Research Topics
| Gerald PollackSummaryAffiliation: University of Washington Country: USA Publications
Research Grants
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Detail Information
Publications
The role of aqueous interfaces in the cellGerald H Pollack
Department of Bioengineering 357962, University of Washington, Seattle, WA 98195, USA
Adv Colloid Interface Sci 103:173-96. 2003..Here, we pursue this approach. We set up a polymer-gel-based foundation for cell behavior, and explore the extent to which this foundation explains how the cell achieves its everyday tasks...- Revitalizing science in a risk-averse culture: reflections on the syndrome and prescriptions for its cureG H Pollack
Dept of Bioengineering, University of Washington, Seattle, WA 98195, USA
Cell Mol Biol (Noisy-le-grand) 51:815-20. 2005..This discourages the fresh approaches that may bring important breakthroughs. The paper then suggests remedies that could restore the scientific enterprise to one that is friendlier to fresh thinking... - Phase transitions and molecular motion in the cellG H Pollack
Dept of Bioengineering, University of Washington, Seattle 98195, USA
Cell Mol Biol (Noisy-le-grand) 47:885-900. 2001..These changes shift solutes and solvent in a characteristic way that depends on the respective organelle's structure. Phase-transitions are simple, powerful mechanisms that may be responsible for many, if not all, biological motions... - Is the cell a gel--and why does it matter?G H Pollack
Department of Bioengineering 357962, University of Washington, Seattle, WA 98195, USA
Jpn J Physiol 51:649-60. 2001..If there is a common underlying mechanism of cell function, it appears that the polymer gel phase-transition could well be a candidate... 
Direct measurement of single synthetic vertebrate thick filament elasticity using nanofabricated cantileversDwayne Dunaway
Department of Bioengineering, University of Washington, Seattle, Washington 98195, USA
Biophys J 82:3128-33. 2002..Recognition of thick filament elasticity is important because it affects the interpretation of mechanical experiments and inferences drawn on the molecular mechanism of contraction...- Stepwise length changes in single invertebrate thick filamentsEkaterina M Nagornyak
Department of Bioengineering, University of Washington, Seattle, WA 98195, USA
Biophys J 89:3269-76. 2005.... - Passive stiffness of Drosophila IFM myofibrils: a novel, high accuracy measurement methodYudong Hao
Department of Bioengineering, University of Washington, Seattle, Washington 98195, USA
J Muscle Res Cell Motil 25:359-66. 2004..Remarkably consistent results were obtained from Drosophila IFM myofibrils. This novel, high accuracy method is potentially an effective tool for detecting small passive stiffness change in muscle mutants... - Molecules, water, and radiant energy: new clues for the origin of lifeGerald H Pollack
Department of Bioengineering, Box 355061, University of Washington, Seattle WA, 98195, USA E Mails X F Q Z
Int J Mol Sci 10:1419-29. 2009..This condensation mechanism puts water as a central protagonist in life rather than as an incidental participant, and thereby helps explain why life requires water... - Labview virtual instruments for calcium buffer calculationsFrederick B Reitz
Department of Bioengineering, University of Washington, Box 357962, Seattle, WA 98195 7962, USA
Comput Methods Programs Biomed 70:61-9. 2003..As Labview VIs are inherently graphical, these VIs may serve as useful templates for those wishing to adapt this software to other platforms... - Dynamics of individual sarcomeres during and after stretch in activated single myofibrilsDilson E Rassier
Department of Bioengineering, University of Washington, Seattle, WA 98195, USA
Proc Biol Sci 270:1735-40. 2003..Sarcomeres never lengthened to a point beyond thick and thin filament overlap. We conclude that sarcomeres are non-uniform but generally stable on the descending limb of the force-length relationship... - Connecting filament mechanics in the relaxed sarcomereEkaterina Nagornyak
Department of Bioengineering, University of Washington, 357962, Seattle, WA 98195, USA
J Muscle Res Cell Motil 26:303-6. 2005..7 nm... - Stretch-induced force enhancement and stability of skeletal muscle myofibrilsDilson E Rassier
Department of Bioengineering, University of Washington, Seattle, WA 98195, USA
Adv Exp Med Biol 538:501-15; discussion 515. 2003..It is concluded that sarcomeres are stable, and therefore the increased force observed after stretch must be a sarcomeric property, not associated with continuous length changes of unstable sarcomeres, as had been assumed in the past... - Fundamental step size in single cardiac and skeletal sarcomeresOlga Yakovenko
Department of Bioengineering, University of Washington, Seattle 98195, USA
Am J Physiol Cell Physiol 283:C735-42. 2002..This value is equal to the linear repeat of actin monomers along the thin filament, a result that ties dynamic events to molecular structure and places narrow constraints on any proposed molecular mechanism... - Passive stiffness in Drosophila indirect flight muscle reduced by disrupting paramyosin phosphorylation, but not by embryonic myosin S2 hinge substitutionYudong Hao
Department of Bioengineering, University of Washington, Seattle, WA, USA
Biophys J 91:4500-6. 2006.... - Translation step size measured in single sarcomeres and single filament pairsGerald H Pollack
Department of Bioengineering, University of Washington, Seattle, WA 98195, USA
Adv Exp Med Biol 538:129-40; discussion 141. 2003 - Effect of sarcomere length on step size in relaxed rabbit psoas muscleEkaterina Nagornyak
Department of Bioengineering 357962, University of Washington, Seattle, WA 98195, USA
J Muscle Res Cell Motil 25:37-43. 2004..7 nm... - Mechanics of F-actin characterized with microfabricated cantileversXiumei Liu
Department of Bioengineering, University of Washington, Seattle, WA 98195 USA
Biophys J 83:2705-15. 2002..75 microm was derived. These results suggest that F-actin is more compliant than previously thought and that thin filament compliance may account for a substantial fraction of the sarcomere's elasticity... 
