Victoria Ploplis

Summary

Affiliation: University of Notre Dame
Country: USA

Publications

  1. ncbi Effects of altered plasminogen activator inhibitor-1 expression on cardiovascular disease
    Victoria A Ploplis
    W M Keck Center for Transgene Research and Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana, USA
    Curr Drug Targets 12:1782-9. 2011
  2. ncbi A urokinase-type plasminogen activator deficiency diminishes the frequency of intestinal adenomas in ApcMin/+ mice
    V A Ploplis
    WM Keck Center for Transgene Research, University of Notre Dame, Notre Dame, IN 46556, USA
    J Pathol 213:266-74. 2007
  3. ncbi Enhanced in vitro proliferation of aortic endothelial cells from plasminogen activator inhibitor-1-deficient mice
    Victoria A Ploplis
    W M Keck Center for Transgene Research and the Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, USA
    J Biol Chem 279:6143-51. 2004
  4. ncbi A deficiency of uPAR alters endothelial angiogenic function and cell morphology
    Rashna D Balsara
    W, M, Keck Center for Transgene Research, University of Notre Dame, 230 Raclin Carmichael Hall, Notre Dame, Indiana 46556, USA
    Vasc Cell 3:10. 2011
  5. ncbi Tumor development is retarded in mice lacking the gene for urokinase-type plasminogen activator or its inhibitor, plasminogen activator inhibitor-1
    L S Gutierrez
    Walther Cancer Center, University of Notre Dame, Indiana 46556, USA
    Cancer Res 60:5839-47. 2000
  6. ncbi The characterization of mice with a targeted combined deficiency of protein c and factor XI
    J C Chan
    Department of Chemistry and Biochemistry, W M Keck Center for Transgene Research, and the Freimann Life Science Center, University of Notre Dame, Notre Dame, Indiana 46556, USA
    Am J Pathol 158:469-79. 2001
  7. ncbi Attenuation of neointima formation following arterial injury in PAI-1 deficient mice
    V A Ploplis
    W.M. Keck Center for Transgene Research, Notre Dame, Indiana, USA
    Ann N Y Acad Sci 936:466-8. 2001
  8. ncbi Nonfibrinolytic functions of plasminogen
    V A Ploplis
    W M Keck Center for Transgene Research and Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, USA
    Methods 21:103-10. 2000
  9. ncbi The protein C pathway and pathologic processes
    F J Castellino
    W M Keck Center for Transgene Research, and Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA
    J Thromb Haemost 7:140-5. 2009
  10. ncbi Gene targeting in hemostasis. plasminogen
    V A Ploplis
    W M Keck Center for Transgene Research and the Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA
    Front Biosci 6:D555-69. 2001

Research Grants

  1. PATHOLOGICAL CONSEQUENCES OF THE PLASMINOGEN SYSTEM
    Victoria Ploplis; Fiscal Year: 2007
  2. PATHOLOGICAL CONSEQUENCES OF THE PLASMINOGEN SYSTEM
    Victoria Ploplis; Fiscal Year: 2002
  3. PATHOLOGICAL CONSEQUENCES OF THE PLASMINOGEN SYSTEM
    Victoria Ploplis; Fiscal Year: 2010

