Thomas A E Platts-Mills

Summary

Affiliation: University of Virginia
Country: USA

Publications

  1. doi request reprint Emerging antigens involved in allergic responses
    Thomas A E Platts-Mills
    Department of Medicine, Division of Allergy and Immunology, University of Virginia Health System, Charlottesville, VA, USA Electronic address
    Curr Opin Immunol 25:769-74. 2013
  2. doi request reprint Allergy in evolution
    Thomas A E Platts-Mills
    Asthma and Allergy Disease Center, University of Virginia, Charlottesville, VA 22908, USA
    Chem Immunol Allergy 96:1-6. 2012
  3. pmc Impact of early life exposures to geohelminth infections on the development of vaccine immunity, allergic sensitization, and allergic inflammatory diseases in children living in tropical Ecuador: the ECUAVIDA birth cohort study
    Philip J Cooper
    Molecular and Biochemical Parasitology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK
    BMC Infect Dis 11:184. 2011
  4. pmc Specific and nonspecific obstructive lung disease in childhood: causes of changes in the prevalence of asthma
    T A Platts-Mills
    Asthma and Allergic Diseases Center, University of Virginia, Charlottesville, Virginia 22908, USA
    Environ Health Perspect 108:725-31. 2000
  5. doi request reprint Allergen avoidance in the treatment of asthma: problems with the meta-analyses
    Thomas A E Platts-Mills
    Asthma and Allergic Diseases Center, University of Virginia, Charlottesville, VA 22908, USA
    J Allergy Clin Immunol 122:694-6. 2008
  6. ncbi request reprint Prevalence and titer of IgE antibodies to mouse allergens
    Thomas A E Platts-Mills
    Asthma and Allergic Diseases Center, University of Virginia, Charlottesville, VA 22908, USA
    J Allergy Clin Immunol 120:1058-64. 2007
  7. ncbi request reprint Animal danders
    Elizabeth A Erwin
    Asthma and Allergic Diseases Center, University of Virginia, PO Box 801355, Charlottesville, VA 22908, USA
    Immunol Allergy Clin North Am 23:469-81. 2003
  8. ncbi request reprint Mechanisms of tolerance to inhalant allergens: the relevance of a modified Th2 response to allergens from domestic animals
    Thomas A E Platts-Mills
    Asthma and Allergic Disease Center, University of Virginia, University Health Systems, Charlottesville 22908 1355, USA
    Springer Semin Immunopathol 25:271-9. 2004
  9. ncbi request reprint Environmental factors influencing allergy and asthma
    Thomas A E Platts-Mills
    Asthma and Allergic Disease Center, University of Virginia, Charlottesville, VA 22908, USA
    Chem Immunol Allergy 91:3-15. 2006
  10. ncbi request reprint Asthma and indoor air: contrasts in the dose response to cat and dust-mite
    E A Erwin
    University of Virginia, Asthma and Allergic Diseases Center, Charlottesville, VA 22908 1355, USA
    Indoor Air 15:33-9. 2005

Research Grants

  1. DUST MITE, COCKROACH AND CAT ALLERGENS IN ASTHMA
    Thomas A Platts Mills; Fiscal Year: 2010
  2. Dust Mite, Cockroach and Cat Allergens: Asthma
    Thomas Platts Mills; Fiscal Year: 2006
  3. UVA Asthma and Allergic Diseases Center
    Thomas Platts Mills; Fiscal Year: 2005
  4. ASTHMA AND ALLERGIC DISEASE CENTER
    Thomas Platts Mills; Fiscal Year: 2007
  5. DUST MITE, COCKROACH AND CAT ALLERGENS IN ASTHMA
    Thomas Platts Mills; Fiscal Year: 2009
  6. DUST MITE, COCKROACH AND CAT ALLERGENS IN HOUSES/ASTHMA
    Thomas Platts Mills; Fiscal Year: 1991
  7. DUST MITE, COCKROACH AND CAT ALLERGENS IN HOUSES/ASTHMA
    Thomas Platts Mills; Fiscal Year: 1992

Detail Information

Publications77

  1. doi request reprint Emerging antigens involved in allergic responses
    Thomas A E Platts-Mills
    Department of Medicine, Division of Allergy and Immunology, University of Virginia Health System, Charlottesville, VA, USA Electronic address
    Curr Opin Immunol 25:769-74. 2013
    ..This disease challenges many previous rules about food allergy and provides a striking model of an emerging allergic disease. ..