Automatic step-detection algorithm for analysis of sarcomere dynamicsChenyang Wang
Department of Bioengineering, University of Washington, Seattle, WA, USA
Comput Methods Biomech Biomed Engin 11:609-14. 2008..The algorithm presented here offers a versatile and accurate tool that should be useful not only within muscle contraction and motility fields, but in fields which quantal phenomena play a role...- Long-range forces extending from polymer-gel surfacesJian-ming Zheng
Department of Bioengineering, Box 357962, University of Washington, Seattle, Washington 98195, USA
Phys Rev E Stat Nonlin Soft Matter Phys 68:031408. 2003..The observations imply that solutes may interact over an unexpectedly long range... - Cylindrical phase separation in colloidal suspensionsKate Ovchinnikova
Department of Bioengineering, University of Washington, Box 355061, Seattle, Washington 98195, USA
Phys Rev E Stat Nonlin Soft Matter Phys 79:036117. 2009..So long as suspension parameters were set within certain ranges, the cylindrical pattern occurred regularly... - Stepwise sliding of single actin and Myosin filamentsXiumei Liu
Department of Bioengineering, University of Washington, Seattle, Washington 98195, USA
Biophys J 86:353-8. 2004..This size paradigm is parallel to that seen in the kinesin-microtubule system, where step size is an integer multiple of the tubulin repeat along the microtubule... - Fluorescence anisotropy near-field scanning optical microscopy (FANSOM): a new technique for nanoscale microviscometryFrederick B Reitz
Department of Bioengineering, University of Washington, Seattle 98195-7962, USA
Ultramicroscopy 90:259-64. 2002..Water above a cleaved mica surface was found to have a decreased microviscosity, while water above a hydrophobic surface showed no change (detection limit approximately 0.1 cP at approximately 30 + nm from the surface)... - Sarcomere dynamics, stepwise shortening and the nature of contractionGerald H Pollack
Dept. of Bioengineering, Univ. of Washington, Seattle WA 98195, USA
Adv Exp Med Biol 565:113-25; discussion 125-6, 371-7. 2005
Research Grants
- Unexpectedly Profound Role of Water in Biology and MedicineGerald H Pollack; Fiscal Year: 2010..The experiments will test for a more central role of water than has been previously estimated. If the proposed hypotheses are validated, then a fresh understanding of biomedical principles should result. ..
- Stepwise translation of myofilamentsGerald Pollack; Fiscal Year: 2009..Hence, the experiments should yield valuable information on the near-molecular nature of the contractile process. ..
- Stepwise translation of myofilamentsGerald H Pollack; Fiscal Year: 2010..Hence, the experiments should yield valuable information on the near-molecular nature of the contractile process. ..
- Stepwise translation of myofilamentsGerald Pollack; Fiscal Year: 2007..Hence, the experiments should yield valuable information on the near-molecular nature of the contractile process. ..
- Surface-induced informaton storage in water aggregatesGerald Pollack; Fiscal Year: 2006..abstract_text> ..
- Physical properties of interfacial and structured waterGerald Pollack; Fiscal Year: 2005..These are pilot studies designed to obtain preliminary data that may be useful for subsequent, more detailed investigations on the molecular basis of homeopathic procedures. ..
- 2004 Interfacial Biology in WaterGerald Pollack; Fiscal Year: 2004..The meeting will be co-chaired by Gerald Pollack (University of Washington) and Chaim Frenkel (Rutgers University), and will be held at Mt...
- STEPWISE TRANSLATION OF MYOFIBRILSGerald Pollack; Fiscal Year: 2003..From the results we will learn much about the nature of contractile dynamics in the single sarcomere, and possibly also about the size and character of the molecular stroke. ..