Affiliation: University of Alabama at Birmingham
Piyathilake C, Badiga S, Alvarez R, Partridge E, Johanning G. A lower degree of PBMC L1 methylation is associated with excess body weight and higher HOMA-IR in the presence of lower concentrations of plasma folate. PLoS ONE. 2013;8:e54544 pubmed publisher
..78, 95% CI:1.02-3.13, P = 0.041). Our results demonstrated that a lower degree of PBMC L1 methylation is associated with excess body weight and higher HOMA-IR, especially in the presence of lower concentrations of plasma folate. ..
Piyathilake C, Macaluso M, Chambers M, Badiga S, Siddiqui N, Bell W, et al
. Folate and vitamin B12 may play a critical role in lowering the HPV 16 methylation-associated risk of developing higher grades of CIN. Cancer Prev Res (Phila). 2014;7:1128-37 pubmed publisher
Piyathilake C, Azrad M, Macaluso M, Johanning G, Cornwell P, Partridge E, et al
. Protective association of MTHFR polymorphism on cervical intraepithelial neoplasia is modified by riboflavin status. Nutrition. 2007;23:229-35 pubmed
..The practical implications of this complex gene-nutrient-disease interaction will require further investigation. ..
Sudenga S, Shrestha S, Macaluso M, Partridge E, Johanning G, Piyathilake C. Functional variants in CYP1A1 and GSTM1 are associated with clearance of cervical HPV infection. Gynecol Oncol. 2014;135:560-4 pubmed publisher
..39, p=0.006). The polymorphism in GSTT1 was not significantly associated with time to clearance of HR-HPV. Xenobiotic metabolism genes may influence the natural history of HR-HPV infection and its progression to cervical cancer. ..
Piyathilake C, Ollberding N, Kumar R, Macaluso M, Alvarez R, Morrow C. Cervical Microbiota Associated with Higher Grade Cervical Intraepithelial Neoplasia in Women Infected with High-Risk Human Papillomaviruses. Cancer Prev Res (Phila). 2016;9:357-66 pubmed publisher
..Our results provide little evidence that DNA oxidative damage mediates the effect of the microbiome on the natural history of HPV infection and CIN severity. Cancer Prev Res; 9(5); 357-66. Â©2016 AACR. ..
Piyathilake C, Robinson C, Cornwell P. A practical approach to red blood cell folate analysis. Anal Chem Insights. 2007;2:107-10 pubmed
Piyathilake C, Macaluso M, Alvarez R, Chen M, Badiga S, Siddiqui N, et al
. A higher degree of LINE-1 methylation in peripheral blood mononuclear cells, a one-carbon nutrient related epigenetic alteration, is associated with a lower risk of developing cervical intraepithelial neoplasia. Nutrition. 2011;27:513-9 pubmed publisher
..These results suggest that a higher degree of LINE-1 methylation in PBMCs, a one-carbon nutrient-related epigenetic alteration, is associated with a lower risk of developing CIN. ..