Nick C Polfer

Summary

Affiliation: University of Florida
Country: USA

Publications

  1. doi request reprint Structures of biomolecular ions in the gas phase probed by infrared light sources
    Corey N Stedwell
    Department of Chemistry, University of Florida, Gainesville, Florida 32611 7200, USA
    Annu Rev Anal Chem (Palo Alto Calif) 6:267-85. 2013
  2. doi request reprint Infrared multiple photon dissociation spectroscopy of trapped ions
    Nick C Polfer
    University of Florida Chemistry, Buckman Drive P O Box 117200, Gainesville, Florida 32611, USA
    Chem Soc Rev 40:2211-21. 2011
  3. pmc On the dynamics of fragment isomerization in collision-induced dissociation of peptides
    Nick C Polfer
    Department of Chemistry, University of Florida, Gainesville, Florida 32611, USA
    J Phys Chem A 112:1286-93. 2008
  4. doi request reprint Vibrational spectroscopy of bare and solvated ionic complexes of biological relevance
    Nick C Polfer
    Chemistry Department, University of Florida, Gainesville, Florida 32611, USA
    Mass Spectrom Rev 28:468-94. 2009
  5. doi request reprint Disfavoring macrocycle b fragments by constraining torsional freedom: the "twisted" case of QWFGLM b6
    Marcus Tirado
    Department of Chemistry, University of Florida, P O Box 117200, Gainesville, FL, 32611 7200, USA
    J Am Soc Mass Spectrom 23:475-82. 2012
  6. doi request reprint Cyclic peptide as reference system for b ion structural analysis in the gas phase
    Xian Chen
    Department of Chemistry, University of Florida, Gainesville, Florida 32611, United States
    J Mass Spectrom 46:1011-5. 2011
  7. doi request reprint Oxazolone versus macrocycle structures for Leu-enkephalin b2-b4: insights from infrared multiple-photon dissociation spectroscopy and gas-phase hydrogen/deuterium exchange
    Xian Chen
    Department of Chemistry, University of Florida, Gainesville, Florida 32611 7200, USA
    J Am Soc Mass Spectrom 21:1313-21. 2010
  8. doi request reprint Dimeric complexes of tryptophan with M2+ metal ions
    Robert C Dunbar
    Department of Chemistry, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Phys Chem A 113:845-51. 2009
  9. doi request reprint Diagnostic NH and OH vibrations for oxazolone and diketopiperazine structures: b2 from protonated triglycine
    Da Wang
    Department of Chemistry, University of Florida, Gainesville, FL 32611 7200, USA
    J Am Soc Mass Spectrom 22:1197-203. 2011
  10. doi request reprint Alkali metal complexes of the dipeptides PheAla and AlaPhe: IRMPD spectroscopy
    Nick C Polfer
    Chemistry Department, University of Florida, Gainesville, FL 32611, USA
    Chemphyschem 9:579-89. 2008

