Kathrin Plath

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Xist RNA and the mechanism of X chromosome inactivation
    Kathrin Plath
    Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California 94143, USA
    Annu Rev Genet 36:233-78. 2002
  2. ncbi request reprint Developmental regulation of Suz 12 localization
    Cecile C de la Cruz
    Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143, USA
    Chromosoma 114:183-92. 2005
  3. ncbi request reprint Mapping post-translational modifications of the histone variant MacroH2A1 using tandem mass spectrometry
    Feixia Chu
    Mass Spectrometry Facility and Department of Pharmaceutical Chemistry, University of California, San Francisco, 94143, USA
    Mol Cell Proteomics 5:194-203. 2006
  4. pmc The histone domain of macroH2A1 contains several dispersed elements that are each sufficient to direct enrichment on the inactive X chromosome
    Dmitri A Nusinow
    Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143, USA
    J Mol Biol 371:11-8. 2007
  5. pmc Chd1 regulates open chromatin and pluripotency of embryonic stem cells
    Alexandre Gaspar-Maia
    Department of Ob Gyn and Pathology, Center for Reproductive Sciences and Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, California 94143 0525, USA
    Nature 460:863-8. 2009
  6. ncbi request reprint Role of histone H3 lysine 27 methylation in X inactivation
    Kathrin Plath
    Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA 94143, USA
    Science 300:131-5. 2003
  7. ncbi request reprint A bivalent chromatin structure marks key developmental genes in embryonic stem cells
    Bradley E Bernstein
    Molecular Pathology Unit and Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Cell 125:315-26. 2006

Collaborators

Detail Information

Publications7

  1. ncbi request reprint Xist RNA and the mechanism of X chromosome inactivation
    Kathrin Plath
    Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California 94143, USA
    Annu Rev Genet 36:233-78. 2002
    ..We are now on the threshold of discovering the factors that regulate and interact with Xist to control X-inactivation, and closer to an understanding of the molecular mechanisms that underlie this complex process...
  2. ncbi request reprint Developmental regulation of Suz 12 localization
    Cecile C de la Cruz
    Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143, USA
    Chromosoma 114:183-92. 2005
    ..These results suggest that Suz12 may have a function that is not mediated by its association with Eed and Ezh2, and that this additional function is not involved in the regulation of X-inactivation...
  3. ncbi request reprint Mapping post-translational modifications of the histone variant MacroH2A1 using tandem mass spectrometry
    Feixia Chu
    Mass Spectrometry Facility and Department of Pharmaceutical Chemistry, University of California, San Francisco, 94143, USA
    Mol Cell Proteomics 5:194-203. 2006
    ..2, suggesting that, like canonical H2A, this variant H2A is subject to regulation by combinatorial use of covalent modifications...
  4. pmc The histone domain of macroH2A1 contains several dispersed elements that are each sufficient to direct enrichment on the inactive X chromosome
    Dmitri A Nusinow
    Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143, USA
    J Mol Biol 371:11-8. 2007
    ..These sequences map to the surface of the macroH2A1/H2B dimer, but are buried in the crystal structure of the macroH2A1 containing nucleosome, suggesting that they may contribute to recognition by macroH2A1/H2B deposition factors...
  5. pmc Chd1 regulates open chromatin and pluripotency of embryonic stem cells
    Alexandre Gaspar-Maia
    Department of Ob Gyn and Pathology, Center for Reproductive Sciences and Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, California 94143 0525, USA
    Nature 460:863-8. 2009
    ..Our results indicate that Chd1 is essential for open chromatin and pluripotency of embryonic stem cells, and for somatic cell reprogramming to the pluripotent state...
  6. ncbi request reprint Role of histone H3 lysine 27 methylation in X inactivation
    Kathrin Plath
    Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA 94143, USA
    Science 300:131-5. 2003
    ..Together, our results suggest a role for Eed-Ezh2-mediated H3-K27 methylation during initiation of both imprinted and random X inactivation and demonstrate that H3-K27 methylation is not sufficient for silencing of the Xi...
  7. ncbi request reprint A bivalent chromatin structure marks key developmental genes in embryonic stem cells
    Bradley E Bernstein
    Molecular Pathology Unit and Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Cell 125:315-26. 2006
    ..These results highlight the importance of DNA sequence in defining the initial epigenetic landscape and suggest a novel chromatin-based mechanism for maintaining pluripotency...