of Neurosurgery, University of Pittsburgh Medical Center and the Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Neurosurgery 50:1238-44; discussion 1244-5. 2002
    ....
  19. pmc Akt activation is a common event in pediatric malignant gliomas and a potential adverse prognostic marker: a report from the Children's Oncology Group
    Ian F Pollack
    Department of Neurosurgery, Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, 4401 Penn Avenue, Pittsburgh, PA 15224, USA
    J Neurooncol 99:155-63. 2010
    ..In view of the frequency of Akt activation, the evaluation of molecularly targeted therapies that inhibit this pathway warrants consideration for these tumors...
  20. ncbi Inhibition of STAT3 promotes the efficacy of adoptive transfer therapy using type-1 CTLs by modulation of the immunological microenvironment in a murine intracranial glioma
    Mitsugu Fujita
    Department of Neurological Surgery and Brain Tumor Program, University of Pittsburgh School of Medicine, Pittsburgh, PA 15232, USA
    J Immunol 180:2089-98. 2008
    ....
  21. pmc A phase 1 study of vinblastine in combination with carboplatin for children with low-grade gliomas: a Children's Oncology Group phase 1 consortium study
    Regina I Jakacki
    Children s Hospital of Pittsburgh, Pittsburgh, PA 15224, USA
    Neuro Oncol 13:910-5. 2011
    ..The recommended phase 2 dose and schedule is carboplatin, 400 mg/m(2)/dose on day 1, and vinblastine, 4 mg/m(2)/dose, weekly × 3, repeated every 4 weeks. Further study of this regimen in patients with low-grade glioma is warranted...
  22. ncbi Albumin marks pseudopodia of astrocytoma cells responding to hepatocyte growth factor or serum
    Marie E Beckner
    Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Lab Invest 86:1103-14. 2006
    ..Thus, albumin potentially aids and marks invasion as it accumulates in these tumors...
  23. pmc YM-155 potentiates the effect of ABT-737 in malignant human glioma cells via survivin and Mcl-1 downregulation in an EGFR-dependent context
    Esther P Jane
    Department of Neurosurgery, Children s Hospital of Pittsburgh, Pittsburgh, PA 15224, USA
    Mol Cancer Ther 12:326-38. 2013
    ....
  24. pmc LOH in the HLA class I region at 6p21 is associated with shorter survival in newly diagnosed adult glioblastoma
    Jacky T Yeung
    Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Clin Cancer Res 19:1816-26. 2013
    ..In this study, we examined the prevalence of these LOH events and their relations with overall survival in GBM...
  25. pmc Survivin inhibitor YM-155 sensitizes tumor necrosis factor- related apoptosis-inducing ligand-resistant glioma cells to apoptosis through Mcl-1 downregulation and by engaging the mitochondrial death pathway
    Daniel R Premkumar
    Department of Neurosurgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA
    J Pharmacol Exp Ther 346:201-10. 2013
    ..The significantly enhanced antitumor activity of the combination of YM-155 and TRAIL may have applications for therapy of malignant glioma. ..
  26. pmc AG490 influences UCN-01-induced cytotoxicity in glioma cells in a p53-dependent fashion, correlating with effects on BAX cleavage and BAD phosphorylation
    Esther P Jane
    Department of Neurosurgery, Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Cancer Lett 257:36-46. 2007
    ....
  27. pmc Autologous glioma cell vaccine admixed with interleukin-4 gene transfected fibroblasts in the treatment of patients with malignant gliomas
    Hideho Okada
    Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Transl Med 5:67. 2007
    ..The prognosis for malignant gliomas remains dismal. We addressed the safety, feasibility and preliminary clinical activity of the vaccinations using autologous glioma cells and interleukin (IL)-4 gene transfected fibroblasts...
  28. ncbi Glycolytic glioma cells with active glycogen synthase are sensitive to PTEN and inhibitors of PI3K and gluconeogenesis
    Marie E Beckner
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Lab Invest 85:1457-70. 2005
    ..These findings confirm that glycolytic glioma cells can migrate invasively and that the loss of PTEN is supportive, with activated glycogenic potential included among the relevant downstream effects...
