Eckhard R Podack

Summary

Affiliation: University of Miami
Country: USA

Publications

  1. ncbi request reprint Allogeneic vaccination with a B7.1 HLA-A gene-modified adenocarcinoma cell line in patients with advanced non-small-cell lung cancer
    Luis E Raez
    Division of Hematology Oncology, Sylvester Comprehensive Cancer Center, University of Miami School of Medicine, 1475 NW 12 Ave 3510, Miami, FL 33136, USA
    J Clin Oncol 22:2800-7. 2004
  2. ncbi request reprint Allogeneic tumor-cell-based vaccines secreting endoplasmic reticulum chaperone gp96
    Eckhard R Podack
    University of Miami School of Medicine, Department of Microbiology and Immunology, 1600 NW 10th Avenue, Room 3045D, Miami, FL 33136, USA
    Expert Opin Biol Ther 7:1679-88. 2007
  3. doi request reprint How to polymerize in order to survive
    Eckhard R Podack
    Department of Microbiology and Immunology, University of Miami, Leonard Miller School of Medicine, Miami, FL 33136, USA
    Immunity 30:668-70. 2009
  4. doi request reprint Cloning, expression, and functional characterization of TL1A-Ig
    Samia Q Khan
    Sheila and David Fuente Program in Cancer Biology, University of Miami Miller School of Medicine, Miami, FL 33101, USA
    J Immunol 190:1540-50. 2013
  5. pmc Cutting edge: novel vaccination modality provides significant protection against mucosal infection by highly pathogenic simian immunodeficiency virus
    Natasa Strbo
    Department of Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
    J Immunol 190:2495-9. 2013
  6. ncbi request reprint Molecular and cellular requirements for enhanced antigen cross-presentation to CD8 cytotoxic T lymphocytes
    Satoshi Oizumi
    Department of Microbiology and Immunology, University of Miami, Miller School of Medicine, Miami, FL 33136, USA
    J Immunol 179:2310-7. 2007
  7. pmc T cell costimulation by TNFR superfamily (TNFRSF)4 and TNFRSF25 in the context of vaccination
    Taylor H Schreiber
    Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL 33101, USA
    J Immunol 189:3311-8. 2012
  8. doi request reprint Surmounting tumor-induced immune suppression by frequent vaccination or immunization in the absence of B cells
    Satoshi Oizumi
    Department of Microbiology and Immunology, Division of Hematology and Oncology and Sylvester Comprehensive Cancer Center, University of Miami, Miller School of Medicine, Miami, FL 33136, USA
    J Immunother 31:394-401. 2008
  9. pmc Tumor-induced suppression of CTL expansion and subjugation by gp96-Ig vaccination
    Taylor H Schreiber
    Sheila and David Fuente Program in Cancer Biology, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida 33101, USA
    Cancer Res 69:2026-33. 2009
  10. doi request reprint B lymphocyte inhibition of anti-tumor response depends on expansion of Treg but is independent of B-cell IL-10 secretion
    Yu Zhang
    Division of Hematology Oncology, Department of Medicine, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Cancer Immunol Immunother 62:87-99. 2013

Collaborators

Detail Information

Publications48

  1. ncbi request reprint Allogeneic vaccination with a B7.1 HLA-A gene-modified adenocarcinoma cell line in patients with advanced non-small-cell lung cancer
    Luis E Raez
    Division of Hematology Oncology, Sylvester Comprehensive Cancer Center, University of Miami School of Medicine, 1475 NW 12 Ave 3510, Miami, FL 33136, USA
    J Clin Oncol 22:2800-7. 2004
    ..To determine the safety, immunogenicity, and clinical response to an allogeneic tumor vaccine for non-small-cell lung cancer, we conducted a phase I trial in patients with advanced metastatic disease...
