Charles Plopper

Summary

Affiliation: University of California
Country: USA

Publications

  1. doi request reprint Lung effects of inhaled corticosteroids in a rhesus monkey model of childhood asthma
    C G Plopper
    Respiratory Diseases Unit, California National Primate Research Center, University of California, One Shields Ave, Davis, CA 95616, USA
    Clin Exp Allergy 42:1104-18. 2012
  2. ncbi request reprint Elevation of susceptibility to ozone-induced acute tracheobronchial injury in transgenic mice deficient in Clara cell secretory protein
    C G Plopper
    Department of Anatomy, Physiology and Cell Biology, California National Primate Center, School of Veterinary Medicine, 1 Shields Avenue, University of California, Davis, CA 95616, USA
    Toxicol Appl Pharmacol 213:74-85. 2006
  3. ncbi request reprint Asthma/allergic airways disease: does postnatal exposure to environmental toxicants promote airway pathobiology?
    Charles G Plopper
    Department of Anatomy, Physiology, and Cell Biology, University of California, Davis, CA 95616, USA
    Toxicol Pathol 35:97-110. 2007
  4. ncbi request reprint Early events in naphthalene-induced acute Clara cell toxicity. II. Comparison of glutathione depletion and histopathology by airway location
    C G Plopper
    Department of Anatomy, School of Veterinary Medicine, University of California Davis, Davis 95616, USA
    Am J Respir Cell Mol Biol 24:272-81. 2001
  5. doi request reprint The non-human primate as a model for studying COPD and asthma
    Charles G Plopper
    California National Primate Research Center and School of Veterinary Medicine, University of California, One Shields Avenue, Davis, CA 95616, USA
    Pulm Pharmacol Ther 21:755-66. 2008
  6. ncbi request reprint Characterization of the cytochrome P-450 monooxygenase system in nonciliated bronchiolar epithelial (Clara) cells isolated from mouse lung
    C H Chichester
    School of Veterinary Medicine, Department of Anatomy, University of California, Davis 95616
    Am J Respir Cell Mol Biol 4:179-86. 1991
  7. ncbi request reprint In situ naphthalene bioactivation and nasal airflow cause region-specific injury patterns in the nasal mucosa of rats exposed to naphthalene by inhalation
    Myong Gyong Lee
    Department of Anatomy, Physiology, and Cell Biology, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    J Pharmacol Exp Ther 314:103-10. 2005
  8. ncbi request reprint Inhaled naphthalene causes dose dependent Clara cell cytotoxicity in mice but not in rats
    J A West
    Department of Anatomy, Physiology, and Cell Biology, University of California, Davis, California 95616, USA
    Toxicol Appl Pharmacol 173:114-9. 2001
  9. ncbi request reprint Factors modulating the epithelial response to toxicants in tracheobronchial airways
    C G Plopper
    VM: Anatomy, Physiology and Cell Biology, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    Toxicology 160:173-80. 2001
  10. ncbi request reprint Smooth muscle hypertrophy in distal airways of sensitized infant rhesus monkeys exposed to house dust mite allergen
    M U T Tran
    Department of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    Clin Exp Allergy 34:1627-33. 2004

Research Grants

  1. LUNG TOXICOLOGY AND THE IMMATURE CLARA CELL
    Charles Plopper; Fiscal Year: 2003
  2. DEVELOPMENTAL LUNG TOXICOLOGY & THE IMMATURE CLARA CELL
    Charles Plopper; Fiscal Year: 2009

Detail Information

Publications89

  1. doi request reprint Lung effects of inhaled corticosteroids in a rhesus monkey model of childhood asthma
    C G Plopper
    Respiratory Diseases Unit, California National Primate Research Center, University of California, One Shields Ave, Davis, CA 95616, USA
    Clin Exp Allergy 42:1104-18. 2012
    ..The current study employs a primate experimental model to identify the risks posed by ICS therapy...
  2. ncbi request reprint Elevation of susceptibility to ozone-induced acute tracheobronchial injury in transgenic mice deficient in Clara cell secretory protein
    C G Plopper
    Department of Anatomy, Physiology and Cell Biology, California National Primate Center, School of Veterinary Medicine, 1 Shields Avenue, University of California, Davis, CA 95616, USA
    Toxicol Appl Pharmacol 213:74-85. 2006
    ..Whether this is due to the presence of CCSP on the acellular lining layer surface and/or its intracellular distribution in the secretory cell population needs to be defined...
  3. ncbi request reprint Asthma/allergic airways disease: does postnatal exposure to environmental toxicants promote airway pathobiology?
    Charles G Plopper
    Department of Anatomy, Physiology, and Cell Biology, University of California, Davis, CA 95616, USA
    Toxicol Pathol 35:97-110. 2007
    ..And, exposure of infants during early postnatal lung development initiates compromises in airway growth and development that persist or worsen as growth continues, even with cessation of exposure...
  4. ncbi request reprint Early events in naphthalene-induced acute Clara cell toxicity. II. Comparison of glutathione depletion and histopathology by airway location
    C G Plopper
    Department of Anatomy, School of Veterinary Medicine, University of California Davis, Davis 95616, USA
    Am J Respir Cell Mol Biol 24:272-81. 2001
    ....