Collaborators

Detail Information

Publications35

  1. ncbi Effects of altered plasminogen activator inhibitor-1 expression on cardiovascular disease
    Victoria A Ploplis
    W M Keck Center for Transgene Research and Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana, USA
    Curr Drug Targets 12:1782-9. 2011
    ..Further investigations involving regulation of cell function could potentially resolve paradoxical issues associated with the function of this protein in regulating cardiovascular disease...
  2. ncbi A urokinase-type plasminogen activator deficiency diminishes the frequency of intestinal adenomas in ApcMin/+ mice
    V A Ploplis
    WM Keck Center for Transgene Research, University of Notre Dame, Notre Dame, IN 46556, USA
    J Pathol 213:266-74. 2007
    ..The results from this study suggest that uPA plays dual and opposing roles in regulating lesion development: one early, during the transition from normal epithelia to dysplastic lesions, and another later during tumour growth...
  3. ncbi Enhanced in vitro proliferation of aortic endothelial cells from plasminogen activator inhibitor-1-deficient mice
    Victoria A Ploplis
    W M Keck Center for Transgene Research and the Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, USA
    J Biol Chem 279:6143-51. 2004
    ....
  4. ncbi A deficiency of uPAR alters endothelial angiogenic function and cell morphology
    Rashna D Balsara
    W, M, Keck Center for Transgene Research, University of Notre Dame, 230 Raclin Carmichael Hall, Notre Dame, Indiana 46556, USA
    Vasc Cell 3:10. 2011
    ..Collectively, these results indicate that a uPAR deficiency leads to decreased angiogenic functions of endothelial cells...
  5. ncbi Tumor development is retarded in mice lacking the gene for urokinase-type plasminogen activator or its inhibitor, plasminogen activator inhibitor-1
    L S Gutierrez
    Walther Cancer Center, University of Notre Dame, Indiana 46556, USA
    Cancer Res 60:5839-47. 2000
    ....
  6. ncbi The characterization of mice with a targeted combined deficiency of protein c and factor XI
    J C Chan
    Department of Chemistry and Biochemistry, W M Keck Center for Transgene Research, and the Freimann Life Science Center, University of Notre Dame, Notre Dame, Indiana 46556, USA
    Am J Pathol 158:469-79. 2001
    ....
  7. ncbi Attenuation of neointima formation following arterial injury in PAI-1 deficient mice
    V A Ploplis
    W.M. Keck Center for Transgene Research, Notre Dame, Indiana, USA
    Ann N Y Acad Sci 936:466-8. 2001
    ....
  8. ncbi Nonfibrinolytic functions of plasminogen
    V A Ploplis
    W M Keck Center for Transgene Research and Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, USA
    Methods 21:103-10. 2000
    ....
  9. ncbi The protein C pathway and pathologic processes
    F J Castellino
    W M Keck Center for Transgene Research, and Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA
    J Thromb Haemost 7:140-5. 2009
    ..Studies to elucidate further the structural elements that differentiate the various functions of PC will serve to identify novel therapeutic approaches toward regulating these and other diseases...
  10. ncbi Gene targeting in hemostasis. plasminogen
    V A Ploplis
    W M Keck Center for Transgene Research and the Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA
    Front Biosci 6:D555-69. 2001
    ..As a result, fibrinolytic and nonfibrinolytic functions have been identified from studies in which these mice were challenged utilizing a number of models that mimic both normal biological and pathological events...
  11. ncbi Remodeling of the vessel wall after copper-induced injury is highly attenuated in mice with a total deficiency of plasminogen activator inhibitor-1
    V A Ploplis
    W M Keck Center for Transgene Research and Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, USA
    Am J Pathol 158:107-17. 2001
    ....
  12. ncbi A coagulation factor VII deficiency protects against acute inflammatory responses in mice
    H Xu
    WM Keck Center for Transgene Research, University of Notre Dame, Notre Dame, IN 46556, USA
    J Pathol 210:488-96. 2006
    ....
  13. ncbi Accelerated skin wound healing in plasminogen activator inhibitor-1-deficient mice
    J C Chan
    W M Keck Center for Transgene Research and the Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, USA
    Am J Pathol 159:1681-8. 2001
    ..While the cellular events associated with the healing process are similar between wild-type (WT) and PAI-1(-/-) mice, the rate of wound closure is significantly accelerated in PAI-1(-/-) mice...
  14. ncbi Severe deficiency of coagulation Factor VII results in spontaneous cardiac fibrosis in mice