  2. ncbi request reprint Allogeneic tumor-cell-based vaccines secreting endoplasmic reticulum chaperone gp96
    Eckhard R Podack
    University of Miami School of Medicine, Department of Microbiology and Immunology, 1600 NW 10th Avenue, Room 3045D, Miami, FL 33136, USA
    Expert Opin Biol Ther 7:1679-88. 2007
    ..The authors briefly review here the generation of cytotoxic T lymphocyte responses by gp96 and the most up to date clinical data in the use of gp96-based cancer vaccines...
  3. doi request reprint How to polymerize in order to survive
    Eckhard R Podack
    Department of Microbiology and Immunology, University of Miami, Leonard Miller School of Medicine, Miami, FL 33136, USA
    Immunity 30:668-70. 2009
    ..In this issue of Immunity, Baran et al. (2009) identify the molecular mechanism initiating polymerization as charge interactions in the MACPF domain...
  4. doi request reprint Cloning, expression, and functional characterization of TL1A-Ig
    Samia Q Khan
    Sheila and David Fuente Program in Cancer Biology, University of Miami Miller School of Medicine, Miami, FL 33101, USA
    J Immunol 190:1540-50. 2013
    ..Thus, TL1A-Ig fusion proteins are highly active and tightly controllable agents to stimulate Treg proliferation in vivo, and they are uniquely able to maintain high levels of expanded Tregs by repeated administration...
  5. pmc Cutting edge: novel vaccination modality provides significant protection against mucosal infection by highly pathogenic simian immunodeficiency virus
    Natasa Strbo
    Department of Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
    J Immunol 190:2495-9. 2013
    ..27, corresponding to a highly significant, 73% reduced risk for viral acquisition. The apparent success of the novel vaccine modality recommends further study...
  6. ncbi request reprint Molecular and cellular requirements for enhanced antigen cross-presentation to CD8 cytotoxic T lymphocytes
    Satoshi Oizumi
    Department of Microbiology and Immunology, University of Miami, Miller School of Medicine, Miami, FL 33136, USA
    J Immunol 179:2310-7. 2007
    ..This pathway may constitute a critically important, early detection, and rapid response mechanism that is operative in parenchymal tissues for effective defense against tissue damaging antigenic agents...
  7. pmc T cell costimulation by TNFR superfamily (TNFRSF)4 and TNFRSF25 in the context of vaccination
    Taylor H Schreiber
    Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL 33101, USA
    J Immunol 189:3311-8. 2012
    ..These studies highlight the overlapping but nonredundant activities of TNFRSF4 and TNFRSF25 in T cell immunity, which may guide the application of receptor agonistic agents as vaccine adjuvants for infectious disease and tumor immunity...
  8. doi request reprint Surmounting tumor-induced immune suppression by frequent vaccination or immunization in the absence of B cells
    Satoshi Oizumi
    Department of Microbiology and Immunology, Division of Hematology and Oncology and Sylvester Comprehensive Cancer Center, University of Miami, Miller School of Medicine, Miami, FL 33136, USA
    J Immunother 31:394-401. 2008
    ..Frequent vaccination with cellular vaccines and concurrent B-cell depletion may greatly enhance the activity of anticancer vaccine therapy in patients...
  9. pmc Tumor-induced suppression of CTL expansion and subjugation by gp96-Ig vaccination
    Taylor H Schreiber
    Sheila and David Fuente Program in Cancer Biology, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida 33101, USA
    Cancer Res 69:2026-33. 2009
    ..Taken together, our data suggest that established tumors may escape immunosurveillance by preventing clonal expansion of tumor-specific CTL without inducing anergy...
  10. doi request reprint B lymphocyte inhibition of anti-tumor response depends on expansion of Treg but is independent of B-cell IL-10 secretion
    Yu Zhang
    Division of Hematology Oncology, Department of Medicine, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Cancer Immunol Immunother 62:87-99. 2013
    ....
  11. doi request reprint Secreted heat shock protein gp96-Ig: an innovative vaccine approach
    Natasa Strbo
    Department of Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, FL, USA
    Am J Reprod Immunol 59:407-16. 2008
    ..The immunological properties of secreted gp96 and its implications for vaccine in human cancer and infectious diseases will be discussed...