  5. doi request reprint The non-human primate as a model for studying COPD and asthma
    Charles G Plopper
    California National Primate Research Center and School of Veterinary Medicine, University of California, One Shields Avenue, Davis, CA 95616, USA
    Pulm Pharmacol Ther 21:755-66. 2008
    ..We conclude that nonhuman primate models are appropriate for defining mechanisms as they relate to allergic airways disease and COPD in humans...
  6. ncbi request reprint Characterization of the cytochrome P-450 monooxygenase system in nonciliated bronchiolar epithelial (Clara) cells isolated from mouse lung
    C H Chichester
    School of Veterinary Medicine, Department of Anatomy, University of California, Davis 95616
    Am J Respir Cell Mol Biol 4:179-86. 1991
    ..abstract truncated at 250 words)..
  7. ncbi request reprint In situ naphthalene bioactivation and nasal airflow cause region-specific injury patterns in the nasal mucosa of rats exposed to naphthalene by inhalation
    Myong Gyong Lee
    Department of Anatomy, Physiology, and Cell Biology, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    J Pharmacol Exp Ther 314:103-10. 2005
    ....
  8. ncbi request reprint Inhaled naphthalene causes dose dependent Clara cell cytotoxicity in mice but not in rats
    J A West
    Department of Anatomy, Physiology, and Cell Biology, University of California, Davis, California 95616, USA
    Toxicol Appl Pharmacol 173:114-9. 2001
    ....
  9. ncbi request reprint Factors modulating the epithelial response to toxicants in tracheobronchial airways
    C G Plopper
    VM: Anatomy, Physiology and Cell Biology, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    Toxicology 160:173-80. 2001
    ....
  10. ncbi request reprint Smooth muscle hypertrophy in distal airways of sensitized infant rhesus monkeys exposed to house dust mite allergen
    M U T Tran
    Department of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    Clin Exp Allergy 34:1627-33. 2004
    ..Airway smooth muscle hypertrophy is closely associated with the pathophysiology of hyper-reactive airways in allergic asthma...
  11. pmc Toxicity and metabolism of methylnaphthalenes: comparison with naphthalene and 1-nitronaphthalene
    Ching Yu Lin
    Department of Molecular Biosciences and Anatomy, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    Toxicology 260:16-27. 2009
    ....
  12. ncbi request reprint Lentiviral vector gene transfer into fetal rhesus monkeys (Macaca mulatta): lung-targeting approaches
    A F Tarantal
    California Regional Primate Research Center, University of California, Davis, California 95616 8542, USA
    Mol Ther 4:614-21. 2001
    ....
  13. ncbi request reprint Three-dimensional mapping of smooth muscle in the distal conducting airways of mouse, rabbit, and monkey
    S M Smiley-Jewell
    Department of Anatomy, Physiology, and Cell Biology, School of Veterinary Medicine, University of California, Davis, California 95616 8732, USA
    J Appl Physiol 93:1506-14. 2002
    ..This study defines the normal distribution of smooth muscle in three test species and provides a basis for future comparisons with the diseased state...
  14. ncbi request reprint Airway generation-specific differences in the spatial distribution of immune cells and cytokines in allergen-challenged rhesus monkeys
    L A Miller
    Center for Comparative Respiratory Biology and Medicine and the California Regional Primate Research Center, University of California, Davis, CA 95616, USA
    Clin Exp Allergy 35:894-906. 2005
    ..It has been postulated that peripheral regions of the lung play a more significant role than proximal airways with regard to inflammatory events and airflow obstruction...
  15. ncbi request reprint Prevention of naphthalene-induced pulmonary toxicity by glutathione prodrugs: roles for glutathione depletion in adduct formation and cell injury
    A J Phimister
    Department of Molecular Biosciences, University of California, 1311 Haring Hall, Davis, CA 95616, USA
    J Biochem Mol Toxicol 19:42-51. 2005
    ....
  16. ncbi request reprint Immune and airway effects of house dust mite aeroallergen exposures during postnatal development of the infant rhesus monkey
    L A Miller
    Department of Anatomy, Physiology, and Cell Biology, School of Veterinary Medicine and the California Regional Primate Research Center, University of California, Davis, CA 95616, USA
    Clin Exp Allergy 33:1686-94. 2003
    ..The effect of chronic environmental aeroallergen exposure on the immune system and airways has not been experimentally defined in very young children...
  17. ncbi request reprint The remodelled tracheal basement membrane zone of infant rhesus monkeys after 6 months of recovery
    M J Evans
    Department of Anatomy, Physiology and Cell Biology Center for Comparative Respiratory Biology and Medicine, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    Clin Exp Allergy 34:1131-6. 2004
    ..0 microm in width)...
  18. ncbi request reprint Glutathione depletion is a major determinant of inhaled naphthalene respiratory toxicity and naphthalene metabolism in mice
    A J Phimister
    Department of Anatomy, Physiology, and Cell Biology, University of California, Davis, CA 95616, USA
    Toxicol Sci 82:268-78. 2004
    ....