  29. pmc Enzastaurin induces H2AX phosphorylation to regulate apoptosis via MAPK signalling in malignant glioma cells
    Esther P Jane
    Department of Neurosurgery, University of Pittsburgh School of Medicine, University of Pittsburgh Cancer Institute Brain Tumor Center, Pittsburgh, PA 15213, USA
    Eur J Cancer 46:412-9. 2010
    ..These data call attention to a novel signalling pathway (MAPK/H2AX) to regulate apoptosis in malignant glioma cells...
  30. pmc The heat shock protein antagonist 17-AAG potentiates the activity of enzastaurin against malignant human glioma cells
    Esther P Jane
    Department of Neurosurgery, University of Pittsburgh School of Medicine, University of Pittsburgh Cancer Institute Brain Tumor Center, 3705 Fifth Avenue, Pittsburgh, PA 15213, USA
    Cancer Lett 268:46-55. 2008
    ....
  31. ncbi The characterization of tumor apoptosis after experimental radiosurgery
    Timothy F Witham
    Department of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15213 2582, USA
    Stereotact Funct Neurosurg 83:17-24. 2005
    ..The time course of this radiobiologic phenomenon begins at approximately 6 h following radiosurgery, continues up to 48 h, and begins to decline by 72 h...
  32. pmc Mismatch repair deficiency is an uncommon mechanism of alkylator resistance in pediatric malignant gliomas: a report from the Children's Oncology Group
    Ian F Pollack
    Department of Neurosurgery, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Pediatr Blood Cancer 55:1066-71. 2010
    ..However, the frequency of this abnormality as a clinical resistance mechanism in childhood malignant gliomas has not been well characterized...
  33. pmc Abrogation of mitogen-activated protein kinase and Akt signaling by vandetanib synergistically potentiates histone deacetylase inhibitor-induced apoptosis in human glioma cells
    Esther P Jane
    Department of Neurosurgery, University of Pittsburgh School of Medicine, Pennsylvania, USA
    J Pharmacol Exp Ther 331:327-37. 2009
    ....
  34. pmc Induction of CD8+ T-cell responses against novel glioma-associated antigen peptides and clinical activity by vaccinations with {alpha}-type 1 polarized dendritic cells and polyinosinic-polycytidylic acid stabilized by lysine and carboxymethylcellulose in
    Hideho Okada
    G12 a Research Pavilion at the Hillman Cancer Center, 5117 Centre Ave, Pittsburgh, PA 15213 1863, USA
    J Clin Oncol 29:330-6. 2011
    ..GAAs for these peptides are EphA2, interleukin (IL)-13 receptor-α2, YKL-40, and gp100...
  35. pmc A phase I trial of temozolomide and lomustine in newly diagnosed high-grade gliomas of childhood
    Regina I Jakacki
    Children s Hospital of Pittsburgh, Pittsburgh, PA 15213, USA
    Neuro Oncol 10:569-76. 2008
    ..Radiographic changes following RT make determination of early tumor progression difficult. Metastatic disease is common prior to death...
  36. pmc Expression of glioma-associated antigens in pediatric brain stem and non-brain stem gliomas
    Hideho Okada
    Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Neurooncol 88:245-50. 2008
    ..These results suggest that EphA2, IL-13Ralpha2 and Survivin are suitable targets for developing vaccine strategies for pediatric glioma...
  37. ncbi Stereotactic radiosurgery for pilocytic astrocytomas part 2: outcomes in pediatric patients
    Hideyuki Kano
    Department of Neurological Surgery, University of Pittsburgh School of Medicine, Suite B 400, UPMC Presbyterian, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    J Neurooncol 95:219-29. 2009
    ..Stereotactic radiosurgery for pediatric pilocytic astrocytomas should be considered when resection is not feasible, or if there is an early recurrence. The best response was observed in small volume residual solid tumors...
