Kathrin Plath

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi Signed weighted gene co-expression network analysis of transcriptional regulation in murine embryonic stem cells
    Mike J Mason
    Statistics, University of California, Los Angeles, CA 90095, USA
    BMC Genomics 10:327. 2009
  2. ncbi Progress in understanding reprogramming to the induced pluripotent state
    Kathrin Plath
    David Geffen School of Medicine, Department of Biological Chemistry, University of California Los Angeles, California, USA
    Nat Rev Genet 12:253-65. 2011
  3. ncbi Female human iPSCs retain an inactive X chromosome
    Jason Tchieu
    Department of Biological Chemistry, Jonsson Comprehensive Cancer Center, Molecular Biology Institute, David Geffen School of Medicine, and Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California Los Angeles, Los Angeles, CA 90024, USA
    Cell Stem Cell 7:329-42. 2010
  4. ncbi Role of the murine reprogramming factors in the induction of pluripotency
    Rupa Sridharan
    David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Cell 136:364-77. 2009
  5. ncbi Mediator coordinates PIC assembly with recruitment of CHD1
    Justin J Lin
    Department of Biological Chemistry, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    Genes Dev 25:2198-209. 2011
  6. ncbi Directed differentiation of human-induced pluripotent stem cells generates active motor neurons
    Saravanan Karumbayaram
    Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    Stem Cells 27:806-11. 2009
  7. ncbi Molecular analyses of human induced pluripotent stem cells and embryonic stem cells
    Mark H Chin
    Department of Biological Chemistry, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
    Cell Stem Cell 7:263-9. 2010
  8. ncbi Induced pluripotent stem cells and embryonic stem cells are distinguished by gene expression signatures
    Mark H Chin
    Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Cell Stem Cell 5:111-23. 2009
  9. ncbi Mediator and SAGA have distinct roles in Pol II preinitiation complex assembly and function
    Xiao Fen Chen
    Department of Biological Chemistry, David Geffen School of Medicine, University of California, BSRB 351A, 615 Charles E Young Drive, Los Angeles, CA 90095 1737, USA
    Cell Rep 2:1061-7. 2012
  10. ncbi Concise review: Pluripotency and the transcriptional inactivation of the female Mammalian X chromosome
    Alissa Minkovsky
    Department of Biological Chemistry, Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA
    Stem Cells 30:48-54. 2012

Collaborators

  • William E Lowry
  • Michael Carey
  • Amander Clark
  • Qing Zhou
  • Matteo Pellegrini
  • Mike J Mason
  • Jing Huang
  • Stefano Volinia
  • Guoping Fan
  • S Horvath
  • Rupa Sridharan
  • Mark H Chin
  • Justin J Lin
  • Jason Tchieu
  • Alissa Minkovsky
  • Xiao Fen Chen
  • Ritchie Ho
  • Bernadett Papp
  • Edward Kuoy
  • Otaren Aimiuwu
  • Michaela Patterson
  • April D Pyle
  • Anne Lindgren
  • Saravanan Karumbayaram
  • Jonathan P Saxe
  • Laura Richter
  • Ryan Schmidt
  • Robin McKee
  • Sanjeet Patel
  • Chengyang Huang
  • James Wohlschlegel
  • Amber Mosley
  • Roberto Ferrari
  • Ajay Vashisht
  • Lynn Lehmann
  • Siavash K Kurdistani
  • James A Wohlschlegel
  • Giancarlo Bonora
  • Nancy Tran
  • Lynn W Lehmann
  • Ajay A Vashisht
  • Constantinos Chronis
  • Jerome A Zack
  • Sean P Sherman
  • Hung Trinh
  • Shahrad Hakimian
  • Hans R Scholer
  • Martina Wiedau-Pazos
  • Joy A Umbach
  • Nissim Benvenisty
  • Robin Yachechko
  • Anne E Conway
  • Tim Baxter
  • Gayane Ambartsumyan
  • Mike Singer
  • Steve A Goldman
  • Mike A Teitell
  • Harley I Kornblum
  • Wei Xie
  • Vanessa Ott
  • Ivan Khvorostov
  • Carlo M Croce
  • Alexey Tomilin
  • Cory Peterson
  • Neta Lavon
  • Jin Zhang
  • Matteo Pelegrini
  • Bennett G Novitch
  • Michael Grunstein