  2. doi request reprint Allergy in evolution
    Thomas A E Platts-Mills
    Asthma and Allergy Disease Center, University of Virginia, Charlottesville, VA 22908, USA
    Chem Immunol Allergy 96:1-6. 2012
    ..The challenge is to understand how changes in both hygiene and lifestyle have contributed to the changes in allergic disease...
  3. pmc Impact of early life exposures to geohelminth infections on the development of vaccine immunity, allergic sensitization, and allergic inflammatory diseases in children living in tropical Ecuador: the ECUAVIDA birth cohort study
    Philip J Cooper
    Molecular and Biochemical Parasitology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK
    BMC Infect Dis 11:184. 2011
    ....
  4. pmc Specific and nonspecific obstructive lung disease in childhood: causes of changes in the prevalence of asthma
    T A Platts-Mills
    Asthma and Allergic Diseases Center, University of Virginia, Charlottesville, Virginia 22908, USA
    Environ Health Perspect 108:725-31. 2000
    ..What is clear is that current theories do not provide either an adequate explanation of the increase or a practical approach to reversing the current trend...
  5. doi request reprint Allergen avoidance in the treatment of asthma: problems with the meta-analyses
    Thomas A E Platts-Mills
    Asthma and Allergic Diseases Center, University of Virginia, Charlottesville, VA 22908, USA
    J Allergy Clin Immunol 122:694-6. 2008
    ..The conclusion is that the criticisms of the recommendations in the 2007 guidelines were not well founded...
  6. ncbi request reprint Prevalence and titer of IgE antibodies to mouse allergens
    Thomas A E Platts-Mills
    Asthma and Allergic Diseases Center, University of Virginia, Charlottesville, VA 22908, USA
    J Allergy Clin Immunol 120:1058-64. 2007
    ..Positive skin tests to allergens derived from mouse urine have been reported among patients with asthma. Very few data are available detailing the titer of IgE Ab to mouse allergen and how it varies by location and population...
  7. ncbi request reprint Animal danders
    Elizabeth A Erwin
    Asthma and Allergic Diseases Center, University of Virginia, PO Box 801355, Charlottesville, VA 22908, USA
    Immunol Allergy Clin North Am 23:469-81. 2003
    ..The most probable explanations are related to the form and quantity of airborne allergens...
  8. ncbi request reprint Mechanisms of tolerance to inhalant allergens: the relevance of a modified Th2 response to allergens from domestic animals
    Thomas A E Platts-Mills
    Asthma and Allergic Disease Center, University of Virginia, University Health Systems, Charlottesville 22908 1355, USA
    Springer Semin Immunopathol 25:271-9. 2004
    ..Dust mite and cockroach differ from cat (and rat) allergens not only in the quantity inhaled and the particles' sizes but also in the biochemistry of the molecule...
  9. ncbi request reprint Environmental factors influencing allergy and asthma
    Thomas A E Platts-Mills
    Asthma and Allergic Disease Center, University of Virginia, Charlottesville, VA 22908, USA
    Chem Immunol Allergy 91:3-15. 2006
    ..Although there have been many changes in our environment, none of these alone explains the consistency or the scale of the rise in asthma over the 40 years between 1960 and 2000...
  10. ncbi request reprint Asthma and indoor air: contrasts in the dose response to cat and dust-mite
    E A Erwin
    University of Virginia, Asthma and Allergic Diseases Center, Charlottesville, VA 22908 1355, USA
    Indoor Air 15:33-9. 2005
    ..Equally the results may give insight into a form of tolerance that could be a target for protecting patients against allergic disease...
  11. ncbi request reprint Decreased physical activity among Head Start children with a history of wheezing: use of an accelerometer to measure activity
    Vincent Firrincieli
    Department of Medicine, Allergy and Immunology, University of Virginia, Charlottesville, VA 22908, USA
    Pediatr Pulmonol 40:57-63. 2005
    ..Decreased physical activity could contribute to persistence of asthma or put children at higher risk for obesity and other chronic diseases...
  12. doi request reprint Allergens and their role in the allergic immune response
    Thomas A E Platts-Mills
    Asthma and Allergic Diseases Center, University of Virginia Health System, Charlottesville, VA 22908 1355, USA
    Immunol Rev 242:51-68. 2011
    ..By contrast, it is now evident that delivery of foreign proteins by the oral route or sublingually will favor the generation of tolerance...
  13. ncbi request reprint The role of immunoglobulin E in allergy and asthma
    T A Platts-Mills
    Division of Allergy and Immunology, University of Virginia, Charlottesville, Virginia, USA
    Am J Respir Crit Care Med 164:S1-5. 2001
    ....