    H Xu
    W M Keck Center for Transgene Research and the Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA
    J Pathol 217:362-71. 2009
    ....
  15. ncbi Delayed inflammatory responses to endotoxin in fibrinogen-deficient mice
    D Cruz-Topete
    WM Keck Center for Transgene Research and the Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA
    J Pathol 210:325-33. 2006
    ..These results suggest that fibrin(ogen) plays a role as an early mediator in the cross-talk between coagulation and inflammation...
  16. ncbi Combined factor VII/protein C deficiency results in intrauterine coagulopathy in mice
    J C Chan
    W M Keck Center for Transgene Research and the Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, USA
    J Clin Invest 105:897-903. 2000
    ..The presence of fibrin in embryos in the absence of fetal FVII suggests that significant clot-generating potential exists outside of the embryonic factor VII-dependent pathway...
  17. ncbi A total fibrinogen deficiency is compatible with the development of pulmonary fibrosis in mice
    V A Ploplis
    W M Keck Center for Transgene Research and the Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, USA
    Am J Pathol 157:703-8. 2000
    ..This indicates that Fg and/or Fn are not essential for the development of bleomycin-induced pulmonary fibrosis...
  18. ncbi Development of pulmonary fibrosis in fibrinogen-deficient mice
    J A Wilberding
    W.M. Keck Center for Transgene Research, Notre Dame, Indiana, USA
    Ann N Y Acad Sci 936:542-8. 2001
    ..These studies suggest that, although fibrinogen is not required for collagen deposition at the later stage of the disease, it may play a role in the early acute inflammation stage...
  19. ncbi Targeting plasminogen activator inhibitor-1: role in cell signaling and the biology of domain-specific knock-in mice
    R D Balsara
    W M Keck Center for Transgene Research, University of Notre Dame, Indiana 46556, USA
    Curr Drug Targets 8:982-95. 2007
    ....
  20. ncbi Rapid selection of Drosophila S2 cells with the puromycin resistance gene
    Takayuki Iwaki
    Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA
    Biotechniques 35:482-4, 486. 2003
  21. ncbi Gene targeting of components of the fibrinolytic system
    Victoria A Ploplis
    W. M. Keck Center for Transgene Research and the Department of Chemistry and Biochemistry, University of Notre Dame, IN 46556, USA
    Thromb Haemost 87:22-31. 2002
    ....
  22. ncbi Sulindac treatment alters collagen and matrilysin expression in adenomas of ApcMin/+ mice
    Hector Guillen-Ahlers
    W M Keck Center for Transgene Research, University of Notre Dame, Notre Dame, IN 46556, USA
    Carcinogenesis 29:1421-7. 2008
    ....
  23. ncbi The lack of binding of VEK-30, an internal peptide from the group A streptococcal M-like protein, PAM, to murine plasminogen is due to two amino acid replacements in the plasminogen kringle-2 domain
    Qihua Fu
    W M Keck Center for Transgene Research and the Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA
    J Biol Chem 283:1580-7. 2008
    ..These mechanisms for accumulation of protease activity on GAS likely contribute to the virulence of PAM(+)-GAS strains and identify targets for new therapeutic interventions...
  24. ncbi Focal arterial inflammation is augmented in mice with a deficiency of the protein C gene
    Francis J Castellino
    W M Keck Center for Transgene Research and Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA
    Thromb Haemost 96:794-801. 2006
    ..These results indicate that PC+/- mice subjected to this challenge displayed enhanced focal arterial inflammation and thrombosis, leading to larger neointimas and subsequent localized occlusion, as compared to their WT counterparts...
  25. ncbi Conservation of critical functional domains in murine plasminogen activator inhibitor-1
    Zhi Xu
    W M Keck Center for Transgene Research and Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, USA
    J Biol Chem 279:17914-20. 2004
    ..Further, this study provides additional evidence that the human hemostasis system can be studied effectively in the mouse, which is a great asset for investigations with gene-altered mice...
  26. ncbi Thrombospondin 1--a regulator of adenoma growth and carcinoma progression in the APC(Min/+) mouse model
    Linda S Gutierrez
    Walther Cancer Research Center, W M Keck Center for Transgene Research, Department of Chemistry and Biochemistry, Freimann Life Sciences Center University of Notre Dame, Notre Dame, IN 46556, USA
    Carcinogenesis 24:199-207. 2003