Collaborators

Detail Information

Publications22

  1. doi request reprint Structures of biomolecular ions in the gas phase probed by infrared light sources
    Corey N Stedwell
    Department of Chemistry, University of Florida, Gainesville, Florida 32611 7200, USA
    Annu Rev Anal Chem (Palo Alto Calif) 6:267-85. 2013
    ..We discuss the most promising applications in bioanalytical mass spectrometry in view of recent experimental results, as well as future applications based on bioinformatics...
  2. doi request reprint Infrared multiple photon dissociation spectroscopy of trapped ions
    Nick C Polfer
    University of Florida Chemistry, Buckman Drive P O Box 117200, Gainesville, Florida 32611, USA
    Chem Soc Rev 40:2211-21. 2011
    ..The merits of different trapping approaches in mass spectrometry are discussed in the light of photodissociation experiments. This tutorial discusses current capabilities, as well as limitations of the technique...
  3. pmc On the dynamics of fragment isomerization in collision-induced dissociation of peptides
    Nick C Polfer
    Department of Chemistry, University of Florida, Gainesville, Florida 32611, USA
    J Phys Chem A 112:1286-93. 2008
    ..It is demonstrated here that cyclic and linear a4 structures can interconvert freely as a result of collisional activation, implying that isomerization takes place prior to dissociation...
  4. doi request reprint Vibrational spectroscopy of bare and solvated ionic complexes of biological relevance
    Nick C Polfer
    Chemistry Department, University of Florida, Gainesville, Florida 32611, USA
    Mass Spectrom Rev 28:468-94. 2009
    ....
  5. doi request reprint Disfavoring macrocycle b fragments by constraining torsional freedom: the "twisted" case of QWFGLM b6
    Marcus Tirado
    Department of Chemistry, University of Florida, P O Box 117200, Gainesville, FL, 32611 7200, USA
    J Am Soc Mass Spectrom 23:475-82. 2012
    ..These results show that some primary structures have an intrinsic propensity to form macrocycle structures, which is difficult to disrupt, even using residues with limited torsional flexibility...
  6. doi request reprint Cyclic peptide as reference system for b ion structural analysis in the gas phase
    Xian Chen
    Department of Chemistry, University of Florida, Gainesville, Florida 32611, United States
    J Mass Spectrom 46:1011-5. 2011
    ....
  7. doi request reprint Oxazolone versus macrocycle structures for Leu-enkephalin b2-b4: insights from infrared multiple-photon dissociation spectroscopy and gas-phase hydrogen/deuterium exchange
    Xian Chen
    Department of Chemistry, University of Florida, Gainesville, Florida 32611 7200, USA
    J Am Soc Mass Spectrom 21:1313-21. 2010
    ..This indicates that the chemistry of "head-to-tail" cyclization depends on subtle differences in the sequence as well as the size of the b fragment...
  8. doi request reprint Dimeric complexes of tryptophan with M2+ metal ions
    Robert C Dunbar
    Department of Chemistry, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Phys Chem A 113:845-51. 2009
    ..The presence of a CS ligand in all the dimeric complexes of the 2+ metals is an interesting contrast with the monomer complex Ba(2+)Trp, in which the ligand is ZW...
  9. doi request reprint Diagnostic NH and OH vibrations for oxazolone and diketopiperazine structures: b2 from protonated triglycine
    Da Wang
    Department of Chemistry, University of Florida, Gainesville, FL 32611 7200, USA
    J Am Soc Mass Spectrom 22:1197-203. 2011
    ....
  10. doi request reprint Alkali metal complexes of the dipeptides PheAla and AlaPhe: IRMPD spectroscopy
    Nick C Polfer
    Chemistry Department, University of Florida, Gainesville, FL 32611, USA
    Chemphyschem 9:579-89. 2008
    ..The spectroscopic findings are in better agreement with the MPW1PW91 DFT functional calculations of the thermochemistry compared with the B3LYP functional, which seems to underestimate the importance of the cation-pi interaction...
  11. doi request reprint Glycine and its hydrated complexes: a matrix isolation infrared study
    Clifton Espinoza
    Department of Chemistry and Center for Chemical Physics, University of Florida, Gainesville, Florida 32611 7200, USA
    J Phys Chem A 114:5919-27. 2010
    ..e., approximately 2%) of the experimental frequencies for glycine and glycine.H(2)O, provided that the potential energy surfaces are modeled with high-level ab initio approaches (MP2/aug-cc-pVDZ)...
  12. doi request reprint Periodicity of monoisotopic mass isomers and isobars in proteomics
    Long Yu
    Department of Chemistry, University of Florida, P O Box 117200, Gainesville, Florida 32611 7200, USA
    Anal Chem 83:8019-23. 2011
    ..e., <500 da)...