  14. ncbi request reprint The role of allergens in the induction of asthma
    Thomas A E Platts-Mills
    Asthma and Allergic Diseases Center, University of Virginia, PO Box 801355, Charlottesville, VA 22908, USA
    Curr Allergy Asthma Rep 2:175-80. 2002
    ..Taken together, the findings do not support a simple view about the balance between TH1 and TH2 responses, but strongly support the relevance of IgE to the risk of asthma...
  15. ncbi request reprint Sensitisation, asthma, and a modified Th2 response in children exposed to cat allergen: a population-based cross-sectional study
    T Platts-Mills
    University of Virginia Asthma and Allergic Diseases Center, University of Virginia Department of Medicine, Charlottesville, USA
    Lancet 357:752-6. 2001
    ..We investigated the immune response to cat and mite allergens, and asthma among children with a wide range of allergen exposure...
  16. pmc Galactose-α-1,3-galactose and delayed anaphylaxis, angioedema, and urticaria in children
    Joshua L Kennedy
    Division of Allergy and Immunology, Department of Internal Medicine, University of Virginia Health System, Charlottesville, VA 22908, USA
    Pediatrics 131:e1545-52. 2013
    ..We sought to determine whether IgE antibody to α-Gal was present in sera of pediatric patients who reported idiopathic anaphylaxis or urticaria...
  17. pmc Galactose-α-1,3-galactose-specific IgE is associated with anaphylaxis but not asthma
    Scott P Commins
    Division of Allergy and Immunology, University of Virginia, Charlottesville, Virginia, USA
    Am J Respir Crit Care Med 185:723-30. 2012
    ..These antibodies, which are induced by ectoparasitic ticks, can give rise to positive skin tests or serum assays with cat extract...
  18. ncbi request reprint Quantitative measurement of IgE antibodies to purified allergens using streptavidin linked to a high-capacity solid phase
    Elizabeth A Erwin
    University of Virginia Astma and Allergic Diseases Center, Charlottesville, VA 22908 1355, USA
    J Allergy Clin Immunol 115:1029-35. 2005
    ..Commercially available assays for IgE antibody provide results in international units per milliliter for many allergen extracts, but this is not easily achieved with purified or novel allergens...
  19. pmc The indoor air and asthma: the role of cat allergens
    Libby A Kelly
    University of Virginia Asthma and Allergic Diseases Center, University of Virginia Health System, Charlottesville, VA 22908, USA
    Curr Opin Pulm Med 18:29-34. 2012
    ..The objective is to discuss recent progress in our understanding of the role of the indoor environment in asthma, focusing on the special role of cat allergens...
  20. ncbi request reprint Viral infections in relation to age, atopy, and season of admission among children hospitalized for wheezing
    Peter W Heymann
    Department of Pediatrics, University of Virginia Health System, Charlottesville, VA 22908 0386, USA
    J Allergy Clin Immunol 114:239-47. 2004
    ..However, information about the relationship between viral infections and atopy among children whose attacks of wheezing lead to hospitalization is unclear...
  21. pmc Delayed anaphylaxis to red meat in patients with IgE specific for galactose alpha-1,3-galactose (alpha-gal)
    Scott P Commins
    Department of Internal Medicine and Pediatrics, Division of Allergy and Immunology, University of Virginia Health System, Charlottesville, VA 22908, USA
    Curr Allergy Asthma Rep 13:72-7. 2013
    ..This IgE Ab response cross-reacts with cat and dog but does not appear to pose a risk for asthma; however, it may impair diagnostic testing in some situations...
  22. ncbi request reprint Contribution of dust mite and cat specific IgE to total IgE: relevance to asthma prevalence
    Elizabeth A Erwin
    University of Virginia Asthma and Allergic Diseases Center, Charlottesville, VA, USA
    J Allergy Clin Immunol 119:359-65. 2007
    ..The prevalence of asthma is strikingly different in some Westernized countries: approximately 20% in New Zealand and approximately 8% in northern Sweden...
  23. ncbi request reprint A role for IL-10-mediated HLA-DR7-restricted T cell-dependent events in development of the modified Th2 response to cat allergen
    Amanda J Reefer
    Asthma and Allergic Diseases Center, Department of Internal Medicine, University of Virginia, Charlottesville, VA 22908, USA
    J Immunol 172:2763-72. 2004
    ..We conclude that IL-10-producing T cells specific for chain 2 epitopes are relevant to tolerance induction, and that DR7-restricted recognition of these epitopes favors a modified Th2 response...
