Research Topics
| Chandrika PiyathilakeSummaryAffiliation: University of Alabama at Birmingham Country: USA Publications
Research Grants
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Detail Information
Publications
A lower degree of PBMC L1 methylation is associated with excess body weight and higher HOMA-IR in the presence of lower concentrations of plasma folateChandrika J Piyathilake
the Department of Nutrition Sciences, University of Alabama at Birmingham UAB, Birmingham, Alabama, USA
PLoS ONE 8:e54544. 2013....
A dietary pattern associated with LINE-1 methylation alters the risk of developing cervical intraepithelial neoplasiaChandrika J Piyathilake
Department of Nutrition Sciences, University of Alabama at Birmingham, 1675 University Blvd, Webb 326, Birmingham, AL 35294, USA
Cancer Prev Res (Phila) 5:385-92. 2012..The degree of PBMC L1 methylation may serve as a biomarker for monitoring the effectiveness of dietary modifications needed for reducing the risk of CIN 2+...- Aflatoxin levels, plasma vitamins A and E concentrations, and their association with HIV and hepatitis B virus infections in Ghanaians: a cross-sectional studyFrancis A Obuseh
Department of Health Care Organization and Policy, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, USA
J Int AIDS Soc 14:53. 2011.... - Pattern of nonspecific (or global) DNA methylation in oral carcinogenesisChandrika J Piyathilake
Department of Nutrition Sciences, Division of Nutritional Biochemistry and Molecular Biology, University of Alabama at Birmingham, University Station, Birmingham, AL 35294, USA
Head Neck 27:1061-7. 2005.... 
Patterns of global DNA and histone methylation appear to be similar in normal, dysplastic and neoplastic oral epithelium of humansChandrika J Piyathilake
Department of Nutrition Sciences, University of Alabama at Birmingham, AL 35294, USA
Dis Markers 21:147-51. 2005..77, p< 0.001). Patterns of DNA and histone methylation are similar in tissues across the spectrum of oral carcinogenesis, and there is a significant positive association between these two epigenetic mechanisms...- Mandatory fortification with folic acid in the United States is not associated with changes in the degree or the pattern of global DNA methylation in cells involved in cervical carcinogenesisChandrika J Piyathilake
Department of Nutrition Sciences, The University of Alabama at Birmingham, AL 35294, USA
Cancer Biomark 2:259-66. 2006..These results suggest that mandatory fortification with folic acid in the United States has not resulted in a change in the degree or the pattern of global DNA methylation in cells involved in cervical carcinogenesis... - Protective association of MTHFR polymorphism on cervical intraepithelial neoplasia is modified by riboflavin statusChandrika J Piyathilake
University of Alabama at Birmingham, Birmingham, Alabama, USA
Nutrition 23:229-35. 2007..40, 95% confidence interval [CI] 0.21-0.78, P = 0.007). In the present study, we tested whether this protective association is modified by circulating riboflavin status in the same study population... 