  12. ncbi request reprint Tregs expanded in vivo by TNFRSF25 agonists promote cardiac allograft survival
    Dietlinde Wolf
    Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL 33101, USA
    Transplantation 94:569-74. 2012
    ..In the present study, we investigate the role of Tregs expanded in vivo by TNFRSF25 on cardiac allograft survival in a mouse model of fully major histocompatibility complex-mismatched ectopic heart transplants...
  13. ncbi request reprint Adoptively transferred tumor-specific T cells stimulated ex vivo using herpes simplex virus amplicons encoding 4-1BBL persist in the host and show antitumor activity in vivo
    Kyung H Yi
    Department of Microbiology and Immunology, University of Miami Miller School of Medicine, and University of Miami Sylvester Comprehensive Cancer Center, Miami, Florida 33136, USA
    Cancer Res 67:10027-37. 2007
    ..Tumor-specific T cells stimulated ex vivo using tumor transduced with HSV.4-1BBL expand in vivo following adoptive transfer, resulting in tumor eradication and the generation of tumor-specific CD44+Ly-6C+CD62L- effector memory T cells...
  14. pmc Therapeutic Treg expansion in mice by TNFRSF25 prevents allergic lung inflammation
    Taylor H Schreiber
    Sheila and David Fuente Program in Cancer Biology, University of Miami Miller School of Medicine, Miami, Florida 33101, USA
    J Clin Invest 120:3629-40. 2010
    ..Our studies define what we believe to be a novel mechanism for Treg control and important functions for TNFR25 in regulating autoaggression that balance its known role in enhancing autoimmunity...
  15. pmc TNF superfamily member 13, APRIL, inhibits allergic lung inflammation
    Yanping Xiao
    Department of Microbiology and Immunology, University of Miami, Leonard Miller School of Medicine, Miami, FL, USA
    Eur J Immunol 41:164-71. 2011
    ..Independent of its effect on IL-4, APRIL suppressed IL-13 expression. APRIL thus may regulate lung inflammation in a dual way, by acting on c-maf expression and by directly controlling IL-13 production...
  16. pmc IL-2 receptor signaling is essential for the development of Klrg1+ terminally differentiated T regulatory cells
    Guoyan Cheng
    Department of Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, FL 33101, USA
    J Immunol 189:1780-91. 2012
    ..These and other properties are analogous to terminally differentiated short-lived CD8(+) T effector cells. Our findings suggest that an important pathway driving Ag-activated conventional T lymphocytes also operates for Tregs...
  17. pmc Lung cancer immunotherapy
    Luis E Raez
    Epidemiology and Public Health, Sylvester Comprehensive Cancer Center, University of Miami School of Medicine, FL 33136, USA
    Clin Med Res 3:221-8. 2005
    ..Understanding the mechanisms of anti-tumor immunity and identifying target antigens will likely improve these therapeutic strategies and provide them with a niche in the future of lung cancer therapy...
  18. ncbi request reprint Clinical trials targeting lung cancer with active immunotherapy: the scope of vaccines
    Luis E Raez
    Division of Hematology Oncology, Sylvester Comprehensive Cancer Center, University of Miami School of Medicine, 1475 NW 12 Avenue, Miami, FL 33136, USA
    Expert Rev Anticancer Ther 5:635-44. 2005
    ..In this review, the rationale and design for induction of immunity to non-small cell lung cancer and clinical trials of the most important lung cancer vaccines in development are discussed...
  19. pmc Essential role of TNF receptor superfamily 25 (TNFRSF25) in the development of allergic lung inflammation
    Lei Fang
    Department of Microbiology and Immunology, Leonard Miller School of Medicine, University of Miami, Miami, FL 33136, USA
    J Exp Med 205:1037-48. 2008
    ..The TNFR25/TL1A pair appears to provide an early signal for Th2 cytokine production in the lung, and therefore may be a drug target in attempts to attenuate lung inflammation in asthmatics...