  38. pmc Increased expression of tumor-associated antigens in pediatric and adult ependymomas: implication for vaccine therapy
    Jacky T Yeung
    Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Neurooncol 111:103-11. 2013
    ..Pediatric and adult ependymomas frequently express EphA2, IL-13Rα2, and Survivin. This provides the basis for the utilization of an established multiple peptide vaccine for ependymoma in a clinical trial setting...
  39. pmc Phase I trial of imatinib in children with newly diagnosed brainstem and recurrent malignant gliomas: a Pediatric Brain Tumor Consortium report
    Ian F Pollack
    Department of Neurosurgery, Children s Hospital of Pittsburgh, 3705 Fifth Avenue, Pittsburgh, PA 15213, USA
    Neuro Oncol 9:145-60. 2007
    ..Imatinib may increase the risk of ITH, although the incidence of spontaneous hemorrhages in brainstem glioma is sufficiently high that this should be considered in studies of agents in which hemorrhage is a concern...
  40. pmc Bortezomib sensitizes malignant human glioma cells to TRAIL, mediated by inhibition of the NF-{kappa}B signaling pathway
    Esther P Jane
    Department of Neurosurgery, Children s Hospital of Pittsburgh, 3705 Fifth Ave, Pittsburgh, PA 15213, USA
    Mol Cancer Ther 10:198-208. 2011
    ....
  41. pmc Ependymomas: development of immunotherapeutic strategies
    Ian F Pollack
    Department of Neurosurgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Expert Rev Neurother 13:1089-98. 2013
    ....
  42. doi Pegylated interferon-α-2b for children with recurrent craniopharyngioma
    Jacky T Yeung
    Department of Neurosurgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA
    J Neurosurg Pediatr 10:498-503. 2012
    ..Pegylaion of interferon-α-2b (PI) prolongs the half-life, allowing sustained exposure of the drug over time, and enhances efficacy. The authors report the results of the use of PI in 5 children with recurrent craniopharyngiomas...
  43. pmc Molecularly targeted therapies for malignant glioma: rationale for combinatorial strategies
    Nikhil G Thaker
    Doris Duke Clinical Research Fellow, Departments of Neurosurgery, Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA
    Expert Rev Neurother 9:1815-36. 2009
    ..This review summarizes the currently implemented single-agent and combination molecularly targeted therapies for MG...
  44. doi Ataxia resulting from posterior fossa tumors of childhood and other mass lesions
    Ian F Pollack
    Department of Neurosurgery, Children s Hospital of Pittsburgh and University of Pittsburgh Cancer Institute Brain Tumor Program, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Handb Clin Neurol 103:161-73. 2012
    ..In most modern centers, children with such tumors are treated in cooperative group studies, which are designed to increase the percentage of children who achieve long-term survival as well as their functional outcome...
  45. doi Endoscopic port surgery for resection of lesions of the cerebellar peduncles: technical note
    Pawel G Ochalski
    Department of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    Neurosurgery 68:1444-50; discussion 1450-1. 2011
    ..Success has been achieved through multiple approaches, but complications can be severe...
  46. ncbi Molecular abnormalities and correlations with tumor response and outcome in glioma patients
    Ian F Pollack
    Department of Neurosurgery, University of Pittsburgh Medical Center and the Children s Hospital of Pittsburgh, 3705 Fifth Avenue, Pittsburgh, PA 15213, USA
    Neuroimaging Clin N Am 12:627-39. 2002
    ....
  47. pmc The influence of central review on outcome associations in childhood malignant gliomas: results from the CCG-945 experience
    Ian F Pollack
    Department of Neurosurgery, University of Pittsburgh School of Medicine and the Children s Hospital of Pittsburgh, Pittsburgh, PA 15213, USA
    Neuro Oncol 5:197-207. 2003
    ....
  48. ncbi Expression of a soluble transforming growth factor-beta (TGFbeta) receptor reduces tumorigenicity by regulating natural killer (NK) cell activity against 9L gliosarcoma in vivo
    Timothy F Witham
    Brain Tumor Center, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213 1863, USA
    J Neurooncol 64:63-9. 2003
    ..Finally, we determined that elimination of CD161+ cells resulted in comparable growth of 9L-neo and 9L-TGFbeta sr in vivo, indicating that NK or NK-like cells were responsible for the anti-tumor effects in this model...