Update on micronutrients and cervical dysplasiaChandrika J Piyathilake
Department of Nutrition Sciences, Division of Nutritional Biochemistry and Genomics, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Ethn Dis 17:S2-14-7. 2007....- Mandatory fortification with folic acid in the United States is associated with increased expression of DNA methyltransferase-1 in the cervixChandrika J Piyathilake
Department of Nutrition Sciences, The University of Alabama at Birmingham, Alabama, USA
Nutrition 24:94-9. 2008.... - Lower risk of cervical intraepithelial neoplasia in women with high plasma folate and sufficient vitamin B12 in the post-folic acid fortification eraChandrika J Piyathilake
Department of Nutrition Sciences, University of Alabama at Birmingham, 1675 University Boulevard, Webb 326, Birmingham, AL 35294, USA
Cancer Prev Res (Phila) 2:658-64. 2009.... - A higher degree of methylation of the HPV 16 E6 gene is associated with a lower likelihood of being diagnosed with cervical intraepithelial neoplasiaChandrika J Piyathilake
Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
Cancer 117:957-63. 2011.... - A higher degree of LINE-1 methylation in peripheral blood mononuclear cells, a one-carbon nutrient related epigenetic alteration, is associated with a lower risk of developing cervical intraepithelial neoplasiaChandrika J Piyathilake
Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, Alabama, USA
Nutrition 27:513-9. 2011..The objective of the study was to evaluate LINE-1 methylation as an intermediate biomarker for the effect of folate and vitamin B12 on the occurrence of higher grades of cervical intraepithelial neoplasia (CIN ≥ 2)... - Folate is associated with the natural history of high-risk human papillomavirusesChandrika J Piyathilake
Departments of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
Cancer Res 64:8788-93. 2004..Improving folate status in subjects at risk of getting infected or already infected with high-risk HPV may have a beneficial impact in the prevention of cervical cancer... - Methylenetetrahydrofolate reductase (MTHFR) polymorphism increases the risk of cervical intraepithelial neoplasiaC J Piyathilake
Biochemistry and Molecular Biology Division, School of Health Related Professions, University Alabama at Birmingham 35294 3360, USA
Anticancer Res 20:1751-7. 2000..Tissue folate deficiency, in turn, could increase the risk of CIN in the affected women... - Immunohistochemical evaluation of global DNA methylation: comparison with in vitro radiolabeled methyl incorporation assayC J Piyathilake
Department of Nutrition Sciences, The University of Alabama at Birmingham, 35294, USA
Biotech Histochem 75:251-8. 2000.... - Differential expression of growth factors in squamous cell carcinoma and precancerous lesions of the lungChandrika J Piyathilake
Department Nutrition Sciences, Heidi Weiss Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
Clin Cancer Res 8:734-44. 2002.... - Cellular vitamins, DNA methylation and cancer riskChandrika J Piyathilake
Department of Nutrition Sciences, The University of Alabama at Birmingham, 35294, USA
J Nutr 132:2340S-2344S. 2002.... - The pattern of expression of Mn and Cu-Zn superoxide dismutase varies among squamous cell cancers of the lung, larynx, and oral cavityChandrika J Piyathilake
Division of Nutritional Biochemistry and Molecular Biology, University of Alabama at Birmingham, University Station, Birmingham, Alabama 35294, USA
Head Neck 24:859-67. 2002..Despite the importance of reactive oxygen species (ROS) in the development of smoking-related cancers, little is known about the pattern of expression of ROS scavengers in these cancers... - Nuclear accumulation of p53 is a potential marker for the development of squamous cell lung cancer in smokersChandrika J Piyathilake
Department of Nutrition Sciences, The University of Alabama, Birmingham, AL 35294, USA
Chest 123:181-6. 2003.... - Race- and age-dependent alterations in global methylation of DNA in squamous cell carcinoma of the lung (United States)C J Piyathilake
Department of Nutrition Sciences, University of Alabama at Birmingham, AL 35294, USA
Cancer Causes Control 14:37-42. 2003..The current study investigated the race- and age-dependent alterations in global DNA methylation on the development and progression of squamous cell carcinomas (SCCs) of the lung... - Lower red blood cell folate enhances the HPV-16-associated risk of cervical intraepithelial neoplasiaChandrika J Piyathilake
Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, Alabama, USA
Nutrition 23:203-10. 2007..In the present study conducted in the same study population, we tested whether circulating folate concentrations modify the risk of cervical intraepithelial neoplasia (CIN) > or =2 associated with specific types of HR-HPV... - Retinoids and epigenetic silencing in cancerGary L Johanning