  19. ncbi request reprint Cellular and molecular characteristics of basal cells in airway epithelium
    M J Evans
    Department of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine, University of California, Davis 95616, USA
    Exp Lung Res 27:401-15. 2001
    ..It should be pointed out that specific studies have not been carried out which test the relationship between the molecular functions we describe in this review and the basal cell in airway epithelium...
  20. ncbi request reprint Differential expression of stress proteins in nonhuman primate lung and conducting airway after ozone exposure
    R Wu
    Division of Pulmonary and Critical Care Medicine, University of California, Davis, California 95616, USA
    Am J Physiol 277:L511-22. 1999
    ..Furthermore, differences between in vitro and in vivo with regard to activation of HSPs and GRPs suggest a secondary mechanism in vivo, perhaps related to inflammatory response after ozone exposure...
  21. ncbi request reprint Development of phase II xenobiotic metabolizing enzymes in differentiating murine clara cells
    M V Fanucchi
    Department of Veterinary Anatomy, Physiology, and Cell Biology, School of Veterinary Medicine, Davis, California 95616, USA
    Toxicol Appl Pharmacol 168:253-67. 2000
    ....
  22. ncbi request reprint Glutathione conjugation of electrophilic metabolites of 1-nitronaphthalene in rat tracheobronchial airways and liver: identification by mass spectrometry and proton nuclear magnetic resonance spectroscopy
    K C Watt
    Department of Molecular Biosciences, School of Veterinary Medicine, Department of Chemistry, Facility for Advanced Instrumentation, University of California at Davis 95616, USA
    Chem Res Toxicol 12:831-9. 1999
    ..HPLC radioactivity profiles demonstrated that major conjugates generated in the lung were derived from the C(7), C(8)-epoxide, whereas the most prominent metabolites in the liver were derived from the C(5),C(6)-epoxide...
  23. ncbi request reprint Long-term exposure to ozone increases acute pulmonary centriacinar injury by 1-nitronaphthalene: I. Region-specific enzyme activity
    R C Paige
    Department of Anatomy, Physiology, and Cell Biology, University of California, Davis, California 95616, USA
    J Pharmacol Exp Ther 295:934-41. 2000
    ..Long-term exposure to O(3) elevates both CYP 2B activity and 1-NN metabolism in an airway-specific manner...
  24. ncbi request reprint Three-dimensional organization of the lamina reticularis in the rat tracheal basement membrane zone
    M J Evans
    Department of Anatomy, Physiology, and Cell Biology and Center for Comparative Respiratory Biology and Medicine, School of Veterinary Medicine, University of California, Davis, 95616, USA
    Am J Respir Cell Mol Biol 22:393-7. 2000
    ..The present studies demonstrate that the structural proteins of the lamina reticularis in the rat trachea are arranged as fibers in a highly organized manner...
  25. ncbi request reprint Acute injury to differentiating Clara cells in neonatal rabbits results in age-related failure of bronchiolar epithelial repair
    S M Smiley-Jewell
    Department of Anatomy, Physiology, and Cell Biology, School of Veterinary Medicine, University of California, Davis 95616 8732, USA
    Toxicol Pathol 28:267-76. 2000
    ..Animals treated during late stages were similar to controls. Thus, differentiating Clara cells are susceptible to injury by the P450-mediated cytotoxicant IPO, but the extent of repair varies based on when the initial injury occurs...
  26. ncbi request reprint Early events in naphthalene-induced acute Clara cell toxicity: comparison of membrane permeability and ultrastructure
    L S Van Winkle
    Department of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine, University of California Davis, Davis, California, USA
    Am J Respir Cell Mol Biol 21:44-53. 1999
    ..We conclude that the early stages of injury include SER swelling and bleb formation which precede increases in cell membrane permeability after acute naphthalene injury to bronchiolar Clara cells in vivo...
  27. pmc Distribution of particulate matter and tissue remodeling in the human lung
    K E Pinkerton
    Department of Anatomy, Physiology, and Cell Biology, School of Veterinary Medicine and Department of Epidemiology and Preventive Medicine, School of Medicine, University of California, Davis, California 95616 5270, USA
    Environ Health Perspect 108:1063-9. 2000
    ..Furthermore, there is significant remodeling of this transitional zone in humans exposed to ambient particulate matter...
  28. ncbi request reprint Effect of chronic daily ozone exposure on Clara cell secretory protein mRNA expression in the adult rat lung
    F H Royce
    Department of Pediatrics, School of Medicine, University of California, Davis, Sacramento 95817, USA
    Exp Lung Res 23:51-64. 1997
    ..The results showed that (1) CCSP mRNA expression, GAPDH, and beta-actin do not change as a result of ozone injury, (2) mRNA levels are more variable as a result of ozone injury and (3) CCSP mRNA expression increases with age...
  29. pmc Allergic asthma induced in rhesus monkeys by house dust mite (Dermatophagoides farinae)
    E S Schelegle
    Department of Anatomy, Physiology, and Cell Biology, School of Veterinary Medicine, University of California, Davis 95616, USA
    Am J Pathol 158:333-41. 2001
    ..We conclude that a model of allergic asthma can be induced in rhesus monkeys using a protocol consisting of subcutaneous injection, intranasal instillation, and aerosol challenge with HDMA...