  24. ncbi request reprint Cat and dust mite sensitivity and tolerance in relation to wheezing among children raised with high exposure to both allergens
    Elizabeth A Erwin
    University of Virginia Asthma and Allergic Diseases Center, Charlottesville, VA 22908, USA
    J Allergy Clin Immunol 115:74-9. 2005
    ..Recent evidence has suggested that high exposure to cat allergens is associated with decreased prevalence of sensitization to cat and, in some studies, decreased asthma...
  25. pmc Delayed anaphylaxis, angioedema, or urticaria after consumption of red meat in patients with IgE antibodies specific for galactose-alpha-1,3-galactose
    Scott P Commins
    Asthma and Allergic Diseases Center, University of Virginia Health System, Charlottesville, VA, USA
    J Allergy Clin Immunol 123:426-33. 2009
    ..Recent work, however, has shown that IgE antibodies to galactose-alpha-1,3-galactose (alpha-gal), a carbohydrate commonly expressed on nonprimate mammalian proteins, are capable of eliciting serious, even fatal, reactions...
  26. pmc Allergenicity of carbohydrates and their role in anaphylactic events
    Scott P Commins
    Allergy Division, University of Virginia Health System, Charlottesville, VA 22908 1355, USA
    Curr Allergy Asthma Rep 10:29-33. 2010
    ..However, the current evidence does not fully resolve why these IgE antibodies are so common in the Southeast or why the anaphylactic or urticarial reactions to red meat are delayed...
  27. ncbi request reprint Variation in total and specific IgE: effects of ethnicity and socioeconomic status
    Augusto A Litonjua
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    J Allergy Clin Immunol 115:751-7. 2005
    ..Asthma is common in minority and disadvantaged populations, whereas atopic disorders other than asthma appear to be less prevalent. It is unclear whether the same holds true for objective markers of sensitization...
  28. ncbi request reprint Airborne endotoxin in homes with domestic animals: implications for cat-specific tolerance
    James A Platts-Mills
    Asthma and Allergic Diseases Center, University of Virginia, VA, USA
    J Allergy Clin Immunol 116:384-9. 2005
    ..Similarly, the presence of an animal in the home has been associated with decreased sensitization to animal allergens. It has been suggested that the effect of animals could be explained by increased endotoxin exposure...
  29. pmc The relevance of tick bites to the production of IgE antibodies to the mammalian oligosaccharide galactose-α-1,3-galactose
    Scott P Commins
    Asthma and Allergic Diseases Center, University of Virginia Health System, Charlottesville, VA, USA
    J Allergy Clin Immunol 127:1286-93.e6. 2011
    ..Most of these patients had tolerated meat for many years previously. The implication is that some exposure in adult life had stimulated the production of these IgE antibodies...
  30. ncbi request reprint The variability of regional airflow obstruction within the lungs of patients with asthma: assessment with hyperpolarized helium-3 magnetic resonance imaging
    Eduard E de Lange
    Department of Radiology, University of Virginia, Charlottesville, VA 22908, USA
    J Allergy Clin Immunol 119:1072-8. 2007
    ..With hyperpolarized helium-3 magnetic resonance (H(3)HeMR) imaging, the airspaces are depicted and focal areas of airflow obstruction are shown as "ventilation defects."..
  31. ncbi request reprint Predictors of cord blood IgE levels in children at risk for asthma and atopy
    Christina V Scirica
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Allergy Clin Immunol 119:81-8. 2007
    ..Increased cord blood IgE levels, in conjunction with a family history of atopy, are associated with the development of allergic diseases in children. However, little is known about predictors of cord blood IgE levels...
  32. ncbi request reprint The immune response to intrinsic and extrinsic allergens: determinants of allergic disease
    Judith A Woodfolk
    Asthma and Allergic Diseases Center, University of Virginia, Charlottesville 22908 1355, USA
    Int Arch Allergy Immunol 129:277-85. 2002
    ..The relevance of Th1/Th2 and regulatory cytokines to development of new allergen-specific therapies is also discussed...
  33. ncbi request reprint Specific IgE and IgG antibody-binding patterns to recombinant cockroach allergens
    Shama M Satinover
    Asthma and Allergic Diseases Center, University of Virginia Health System, Charlottesville, VA 22908 1355, USA
    J Allergy Clin Immunol 115:803-9. 2005
    ..The specificity of serum antibody responses to different cockroach allergens has not been studied...
  34. pmc Molecular determinants for antibody binding on group 1 house dust mite allergens
    Maksymilian Chruszcz
    Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, Virginia 22908, USA
    J Biol Chem 287:7388-98. 2012
    ..Mutations of the contact residues abrogate mAb 4C1 binding and reduce IgE antibody binding. These surface-exposed residues are molecular targets that can be exploited for development of recombinant allergen vaccines...