Department of Nutrition Sciences, The University of Alabama at Birmingham, Birmingham, AL 35294-3360, USA
Nutr Rev 61:284-9. 2003..Two recent studies have established a mechanistic link between a vitamin A metabolite and epigenetic alterations of its target promoter that could provide insights about the role of vitamin A in cancer prevention... - DNA methylation and diet in cancerGary L Johanning
Department of Nutrition Sciences, The University of Alabama at Birmingham, USA
J Nutr 132:3814S-3818S. 2002.... - Effect of short-term, high-dose retinol on dark adaptation in aging and early age-related maculopathyCynthia Owsley
Department of Ophthalmology, School of Medicine, University of Alabama at Birmingham, 35294 0009, USA
Invest Ophthalmol Vis Sci 47:1310-8. 2006..To examine the effect of a short course of high-dose retinol (preformed vitamin A) on dark adaptation in older adults with normal retinal health or early age-related maculopathy (ARM)... - Effect of folic acid fortification of foods on folate intake in female smokers with cervical dysplasiaJames M Shikany
Division of Preventive Medicine, the Department of Nutrition Sciences, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294 4410, USA
Nutrition 20:409-14. 2004..We investigated the effect of folic acid fortification of enriched cereal grains on folate intake in women of predominantly childbearing age at high risk for cervical cancer... - Women with polymorphisms of methylenetetrahydrofolate reductase (MTHFR) and methionine synthase (MS) are less likely to have cervical intraepithelial neoplasia (CIN) 2 or 3Olga L Henao
Department of Epidemiology of the University of Alabama at Birmingham, Birmingham, AL, USA
Int J Cancer 113:991-7. 2005..62). We conclude that these polymorphisms in the folate metabolic pathway were associated with a lower likelihood of CIN 2 or 3 in a population exposed to adequate amounts of folate from exposure to food fortification with folic acid... - Exceptionally high protection of photocarcinogenesis by topical application of (--)-epigallocatechin-3-gallate in hydrophilic cream in SKH-1 hairless mouse model: relationship to inhibition of UVB-induced global DNA hypomethylationAnshu Mittal
Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Neoplasia 5:555-65. 2003..These data suggest that hydrophilic cream could be a suitable vehicle for topical application of EGCG, and that EGCG is a promising candidate for future cancer therapies based on its influence on the epigenetic pathway... - Intrinsic cisplatin resistance in lung and ovarian cancer cells propagating in medium acutely depleted of folateMartin A Whiteside
National Cancer Institute, Division of Cancer Prevention, Bethesda, MD 20892, USA
Nutr Cancer 54:274-84. 2006..If these results are confirmed by in vivo human studies, it would suggest that the folate status of the recipient of cisplatin might have an impact on response to that chemotherapeutic agent... - Associations between two common variants C677T and A1298C in the methylenetetrahydrofolate reductase gene and measures of folate metabolism and DNA stability (strand breaks, misincorporated uracil, and DNA methylation status) in human lymphocytes in vivoSabrina Narayanan
Division of Cellular Integrity, Rowett Research Institute, Bucksburn, Aberdeen, United Kingdom
Cancer Epidemiol Biomarkers Prev 13:1436-43. 2004....
Research Grants
- Prognostic Significance of Altered DNA MethylationChandrika Piyathilake; Fiscal Year: 2002..A newly developed and tested immunohistochemical technique, which measures the degree of global methylation in intact and specific types of cells, will be used to evaluate global DNA methylation in the proposed study. ..
- HPV Clearance by Folic Acid SupplementationChandrika Piyathilake; Fiscal Year: 2007..Because this study will be conducted among women positive for HPV 16, the most prevalent and powerful causative agent of CC, the public health significance of this study could be enormous and will complement HPV vaccine studies. ..
- Prognostic Significance of DNA and Histone MethylationChandrika Piyathilake; Fiscal Year: 2007..Investigator talent, equipment, facilities and access to study subjects at UAB are ideal for conducting this study. ..
- Effects of Folate Fortification on Cancer Prevention an*Chandrika Piyathilake; Fiscal Year: 2005....
- HPV Clearance by Folic Acid SupplementationChandrika J Piyathilake; Fiscal Year: 2010..Because this study will be conducted among women positive for HPV 16, the most prevalent and powerful causative agent of CC, the public health significance of this study could be enormous and will complement HPV vaccine studies. ..