Detail Information

Publications15

  1. ncbi Signed weighted gene co-expression network analysis of transcriptional regulation in murine embryonic stem cells
    Mike J Mason
    Statistics, University of California, Los Angeles, CA 90095, USA
    BMC Genomics 10:327. 2009
    ..To that end, we investigated the use of unsigned and signed network analysis to identify pluripotency and differentiation related genes...
  2. ncbi Progress in understanding reprogramming to the induced pluripotent state
    Kathrin Plath
    David Geffen School of Medicine, Department of Biological Chemistry, University of California Los Angeles, California, USA
    Nat Rev Genet 12:253-65. 2011
    ..To inform the next phase in understanding reprogramming, we review the latest findings, highlight ongoing debates and outline future challenges...
  3. ncbi Female human iPSCs retain an inactive X chromosome
    Jason Tchieu
    Department of Biological Chemistry, Jonsson Comprehensive Cancer Center, Molecular Biology Institute, David Geffen School of Medicine, and Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California Los Angeles, Los Angeles, CA 90024, USA
    Cell Stem Cell 7:329-42. 2010
    ....
  4. ncbi Role of the murine reprogramming factors in the induction of pluripotency
    Rupa Sridharan
    David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Cell 136:364-77. 2009
    ..These data uncover temporal and separable contributions of the four factors during the reprogramming process and indicate that ectopic c-Myc predominantly acts before pluripotency regulators are activated...
  5. ncbi Mediator coordinates PIC assembly with recruitment of CHD1
    Justin J Lin
    Department of Biological Chemistry, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    Genes Dev 25:2198-209. 2011
    ..Our data support a model in which the Mediator coordinates PIC assembly along with the recruitment of CHD1. The combined action of the PIC and H3K4me3 provides specificity in targeting CHD1 to active genes...
  6. ncbi Directed differentiation of human-induced pluripotent stem cells generates active motor neurons
    Saravanan Karumbayaram
    Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    Stem Cells 27:806-11. 2009
    ..These findings demonstrate the feasibility of using iPS-derived motor neuron progenitors and motor neurons in regenerative medicine applications and in vitro modeling of motor neuron diseases...
  7. ncbi Molecular analyses of human induced pluripotent stem cells and embryonic stem cells
    Mark H Chin
    Department of Biological Chemistry, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
    Cell Stem Cell 7:263-9. 2010
    ....
  8. ncbi Induced pluripotent stem cells and embryonic stem cells are distinguished by gene expression signatures
    Mark H Chin
    Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Cell Stem Cell 5:111-23. 2009
    ..Together, these data suggest that iPSCs should be considered a unique subtype of pluripotent cell...
  9. ncbi Mediator and SAGA have distinct roles in Pol II preinitiation complex assembly and function
    Xiao Fen Chen
    Department of Biological Chemistry, David Geffen School of Medicine, University of California, BSRB 351A, 615 Charles E Young Drive, Los Angeles, CA 90095 1737, USA
    Cell Rep 2:1061-7. 2012
    ..Moreover, Mediator coordinates assembly of the Pol II initiation factors and chromatin machinery into a PIC in vitro, whereas SAGA acts after PIC assembly to allow transcription on chromatin...
  10. ncbi Concise review: Pluripotency and the transcriptional inactivation of the female Mammalian X chromosome
    Alissa Minkovsky
    Department of Biological Chemistry, Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA
    Stem Cells 30:48-54. 2012
    ..Further, we will summarize advances characterizing XCI states in human pluripotent cells, where surprising differences from the mouse process may have far-reaching implications for human pluripotent cell biology...
  11. ncbi Mechanistic insights into reprogramming to induced pluripotency
    Ritchie Ho
    Department of Biological Chemistry, David Geffen School of Medicine, Jonsson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, California 90024, USA
    J Cell Physiol 226:868-78. 2011
    ..In this review, we discuss our current view of the molecular mechanisms underlying transcription factor-mediated reprogramming to induced pluripotency...
  12. ncbi Reprogramming to pluripotency: stepwise resetting of the epigenetic landscape
    Bernadett Papp
    David Geffen School of Medicine, Department of Biological Chemistry, Jonsson Comprehensive Cancer Center, Molecular Biology Institute, Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California Los Angeles, 615 Charles E Young Drive South, Los Angeles, CA, 90024, USA
    Cell Res 21:486-501. 2011
    ..Understanding reprogramming to pluripotency will inform mechanistic studies of lineage switching, in which differentiated cells from one lineage can be directly reprogrammed into another without going through a pluripotent intermediate...
  13. ncbi Small RNAs loom large during reprogramming
    Rupa Sridharan
    David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Cell Stem Cell 8:599-601. 2011
    ..2011; Miyoshi et al., 2011)...
  14. ncbi Post-translational regulation of Oct4 transcriptional activity
    Jonathan P Saxe
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 4:e4467. 2009
    ..These results provide a mechanism for rapid and reversible alteration of Oct4 transactivation potential in response to extracellular signals...
  15. ncbi Illuminating the black box of reprogramming
    Rupa Sridharan
    Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Cell Stem Cell 2:295-7. 2008
    ..2008). These results also provide important insight into the mechanistic basis of reprogramming...