  30. ncbi request reprint Long-term exposure to ozone increases acute pulmonary centriacinar injury by 1-nitronaphthalene: II. Quantitative histopathology
    R C Paige
    Department of Anatomy, Physiology, and Cell Biology, School of Veterinary Medicine, University of California, Davis, California 95616, USA
    J Pharmacol Exp Ther 295:942-50. 2000
    ..This study demonstrates a site-selective synergy between the copollutants ozone and 1-nitronaphthalene in the production of acute lung injury...
  31. ncbi request reprint Prior exposure to aged and diluted sidestream cigarette smoke impairs bronchiolar injury and repair
    L S Van Winkle
    Department of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine, University of California Davis, Davis, California 95616 8732, USA
    Toxicol Sci 60:152-64. 2001
    ....
  32. ncbi request reprint Neutrophils enhance clearance of necrotic epithelial cells in ozone-induced lung injury in rhesus monkeys
    D M Hyde
    California Regional Primate Research Center and Center for Comparative Respiratory Biology and Medicine, University of California, Davis, California 95616, USA
    Am J Physiol 277:L1190-8. 1999
    ..These data indicate that neutrophil influx in ozone-induced injury in primates is CD18 dependent and that neutrophils contribute to the repair of airway epithelium by removal of injured epithelial cells...
  33. ncbi request reprint Site-specific metabolism of naphthalene and 1-nitronaphthalene in dissected airways of rhesus macaques
    Bridget Boland
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California Davis, Davis, CA 95616, USA
    J Pharmacol Exp Ther 310:546-54. 2004
    ....
  34. ncbi request reprint Morphometric assessment of pulmonary toxicity in the rodent lung
    D M Hyde
    Department of Anatomy, School of Veterinary Medicine, University of California Davis 95616
    Toxicol Pathol 19:428-46. 1991
    ..These unbiased stereological approaches are critical in a quantitative evaluation of toxicological injury of rat tracheobronchial airways...
  35. ncbi request reprint Cellular characterization of leukotoxin diol-induced mitochondrial dysfunction
    M F Sisemore
    Department of Entomology, University of California, Davis, California 95616, USA
    Arch Biochem Biophys 392:32-7. 2001
    ....
  36. ncbi request reprint Design-based sampling and quantitation of the respiratory airways
    Dallas M Hyde
    California National Primate Research Center, University of California, Davis, California 95615, USA
    Toxicol Pathol 34:286-95. 2006
    ..True biological variance and the average sampling variance of the stereological measurement define the minimal sampling required to achieve precise estimates of the nasal cavity, larynx and conducting airways...
  37. pmc In vivo effects of ozone exposure on protein adduct formation by 1-nitronaphthalene in rat lung
    Asa M Wheelock
    Department of Molecular Biosciences and Anatomy, School of Veterinary Medicine, University of California, Davis, USA
    Am J Respir Cell Mol Biol 33:130-7. 2005
    ..These studies identified in vivo protein targets for reactive 1-NN metabolites that are potentially associated with the mechanism of 1-NN toxicity and the synergistic effects of ozone...
  38. ncbi request reprint Consequences of abrupt glutathione depletion in murine Clara cells: ultrastructural and biochemical investigations into the role of glutathione loss in naphthalene cytotoxicity
    Andrew J Phimister
    Department of Molecular Biosciences, University of California, Davis, CA 95616, USA
    J Pharmacol Exp Ther 314:506-13. 2005
    ..This suggests that glutathione depletion may be responsible for some aspects of naphthalene cytotoxicity, but it is not sufficient to cause cell death without further stresses...
  39. ncbi request reprint The effects of inhaled corticosteroids on intrinsic responsiveness and histology of airways from infant monkeys exposed to house dust mite allergen and ozone
    Jesse P Joad
    Department of Pediatrics, School of Medicine, University of California at Davis, Davis, CA 95616, USA
    Toxicol Appl Pharmacol 226:153-60. 2008
    ..ICS change morphology and function in normal airways as well as allergen/ozone-exposed airways, suggesting that they should be reserved for infants with active symptoms...
  40. ncbi request reprint Assessing the health effects and risks associated with children's inhalation exposures--asthma and allergy
    MaryJane K Selgrade
    National Health and Environmental Effects Research Laboratory, North California, USA
    J Toxicol Environ Health A 71:196-207. 2008
    ..Because asthma is a complex (multiple genes, phenotypes, organ systems) disease, this area is ripe for systems biology approaches...
  41. pmc Chronic aeroallergen during infancy enhances eotaxin-3 expression in airway epithelium and nerves
    Debbie L Chou
    Center for Comparative Respiratory Biology and Medicine, University of California Davis, 95616, USA
    Am J Respir Cell Mol Biol 33:1-8. 2005
    ..We conclude that localized expression of eotaxin-3 plays an important role in the recruitment of diverse CCR3+ cell populations to different anatomic microenvironments within the infant airway in response to chronic allergen exposure...