  35. doi request reprint Drug allergens and food--the cetuximab and galactose-α-1,3-galactose story
    Emily A Berg
    Department of Internal Medicine, Division of Allergy and Immunology, University of Virginia Health System, Charlottesville, Virginia
    Ann Allergy Asthma Immunol 112:97-101. 2014
    ..Ongoing work regarding the etiology, distribution, clinical management, and cellular mechanisms of the IgE response to the oligosaccharide galactose-α-1,3-galactose (α-gal) is reviewed...
  36. doi request reprint Tick bites and red meat allergy
    Scott P Commins
    Department of Internal Medicine, Division of Allergy and Immunology, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    Curr Opin Allergy Clin Immunol 13:354-9. 2013
    ..Ongoing work regarding the cause and distribution of this IgE response is reviewed...
  37. pmc Asthma severity and prevalence: an ongoing interaction between exposure, hygiene, and lifestyle
    Thomas A E Platts-Mills
    University of Virginia Asthma and Allergic Diseases Center, Charlottesville, Virginia, USA
    PLoS Med 2:e34. 2005
  38. pmc Cetuximab-induced anaphylaxis and IgE specific for galactose-alpha-1,3-galactose
    Christine H Chung
    Division of Hematology Oncology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, USA
    N Engl J Med 358:1109-17. 2008
    ..A high prevalence of hypersensitivity reactions to cetuximab has been reported in some areas of the United States...
  39. ncbi request reprint Role of viral infections, atopy and antiviral immunity in the etiology of wheezing exacerbations among children and young adults
    Peter W Heymann
    Department of Pediatrics, University of Virginia Asthma and Allergic Diseases Center, PO Box 800386, Charlottesville, VA 22908, USA
    Pediatr Infect Dis J 24:S217-22, discussion S220-1. 2005
    ..Rhinoviruses have often been associated with trivial upper respiratory infections but more recent evidence suggests that they play a significant role in the pathogenesis of asthma exacerbations...
  40. ncbi request reprint Asian ladybugs (Harmonia axyridis): a new seasonal indoor allergen
    Takuya Nakazawa
    Asthma and Allergic Disease Center, University of Virginia, Charlottesville, VA 22908, USA
    J Allergy Clin Immunol 119:421-7. 2007
    ..Harmonia axyridis, the Asian ladybug (ALB), was repeatedly introduced between 1916 and 1990. These beetles are intolerant to cold and move indoors during the winter...
  41. ncbi request reprint The relevance of maternal immune responses to inhalant allergens to maternal symptoms, passive transfer to the infant, and development of antibodies in the first 2 years of life
    Thomas A E Platts-Mills
    University of Virginia Asthma and Allergic Disease Center Charlottesville, VA 22908, USA
    J Allergy Clin Immunol 111:123-30. 2003
    ..Asthma and other atopic diseases are strongly hereditary. Although the mother might play a special role, the mechanisms for such an effect are not clear...
  42. ncbi request reprint Allergens
    Elizabeth A Erwin
    Department of Medicine, Division of Allergy and Immunology, University of Virginia, PO Box 801355, Charlottesville, VA 22908, USA
    Immunol Allergy Clin North Am 25:1-14. 2005
    ..The role of allergens in attacks can be subtle in that they provide the underlying inflammation necessary for other nonspecific agents to have an effect...
  43. pmc Anaphylaxis syndromes related to a new mammalian cross-reactive carbohydrate determinant
    Scott P Commins
    Asthma and Allergic Diseases Center, University of Virginia Health System, Charlottesville, USA
    J Allergy Clin Immunol 124:652-7. 2009
    ..Here we review the evidence relating to carbohydrates in food allergy and anaphylaxis and discuss the implications of a new mammalian cross-reactive carbohydrate determinant...
  44. ncbi request reprint Allergen avoidance in the treatment of asthma and rhinitis
    Thomas A E Platts-Mills
    University of Virginia Asthma and Allergic Disease Center, Charlottesville, USA
    N Engl J Med 349:207-8. 2003
  45. ncbi request reprint Atopy, asthma, and antibodies to Ascaris among rural and urban children in Kenya
    Matthew S Perzanowski
    University of Virginia Asthma and Allergic Diseases Center, Health Sciences Center, Charlottesville, 22908 1355, USA
    J Pediatr 140:582-8. 2002
    ..The purpose of this study was to evaluate differences in the relationship between asthma and immune responses to allergens in children living in rural and urban areas of Kenya...
