Gerald Pollack

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi The role of aqueous interfaces in the cell
    Gerald H Pollack
    Department of Bioengineering 357962, University of Washington, Seattle, WA 98195, USA
    Adv Colloid Interface Sci 103:173-96. 2003
  2. ncbi Revitalizing science in a risk-averse culture: reflections on the syndrome and prescriptions for its cure
    G H Pollack
    Dept of Bioengineering, University of Washington, Seattle, WA 98195, USA
    Cell Mol Biol (Noisy-le-grand) 51:815-20. 2005
  3. ncbi 'Minimum average risk' as a new peak-detection algorithm applied to myofibrillar dynamics
    S Yu Sokolov
    Department of Physics, Ural State University, 51 Lenin Street, 620083 Yekaterinburg, Russia
    Comput Methods Programs Biomed 72:21-6. 2003
  4. pmc Molecules, water, and radiant energy: new clues for the origin of life
    Gerald H Pollack
    Department of Bioengineering, Box 355061, University of Washington, Seattle, WA 98195, USA
    Int J Mol Sci 10:1419-29. 2009
  5. ncbi Phase transitions and molecular motion in the cell
    G H Pollack
    Dept of Bioengineering, University of Washington, Seattle 98195, USA
    Cell Mol Biol (Noisy-le-grand) 47:885-900. 2001
  6. pmc Direct measurement of single synthetic vertebrate thick filament elasticity using nanofabricated cantilevers
    Dwayne Dunaway
    Department of Bioengineering, University of Washington, Seattle, Washington 98195, USA
    Biophys J 82:3128-33. 2002
  7. ncbi Is the cell a gel--and why does it matter?
    G H Pollack
    Department of Bioengineering 357962, University of Washington, Seattle, WA 98195, USA
    Jpn J Physiol 51:649-60. 2001
  8. pmc Stepwise length changes in single invertebrate thick filaments
    Ekaterina M Nagornyak
    Department of Bioengineering, University of Washington, Seattle, WA 98195, USA
    Biophys J 89:3269-76. 2005
  9. ncbi Passive stiffness of Drosophila IFM myofibrils: a novel, high accuracy measurement method
    Yudong Hao
    Department of Bioengineering, University of Washington, Seattle, Washington 98195, USA
    J Muscle Res Cell Motil 25:359-66. 2004
  10. ncbi Labview virtual instruments for calcium buffer calculations
    Frederick B Reitz
    Department of Bioengineering, University of Washington, Box 357962, Seattle, WA 98195 7962, USA
    Comput Methods Programs Biomed 70:61-9. 2003

Research Grants

  1. Unexpectedly Profound Role of Water in Biology and Medicine
    Gerald H Pollack; Fiscal Year: 2010
  2. Stepwise translation of myofilaments
    Gerald Pollack; Fiscal Year: 2009
  3. Stepwise translation of myofilaments
    Gerald H Pollack; Fiscal Year: 2010
  4. Stepwise translation of myofilaments
    Gerald Pollack; Fiscal Year: 2007
  5. Surface-induced informaton storage in water aggregates
    Gerald Pollack; Fiscal Year: 2006
  6. Physical properties of interfacial and structured water
    Gerald Pollack; Fiscal Year: 2005
  7. 2004 Interfacial Biology in Water
    Gerald Pollack; Fiscal Year: 2004
  8. STEPWISE TRANSLATION OF MYOFIBRILS
    Gerald Pollack; Fiscal Year: 2003