  42. doi request reprint Bifurcation model for characterization of pulmonary architecture
    Dongyoub Lee
    Department of Mechanical and Aeronautical Engineering, University of California, Davis, California 95616, USA
    Anat Rec (Hoboken) 291:379-89. 2008
    ..We validated the bifurcation model by comparing it to a computed tomography image of a rat lung cast. Three-dimensional representations of the bifurcation geometry can be viewed at http://mae.ucdavis.edu/wexler/lungs/bifurc.htm...
  43. doi request reprint Pulmonary architecture in the conducting regions of six rats
    Dongyoub Lee
    Department of Mechanical and Aeronautical Engineering, University of California, Davis, California 95616, USA
    Anat Rec (Hoboken) 291:916-26. 2008
    ....
  44. ncbi request reprint Intrapulmonary and intramyocardial gene transfer in rhesus monkeys (Macaca mulatta): safety and efficiency of HIV-1-derived lentiviral vectors for fetal gene delivery
    Alice F Tarantal
    California National Primate Research Center, University of California, Davis, CA 95616, USA
    Mol Ther 12:87-98. 2005
    ....
  45. ncbi request reprint Increased vulnerability of neonatal rats and mice to 1-nitronaphthalene-induced pulmonary injury
    Michelle V Fanucchi
    Department of Veterinary Anatomy, Physiology and Cell Biology, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    Toxicol Appl Pharmacol 201:53-65. 2004
    ..This indicates that neonatal susceptibility to environmental pollutant-induced lung injury cannot be reliably predicted based on adult susceptibility...
  46. pmc Temporal and spatial distribution of ciliogenesis in the tracheobronchial airways of mice
    Elina Toskala
    Department of Otorhinolaryngology, Helsinki University Hospital, Finland
    Am J Physiol Lung Cell Mol Physiol 289:L454-9. 2005
    ..This study provides a healthy basis for investigations of neonatal pulmonary disease or pollutant toxicity affecting cilia and its functions...
  47. pmc Long-term ozone exposure attenuates 1-nitronaphthalene-induced cytotoxicity in nasal mucosa
    Myong Gyong Lee
    Lung Research Lab L4 01, Respiratory Medicine Unit, Department of Medicine, Karolinska Institutet, 171 76 Stockholm, Sweden
    Am J Respir Cell Mol Biol 38:300-9. 2008
    ....
  48. ncbi request reprint Cyclic exposure to ozone alters distal airway development in infant rhesus monkeys
    Michelle V Fanucchi
    Center for Comparative Respiratory Biology and Medicine, California National Primate Research Center, University of California, Davis, CA 95616, USA
    Am J Physiol Lung Cell Mol Physiol 291:L644-50. 2006
    ..These results suggest that episodic exposure to environmental ozone compromises postnatal morphogenesis of tracheobronchial airways...
  49. ncbi request reprint Early postnatal exposure to allergen and ozone leads to hyperinnervation of the pulmonary epithelium
    Radhika Kajekar
    Center for Comparative Respiratory Biology and Medicine, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    Respir Physiol Neurobiol 155:55-63. 2007
    ....
  50. pmc Vascular remodeling is airway generation-specific in a primate model of chronic asthma
    Mark V Avdalovic
    UC Davis Medical Center, Department of Internal Medicine, Division of Pulmonary and Critical Care, 4150 V Street, PSSB 3400, Sacramento, CA 95817, USA
    Am J Respir Crit Care Med 174:1069-76. 2006
    ..Changes in the density of bronchial vessels have been proposed as a part of airway remodeling that occurs in chronic asthma...
  51. ncbi request reprint Age-specific pulmonary cytochrome P-450 3A1 expression in postnatal and adult rats
    Kimberly C Day
    Dept of Veterinary Anatomy, Physiology, and Cell Biology, School of Veterinary Medicine, Univ of California, One Shields Ave, Davis, CA 95616, USA
    Am J Physiol Lung Cell Mol Physiol 291:L75-83. 2006
    ....
  52. ncbi request reprint Identification of proteins adducted by reactive metabolites of naphthalene and 1-nitronaphthalene in dissected airways of rhesus macaques
    Ching Yu Lin
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    Proteomics 6:972-82. 2006
    ....
  53. ncbi request reprint Distribution of Clara cell secretory protein expression in the tracheobronchial airways of rhesus monkeys
    John T Coppens
    Department of Anatomy, Physiology and Cell Biology, University of California, Davis, California 95616 8732, USA
    Am J Physiol Lung Cell Mol Physiol 292:L1155-62. 2007
    ....
  54. ncbi request reprint Three-dimensional mapping of ozone-induced injury in the nasal airways of monkeys using magnetic resonance imaging and morphometric techniques
    Stephan A Carey
    Comparative Medicine and Integrative Biology, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824 1224, USA
    Toxicol Pathol 35:27-40. 2007
    ..These correlations are critical for accurate predictive modeling of exposure-dose-response relationships in the nasal airways, and subsequent extrapolation of nasal findings in animals to humans for determining risk...