  49. ncbi Loss of heterozygosity reveals non-VHL allelic loss in hemangioblastomas at 22q13
    Marie E Beckner
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Hum Pathol 35:1105-11. 2004
    ..LOH for the 22q13.2 region in HBs suggests that the loss of another tumor suppressor gene is involved in the pathogenesis of HBs in addition to VHL. Absence of LOH for glioma markers is consistent with the low-grade behavior of HBs...
  50. pmc A novel SNP analysis method to detect copy number alterations with an unbiased reference signal directly from tumor samples
    Alex Lisovich
    Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    BMC Med Genomics 4:14. 2011
    ....
  51. ncbi Proteomic characterization of harvested pseudopodia with differential gel electrophoresis and specific antibodies
    Marie E Beckner
    Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Lab Invest 85:316-27. 2005
    ....
  52. doi Designing, optimizing, and implementing high-throughput siRNA genomic screening with glioma cells for the discovery of survival genes and novel drug targets
    Nikhil G Thaker
    Doris Duke Clinical Research Fellowship, University of Pittsburgh, Pittsburgh, PA 15260, USA
    J Neurosci Methods 185:204-12. 2010
    ..Successful implementation and analysis of this siRNA screen validates our transfection optimization approach and provides guidance for the rapid development of high-throughput siRNA screens in human glioma cells...
  53. ncbi Epidermal growth factor receptor-transfected bone marrow stromal cells exhibit enhanced migratory response and therapeutic potential against murine brain tumors
    Hidemitsu Sato
    Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213 1863, USA
    Cancer Gene Ther 12:757-68. 2005
    ..These data indicate that EGFR-MSCs may serve as attractive vehicles for infiltrating brain malignancies such as malignant gliomas...
  54. pmc Alkylation sensitivity screens reveal a conserved cross-species functionome
    David Svilar
    Departments of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213 1863, USA
    Mol Cancer Res 10:1580-96. 2012
    ..Importantly, these studies provide potential new targets to overcome alkylating agent resistance...
  55. doi Childhood brain tumors: epidemiology, current management and future directions
    Ian F Pollack
    Department of Neurosurgery, Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, 4401 Penn Avenue, Pittsburgh, PA 15224, USA
    Nat Rev Neurol 7:495-506. 2011
    ..The latest insights from molecular correlative studies that hold potential for future refinements in therapy will also be discussed...
  56. doi Fractures of the clivus and traumatic diastasis of the central skull base in the pediatric population
    Pawel G Ochalski
    Department of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    J Neurosurg Pediatr 7:261-7. 2011
    ..The incidence, outcome, and biomechanics associated with these fractures have been difficult to ascertain secondary to the lack of literature pertaining to their occurrence...
  57. ncbi Cytokine gene therapy for malignant glioma
    Hideho Okada
    University of Pittsburgh Medical Center Cancer Institute, Department of Neurological Surgery, Brain Tumor Program, G12 a Research Pavilion at the Hillman Cancer Center, 5117 Centre Ave, Pittsburgh, PA 15213 1863, USA
    Expert Opin Biol Ther 4:1609-20. 2004
    ..Successful immunogene therapy for brain tumours requires detailed understanding of cytokine functions and the use of them at the appropriate stages/sites of the immunological milieu...
  58. pmc Diagnostic and therapeutic stratification of childhood brain tumors: implications for translational research
    Ian F Pollack
    Department of Neurosurgery, Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Child Neurol 23:1179-85. 2008
    ....
  59. ncbi Individualized treatment of pediatric craniopharyngiomas
    A Leland Albright
    Department of Neurosurgery, Childrens Hospital of Pittsburgh, 3705 Fifth Avenue, Pittsburgh, PA 15213, USA
    Childs Nerv Syst 21:649-54. 2005
    ..We performed this study to correlate the clinical and radiographic features at the time of presentation with the multimodality treatments the children received...
