Chandrika Piyathilake

Summary

Affiliation: University of Alabama at Birmingham
Country: USA

Publications

  1. pmc A lower degree of PBMC L1 methylation is associated with excess body weight and higher HOMA-IR in the presence of lower concentrations of plasma folate
    Chandrika J Piyathilake
    the Department of Nutrition Sciences, University of Alabama at Birmingham UAB, Birmingham, Alabama, USA
    PLoS ONE 8:e54544. 2013
  2. doi request reprint A dietary pattern associated with LINE-1 methylation alters the risk of developing cervical intraepithelial neoplasia
    Chandrika J Piyathilake
    Department of Nutrition Sciences, University of Alabama at Birmingham, 1675 University Blvd, Webb 326, Birmingham, AL 35294, USA
    Cancer Prev Res (Phila) 5:385-92. 2012
  3. pmc Aflatoxin levels, plasma vitamins A and E concentrations, and their association with HIV and hepatitis B virus infections in Ghanaians: a cross-sectional study
    Francis A Obuseh
    Department of Health Care Organization and Policy, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, USA
    J Int AIDS Soc 14:53. 2011
  4. pmc Pattern of nonspecific (or global) DNA methylation in oral carcinogenesis
    Chandrika J Piyathilake
    Department of Nutrition Sciences, Division of Nutritional Biochemistry and Molecular Biology, University of Alabama at Birmingham, University Station, Birmingham, AL 35294, USA
    Head Neck 27:1061-7. 2005
  5. ncbi request reprint Patterns of global DNA and histone methylation appear to be similar in normal, dysplastic and neoplastic oral epithelium of humans
    Chandrika J Piyathilake
    Department of Nutrition Sciences, University of Alabama at Birmingham, AL 35294, USA
    Dis Markers 21:147-51. 2005
  6. ncbi request reprint Mandatory fortification with folic acid in the United States is not associated with changes in the degree or the pattern of global DNA methylation in cells involved in cervical carcinogenesis
    Chandrika J Piyathilake
    Department of Nutrition Sciences, The University of Alabama at Birmingham, AL 35294, USA
    Cancer Biomark 2:259-66. 2006
  7. pmc Protective association of MTHFR polymorphism on cervical intraepithelial neoplasia is modified by riboflavin status
    Chandrika J Piyathilake
    University of Alabama at Birmingham, Birmingham, Alabama, USA
    Nutrition 23:229-35. 2007
  8. pdf Update on micronutrients and cervical dysplasia
    Chandrika J Piyathilake
    Department of Nutrition Sciences, Division of Nutritional Biochemistry and Genomics, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Ethn Dis 17:S2-14-7. 2007
  9. pmc Mandatory fortification with folic acid in the United States is associated with increased expression of DNA methyltransferase-1 in the cervix
    Chandrika J Piyathilake
    Department of Nutrition Sciences, The University of Alabama at Birmingham, Alabama, USA
    Nutrition 24:94-9. 2008
  10. doi request reprint Lower risk of cervical intraepithelial neoplasia in women with high plasma folate and sufficient vitamin B12 in the post-folic acid fortification era
    Chandrika J Piyathilake
    Department of Nutrition Sciences, University of Alabama at Birmingham, 1675 University Boulevard, Webb 326, Birmingham, AL 35294, USA
    Cancer Prev Res (Phila) 2:658-64. 2009

Research Grants

  1. Prognostic Significance of Altered DNA Methylation
    Chandrika Piyathilake; Fiscal Year: 2002
  2. HPV Clearance by Folic Acid Supplementation
    Chandrika Piyathilake; Fiscal Year: 2007
  3. Prognostic Significance of DNA and Histone Methylation
    Chandrika Piyathilake; Fiscal Year: 2007
  4. Effects of Folate Fortification on Cancer Prevention an*
    Chandrika Piyathilake; Fiscal Year: 2005
  5. HPV Clearance by Folic Acid Supplementation
    Chandrika J Piyathilake; Fiscal Year: 2010