  55. ncbi request reprint Morphometry of the respiratory tract: avoiding the sampling, size, orientation, and reference traps
    Dallas M Hyde
    California National Primate Research Center, University of California, Davis 95616, USA
    Toxicol Pathol 35:41-8. 2007
    ..An example is provided using wildtype and transgenic mice expressing transforming growth factor-alpha to show the importance of the reference trap in stereologic estimates of postnatal lung growth...
  56. ncbi request reprint Characterization of a structurally intact in situ lung model and comparison of naphthalene protein adducts generated in this model vs lung microsomes
    Ching Yu Lin
    Department of Molecular Biosciences, School of Veterinary Medicine, Molecular Structure Facility, University of California, Davis, California 95616, USA
    Chem Res Toxicol 18:802-13. 2005
    ..The proteins adducted and identified from in situ incubations were not the same proteins identified from microsomal incubations...
  57. ncbi request reprint Structural and functional localization of airway effects from episodic exposure of infant monkeys to allergen and/or ozone
    Jesse P Joad
    Department of Pediatrics, School of Medicine, University of California, Davis, 2516 Stockton Boulevard, Sacramento, CA 95817, USA
    Toxicol Appl Pharmacol 214:237-43. 2006
    ..In bronchi, eosinophils and neuroendocrine cells may play a role in the development of airway hyperresponsiveness...
  58. ncbi request reprint Impaired recovery from naphthalene-induced bronchiolar epithelial injury in mice exposed to aged and diluted sidestream cigarette smoke
    Laura S Van Winkle
    Department of Anatomy, Physiology and Cell Biology, Center for Comparative Respiratory Biology and Medicine, School of Veterinary Medicine, One Shields Avenue, University of California Davis, Davis, CA 95616 8732, USA
    Toxicol Lett 154:1-9. 2004
    ..Animals exposed only to TS had epithelium similar to controls. While TS exposure impairs bronchiolar epithelial repair after NA exposure, this effect appears to be slowly resolving over time...
  59. ncbi request reprint Atypical development of the tracheal basement membrane zone of infant rhesus monkeys exposed to ozone and allergen
    Michael J Evans
    Dept of Anatomy, Physiology, and Cell Biology, School of Veterinary Medicine, Univ of California, Davis, CA 95616, USA
    Am J Physiol Lung Cell Mol Physiol 285:L931-9. 2003
    ....
  60. ncbi request reprint Repeated inhalation exposures to the bioactivated cytotoxicant naphthalene (NA) produce airway-specific Clara cell tolerance in mice
    Jay A A West
    Department of Anatomy, Physiology, and Cell Biology, School of Veterinary Medicine, University of California, Davis, California 95616, USA
    Toxicol Sci 75:161-8. 2003
    ....
  61. ncbi request reprint The three-dimensional distribution of nerves along the entire intrapulmonary airway tree of the adult rat and the anatomical relationship between nerves and neuroepithelial bodies
    Shawnessy D Larson
    Department of Anatomy, Physiology, and Cell Biology, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    Am J Respir Cell Mol Biol 28:592-9. 2003
    ..We conclude that the distribution of nervous elements (nerve fibers and neuroendocrine cells) within the intrapulmonary airways is highly heterogeneous, varying between airway levels and locally within a specific airway level...
  62. ncbi request reprint The effect of house dust mite aeroallergen and air pollutant exposures during infancy
    Lisa A Miller
    Center for Comparative Respiratory Biology and Medicine and the California Regional Primate Research Center, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    Chest 123:434S. 2003
  63. ncbi request reprint Repeated episodes of ozone inhalation attenuates airway injury/repair and release of substance P, but not adaptation
    Edward S Schelegle
    Department of Anatomy, Physiology, and Cell Biology, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    Toxicol Appl Pharmacol 186:127-42. 2003
    ..This depressed cell proliferative response may be in part the result of diminished neutrophil inflammation and/or release of mitogenic neuropeptides in response to ozone-induced injury...
  64. ncbi request reprint Mild hypoxia impairs alveolarization in the endothelial nitric oxide synthase-deficient mouse
    Vivek Balasubramaniam
    Pediatric Heart Lung Center and Section of Pediatric Pulmonary Medicine, University of Colorado School of Medicine, Denver, Colorado 80218, USA
    Am J Physiol Lung Cell Mol Physiol 284:L964-71. 2003
    ..We speculate that NO preserves normal distal lung growth during hypoxic stress, perhaps through preservation of VEGFR-2 signaling...
  65. ncbi request reprint Tethering tracheobronchial airways within the lungs
    Charles G Plopper
    Am J Respir Crit Care Med 167:2-3. 2003
  66. ncbi request reprint Fibroblast growth factor-2 in remodeling of the developing basement membrane zone in the trachea of infant rhesus monkeys sensitized and challenged with allergen
    Michael J Evans
    Department of Anatomy, Physiology, and Cell Biology, Center for Comparative Respiratory Biology and Medicine, School of Veterinary Medicine, University of California, Davis, California 95616, USA
    Lab Invest 82:1747-54. 2002
    ..We conclude that basal cells and FGF-2 are involved with significant remodeling of the BMZ in the developing trachea of infant rhesus monkeys exposed to HDMA...
