Kathrin Plath

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Signed weighted gene co-expression network analysis of transcriptional regulation in murine embryonic stem cells
    Mike J Mason
    Statistics, University of California, Los Angeles, CA 90095, USA
    BMC Genomics 10:327. 2009
  2. pmc Progress in understanding reprogramming to the induced pluripotent state
    Kathrin Plath
    David Geffen School of Medicine, Department of Biological Chemistry, University of California Los Angeles, California, USA
    Nat Rev Genet 12:253-65. 2011
  3. pmc Proteomic and genomic approaches reveal critical functions of H3K9 methylation and heterochromatin protein-1γ in reprogramming to pluripotency
    Rupa Sridharan
    University of California Los Angeles, David Geffen School of Medicine, Department of Biological Chemistry, Jonsson Comprehensive Cancer Center, Molecular Biology Institute, Bioinformatics Interdepartmental Degree Program, Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, Los Angeles, California 90095, USA
    Nat Cell Biol 15:872-82. 2013
  4. pmc Female human iPSCs retain an inactive X chromosome
    Jason Tchieu
    Department of Biological Chemistry, Jonsson Comprehensive Cancer Center, Molecular Biology Institute, David Geffen School of Medicine, and Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California Los Angeles, Los Angeles, CA 90024, USA
    Cell Stem Cell 7:329-42. 2010
  5. pmc Epigenetics of reprogramming to induced pluripotency
    Bernadett Papp
    Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Cell 152:1324-43. 2013
  6. pmc The pluripotency factor-bound intron 1 of Xist is dispensable for X chromosome inactivation and reactivation in vitro and in vivo
    Alissa Minkovsky
    Department of Biological Chemistry, David Geffen School of Medicine, Jonsson Comprehensive Cancer Center, Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Cell Rep 3:905-18. 2013
  7. pmc Mediator and SAGA have distinct roles in Pol II preinitiation complex assembly and function
    Xiao Fen Chen
    Department of Biological Chemistry, David Geffen School of Medicine, University of California, BSRB 351A, 615 Charles E Young Drive, Los Angeles, CA 90095 1737, USA
    Cell Rep 2:1061-7. 2012
  8. pmc Characterization and therapeutic potential of induced pluripotent stem cell-derived cardiovascular progenitor cells
    Ali Nsair
    Department of Medicine and Physiology, Cardiovascular Research Laboratory, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 7:e45603. 2012
  9. pmc Role of the murine reprogramming factors in the induction of pluripotency
    Rupa Sridharan
    David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Cell 136:364-77. 2009
  10. pmc Stage-specific regulation of reprogramming to induced pluripotent stem cells by Wnt signaling and T cell factor proteins
    Ritchie Ho
    Department of Biological Chemistry, Jonsson Comprehensive Cancer Center, Molecular Biology Institute, Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, David Geffen School of Medicine, University of California Los Angeles, 615 Charles E Young Drive South, Los Angeles, CA 90024, USA
    Cell Rep 3:2113-26. 2013