Collaborators

Detail Information

Publications24

  1. ncbi The role of aqueous interfaces in the cell
    Gerald H Pollack
    Department of Bioengineering 357962, University of Washington, Seattle, WA 98195, USA
    Adv Colloid Interface Sci 103:173-96. 2003
    ..Here, we pursue this approach. We set up a polymer-gel-based foundation for cell behavior, and explore the extent to which this foundation explains how the cell achieves its everyday tasks...
  2. ncbi Revitalizing science in a risk-averse culture: reflections on the syndrome and prescriptions for its cure
    G H Pollack
    Dept of Bioengineering, University of Washington, Seattle, WA 98195, USA
    Cell Mol Biol (Noisy-le-grand) 51:815-20. 2005
    ..This discourages the fresh approaches that may bring important breakthroughs. The paper then suggests remedies that could restore the scientific enterprise to one that is friendlier to fresh thinking...
  3. ncbi 'Minimum average risk' as a new peak-detection algorithm applied to myofibrillar dynamics
    S Yu Sokolov
    Department of Physics, Ural State University, 51 Lenin Street, 620083 Yekaterinburg, Russia
    Comput Methods Programs Biomed 72:21-6. 2003
    ..At an equal noise level, the RMS deviation of the minimum average risk algorithm was 1.3 times lower than that of the center of mass method with modeled data and 3-4 times lower with actual data...
  4. pmc Molecules, water, and radiant energy: new clues for the origin of life
    Gerald H Pollack
    Department of Bioengineering, Box 355061, University of Washington, Seattle, WA 98195, USA
    Int J Mol Sci 10:1419-29. 2009
    ..This condensation mechanism puts water as a central protagonist in life rather than as an incidental participant, and thereby helps explain why life requires water...
  5. ncbi Phase transitions and molecular motion in the cell
    G H Pollack
    Dept of Bioengineering, University of Washington, Seattle 98195, USA
    Cell Mol Biol (Noisy-le-grand) 47:885-900. 2001
    ..These changes shift solutes and solvent in a characteristic way that depends on the respective organelle's structure. Phase-transitions are simple, powerful mechanisms that may be responsible for many, if not all, biological motions...
  6. pmc Direct measurement of single synthetic vertebrate thick filament elasticity using nanofabricated cantilevers
    Dwayne Dunaway
    Department of Bioengineering, University of Washington, Seattle, Washington 98195, USA
    Biophys J 82:3128-33. 2002
    ..Recognition of thick filament elasticity is important because it affects the interpretation of mechanical experiments and inferences drawn on the molecular mechanism of contraction...
  7. ncbi Is the cell a gel--and why does it matter?
    G H Pollack
    Department of Bioengineering 357962, University of Washington, Seattle, WA 98195, USA
    Jpn J Physiol 51:649-60. 2001
    ..If there is a common underlying mechanism of cell function, it appears that the polymer gel phase-transition could well be a candidate...
  8. pmc Stepwise length changes in single invertebrate thick filaments
    Ekaterina M Nagornyak
    Department of Bioengineering, University of Washington, Seattle, WA 98195, USA
    Biophys J 89:3269-76. 2005
    ....
  9. ncbi Passive stiffness of Drosophila IFM myofibrils: a novel, high accuracy measurement method
    Yudong Hao
    Department of Bioengineering, University of Washington, Seattle, Washington 98195, USA
    J Muscle Res Cell Motil 25:359-66. 2004
    ..Remarkably consistent results were obtained from Drosophila IFM myofibrils. This novel, high accuracy method is potentially an effective tool for detecting small passive stiffness change in muscle mutants...
  10. ncbi Labview virtual instruments for calcium buffer calculations
    Frederick B Reitz
    Department of Bioengineering, University of Washington, Box 357962, Seattle, WA 98195 7962, USA
    Comput Methods Programs Biomed 70:61-9. 2003
    ..As Labview VIs are inherently graphical, these VIs may serve as useful templates for those wishing to adapt this software to other platforms...
  11. ncbi Fundamental step size in single cardiac and skeletal sarcomeres
    Olga Yakovenko
    Department of Bioengineering, University of Washington, Seattle 98195, USA
    Am J Physiol Cell Physiol 283:C735-42. 2002
    ..This value is equal to the linear repeat of actin monomers along the thin filament, a result that ties dynamic events to molecular structure and places narrow constraints on any proposed molecular mechanism...
  12. pmc Dynamics of individual sarcomeres during and after stretch in activated single myofibrils
    Dilson E Rassier
    Department of Bioengineering, University of Washington, Seattle, WA 98195, USA
    Proc Biol Sci 270:1735-40. 2003
    ..Sarcomeres never lengthened to a point beyond thick and thin filament overlap. We conclude that sarcomeres are non-uniform but generally stable on the descending limb of the force-length relationship...
  13. ncbi Connecting filament mechanics in the relaxed sarcomere
    Ekaterina Nagornyak
    Department of Bioengineering, University of Washington, 357962, Seattle, WA 98195, USA
    J Muscle Res Cell Motil 26:303-6. 2005
    ..7 nm...
  14. ncbi Stretch-induced force enhancement and stability of skeletal muscle myofibrils
    Dilson E Rassier
    Department of Bioengineering, University of Washington, Seattle, WA 98195, USA
    Adv Exp Med Biol 538:501-15; discussion 515. 2003
    ..It is concluded that sarcomeres are stable, and therefore the increased force observed after stretch must be a sarcomeric property, not associated with continuous length changes of unstable sarcomeres, as had been assumed in the past...
  15. pmc Passive stiffness in Drosophila indirect flight muscle reduced by disrupting paramyosin phosphorylation, but not by embryonic myosin S2 hinge substitution
    Yudong Hao
    Department of Bioengineering, University of Washington, Seattle, WA, USA
    Biophys J 91:4500-6. 2006
    ....
  16. ncbi Translation step size measured in single sarcomeres and single filament pairs
    Gerald H Pollack
    Department of Bioengineering, University of Washington, Seattle, WA 98195, USA
    Adv Exp Med Biol 538:129-40; discussion 141. 2003
  17. ncbi Effect of sarcomere length on step size in relaxed rabbit psoas muscle
    Ekaterina Nagornyak
    Department of Bioengineering 357962, University of Washington, Seattle, WA 98195, USA
    J Muscle Res Cell Motil 25:37-43. 2004
    ..7 nm...
  18. doi Automatic step-detection algorithm for analysis of sarcomere dynamics
    Chenyang Wang
    Department of Bioengineering, University of Washington, Seattle, WA, USA
    Comput Methods Biomech Biomed Engin 11:609-14. 2008
    ..The algorithm presented here offers a versatile and accurate tool that should be useful not only within muscle contraction and motility fields, but in fields which quantal phenomena play a role...
  19. pmc Mechanics of F-actin characterized with microfabricated cantilevers
    Xiumei Liu
    Department of Bioengineering, University of Washington, Seattle, WA 98195 USA
    Biophys J 83:2705-15. 2002
    ..75 microm was derived. These results suggest that F-actin is more compliant than previously thought and that thin filament compliance may account for a substantial fraction of the sarcomere's elasticity...
  20. ncbi Long-range forces extending from polymer-gel surfaces
    Jian ming Zheng
    Department of Bioengineering, Box 357962, University of Washington, Seattle, Washington 98195, USA
    Phys Rev E Stat Nonlin Soft Matter Phys 68:031408. 2003
    ..The observations imply that solutes may interact over an unexpectedly long range...
  21. ncbi Cylindrical phase separation in colloidal suspensions
    Kate Ovchinnikova
    Department of Bioengineering, University of Washington, Box 355061, Seattle, Washington 98195, USA
    Phys Rev E Stat Nonlin Soft Matter Phys 79:036117. 2009
    ..So long as suspension parameters were set within certain ranges, the cylindrical pattern occurred regularly...
  22. pmc Stepwise sliding of single actin and Myosin filaments
    Xiumei Liu
    Department of Bioengineering, University of Washington, Seattle, Washington 98195, USA
    Biophys J 86:353-8. 2004
    ..This size paradigm is parallel to that seen in the kinesin-microtubule system, where step size is an integer multiple of the tubulin repeat along the microtubule...
  23. ncbi Sarcomere dynamics, stepwise shortening and the nature of contraction
    Gerald H Pollack
    Dept of Bioengineering, Univ of Washington, Seattle WA 98195, USA
    Adv Exp Med Biol 565:113-25; discussion 125-6, 371-7. 2005
  24. ncbi Fluorescence anisotropy near-field scanning optical microscopy (FANSOM): a new technique for nanoscale microviscometry
    Frederick B Reitz
    Department of Bioengineering, University of Washington, Seattle 98195 7962, USA
    Ultramicroscopy 90:259-64. 2002
    ..Water above a cleaved mica surface was found to have a decreased microviscosity, while water above a hydrophobic surface showed no change (detection limit approximately 0.1 cP at approximately 30 + nm from the surface)...