  60. ncbi Fully endoscopic expanded endonasal approach treating skull base lesions in pediatric patients
    Amin Kassam
    Minimally Invasive endoNeurosurgery Center, University of Pittsburgh School of Medicine, Pennsylvania, USA
    J Neurosurg 106:75-86. 2007
    ....
  61. ncbi Delivery of interferon-alpha transfected dendritic cells into central nervous system tumors enhances the antitumor efficacy of peripheral peptide-based vaccines
    Hideho Okada
    Departments of Neurological Surgery, University of Pittsburgh School of Medicine, PA 15213, USA
    Cancer Res 64:5830-8. 2004
    ..On the basis of these results, we believe that local expression of IFN-alpha by DCs within the intracranial tumor site may enhance the clinical efficacy of peripheral vaccine approaches for brain tumors...
  62. doi LDI-glycerol polyurethane implants exhibit controlled release of DB-67 and anti-tumor activity in vitro against malignant gliomas
    Wesley N Sivak
    Department of Bioengineering, School of Engineering, University of Pittsburgh, Pittsburgh, PA, USA
    Acta Biomater 4:852-62. 2008
    ..These results clearly demonstrate the long-term, slow release of DB-67 from LDI-glycerol polyurethane discs and their potential for postoperative intracranial chemotherapy of cancers...
  63. doi Multidisciplinary management of childhood brain tumors: a review of outcomes, recent advances, and challenges
    Ian F Pollack
    Department of Neurosurgery, Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    J Neurosurg Pediatr 8:135-48. 2011
    ..The goal of this report is to provide an overview of recent progress in the field...
  64. doi Expanded endoscopic endonasal resection of an olfactory schwannoma
    Hilal A Kanaan
    Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Neurosurg Pediatr 2:261-5. 2008
    ....
  65. doi Extraventricular neurocytoma in neurofibromatosis Type 1: case report
    Ali I Raja
    Department of Neurosurgery, Children s Hospital of Pittsburgh, Pittsburgh, PA 15213, USA
    J Neurosurg Pediatr 2:63-7. 2008
    ..The importance of obtaining a biopsy in lesions that have atypical imaging features is highlighted...
  66. ncbi Synergistic interaction between 17-AAG and phosphatidylinositol 3-kinase inhibition in human malignant glioma cells
    Daniel R Premkumar
    Department of Neurosurgery, University of Pittsburgh School of Medicine, University of Pittsburgh Cancer Institute Brain Tumor Center, Pittsburgh, Pennsylvania, USA
    Mol Carcinog 45:47-59. 2006
    ....
  67. doi Parasagittal suture after strip craniectomy
    Christopher R Kinsella
    Divisions of Pediatric Plastic Surgery, Children s Hospital of Pittsburgh of UPMC, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Craniofac Surg 22:66-7. 2011
    ....
  68. ncbi Risk assignment in childhood brain tumors: the emerging role of molecular and biologic classification
    Ian F Pollack
    Department of Neurosurgery, Children s Hospital of Pittsburgh, Main Tower, Floor 3, Room 3705, 3705 Fifth Avenue, Pittsburgh, PA 15213, USA
    Curr Oncol Rep 4:114-22. 2002
    ..This paper summarizes these observations and discusses how they are being applied in a preliminary fashion as a foundation for risk-adapted stratification of childhood brain tumor therapy...
  69. doi Optic pathway glioma as part of a constitutional mismatch-repair deficiency syndrome in a patient meeting the criteria for neurofibromatosis type 1
    Jacky T Yeung
    Doris Duke Clinical Research Fellowship, Department of Neurosurgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Pediatr Blood Cancer 60:137-9. 2013
    ..We report the case of a 3-year-old male with an extensive OPG who met the diagnostic criteria for NF-1. He was subsequently found to have multiple colonic polyps and bi-allelic loss of PMS2. Testing for NF-1 was negative...