  46. ncbi request reprint Evaluation of asthma with hyperpolarized helium-3 MRI: correlation with clinical severity and spirometry
    Eduard E de Lange
    University of Virginia Health Sciences System, Department of Radiology, HSC 800170, Charlottesville, VA 22908, USA
    Chest 130:1055-62. 2006
    ..The objective of this study was to compare the extent of H(3)HeMR ventilation defects with measures of asthma severity and spirometry...
  47. ncbi request reprint Experimental rhinovirus challenges in adults with mild asthma: response to infection in relation to IgE
    Juan C Zambrano
    Department of Pediatrics, University of Virginia Health System, Charlottesville, VA 22908 0386, USA
    J Allergy Clin Immunol 111:1008-16. 2003
    ..Although most children and young adults with asthma are atopic, exacerbations of asthma are frequently associated with viral respiratory tract infections, especially those caused by rhinovirus (HRV)...
  48. pmc Sinus computed tomography scan and markers of inflammation in vocal cord dysfunction and asthma
    Edward J Peters
    Asthma and Allergic Disease Center, Beirne Carter Center, University of Virginia, Charlottesville, Virginia, USA
    Ann Allergy Asthma Immunol 90:316-22. 2003
    ..The inappropriate closure of the vocal cords is characteristic of vocal cord dysfunction (VCD). These patients present with wheezing and frequently receive a misdiagnosis of asthma...
  49. ncbi request reprint Paediatric asthma and obesity
    Sean R Lucas
    University of Virginia Health Systems, Asthma and Allergic Diseases Center, Charlottesville, VA 22908 1355, USA
    Paediatr Respir Rev 7:233-8. 2006
    ..Furthermore, there has been substantial research on the benefits of exercise programmes for paediatric patients with asthma. Longitudinal trials monitoring physical activity, obesity and the development of asthma are needed...
  50. ncbi request reprint Exposure to cat allergen, maternal history of asthma, and wheezing in first 5 years of life
    Juan C Celedon
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Lancet 360:781-2. 2002
    ..There was no association between wheezing and exposure to dog or dog allergen, and the father's allergy status had no effect on the relation between childhood wheezing and cat exposure...
  51. ncbi request reprint Imaging the lungs in asthmatic patients by using hyperpolarized helium-3 magnetic resonance: assessment of response to methacholine and exercise challenge
    Saba Samee
    Department of Internal Medicine, Division of Asthma, Allergy, and Immunology, University of Virginia, Charlottesville, VA 22908 1355, USA
    J Allergy Clin Immunol 111:1205-11. 2003
    ..Hyperpolarized helium-3 (HHe3) provides a new technique for magnetic resonance imaging of lung diseases...
  52. ncbi request reprint Physical activity and exercise in asthma: relevance to etiology and treatment
    Sean R Lucas
    University of Virginia Asthma and Allergic Diseases Center, Charlottesville, VA 22908 1355, USA
    J Allergy Clin Immunol 115:928-34. 2005
    ..If so, the decrease in physical activity might have played a major role in recent increases in asthma prevalence and severity...
  53. ncbi request reprint The role of allergens in asthma
    Thomas Platts-Mills
    Asthma and Allergic Diseases Center, University of Virginia, Charlottesville, USA
    Am Fam Physician 76:675-80. 2007
    ..Information on sensitization can be used to educate patients about the role of allergens in their symptoms, to provide avoidance advice, or to design immunotherapy...
  54. ncbi request reprint Paradoxical effect of domestic animals on asthma and allergic sensitization
    Thomas A E Platts-Mills
    JAMA 288:1012-4. 2002
  55. ncbi request reprint Endotoxin and asthma
    Matthew S Perzanowski
    N Engl J Med 348:171-4; author reply 171-4. 2003
  56. pmc Dust mite, cockroach, cat, and dog allergen concentrations in homes of asthmatic children in the northeastern United States: impact of socioeconomic factors and population density
    Brian P Leaderer
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut 06520 8034, USA
    Environ Health Perspect 110:419-25. 2002
    ..Mite and cockroach allergens have distinct and opposite associations with socioeconomic factors and population density...
  57. pmc Cat ownership is a risk factor for the development of anti-cat IgE but not current wheeze at age 5 years in an inner-city cohort
    Matthew S Perzanowski
    Columbia Center for Children s Environmental Health, Columbia University, New York, NY 10032, USA
    J Allergy Clin Immunol 121:1047-52. 2008
    ..Cat ownership is inversely associated with atopy and asthma in some areas of the world, but the relevance of cat ownership to allergic disease in the inner city is less known...