  20. ncbi request reprint Induction of CD8 T-cell-Ifn-gamma response and positive clinical outcome after immunization with gene-modified allogeneic tumor cells in advanced non-small-cell lung carcinoma
    Luis E Raez
    Department of Medicine, University of Miami School of Medicine, Miami, FL 33136, USA
    Cancer Gene Ther 10:850-8. 2003
    ..The positive clinical outcome suggests that nonimmunogenic tumors may be highly susceptible to immune effector cells generated by immunization...
  21. pmc APRIL (TNFSF13) regulates collagen-induced arthritis, IL-17 production and Th2 response
    Yanping Xiao
    Department of Microbiology and Immunology, University of Miami, Leonard Miller School of Medicine, Miami, FL 33136, USA
    Eur J Immunol 38:3450-8. 2008
    ..Blockade of APRIL thus may be a valuable adjunct in the treatment of rheumatoid arthritis...
  22. pmc Gp96 SIV Ig immunization induces potent polyepitope specific, multifunctional memory responses in rectal and vaginal mucosa
    Natasa Strbo
    Department of Microbiology and Immunology, University of Miami, Miller School of Medicine, Miami, FL 33136, USA
    Vaccine 29:2619-25. 2011
    ..Induction of powerful mucosal effector CD8 CTL responses by cell-based gp96(SIV)-Ig immunization may provide a pathway to the development of safe and effective SIV/HIV vaccines...
  23. ncbi request reprint Present and future of lung cancer vaccines
    Luis E Raez
    Thoracic Oncology Group, Sylvester Comprehensive Cancer Center, Division of Hematology Oncology, University of Miami School of Medicine, 1475 NW 12 Avenue, Miami, FL 33136, USA
    Expert Opin Emerg Drugs 11:445-59. 2006
    ..Initial data from these trials have shown preliminary evidence of induction of immune responses and suggest clinical activity. This paper reviews some of the most important developments in vaccines for lung cancer...
  24. ncbi request reprint Pore formers of the immune system
    Eckhard R Podack
    University of Miami, Department of Microbiology and Immunology, Miller School of Medicine, Miami, Florida 33136, USA
    Adv Exp Med Biol 598:325-41. 2007
  25. ncbi request reprint Donor T cells lacking Fas ligand and perforin retain the capacity to induce severe GvHD in minor histocompatibility antigen mismatched bone-marrow transplantation recipients
    Lianne Marks
    Department of Microbiology and Immunology, University of Miami School of Medicine, Miami, FL 33101, USA
    Transplantation 77:804-12. 2004
    ..In addition, the results suggest that this model will be useful to investigate the regulation of allogeneic donor T-cell expansion after major histocompatibility complex-matched allogeneic BMT...
  26. ncbi request reprint Heat shock protein-based cancer vaccines
    Kelvin P Lee
    Department of Microbiology and Immunology, University of Miami Miller School of Medicine, FL, USA
    Hematol Oncol Clin North Am 20:637-59. 2006
    ..This article is not a definitive compendium of the huge body of relevant literature but rather focuses on the major concepts underlying active specific immunotherapy in general and heat shock protein vaccines in particular...
  27. ncbi request reprint TNF superfamily member 13, APRIL, inhibits allergic lung inflammation
    Yanping Xiao
    Department of Microbiology and Immunology, University of Miami, Leonard Miller School of Medicine, Miami, FL, USA
    Eur J Immunol 41:164-71. 2011
    ..Independent of its effect on IL-4, APRIL suppressed IL-13 expression. APRIL thus may regulate lung inflammation in a dual way, by acting on c-maf expression and by directly controlling IL-13 production...
  28. pmc Killing machines: three pore-forming proteins of the immune system
    Ryan McCormack
    Department of Microbiology and Immunology, Leonard Miller School of Medicine, University of Miami, Miami, FL, USA
    Immunol Res 57:268-78. 2013
    ..Our laboratory has been involved in the discovery and description of each of the three pore-formers that will be reviewed here. ..