Collaborators

Detail Information

Publications29

  1. pmc A lower degree of PBMC L1 methylation is associated with excess body weight and higher HOMA-IR in the presence of lower concentrations of plasma folate
    Chandrika J Piyathilake
    the Department of Nutrition Sciences, University of Alabama at Birmingham UAB, Birmingham, Alabama, USA
    PLoS ONE 8:e54544. 2013
    ....
  2. doi request reprint A dietary pattern associated with LINE-1 methylation alters the risk of developing cervical intraepithelial neoplasia
    Chandrika J Piyathilake
    Department of Nutrition Sciences, University of Alabama at Birmingham, 1675 University Blvd, Webb 326, Birmingham, AL 35294, USA
    Cancer Prev Res (Phila) 5:385-92. 2012
    ..The degree of PBMC L1 methylation may serve as a biomarker for monitoring the effectiveness of dietary modifications needed for reducing the risk of CIN 2+...
  3. pmc Aflatoxin levels, plasma vitamins A and E concentrations, and their association with HIV and hepatitis B virus infections in Ghanaians: a cross-sectional study
    Francis A Obuseh
    Department of Health Care Organization and Policy, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, USA
    J Int AIDS Soc 14:53. 2011
    ....
  4. pmc Pattern of nonspecific (or global) DNA methylation in oral carcinogenesis
    Chandrika J Piyathilake
    Department of Nutrition Sciences, Division of Nutritional Biochemistry and Molecular Biology, University of Alabama at Birmingham, University Station, Birmingham, AL 35294, USA
    Head Neck 27:1061-7. 2005
    ....
  5. ncbi request reprint Patterns of global DNA and histone methylation appear to be similar in normal, dysplastic and neoplastic oral epithelium of humans
    Chandrika J Piyathilake
    Department of Nutrition Sciences, University of Alabama at Birmingham, AL 35294, USA
    Dis Markers 21:147-51. 2005
    ..77, p< 0.001). Patterns of DNA and histone methylation are similar in tissues across the spectrum of oral carcinogenesis, and there is a significant positive association between these two epigenetic mechanisms...
  6. ncbi request reprint Mandatory fortification with folic acid in the United States is not associated with changes in the degree or the pattern of global DNA methylation in cells involved in cervical carcinogenesis
    Chandrika J Piyathilake
    Department of Nutrition Sciences, The University of Alabama at Birmingham, AL 35294, USA
    Cancer Biomark 2:259-66. 2006
    ..These results suggest that mandatory fortification with folic acid in the United States has not resulted in a change in the degree or the pattern of global DNA methylation in cells involved in cervical carcinogenesis...
  7. pmc Protective association of MTHFR polymorphism on cervical intraepithelial neoplasia is modified by riboflavin status
    Chandrika J Piyathilake
    University of Alabama at Birmingham, Birmingham, Alabama, USA
    Nutrition 23:229-35. 2007
    ..40, 95% confidence interval [CI] 0.21-0.78, P = 0.007). In the present study, we tested whether this protective association is modified by circulating riboflavin status in the same study population...
  8. pdf Update on micronutrients and cervical dysplasia
    Chandrika J Piyathilake
    Department of Nutrition Sciences, Division of Nutritional Biochemistry and Genomics, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Ethn Dis 17:S2-14-7. 2007
    ....
  9. pmc Mandatory fortification with folic acid in the United States is associated with increased expression of DNA methyltransferase-1 in the cervix
    Chandrika J Piyathilake
    Department of Nutrition Sciences, The University of Alabama at Birmingham, Alabama, USA
    Nutrition 24:94-9. 2008
    ....
  10. doi request reprint Lower risk of cervical intraepithelial neoplasia in women with high plasma folate and sufficient vitamin B12 in the post-folic acid fortification era
    Chandrika J Piyathilake
    Department of Nutrition Sciences, University of Alabama at Birmingham, 1675 University Boulevard, Webb 326, Birmingham, AL 35294, USA
    Cancer Prev Res (Phila) 2:658-64. 2009
    ....
  11. pmc A higher degree of methylation of the HPV 16 E6 gene is associated with a lower likelihood of being diagnosed with cervical intraepithelial neoplasia
    Chandrika J Piyathilake
    Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Cancer 117:957-63. 2011
    ....
  12. pmc A higher degree of LINE-1 methylation in peripheral blood mononuclear cells, a one-carbon nutrient related epigenetic alteration, is associated with a lower risk of developing cervical intraepithelial neoplasia