    ..This study reports the first in vivo impact of TSP-1 during early stages of tumor initiation and development in an intestinal carcinogenesis model and demonstrates that TSP-1 affects both angiogenesis and tumor cell apoptosis...
  27. ncbi Transcriptional profiling of the transition from normal intestinal epithelia to adenomas and carcinomas in the APCMin/+ mouse
    Nicholas F Paoni
    W M Keck Center for Transgene Research, Walther Cancer Center, and Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, USA
    Physiol Genomics 15:228-35. 2003
    ....
  28. ncbi The fibrinolytic system in dissemination and matrix protein deposition during a mycobacterium infection
    Jun Sato
    W M Keck Center for Transgene Research and the Department of Chemistry, University of Notre Dame, Notre Dame, Indiana, IN 46556, USA
    Am J Pathol 163:517-31. 2003
    ..avium from lungs. Thus, plasmin(ogen) functions in limiting progressive fibrosis in the granuloma during a chronic mycobacterial infection...
  29. ncbi A novel function of plasminogen activator inhibitor-1 in modulation of the AKT pathway in wild-type and plasminogen activator inhibitor-1-deficient endothelial cells
    Rashna D Balsara
    W M Keck Center for Transgene Research, University of Notre Dame, Notre Dame, IN 46556, USA
    J Biol Chem 281:22527-36. 2006
    ..Thus, PAI-1 is a negative regulator of cell growth, exerting its effect on the phosphatidylinositol 3-kinase/Akt pathway and allowing controlled cell proliferation...
  30. ncbi Structure and function of the plasminogen/plasmin system
    Francis J Castellino
    W M Keck Center for Transgene Research, Department of Chemistry and Biochemistry, University of Notre Dame, IN 46556, USA
    Thromb Haemost 93:647-54. 2005
    ....
  31. ncbi Plasminogen activator inhibitor-1 potentiates LPS-induced neutrophil activation through a JNK-mediated pathway
    Sang Hyun Kwak
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Colorado, USA
    Thromb Haemost 95:829-35. 2006
    ..These results demonstrate that PAI-1 and uPA KD enhance LPS-induced neutrophil responses through their effects on JNK mediated pathways...
  32. ncbi A fibrinogen deficiency accelerates the initiation of LDL cholesterol-driven atherosclerosis via thrombin generation and platelet activation in genetically predisposed mice
    Takayuki Iwaki
    W M Keck Center for Transgene Research, 230 Raclin Carmichael Hall, University of Notre Dame, Notre Dame, IN 46556, USA
    Blood 107:3883-91. 2006
    ....
  33. ncbi The hemostasis system in murine atherosclerosis
    Takayuki Iwaki
    W M Keck Center for Transgene Research, Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA
    Curr Drug Targets 9:229-38. 2008
    ..In order to summarize recent progress in this area, this review is focused on mice lacking individual hemostasis genes and their contributions to steps of the atherosclerotic process...
  34. ncbi Fibrinogen stabilizes placental-maternal attachment during embryonic development in the mouse
    Takayuki Iwaki
    W M Keck Center for Transgene Research, Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, USA
    Am J Pathol 160:1021-34. 2002
    ..The results of these studies demonstrate that maternal Fg plays a critical role in maintenance of pregnancy in mice, both by supporting proper development of fetal-maternal vascular communication and stabilization of embryo implantation...
  35. ncbi Coagulation factor Xa modulates airway remodeling in a murine model of asthma
    Kazuhiko Shinagawa
    WM Keck Center for Transgene Research, University of Notre Dame, Notre Dame, IN 46556, USA
    Am J Respir Crit Care Med 175:136-43. 2007
    ..Previous studies have demonstrated that dysregulated coagulation and fibrinolysis contribute to the pathogenesis of asthma...

Research Grants11

  1. PATHOLOGICAL CONSEQUENCES OF THE PLASMINOGEN SYSTEM
    Victoria Ploplis; Fiscal Year: 2007
    ..3.) Further characterize functional deficits of endothelial cells derived from mice described in Aim 2 utilizing analyses described in Aim 1. ..
  2. PATHOLOGICAL CONSEQUENCES OF THE PLASMINOGEN SYSTEM
    Victoria Ploplis; Fiscal Year: 2002
    ..2) study copper cuff induced atherosclerosis by determine qualitative and quantitative changes in the vessel wall and lumen utilizing a battery of histological and immunohistological techniques. ..
  3. PATHOLOGICAL CONSEQUENCES OF THE PLASMINOGEN SYSTEM
    Victoria Ploplis; Fiscal Year: 2010
    ..The hypothesis is that cardiac fibrosis will be regulated by urokinase activity and other functions of PAI-I which will be further pursued in future studies of mice expressing functional mutations of PAI-1. ..