  67. ncbi request reprint Neuroplasticity in nucleus tractus solitarius neurons after episodic ozone exposure in infant primates
    Chao Yin Chen
    Department of Internal Medicine, School of Medicine, University of California at Davis, 95616, USA
    J Appl Physiol 94:819-27. 2003
    ..The finding that NTS neurons undergo plasticity with repeated ozone exposures may help to explain the adaptation of the respiratory motor responses...
  68. ncbi request reprint Fibroblast growth factor-2 during postnatal development of the tracheal basement membrane zone
    Michael J Evans
    Department of Anatomy, Physiology, and Cell Biology, Center for Comparative Respiratory Biology and Medicine, School of Veterinary Medicine, University of California, Davis, California 95616, USA
    Am J Physiol Lung Cell Mol Physiol 283:L1263-70. 2002
    ..FGFR-1 immunoreactivity was expressed by basal cells and cilia and weakly in the nuclei of columnar cells at all time points. These data indicate that development of the BMZ is a postnatal event in the rhesus monkey that involves FGF-2...
  69. ncbi request reprint Clara cell secretory protein deficiency alters clara cell secretory apparatus and the protein composition of airway lining fluid
    Barry R Stripp
    Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    Am J Respir Cell Mol Biol 27:170-8. 2002
    ..We conclude that CCSP is required for the appearance of Clara cell secretory granules and that functional changes to Clara cells that result from CCSP deficiency lead to alterations in the composition of epithelial lining fluid...
  70. pmc Induction of tolerance to naphthalene in Clara cells is dependent on a stable phenotypic adaptation favoring maintenance of the glutathione pool
    Jay A A West
    Department of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine, University of California Davis, California, USA
    Am J Pathol 160:1115-27. 2002
    ....
  71. ncbi request reprint Methacholine responsiveness of proximal and distal airways of monkeys and rats using videomicrometry
    Kayleen S Kott
    Department of Pediatrics, School of Medicine, University of California, Davis, California 95616, USA
    J Appl Physiol 92:989-96. 2002
    ..Airway heterogeneity in young monkeys was greatest with regard to degree of airway closure of respiratory bronchioles. We conclude that responsiveness to methacholine varies with airway wall structure and location...
  72. ncbi request reprint Detection of viral infection in the respiratory tract of virus antibody free mice: advantages of high-resolution imaging for respiratory toxicology
    Andrew J Phimister
    University of California, Davis, School of Veterinary Medicine, Dept of Anatomy, Physiology, and Cell Biology, Davis, CA 95616, USA
    Toxicol Appl Pharmacol 190:286-93. 2003
    ....
  73. ncbi request reprint Repeated episodes of ozone inhalation amplifies the effects of allergen sensitization and inhalation on airway immune and structural development in Rhesus monkeys
    Edward S Schelegle
    Department of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine, University of California, Davis, Davis, CA 95616, USA
    Toxicol Appl Pharmacol 191:74-85. 2003
    ..These results suggest that ozone can amplify the allergic and structural remodeling effects of HDMA sensitization and inhalation...
  74. ncbi request reprint Smooth muscle development during postnatal growth of distal bronchioles in infant rhesus monkeys
    Mai Uyen T Tran
    Dept of Anatomy, Physiology, and Cell Biology, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    J Appl Physiol 97:2364-71; discussion 2354. 2004
    ..We conclude that smooth muscle undergoes marked organizational changes as airways grow during postnatal development...
  75. ncbi request reprint Immunostimulatory oligonucleotides attenuate airways remodeling in allergic monkeys
    Michelle V Fanucchi
    Department of Anatomy, Physiology and Cell Biology, University of California, School of Veterinary Medicine, One Shields Avenue, Davis, CA 95616, USA
    Am J Respir Crit Care Med 170:1153-7. 2004
    ..We conclude that inhaled immunostimulatory oligonucleotides can attenuate the magnitude of airway hyperreactivity and airways remodeling produced in nonhuman primates with experimentally induced allergic airways disease...
  76. ncbi request reprint Epithelial cell distribution and abundance in rhesus monkey airways during postnatal lung growth and development
    Laura S Van Winkle
    Dept of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine, University of California Davis, Davis, CA 95616 8732, USA
    J Appl Physiol 97:2355-63; discussion 2354. 2004
    ..We conclude that growth of the proximal airways occurs primarily in length and lags behind that of the lung parenchyma...
  77. ncbi request reprint Proximal airway mucous cells of ovalbumin-sensitized and -challenged Brown Norway rats accumulate the neuropeptide calcitonin gene-related peptide
    Shawnessy D Larson
    Department of Anatomy, School of Veterinary Medicine, University of California, Davis, CA 95616
    Am J Physiol Lung Cell Mol Physiol 287:L286-95. 2004
    ..We conclude that episodic allergen exposure results in the accumulation of CGRP within mucous cells, creating a new source for the release of this neuropeptide within the airway...