  58. ncbi request reprint The role of indoor allergen sensitization and exposure in causing morbidity in women with asthma
    Sarah A Lewis
    Channing Laboratory, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Am J Respir Crit Care Med 165:961-6. 2002
    ..07), with adjustment for race and poverty. We conclude that cockroach and cat allergens may contribute to asthma morbidity in sensitized women...
  59. ncbi request reprint Effect of cat and dog ownership on sensitization and development of asthma among preteenage children
    Matthew S Perzanowski
    OLIN Studies, Department of Medicine, Sunderby Central Hospital of Norrbotten, Lulea, Sweden
    Am J Respir Crit Care Med 166:696-702. 2002
    ..In a community where cat sensitization was strongly associated with asthma, owning a cat was protective against both prevalent and incident asthma...
  60. ncbi request reprint Diagnosis and treatment of atopic dermatitis in children and adults: European Academy of Allergology and Clinical Immunology/American Academy of Allergy, Asthma and Immunology/PRACTALL Consensus Report
    Cezmi A Akdis
    Swiss Institute of Allergy and Asthma Research, Davos
    J Allergy Clin Immunol 118:152-69. 2006
    ..The consensus report is part of the PRACTALL initiative, which is endorsed by both academies...
  61. ncbi request reprint A prospective study of wheezing in young children: the independent effects of cockroach exposure, breast-feeding and allergic sensitization
    Jorgete M Silva
    Department of Pediatrics, School of Medicine of Ribeirao Preto, University of Sao Paulo, Av Bandeirantes 3900, Ribeirao Preto, Sao Paulo 14049 900, Brazil
    Pediatr Allergy Immunol 16:393-401. 2005
    ..Breast-feeding for at least 1 month was a protective factor. A strong association between allergic sensitization and persistence of wheezing was found in a group of very young children living in a subtropical area...
  62. ncbi request reprint Risk factors for wheezing in a subtropical environment: role of respiratory viruses and allergen sensitization
    Ataide A Camara
    Department of Pediatrics, School of Medicine of Ribeirao Preto, University of Sao Paulo, Brazil
    J Allergy Clin Immunol 113:551-7. 2004
    ..Risk factors for acute wheezing among children in subtropical areas are largely unknown...
  63. ncbi request reprint How do we avoid developing allergy: modifications of the TH2 response from a B-cell perspective
    Rob C Aalberse
    Sanquin Research at CLB and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Postbox 9190, 1006 AD Amsterdam, The Netherlands
    J Allergy Clin Immunol 113:983-6. 2004
    ..These IgG4-switched B memory cells might occasionally undergo a secondary switch to IgE...
  64. ncbi request reprint The role of indoor allergens in chronic allergic disease
    Thomas A E Platts-Mills
    J Allergy Clin Immunol 119:297-302. 2007
  65. ncbi request reprint Allergen avoidance
    Thomas A E Platts-Mills
    J Allergy Clin Immunol 113:388-91. 2004
  66. ncbi request reprint Allergen-induced cytokine production, atopic disease, IgE, and wheeze in children
    J Paola Contreras
    Pulmonary and Critical Care Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Allergy Clin Immunol 112:1072-7. 2003
    ..The early childhood allergen-induced immune responses associated with atopic disease and IgE production in early life are not well understood...
  67. pmc Prediction of residential pet and cockroach allergen levels using questionnaire information
    Ulrike Gehring
    GSF National Research Center for Environment and Health, Institute of Epidemiology, Neuherberg, Germany
    Environ Health Perspect 112:834-9. 2004
    ..Knowledge of past pet ownership can improve pet allergen exposure assessment by means of questionnaire. However, for epidemiologic purposes, measured concentrations of allergens are necessary...
  68. ncbi request reprint Symptoms of wheeze and persistent cough in the first year of life: associations with indoor allergens, air contaminants, and maternal history of asthma
    Kathleen Belanger
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520 8034, USA
    Am J Epidemiol 158:195-202. 2003
    ..23, 95% CI: 1.01, 1.49). This appears to have been the first study to measure all of these home exposures (indoor allergens, nitrogen dioxide, fungi) and to prospectively measure the frequency of infant wheeze and persistent cough...