    Chandrika J Piyathilake
    Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Nutrition 27:513-9. 2011
    ..The objective of the study was to evaluate LINE-1 methylation as an intermediate biomarker for the effect of folate and vitamin B12 on the occurrence of higher grades of cervical intraepithelial neoplasia (CIN ≥ 2)...
  13. ncbi request reprint Folate is associated with the natural history of high-risk human papillomaviruses
    Chandrika J Piyathilake
    Departments of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Cancer Res 64:8788-93. 2004
    ..Improving folate status in subjects at risk of getting infected or already infected with high-risk HPV may have a beneficial impact in the prevention of cervical cancer...
  14. ncbi request reprint Methylenetetrahydrofolate reductase (MTHFR) polymorphism increases the risk of cervical intraepithelial neoplasia
    C J Piyathilake
    Biochemistry and Molecular Biology Division, School of Health Related Professions, University Alabama at Birmingham 35294 3360, USA
    Anticancer Res 20:1751-7. 2000
    ..Tissue folate deficiency, in turn, could increase the risk of CIN in the affected women...
  15. ncbi request reprint Immunohistochemical evaluation of global DNA methylation: comparison with in vitro radiolabeled methyl incorporation assay
    C J Piyathilake
    Department of Nutrition Sciences, The University of Alabama at Birmingham, 35294, USA
    Biotech Histochem 75:251-8. 2000
    ....
  16. ncbi request reprint Differential expression of growth factors in squamous cell carcinoma and precancerous lesions of the lung
    Chandrika J Piyathilake
    Department Nutrition Sciences, Heidi Weiss Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Clin Cancer Res 8:734-44. 2002
    ....
  17. ncbi request reprint Cellular vitamins, DNA methylation and cancer risk
    Chandrika J Piyathilake
    Department of Nutrition Sciences, The University of Alabama at Birmingham, 35294, USA
    J Nutr 132:2340S-2344S. 2002
    ....
  18. ncbi request reprint The pattern of expression of Mn and Cu-Zn superoxide dismutase varies among squamous cell cancers of the lung, larynx, and oral cavity
    Chandrika J Piyathilake
    Division of Nutritional Biochemistry and Molecular Biology, University of Alabama at Birmingham, University Station, Birmingham, Alabama 35294, USA
    Head Neck 24:859-67. 2002
    ..Despite the importance of reactive oxygen species (ROS) in the development of smoking-related cancers, little is known about the pattern of expression of ROS scavengers in these cancers...
  19. ncbi request reprint Nuclear accumulation of p53 is a potential marker for the development of squamous cell lung cancer in smokers
    Chandrika J Piyathilake
    Department of Nutrition Sciences, The University of Alabama, Birmingham, AL 35294, USA
    Chest 123:181-6. 2003
    ....
  20. ncbi request reprint Race- and age-dependent alterations in global methylation of DNA in squamous cell carcinoma of the lung (United States)
    C J Piyathilake
    Department of Nutrition Sciences, University of Alabama at Birmingham, AL 35294, USA
    Cancer Causes Control 14:37-42. 2003
    ..The current study investigated the race- and age-dependent alterations in global DNA methylation on the development and progression of squamous cell carcinomas (SCCs) of the lung...
  21. ncbi request reprint Lower red blood cell folate enhances the HPV-16-associated risk of cervical intraepithelial neoplasia
    Chandrika J Piyathilake
    Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Nutrition 23:203-10. 2007
    ..In the present study conducted in the same study population, we tested whether circulating folate concentrations modify the risk of cervical intraepithelial neoplasia (CIN) > or =2 associated with specific types of HR-HPV...
  22. ncbi request reprint Retinoids and epigenetic silencing in cancer
    Gary L Johanning
    Department of Nutrition Sciences, The University of Alabama at Birmingham, Birmingham, AL 35294 3360, USA
    Nutr Rev 61:284-9. 2003
    ..Two recent studies have established a mechanistic link between a vitamin A metabolite and epigenetic alterations of its target promoter that could provide insights about the role of vitamin A in cancer prevention...
  23. ncbi request reprint DNA methylation and diet in cancer
    Gary L Johanning
    Department of Nutrition Sciences, The University of Alabama at Birmingham, USA