Research Grants16

  1. Unexpectedly Profound Role of Water in Biology and Medicine
    Gerald H Pollack; Fiscal Year: 2010
    ..The experiments will test for a more central role of water than has been previously estimated. If the proposed hypotheses are validated, then a fresh understanding of biomedical principles should result. ..
  2. Stepwise translation of myofilaments
    Gerald Pollack; Fiscal Year: 2009
    ..Hence, the experiments should yield valuable information on the near-molecular nature of the contractile process. ..
  3. Stepwise translation of myofilaments
    Gerald H Pollack; Fiscal Year: 2010
    ..Hence, the experiments should yield valuable information on the near-molecular nature of the contractile process. ..
  4. Stepwise translation of myofilaments
    Gerald Pollack; Fiscal Year: 2007
    ..Hence, the experiments should yield valuable information on the near-molecular nature of the contractile process. ..
  5. Surface-induced informaton storage in water aggregates
    Gerald Pollack; Fiscal Year: 2006
    ..abstract_text> ..
  6. Physical properties of interfacial and structured water
    Gerald Pollack; Fiscal Year: 2005
    ..These are pilot studies designed to obtain preliminary data that may be useful for subsequent, more detailed investigations on the molecular basis of homeopathic procedures. ..
  7. 2004 Interfacial Biology in Water
    Gerald Pollack; Fiscal Year: 2004
    ..The meeting will be co-chaired by Gerald Pollack (University of Washington) and Chaim Frenkel (Rutgers University), and will be held at Mt...
  8. STEPWISE TRANSLATION OF MYOFIBRILS
    Gerald Pollack; Fiscal Year: 2003
    ..From the results we will learn much about the nature of contractile dynamics in the single sarcomere, and possibly also about the size and character of the molecular stroke. ..