  69. ncbi request reprint Nonwoven in contrast to woven mattress encasings accumulate mite and cat allergen
    Jeffrey D Miller
    J Allergy Clin Immunol 120:977-9. 2007
  70. pmc Exposure to dust mite allergen and endotoxin in early life and asthma and atopy in childhood
    Juan C Celedon
    Channing Laboratory, Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Allergy Clin Immunol 120:144-9. 2007
    ..There has been no longitudinal study of the relation between concurrent exposure to dust mite allergen and endotoxin in early life and asthma and atopy at school age...
  71. ncbi request reprint Expression and activity of pH-regulatory glutaminase in the human airway epithelium
    John F Hunt
    Division of Pediatric Respiratory Medicine and Division of Allergy, Asthma and Immunology, The University of Virginia Health System, Charlottesville, Virginia 22908, USA
    Am J Respir Crit Care Med 165:101-7. 2002
    ..58, p < 0.001). These data demonstrate that glutaminase is expressed and active in the human airway epithelium and may be relevant both to the regulation of airway pH and to the pathophysiology of acute asthmatic airway inflammation...
  72. ncbi request reprint American Academy of Allergy, Asthma & Immunology/American College of Allergy, Asthma and Immunology Joint Task Force Report on omalizumab-associated anaphylaxis
    Linda Cox
    Department of Clinical Medicine, Nova Southeastern University College of Osteopathic Medicine, Davie, FL 33334, USA
    J Allergy Clin Immunol 120:1373-7. 2007
    ..The OJTF report provides recommendations for physicians who prescribe Xolair (omalizumab) on (1) the suggested wait periods after administration and (2) patient education regarding anaphylaxis...
  73. ncbi request reprint Revised nomenclature for allergy for global use: Report of the Nomenclature Review Committee of the World Allergy Organization, October 2003
    S G O Johansson
    Department of Medicine, Unit of Clinical Immunology and Allergy, Karolinska University Hospital, L2 04, S 171 76 Stockholm, Sweden
    J Allergy Clin Immunol 113:832-6. 2004
    ..It is assumed that as knowledge about basic causes and mechanisms improves, the nomenclature will need further review...
  74. ncbi request reprint The future of allergy and clinical immunology lies in evaluation, treatment, and research on allergic disease
    Thomas A E Platts-Mills
    J Allergy Clin Immunol 110:565-6. 2002
  75. pmc Sensitization to mouse allergen and asthma and asthma morbidity among women in Boston
    Wanda Phipatanakul
    J Allergy Clin Immunol 120:954-6. 2007
  76. ncbi request reprint Sublingual immunotherapy and subcutaneous immunotherapy: issues in the United States
    Paul A Greenberger
    J Allergy Clin Immunol 120:1466-8. 2007
  77. ncbi request reprint Asthma and neonatal airway colonization
    Amy P Stallings
    N Engl J Med 358:423-4; author reply 424-5. 2008

Research Grants22

  1. DUST MITE, COCKROACH AND CAT ALLERGENS IN ASTHMA
    Thomas A Platts Mills; Fiscal Year: 2010
    ..These studies are relevant to understanding the reasons why the disease is so common and to developing new approaches to treatment. ..
  2. Dust Mite, Cockroach and Cat Allergens: Asthma
    Thomas Platts Mills; Fiscal Year: 2006
    ..The studies proposed have important implications for asthma treatment using allergen avoidance, or for novel strategies for allergen specific immunotherapy. ..
  3. UVA Asthma and Allergic Diseases Center
    Thomas Platts Mills; Fiscal Year: 2005
    ..Understanding the mechanisms involved is essential for defining new approaches to treatment and prevention and also for explaining the increasing prevalence of asthma. ..
  4. ASTHMA AND ALLERGIC DISEASE CENTER
    Thomas Platts Mills; Fiscal Year: 2007
    ..The overall objective is to understand the effects of obesity, physical activity and allergic sensitization in relation to symptoms of breathlessness and airway obstruction. ..
  5. DUST MITE, COCKROACH AND CAT ALLERGENS IN ASTHMA
    Thomas Platts Mills; Fiscal Year: 2009
    ..These studies are relevant to understanding the reasons why the disease is so common and to developing new approaches to treatment. ..
  6. DUST MITE, COCKROACH AND CAT ALLERGENS IN HOUSES/ASTHMA
    Thomas Platts Mills; Fiscal Year: 1991
    ..The results suggest that better understanding of and control of the levels of allergens in houses would be a major contribution to the management of this disease...
  7. DUST MITE, COCKROACH AND CAT ALLERGENS IN HOUSES/ASTHMA
    Thomas Platts Mills; Fiscal Year: 1992
    ..The long term objective is to develop effective and realistic methods for reducing exposure to allergens and to answer whether allergen avoidance should be a first line form of treatment for these patients...