  29. doi request reprint Secreted heat shock protein gp96-Ig: next-generation vaccines for cancer and infectious diseases
    Natasa Strbo
    Department of Microbiology and Immunology, University of Miami Miller School of Medicine, RMSB 3008, 1600 NW 10th Ave, Miami, FL, 33136, USA
    Immunol Res 57:311-25. 2013
    ..Here, we review the vaccine design that utilizes the unique property/ability of endoplasmic HSP gp96 to bind antigenic peptides and deliver them to antigen-presenting cells. ..
  30. pmc Humanized mice: novel model for studying mechanisms of human immune-based therapies
    Louis Gonzalez
    Department of Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, FL, USA
    Immunol Res 57:326-34. 2013
    ....
  31. pmc Inhibition of intracellular bacterial replication in fibroblasts is dependent on the perforin-like protein (perforin-2) encoded by macrophage-expressed gene 1
    Ryan McCormack
    Department of Microbiology and Immunology, University of Miami, Miller School of Medicine, Miami, FL 33136, USA
    J Innate Immun 5:185-94. 2013
    ..We propose the name perforin-2...
  32. doi request reprint B cell regulation of anti-tumor immune response
    Yu Zhang
    Division of Hematology Oncology, Department of Medicine, University of Miami Miller School of Medicine and Sylvester Comprehensive Cancer Center, Miami, FL, 33136, USA
    Immunol Res 57:115-24. 2013
    ..Significant infiltration of human tumors by Treg cells as well as B cells suggests that observations made in murine systems may be applicable to human tumors as well. ..
  33. doi request reprint The allure and peril of hematopoietic stem cell transplantation: overcoming immune challenges to improve success
    Robert G Newman
    Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL, 33131, USA
    Immunol Res 57:125-39. 2013
    ..Lastly, our findings support the notion that the ocular compartment can be locally targeted to regulate visual complications of GVHD which may involve both alloreactive and self-reactive (i.e., autoimmune) responses...
  34. doi request reprint Immunobiology of TNFSF15 and TNFRSF25
    Taylor H Schreiber
    Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL, USA
    Immunol Res 57:3-11. 2013
    ....
  35. doi request reprint CD30: an important new target in hematologic malignancies
    Yehuda E Deutsch
    Department of Medicine, Division of Hematology Oncology, University of Miami Miller School of Medicine and Sylvester Comprehensive Cancer Center, Miami, FL 33136, USA
    Leuk Lymphoma 52:1641-54. 2011
    ..This has defined an important emerging role for targeting of CD30 in the setting of Hodgkin lymphoma, ALCL, and possibly other CD30+ malignancies...
  36. ncbi request reprint Perforin is required for innate and adaptive immunity induced by heat shock protein gp96
    Natasa Strbo
    Department of Microbiology and Immunology, University of Miami School of Medicine, Miami, FL 33136, USA
    Immunity 18:381-90. 2003
    ..The studies also explain how depressed NK activity in patients with tumors or after viral infections could diminish CTL responses...
  37. ncbi request reprint CD30-governor of memory T cells?
    Eckhard R Podack
    Department of Microbiology and Immunology, University of Miami School of Medicine, Miami, Florida 33136, USA
    Ann N Y Acad Sci 975:101-13. 2002
    ..The studies suggest that CD30 regulates CD8 CTL function and survival during memory responses and is important for clonal contraction...
  38. ncbi request reprint Heat shock fusion protein gp96-Ig mediates strong CD8 CTL expansion in vivo
    Natasa Strbo
    Department of Microbiology and Immunology, University of Miami School of Medicine, Miami, FL, USA
    Am J Reprod Immunol 48:220-5. 2002
    ..In this study, we set out to develop a system to quantitatively determine the CD8 CTL response to gp96-Ig and to evaluate the influence of an established wild type tumor...