  70. ncbi Safety of preoperative erythropoietin in surgical calvarial remodeling: an 8-year retrospective review and analysis
    Sanjay Naran
    Division of Plastic Surgery, The Department of Anesthesia, Children s Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA 15224, USA
    Plast Reconstr Surg 130:305e-310e. 2012
    ..5 g/dl may increase the risk of thrombotic events. This study was designed to assess the risks of erythropoietin in the pediatric population...
  71. doi A single-center experience with symptomatic postoperative calvarial growth restriction after extended strip craniectomy for sagittal craniosynostosis
    Matthew A Adamo
    Department of Neurosurgery, Children s Hospital of Pittsburgh, Pennsylvania 15201, USA
    J Neurosurg Pediatr 5:131-5. 2010
    ....
  72. ncbi New delivery approaches for pediatric brain tumors
    Ian F Pollack
    Department of Neurosurgery, Children s Hospital of Pittsburgh, University of Pittsburgh Brain Tumor Center, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Neurooncol 75:315-26. 2005
    ....
  73. ncbi Resolution of Chiari malformation after repair of a congenital thoracic meningocele: case report and literature review
    Ricky Madhok
    Department of Neurosurgery, Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Neurosurgery 51:1489-91; discussion 1491-2. 2002
    ..This supports the importance of an in utero craniospinal pressure gradient as a potential cause for congenital, but reversible, cerebellar herniation...
  74. ncbi Intramedullary spinal cord astrocytomas in children
    Ian F Pollack
    Department of Neurosurgery, Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, University of Pittsburgh Cancer Institute Brain Tumor Center, Pittsburgh, Pennsylvania 15213, USA
    Pediatr Blood Cancer 43:617-8. 2004
  75. ncbi Identification of a novel HLA-A*0201-restricted, cytotoxic T lymphocyte epitope in a human glioma-associated antigen, interleukin 13 receptor alpha2 chain
    Fumiyoshi Okano
    Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    Clin Cancer Res 8:2851-5. 2002
    ..Interleukin 13 receptor alpha2-chain (IL-13Ralpha2) has been reported to be abundantly and specifically overexpressed in glioblastoma multiforme. Here we report the identification of a CTL epitope derived from the IL-13Ralpha2...
  76. ncbi Dermoid inclusion cysts and early spinal cord tethering after fetal surgery for myelomeningocele
    Catherine A Mazzola
    Department of Neurosurgery, University of Pittsburgh and Children s Hospital of Pittsburgh, Pittsburgh 15213, USA
    N Engl J Med 347:256-9. 2002
  77. ncbi Expression of p53 and prognosis in children with malignant gliomas
    Ian F Pollack
    Department of Neurosurgery, University of Pittsburgh Medical Center and Children s Hospital of Pittsburgh, Pittsburgh, PA 15213, USA
    N Engl J Med 346:420-7. 2002
    ..We investigated whether mutations in the TP53 gene or the degree of expression of p53 protein in high-grade gliomas is associated with progression-free survival in children with these tumors...
  78. ncbi Corridor surgery: the current paradigm for skull base surgery
    Stephen M Pirris
    Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Childs Nerv Syst 23:377-84. 2007
    ..In this report, we present the case of a 3-year-old boy who was found to have a large posterior pharyngeal, clival, and posterior fossa tumor detected on a CT scan after a closed head injury...
  79. ncbi Glioma-associated hyaluronan induces apoptosis in dendritic cells via inducible nitric oxide synthase: implications for the use of dendritic cells for therapy of gliomas
    Tianbing Yang
    Brain Tumor Center, University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Cancer Res 62:2583-91. 2002
    ..These data indicate that HA expressed by gliomas may contribute to their immunosuppressive effects by promoting apoptosis among professional antigen-presenting cells such as DCs via iNOS induction after CD44-HA interactions...
  80. ncbi P53 pathway alterations are uncommon in childhood ependymomas
    Ian F Pollack
    Department of Neurosurgery, Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, University of Pittsburgh Cancer Institute Brain Tumor Center, Pittsburgh, Pennsylvania 15213, USA
    Pediatr Blood Cancer 46:531-2. 2006