  13. doi request reprint Effect of peptide fragment size on the propensity of cyclization in collision-induced dissociation: oligoglycine b(2)-b(8)
    Xian Chen
    Department of Chemistry, University of Florida, Gainesville, Florida 32611, USA
    J Am Chem Soc 131:18272-82. 2009
    ..While more studies are required to establish the general propensity for cyclization in b fragments, the implications from this study are troubling in terms of faulty sequence identification...
  14. ncbi request reprint Gas-phase zwitterion stabilization by a metal dication
    Robert C Dunbar
    Chemistry Department, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Am Chem Soc 129:14562-3. 2007
    ..The principal spectroscopic signatures of the SB structure are the appearance of the antisymmetric CO stretch of the carboxylate group at 1600 cm-1 and the umbrella mode of NH3 at 1400 cm-1...
  15. ncbi request reprint Peptide length, steric effects, and ion solvation govern zwitterion stabilization in barium-chelated di- and tripeptides
    Robert C Dunbar
    Chemistry Department, Case Western Reserve University, Cleveland, Ohio 44106, FOM Institute for Plasmaphysics Rijnhuizen, Edisonbaan 14, NL 3439 MN Nieuwegein, The Netherlands, Chemistry Department, University of Florida, Gainesville, Florida 32611, and University of Amsterdam, Nieuwe Achtergracht 166, 1018WV Amsterdam, The Netherlands
    J Phys Chem B 113:10552-4. 2009
    ....
  16. ncbi request reprint Infrared spectroscopy of cationized lysine and epsilon-N-methyllysine in the gas phase: effects of alkali-metal ion size and proton affinity on zwitterion stability
    Matthew F Bush
    Department of Chemistry, University of California, Berkeley, California 94720 1460, USA
    J Phys Chem A 111:7753-60. 2007
    ..The proton affinity of Lys(Me) is 16 kJ/mol higher than that of Lys; the higher proton affinity of a secondary amine can result in its preferential protonation and stabilization of the zwitterionic form...
  17. ncbi request reprint Hybrid quadrupole mass filter∕quadrupole ion trap∕time-of-flight-mass spectrometer for infrared multiple photon dissociation spectroscopy of mass-selected ions
    Kerim Gulyuz
    Department of Chemistry, University of Florida, P O Box 117200, Gainesville, Florida 32611, USA
    Rev Sci Instrum 82:054101. 2011
    ..The appreciable photodissociation yields in these measurements demonstrate that IRMPD spectroscopy of covalently bound ions can be routinely carried out using benchtop OPO setups...
  18. doi request reprint On the relevance of peptide sequence permutations in shotgun proteomics studies
    Long Yu
    Department of Chemistry, University of Florida, P O Box 117200, Gainesville, Florida 32611 7200, United States
    J Proteome Res 10:2409-16. 2011
    ....
  19. ncbi request reprint Vibrational signatures of metal-chelated monosaccharide epimers: gas-phase infrared spectroscopy of Rb+-tagged glucuronic and iduronic acid
    Emilio B Cagmat
    Department of Chemistry, University of Florida, P O Box 117200, Gainesville, FL 32611 7200, USA
    Phys Chem Chem Phys 12:3474-9. 2010
    ..The lack of stronger hydrogen-bonding for IdoA + Rb(+) thus correlates well with the absence of the red-shifted OH stretch band at 3625 cm(-1)...
  20. ncbi request reprint Reaction products in mass spectrometry elucidated with infrared spectroscopy
    Nick C Polfer
    FOM Institute for Plasma Physics Rijnhuizen, Edisonbaan 14, 3439 MN Nieuwegein, The Netherlands
    Phys Chem Chem Phys 9:3804-17. 2007
    ..These results emphasize that more fundamental work is required in order to understand the underlying mechanisms in two of the most important structural techniques in MS...
  21. ncbi request reprint Infrared spectroscopy and theoretical studies on gas-phase protonated leu-enkephalin and its fragments: direct experimental evidence for the mobile proton
    Nick C Polfer
    FOM Institute for Plasma Physics Rijnhuizen, Edisonbaan 14, NL 3439 MN Nieuwegein, The Netherlands
    J Am Chem Soc 129:5887-97. 2007
    ..G.; Young, A. B.; Bleiholder, B.; Suhai, S.; Paizs, B. J. Am. Chem. Soc. 2006, 128, 10364-10365) that result in scrambling of the amino acid sequence upon CID...
  22. ncbi request reprint Differentiation of isomers by wavelength-tunable infrared multiple-photon dissociation-mass spectrometry: application to glucose-containing disaccharides
    Nick C Polfer
    FOM Institute for Plasma Physics, Rijnhuizen, Molecular Dynamics Group, MN Nieuwegein, The Netherlands
    Anal Chem 78:670-9. 2006
    ..Given the multidimensionality of variable-wavelength IR-MPD of lithiated disaccharides, it is expected that this approach can overcome some of the current limitations in isomer differentiation...