  78. ncbi request reprint Postnatal remodeling of the neural components of the epithelial-mesenchymal trophic unit in the proximal airways of infant rhesus monkeys exposed to ozone and allergen
    Shawnessy D Larson
    Department of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine, University of California Davis, 1 Shields Avenue, Davis, CA 95616, USA
    Toxicol Appl Pharmacol 194:211-20. 2004
    ..5 positive cells within the epithelium...
  79. ncbi request reprint Comparison of pulmonary/nasal CYP2F expression levels in rodents and rhesus macaque
    R Michael Baldwin
    Department of Molecular Biosciences, School of Veterinary Medicine, 1311 Haring Hall, University of California Davis, Davis, CA 95616, USA
    J Pharmacol Exp Ther 309:127-36. 2004
    ..These results suggest that rhesus macaques may be refractory to naphthalene-induced pulmonary injury...
  80. ncbi request reprint Foxj1 is required for apical localization of ezrin in airway epithelial cells
    Tao Huang
    Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    J Cell Sci 116:4935-45. 2003
    ..These findings indicate that Foxj1 regulates ERM proteins differentially to selectively direct the apical localization of ezrin for the organization of multi-protein complexes in apical membranes of airway epithelial cells...
  81. ncbi request reprint Assessing gene expression in lung subcompartments utilizing in situ RNA preservation
    Gregory L Baker
    Department of Anatomy, Physiology, and Cell Biology, School of Veterinary Medicine, University of California, Davis, California 95616, USA
    Toxicol Sci 77:135-41. 2004
    ....
  82. ncbi request reprint Isolation of rodent airway epithelial cell proteins facilitates in vivo proteomics studies of lung toxicity
    Asa M Wheelock
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    Am J Physiol Lung Cell Mol Physiol 286:L399-410. 2004
    ..In addition, 36% more protein spots were detectable by two-dimensional gel electrophoresis...
  83. ncbi request reprint Proliferation during early phases of bronchiolar repair in neonatal rabbits following lung injury by 4-ipomeanol
    Suzette M Smiley-Jewell
    Department of Anatomy, Physiology, and Cell Biology, School of Veterinary Medicine, University of California, Davis, CA 95616 8732, USA
    Toxicol Appl Pharmacol 192:69-77. 2003
    ....
  84. ncbi request reprint Gene expression analysis in response to lung toxicants: I. Sequencing and microarray development
    Michael A Shultz
    Global Research, American Biosciences SV Corp, Sunnyvale, California, USA
    Am J Respir Cell Mol Biol 30:296-310. 2004
    ..This is the first in a series of articles employing this microarray for detecting gene expression changes during acute injury produced by 1-nitronaphthalene and subsequent repair...
  85. pmc Mouse strain modulates the role of the ciliated cell in acute tracheobronchial airway injury-distal airways
    Gregory W Lawson
    Department of Anatomy, Physiology, and Cell Biology, School of Veterinary Medicine, University of California Davis, Davis, California 95616, USA
    Am J Pathol 160:315-27. 2002
    ..In addition, our findings reinforce that control animals must be of the same strain, ideally litter mates, when transgenic or knockout mice are used for the study of airway repair processes and mechanisms...
  86. ncbi request reprint An aerosolized fluorescent microsphere technique for evaluating particle deposition in the avian respiratory tract
    Lisa A Tell
    Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis 95616, USA
    Avian Dis 50:238-44. 2006
    ..0 and 10.0) were confined to the upper airway (trachea and primary bronchi). The results from this study allow for a better understanding of particle deposition following positive-pressure ventilation and aerosol exposure in birds...
  87. ncbi request reprint Pulmonary heat shock protein expression after exposure to a metabolically activated Clara cell toxicant: relationship to protein adduct formation
    Kurt J Williams
    Department of Veterinary Anatomy, Physiology, and Cell Biology, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    Toxicol Appl Pharmacol 192:107-18. 2003
    ....
  88. ncbi request reprint DNA oxidation or apoptosis: will the real culprit of dna damage in hyperoxic lung injury please stand up?
    Kurt H Albertine
    Department of Pediatrics, University of Utah, Salt Lake City, Utah 84143 2202, USA
    Am J Respir Cell Mol Biol 26:381-3. 2002
  89. ncbi request reprint Chemokine networks and in vivo T-lymphocyte trafficking in nonhuman primates
    Candice C Clay
    Immunology Graduate Program, University of California at Davis, CA 95616, USA
    J Immunol Methods 293:23-42. 2004
    ..Our data suggest that lymphoid and nonlymphoid organs are under continuous immunosurveillance in healthy macaques, and that this model may serve to investigate aberrant patterns in disease...

Research Grants14

  1. LUNG TOXICOLOGY AND THE IMMATURE CLARA CELL
    Charles Plopper; Fiscal Year: 2003
    ..This work will further our understanding of the basic molecular molecular mechanisms by which environmental insults are involved in the origination of lung diseases that begin in childhood. ..
  2. DEVELOPMENTAL LUNG TOXICOLOGY & THE IMMATURE CLARA CELL
    Charles Plopper; Fiscal Year: 2009
    ..This work will further our understanding of the basic molecular mechanisms by which environmental insults are involved in the origins of lung diseases that begin in childhood. ..