Genomes and Genes
S M Plafker
Affiliation: University of Virginia
- Importin-11, a nuclear import receptor for the ubiquitin-conjugating enzyme, UbcM2S M Plafker
Center for Cell Signaling, Box 800577, HSC and Department of Pharmacology, University of Virginia, Charlottesville, VA 22908, USA
EMBO J 19:5502-13. 2000..These data establish importin-11 as a new member of the karyopherin family of transport receptors, and identify UbcM2 as a nuclear member of the E2 ubiquitin-conjugating enzyme family...
- Ribosomal protein L12 uses a distinct nuclear import pathway mediated by importin 11Scott M Plafker
Center for Cell Signaling and Department of Pharmacology, University of Virginia, Charlottesville, Virginia 22908, USA
Mol Cell Biol 22:1266-75. 2002..Taken together, these results indicate that rpL12 uses a distinct nuclear import pathway that may contribute to a mechanism for regulating ribosome synthesis and/or maturation...
- Ubiquitin charging of human class III ubiquitin-conjugating enzymes triggers their nuclear importScott M Plafker
Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
J Cell Biol 167:649-59. 2004..Together, these findings reveal that Ub charging can function as a nuclear import trigger, and identify a novel link between E2 regulation and karyopherin-mediated transport...
- Mammalian DET1 regulates Cul4A activity and forms stable complexes with E2 ubiquitin-conjugating enzymesElah Pick
Department of Molecualr, Cellular and Developmental Biology, Yale University, New Haven, CT 06520, USA
Mol Cell Biol 27:4708-19. 2007..Overexpression of DET1 inhibits UV-induced CDT1 degradation in cultured cells. These findings demonstrate that the conserved DET1 complex modulates Cul4A functions by a novel mechanism...