Jeffrey Platt

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. doi request reprint New and old technologies for organ replacement
    Jeffrey L Platt
    Department of Surgery, University of Michigan, Ann Arbor, Michigan, USA
    Curr Opin Organ Transplant 18:179-85. 2013
  2. pmc Donor specific antibodies after transplantation
    Jeffrey L Platt
    Department of Surgery, University of Michigan, Ann Arbor, MI 48109 2200, USA
    Pediatr Transplant 15:686-90. 2011
  3. pmc Antibodies in transplantation
    Jeffrey L Platt
    Department of Surgery, University of Michigan, Ann Arbor, Michigan 48109, USA
    Discov Med 10:125-33. 2010
  4. pmc Lessons from cardiac transplantation in infancy
    Jeffrey L Platt
    Department of Surgery, Microbiology and Immunology, University of Michigan, Ann Arbor, MI 48109 2200, USA
    Pediatr Transplant 13:814-9. 2009
  5. doi request reprint Molecular and cellular mechanisms of mammalian cell fusion
    Xiaofeng Zhou
    Transplantation Biology, Department of Surgery, University of Michigan, Ann Arbor, MI 48109 2200, USA
    Adv Exp Med Biol 713:33-64. 2011
  6. pmc The role of antibodies in transplantation
    Alexander T Chang
    Department of Surgery, Mayo Clinic, Rochester, MN 55905, USA
    Transplant Rev (Orlando) 23:191-8. 2009
  7. ncbi request reprint Recommendations of the National Heart, Lung, and Blood Institute Heart and Lung Xenotransplantation Working Group
    Jeffrey Platt
    Department of Surgery, Immunology, and Pediatrics, Mayo Clinic, Rochester, Minn, USA
    Circulation 106:1043-7. 2002
  8. pmc Noncognate function of B cells in transplantation
    Samuel J Balin
    Department of Surgery and Microbiology, University of Michigan, Ann Arbor, MI 48109, USA
    Transpl Int 22:593-8. 2009
  9. ncbi request reprint Accommodation in ABO-incompatible kidney allografts, a novel mechanism of self-protection against antibody-mediated injury
    Walter D Park
    Department of Surgery, Mayo Clinic, Rochester, MN, USA
    Am J Transplant 3:952-60. 2003
  10. ncbi request reprint Treatment of cirrhosis and liver failure in rats by hepatocyte xenotransplantation
    Hideo Nagata
    Department of Surgery, University of Nebraska Medical Center, Omaha 68198, USA
    Gastroenterology 124:422-31. 2003

Research Grants

Collaborators

  • Marilia Cascalho
  • J Gloor
  • Mark Stegall
  • Raymond J Lynch
  • Xiaofeng Zhou
  • Samuel J Balin
  • Alexander T Chang
  • Edward Cantu
  • Soheyla Saadi
  • Kiyoshi Ogata
  • Walter D Park
  • Hideo Nagata
  • Zoie E Holzknecht
  • Robert A Holzknecht
  • William Parker
  • R Duane Davis
  • Takao Takahashi
  • Jin Cai
  • Ira J Fox
  • Joseph P Grande
  • Albert S Edge
  • Karl A Nath
  • Masahiro Ito
  • Dora Ninova
  • Matilda Bustos
  • Karisha L Kuypers
  • Gregory J Brunn
  • Timothy B Plummer
  • Gregory J Gores
  • Josie Williams