    J Nutr 132:3814S-3818S. 2002
    ....
  24. ncbi request reprint Effect of short-term, high-dose retinol on dark adaptation in aging and early age-related maculopathy
    Cynthia Owsley
    Department of Ophthalmology, School of Medicine, University of Alabama at Birmingham, 35294 0009, USA
    Invest Ophthalmol Vis Sci 47:1310-8. 2006
    ..To examine the effect of a short course of high-dose retinol (preformed vitamin A) on dark adaptation in older adults with normal retinal health or early age-related maculopathy (ARM)...
  25. ncbi request reprint Effect of folic acid fortification of foods on folate intake in female smokers with cervical dysplasia
    James M Shikany
    Division of Preventive Medicine, the Department of Nutrition Sciences, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294 4410, USA
    Nutrition 20:409-14. 2004
    ..We investigated the effect of folic acid fortification of enriched cereal grains on folate intake in women of predominantly childbearing age at high risk for cervical cancer...
  26. ncbi request reprint Women with polymorphisms of methylenetetrahydrofolate reductase (MTHFR) and methionine synthase (MS) are less likely to have cervical intraepithelial neoplasia (CIN) 2 or 3
    Olga L Henao
    Department of Epidemiology of the University of Alabama at Birmingham, Birmingham, AL, USA
    Int J Cancer 113:991-7. 2005
    ..62). We conclude that these polymorphisms in the folate metabolic pathway were associated with a lower likelihood of CIN 2 or 3 in a population exposed to adequate amounts of folate from exposure to food fortification with folic acid...
  27. pmc Exceptionally high protection of photocarcinogenesis by topical application of (--)-epigallocatechin-3-gallate in hydrophilic cream in SKH-1 hairless mouse model: relationship to inhibition of UVB-induced global DNA hypomethylation
    Anshu Mittal
    Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Neoplasia 5:555-65. 2003
    ..These data suggest that hydrophilic cream could be a suitable vehicle for topical application of EGCG, and that EGCG is a promising candidate for future cancer therapies based on its influence on the epigenetic pathway...
  28. ncbi request reprint Intrinsic cisplatin resistance in lung and ovarian cancer cells propagating in medium acutely depleted of folate
    Martin A Whiteside
    National Cancer Institute, Division of Cancer Prevention, Bethesda, MD 20892, USA
    Nutr Cancer 54:274-84. 2006
    ..If these results are confirmed by in vivo human studies, it would suggest that the folate status of the recipient of cisplatin might have an impact on response to that chemotherapeutic agent...
  29. ncbi request reprint Associations between two common variants C677T and A1298C in the methylenetetrahydrofolate reductase gene and measures of folate metabolism and DNA stability (strand breaks, misincorporated uracil, and DNA methylation status) in human lymphocytes in vivo
    Sabrina Narayanan
    Division of Cellular Integrity, Rowett Research Institute, Bucksburn, Aberdeen, United Kingdom
    Cancer Epidemiol Biomarkers Prev 13:1436-43. 2004
    ....

Research Grants11

  1. Prognostic Significance of Altered DNA Methylation
    Chandrika Piyathilake; Fiscal Year: 2002
    ..A newly developed and tested immunohistochemical technique, which measures the degree of global methylation in intact and specific types of cells, will be used to evaluate global DNA methylation in the proposed study. ..
  2. HPV Clearance by Folic Acid Supplementation
    Chandrika Piyathilake; Fiscal Year: 2007
    ..Because this study will be conducted among women positive for HPV 16, the most prevalent and powerful causative agent of CC, the public health significance of this study could be enormous and will complement HPV vaccine studies. ..
  3. Prognostic Significance of DNA and Histone Methylation
    Chandrika Piyathilake; Fiscal Year: 2007
    ..Investigator talent, equipment, facilities and access to study subjects at UAB are ideal for conducting this study. ..
  4. Effects of Folate Fortification on Cancer Prevention an*
    Chandrika Piyathilake; Fiscal Year: 2005
    ....
  5. HPV Clearance by Folic Acid Supplementation
    Chandrika J Piyathilake; Fiscal Year: 2010
    ..Because this study will be conducted among women positive for HPV 16, the most prevalent and powerful causative agent of CC, the public health significance of this study could be enormous and will complement HPV vaccine studies. ..