  39. ncbi request reprint Murine cytomegalovirus retinitis during retrovirus-induced immunodeficiency (MAIDS) in mice: interleukin-2 immunotherapy correlates with increased intraocular levels of perforin mRNA
    Richard D Dix
    Harvery and Bernice Jones Eye Institute, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Antiviral Res 59:111-9. 2003
    ..Our findings support the hypothesis that systemic IL-2 immunotherapy during MAIDS provides protection against MCMV retinitis by upregulation of perforin-mediated cytotoxicity used by cytotoxic lymphocytes to kill virus-infected cells...
  40. ncbi request reprint Systemic and local expression of perforin in lymphocyte subsets in acute and chronic rheumatoid arthritis
    Gordan Gulan
    Department of Orthopaedic Surgery, Faculty of Medicine, University of Rijeka, Rijeka, Croatia
    J Rheumatol 30:660-70. 2003
    ..Cells from patients with osteoarthritis were used as controls...
  41. ncbi request reprint Decrease in CD3-negative-CD8dim(+) and Vdelta2/Vgamma9 TcR+ peripheral blood lymphocyte counts, low perforin expression and the impairment of natural killer cell activity is associated with chronic hepatitis C virus infection
    Gabriella Par
    Institute of Microbiology and Immunology, University of Pecs, Pecs, Hungary
    J Hepatol 37:514-22. 2002
    ....
  42. ncbi request reprint IL-18 is present at the maternal-fetal interface and enhances cytotoxic activity of decidual lymphocytes
    Vlatka S Tokmadzić
    Department of Physiology and Immunology, Medical Faculty, University of Rijeka, Rijeka, Croatia
    Am J Reprod Immunol 48:191-200. 2002
    ..Perforin expressing uterine natural killer (uNK) cells are under complex cytokine influence. The aim of the study was to investigate the presence and role of interleukin (IL)-18 on NK cytolytic potential at maternal-fetal (M-F) interface...
  43. ncbi request reprint CD30/CD30 ligand (CD153) interaction regulates CD4+ T cell-mediated graft-versus-host disease
    Bruce R Blazar
    Cancer Center and Department of Pediatrics, Division of Bone Marrow Transplantation, University of Minnesota, Minneapolis, MN 55455, USA
    J Immunol 173:2933-41. 2004
    ..Blockade of the CD30/CD153 pathway represents a new approach for preventing CD4(+) T cell-mediated GVHD...
  44. ncbi request reprint A novel role of CD30/CD30 ligand signaling in the generation of long-lived memory CD8+ T cells
    Hitoshi Nishimura
    Division of Host Defense, Center for Prevention of Infectious Disease, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
    J Immunol 175:4627-34. 2005
    ..These results suggest that CD30/CD30 ligand signaling plays an important role in the generation of long-lived memory CD8+ T cells at least partly by triggering homing receptors for T(CM) cells...
  45. pmc Loss of the perforin cytotoxic pathway predisposes mice to experimental cytomegalovirus retinitis
    Richard D Dix
    Department of Ophthalmology, Harvey and Bernice Jones Eye Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    J Virol 77:3402-8. 2003
    ....
  46. ncbi request reprint Short-term cytolytic mediators' expression in decidual lymphocytes is enhanced by interleukin-15
    Natasa Strbo
    Department of Physiology and Immunology, Medical Faculty, University of Rijeka, Rijeka, Croatia
    Am J Reprod Immunol 55:217-25. 2006
    ..We investigated whether decidual adherent cells (DAC) and interleukin (IL)-15, in comparison to interleukin (IL)-2 affect cytolytic potential of first trimester decidual lymphocytes (DL)...
  47. ncbi request reprint Progesterone induced blocking factor (PIBF) mediates progesterone induced suppression of decidual lymphocyte cytotoxicity
    Gordana Laskarin
    Department of Physiology and Immunology, Medical Faculty, University of Rijeka, Rijeka, Croatia
    Am J Reprod Immunol 48:201-9. 2002
    ..Cytolytic activity of non-adherent DL was measured by PKH-26 (red) 2 hr cytolytic assay and flow cytometry. Perforin positive DL were detected by immunofluorescency and PIBF-positive cells by immunohistology...