Detail Information

Publications16

  1. doi request reprint New and old technologies for organ replacement
    Jeffrey L Platt
    Department of Surgery, University of Michigan, Ann Arbor, Michigan, USA
    Curr Opin Organ Transplant 18:179-85. 2013
    ..Whether and how new or old technologies separately or together could be applied to replacing organs will thus remain a question of importance...
  2. pmc Donor specific antibodies after transplantation
    Jeffrey L Platt
    Department of Surgery, University of Michigan, Ann Arbor, MI 48109 2200, USA
    Pediatr Transplant 15:686-90. 2011
    ..Here, we explain why answers to these questions might interest the basic scientist and clinician...
  3. pmc Antibodies in transplantation
    Jeffrey L Platt
    Department of Surgery, University of Michigan, Ann Arbor, Michigan 48109, USA
    Discov Med 10:125-33. 2010
    ..Reviewed here are potential limitations in the use of antibodies as an index of immunity and the ways antibodies cause and/or prevent injury...
  4. pmc Lessons from cardiac transplantation in infancy
    Jeffrey L Platt
    Department of Surgery, Microbiology and Immunology, University of Michigan, Ann Arbor, MI 48109 2200, USA
    Pediatr Transplant 13:814-9. 2009
    ..These subjects can have a dramatic contraction of T cell diversity, allowing the testing of how diversity contributes to function...
  5. doi request reprint Molecular and cellular mechanisms of mammalian cell fusion
    Xiaofeng Zhou
    Transplantation Biology, Department of Surgery, University of Michigan, Ann Arbor, MI 48109 2200, USA
    Adv Exp Med Biol 713:33-64. 2011
    ..The understanding of the mechanisms of cell fusion may provide new opportunities in correcting development disorders or regenerating damaged tissues by inhibiting or promoting molecular events associated with fusion...
  6. pmc The role of antibodies in transplantation
    Alexander T Chang
    Department of Surgery, Mayo Clinic, Rochester, MN 55905, USA
    Transplant Rev (Orlando) 23:191-8. 2009
    ....
  7. ncbi request reprint Recommendations of the National Heart, Lung, and Blood Institute Heart and Lung Xenotransplantation Working Group
    Jeffrey Platt
    Department of Surgery, Immunology, and Pediatrics, Mayo Clinic, Rochester, Minn, USA
    Circulation 106:1043-7. 2002
    ..This report is a summary of those discussions...
  8. pmc Noncognate function of B cells in transplantation
    Samuel J Balin
    Department of Surgery and Microbiology, University of Michigan, Ann Arbor, MI 48109, USA
    Transpl Int 22:593-8. 2009
    ..In this study, we explain why the importance of B cells was overlooked in the past and consider the range of noncognate functions of B cells that may determine the outcome of transplants...
  9. ncbi request reprint Accommodation in ABO-incompatible kidney allografts, a novel mechanism of self-protection against antibody-mediated injury
    Walter D Park
    Department of Surgery, Mayo Clinic, Rochester, MN, USA
    Am J Transplant 3:952-60. 2003
    ..This self-protection against antibody-mediated damage may involve several novel mechanisms including the disruption of normal signal transduction, attenuation of cellular adhesion and the prevention of apoptosis...
  10. ncbi request reprint Treatment of cirrhosis and liver failure in rats by hepatocyte xenotransplantation
    Hideo Nagata
    Department of Surgery, University of Nebraska Medical Center, Omaha 68198, USA
    Gastroenterology 124:422-31. 2003
    ..The use of porcine hepatocytes might address this problem; however, xenogeneic hepatocytes are thought to be functionally incompatible across species and susceptible to irreversible rejection...
  11. ncbi request reprint Apoptosis and cellular activation in the pathogenesis of acute vascular rejection
    Zoie E Holzknecht
    Department of Surgery, Mayo Clinic, Rochester, Minn 55905, USA
    Circ Res 91:1135-41. 2002
    ..These findings suggest that acute vascular rejection is caused by an active metabolic process and not by apoptosis in the endothelium...
  12. pmc Accommodation in renal transplantation: unanswered questions
    Raymond J Lynch
    Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA
    Curr Opin Organ Transplant 15:481-5. 2010
    ..This communication summarizes recent advances in addressing these questions...
  13. pmc Escaping from rejection
    Raymond J Lynch
    Department of Surgery, University of Michigan, Ann Arbor, Michigan 48109, USA
    Transplantation 88:1233-6. 2009
    ..Further study of these controls, including structural and conditional tolerance and accommodation, will offer insight into new therapies for allo- and xenotransplantation...
  14. ncbi request reprint Cardiac xenotransplantation: future and limitations
    Kiyoshi Ogata
    Transplantation Biology, Department of Surgery, Mayo Clinic, Rochester, MN 55905, USA
    Cardiology 101:144-55. 2004
    ..Here, we discuss the rationale for xenotransplantation beyond overcoming the shortage of human organs, and we weigh xenotransplantation against other new technologies that might be used for the treatment of cardiac failure...
  15. pmc Pathways to acute humoral rejection
    Soheyla Saadi
    Department of Surgery, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Pathol 164:1073-80. 2004
    ..These findings suggest IL-1 plays an important role in initiation of acute humoral rejection...
  16. ncbi request reprint Pulmonary xenotransplantation: rapidly progressing into the unknown
    Edward Cantu
    Department of Surgery, Duke University Medical Center, Durham, NC, USA
    Am J Transplant 4:25-35. 2004
    ..This progress provides a basis for future work and for a hope that the shortage of human lungs for transplantation will not always be a matter of life and death...

Research Grants11

  1. Heparan Sulfate-TLR in Health, Injury and Immunity
    Jeffrey Platt; Fiscal Year: 2006
    ..The research will determine how toll-like receptors function in the generation of T cell independent and T cell dependent B cell responses. ..
  2. HEPARAN SULFATE IN CELLULAR IMMUNITY AND GRAFT REJECTION
    Jeffrey Platt; Fiscal Year: 2003
    ..These studies will use allo- and xenotransplant models. ..
  3. Heparan Sulfate-TLR in Health, Injury and Immunity
    Jeffrey Platt; Fiscal Year: 2003
    ..The research will determine how toll-like receptors function in the generation of T cell independent and T cell dependent B cell responses. ..
  4. HEPARAN SULFATE IN CELLULAR IMMUNITY AND GRAFT REJECTION
    Jeffrey Platt; Fiscal Year: 1999
    ..These strategies will be tested for their ability to prevent the untoward metabolism of heparan sulfate proteoglycan and for the effects on the outcome of experimental renal allografts. ..
  5. Heparan Sulfate-TLR in Health, Injury and Immunity
    Jeffrey Platt; Fiscal Year: 2007
    ..The research will determine how toll-like receptors function in the generation of T cell independent and T cell dependent B cell responses. ..