Collaborators

Detail Information

Publications21

  1. pmc Signed weighted gene co-expression network analysis of transcriptional regulation in murine embryonic stem cells
    Mike J Mason
    Statistics, University of California, Los Angeles, CA 90095, USA
    BMC Genomics 10:327. 2009
    ..To that end, we investigated the use of unsigned and signed network analysis to identify pluripotency and differentiation related genes...
  2. pmc Progress in understanding reprogramming to the induced pluripotent state
    Kathrin Plath
    David Geffen School of Medicine, Department of Biological Chemistry, University of California Los Angeles, California, USA
    Nat Rev Genet 12:253-65. 2011
    ..To inform the next phase in understanding reprogramming, we review the latest findings, highlight ongoing debates and outline future challenges...
  3. pmc Proteomic and genomic approaches reveal critical functions of H3K9 methylation and heterochromatin protein-1γ in reprogramming to pluripotency
    Rupa Sridharan
    University of California Los Angeles, David Geffen School of Medicine, Department of Biological Chemistry, Jonsson Comprehensive Cancer Center, Molecular Biology Institute, Bioinformatics Interdepartmental Degree Program, Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, Los Angeles, California 90095, USA
    Nat Cell Biol 15:872-82. 2013
    ..Together, our findings demonstrate that Cbx3 and H3K9 methylation restrict late reprogramming events, and suggest that a marked change in global chromatin character constitutes an epigenetic roadblock for reprogramming. ..
  4. pmc Female human iPSCs retain an inactive X chromosome
    Jason Tchieu
    Department of Biological Chemistry, Jonsson Comprehensive Cancer Center, Molecular Biology Institute, David Geffen School of Medicine, and Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California Los Angeles, Los Angeles, CA 90024, USA
    Cell Stem Cell 7:329-42. 2010
    ....
  5. pmc Epigenetics of reprogramming to induced pluripotency
    Bernadett Papp
    Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Cell 152:1324-43. 2013
    ..However, recent studies have also uncovered an epigenetic instability of the X chromosome in human iPSCs that warrants careful consideration...
  6. pmc The pluripotency factor-bound intron 1 of Xist is dispensable for X chromosome inactivation and reactivation in vitro and in vivo
    Alissa Minkovsky
    Department of Biological Chemistry, David Geffen School of Medicine, Jonsson Comprehensive Cancer Center, Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Cell Rep 3:905-18. 2013
    ..Altogether, our findings demonstrate that intron 1 is dispensable for the developmental dynamics of Xist expression...
  7. pmc Mediator and SAGA have distinct roles in Pol II preinitiation complex assembly and function
    Xiao Fen Chen
    Department of Biological Chemistry, David Geffen School of Medicine, University of California, BSRB 351A, 615 Charles E Young Drive, Los Angeles, CA 90095 1737, USA
    Cell Rep 2:1061-7. 2012
    ..Moreover, Mediator coordinates assembly of the Pol II initiation factors and chromatin machinery into a PIC in vitro, whereas SAGA acts after PIC assembly to allow transcription on chromatin...
  8. pmc Characterization and therapeutic potential of induced pluripotent stem cell-derived cardiovascular progenitor cells
    Ali Nsair
    Department of Medicine and Physiology, Cardiovascular Research Laboratory, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 7:e45603. 2012
    ..Study of endogenous and induced pluripotent stem cell (iPSC)-derived CPCs has been limited due to the lack of specific cell surface markers to isolate them and conditions for their in vitro expansion that maintain their multipotency...
  9. pmc Role of the murine reprogramming factors in the induction of pluripotency
    Rupa Sridharan
    David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Cell 136:364-77. 2009
    ..These data uncover temporal and separable contributions of the four factors during the reprogramming process and indicate that ectopic c-Myc predominantly acts before pluripotency regulators are activated...
  10. pmc Stage-specific regulation of reprogramming to induced pluripotent stem cells by Wnt signaling and T cell factor proteins
    Ritchie Ho
    Department of Biological Chemistry, Jonsson Comprehensive Cancer Center, Molecular Biology Institute, Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, David Geffen School of Medicine, University of California Los Angeles, 615 Charles E Young Drive South, Los Angeles, CA 90024, USA
    Cell Rep 3:2113-26. 2013
    ..Together, our data indicate that the stepwise process of reprogramming to iPSCs is critically dependent on the stage-specific control and action of all four Tcfs and Wnt signaling. ..
  11. pmc Mediator coordinates PIC assembly with recruitment of CHD1
    Justin J Lin
    Department of Biological Chemistry, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    Genes Dev 25:2198-209. 2011
    ..Our data support a model in which the Mediator coordinates PIC assembly along with the recruitment of CHD1. The combined action of the PIC and H3K4me3 provides specificity in targeting CHD1 to active genes...
  12. pmc Directed differentiation of human-induced pluripotent stem cells generates active motor neurons
    Saravanan Karumbayaram
    Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    Stem Cells 27:806-11. 2009
    ..These findings demonstrate the feasibility of using iPS-derived motor neuron progenitors and motor neurons in regenerative medicine applications and in vitro modeling of motor neuron diseases...
  13. pmc Molecular analyses of human induced pluripotent stem cells and embryonic stem cells
    Mark H Chin
    Department of Biological Chemistry, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
    Cell Stem Cell 7:263-9. 2010
    ....
  14. pmc Induced pluripotent stem cells and embryonic stem cells are distinguished by gene expression signatures
    Mark H Chin
    Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Cell Stem Cell 5:111-23. 2009
    ..Together, these data suggest that iPSCs should be considered a unique subtype of pluripotent cell...
  15. doi request reprint Stem cells in the land of the rising sun: ISSCR 2012
    Kathrin Plath
    Department of Biological Chemistry, Jonsson Comprehensive Cancer Center, Molecular Biology Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90024, USA
    Cell Stem Cell 11:607-14. 2012
    ..Held in Japan, the meeting showcased recent discoveries and surveyed the remarkable progress that has been made in a decade of stem cell research...
  16. pmc Concise review: Pluripotency and the transcriptional inactivation of the female Mammalian X chromosome
    Alissa Minkovsky
    Department of Biological Chemistry, Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA
    Stem Cells 30:48-54. 2012
    ..Further, we will summarize advances characterizing XCI states in human pluripotent cells, where surprising differences from the mouse process may have far-reaching implications for human pluripotent cell biology...
  17. pmc Post-translational regulation of Oct4 transcriptional activity
    Jonathan P Saxe
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 4:e4467. 2009
    ..These results provide a mechanism for rapid and reversible alteration of Oct4 transactivation potential in response to extracellular signals...
  18. pmc Reprogramming to pluripotency: stepwise resetting of the epigenetic landscape
    Bernadett Papp
    David Geffen School of Medicine, Department of Biological Chemistry, Jonsson Comprehensive Cancer Center, Molecular Biology Institute, Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California Los Angeles, 615 Charles E Young Drive South, Los Angeles, CA, 90024, USA
    Cell Res 21:486-501. 2011
    ..Understanding reprogramming to pluripotency will inform mechanistic studies of lineage switching, in which differentiated cells from one lineage can be directly reprogrammed into another without going through a pluripotent intermediate...
  19. pmc Mechanistic insights into reprogramming to induced pluripotency
    Ritchie Ho
    Department of Biological Chemistry, David Geffen School of Medicine, Jonsson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, California 90024, USA
    J Cell Physiol 226:868-78. 2011
    ..In this review, we discuss our current view of the molecular mechanisms underlying transcription factor-mediated reprogramming to induced pluripotency...
  20. pmc Small RNAs loom large during reprogramming
    Rupa Sridharan
    David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Cell Stem Cell 8:599-601. 2011
    ..2011; Miyoshi et al., 2011)...
  21. doi request reprint Illuminating the black box of reprogramming
    Rupa Sridharan
    Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Cell Stem Cell 2:295-7. 2008
    ..2008). These results also provide important insight into the mechanistic basis of reprogramming...