IRAKLIS ILIAS PIPINOS

Summary

Affiliation: University of Nebraska Medical Center
Country: USA

Publications

  1. pmc Human enterovirus in the gastrocnemius of patients with peripheral arterial disease
    Julian K S Kim
    Department of Surgery, College of Medicine, University of Nebraska Medical Center, Omaha, NE
    J Am Heart Assoc 2:e000082. 2013
  2. pmc Oxidative damage and myofiber degeneration in the gastrocnemius of patients with peripheral arterial disease
    Dustin J Weiss
    Department of Surgery, University of Nebraska Medical Center, Omaha, NE 68198 5182, USA
    J Transl Med 11:230. 2013
  3. pmc The effect of pharmacological treatment on gait biomechanics in peripheral arterial disease patients
    Jessie M Huisinga
    Nebraska Biomechanics Core Facility, University of Nebraska at Omaha, 6001 Dodge Street Omaha, NE, 68182, USA
    J Neuroeng Rehabil 7:25. 2010
  4. doi request reprint The myopathy of peripheral arterial occlusive disease: part 1. Functional and histomorphological changes and evidence for mitochondrial dysfunction
    Iraklis I Pipinos
    Department of Surgery, University of Nebraska Medical Center, Omaha, NE 68198 3280, USA
    Vasc Endovascular Surg 41:481-9. 2007
  5. doi request reprint The myopathy of peripheral arterial occlusive disease: Part 2. Oxidative stress, neuropathy, and shift in muscle fiber type
    Iraklis I Pipinos
    Department of Surgery, University of Nebraska Medical Center and Nebraska Western Iowa Veterans Affairs Medical Center, Omaha, Nebraska 68193 3280, USA
    Vasc Endovascular Surg 42:101-12. 2008
  6. ncbi request reprint Mitochondrial defects and oxidative damage in patients with peripheral arterial disease
    Iraklis I Pipinos
    Department of Surgery, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Free Radic Biol Med 41:262-9. 2006
  7. pmc Chronically ischemic mouse skeletal muscle exhibits myopathy in association with mitochondrial dysfunction and oxidative damage
    Iraklis I Pipinos
    Department of Surgery, University of Nebraska Medical Center, Omaha, Nebraska 68198 3280, USA
    Am J Physiol Regul Integr Comp Physiol 295:R290-6. 2008
  8. doi request reprint One patent intracranial collateral predicts tolerance of flow reversal during carotid angioplasty and stenting
    Iraklis I Pipinos
    Department of Surgery, University of Nebraska Medical Center, Omaha, NE 68198 3280, USA
    Ann Vasc Surg 23:32-8. 2009
  9. ncbi request reprint Transcervical approach with protective flow reversal for carotid angioplasty and stenting
    Iraklis I Pipinos
    Department of Surgery, University of Nebraska Medical Center, Omaha, Nebraska 68198 3280, USA
    J Endovasc Ther 12:446-53. 2005
  10. ncbi request reprint Abnormal mitochondrial respiration in skeletal muscle in patients with peripheral arterial disease
    Iraklis I Pipinos
    Department of Surgery, University of Nebraska Medical Center, 983280 Nebraska Medical Center, Omaha, NE 68198 3280, USA
    J Vasc Surg 38:827-32. 2003

Research Grants

Collaborators

  • T G Lynch
  • Stephen Dodd
  • BERNARD BAXTER
  • MICHAEL BOSKA
  • George T Pisimisis
  • Corrigan L McBride
  • Jon S Thompson
  • Frank R Arko
  • H N Sabbah
  • C K Zarins
  • Jason M Johanning
  • Sara A Myers
  • Dustin J Weiss
  • Jessie M Huisinga
  • Nicholas Stergiou
  • Nitin Garg
  • G Matthew Longo
  • Zhen Zhu
  • Nick Stergiou
  • Melissa M Scott-Pandorf
  • Julian K S Kim
  • Dimitrios Miserlis
  • Panagiotis Koutakis
  • George P Casale
  • Stanley A Swanson
  • Aikaterini A Nella
  • Prateek K Gupta
  • George Kasotakis
  • Rolando Celis
  • Leon Robinson
  • Christa M Trigilio-Black
  • Konstantinos I Makris
  • Rajdeep S Sandhu
  • Konstantinos A Filis
  • Rodney D McComb
  • Gleb Haynatzki
  • GEORGE CASALE
  • Stanley Swanson
  • Siobain M Horan
  • Kiran K Turaga
  • Weldon J Miller
  • Nikolaos Karagiorgos
  • Davendra P S Sohal
  • Rolando I Celis
  • G Mathew Longo
  • Frank J Rutar
  • William E Thorell
  • Andrew R Judge
  • Victor J Sorensen
  • Chad D Ringley
  • Tanuja L Gutti
  • E John Harris
  • Bonnie L Johnson
  • Cornelius Olcott

Detail Information

Publications30

  1. pmc Human enterovirus in the gastrocnemius of patients with peripheral arterial disease
    Julian K S Kim
    Department of Surgery, College of Medicine, University of Nebraska Medical Center, Omaha, NE
    J Am Heart Assoc 2:e000082. 2013
    ..However, its association with PAD has not been studied. In this study, we tested the hypothesis that infectious HEV is present in skeletal muscle of patients with PAD and is associated with severity of disease...
  2. pmc Oxidative damage and myofiber degeneration in the gastrocnemius of patients with peripheral arterial disease
    Dustin J Weiss
    Department of Surgery, University of Nebraska Medical Center, Omaha, NE 68198 5182, USA
    J Transl Med 11:230. 2013
    ..The data establish oxidative damage to myofibers as a possible cause of PAD myopathy...
  3. pmc The effect of pharmacological treatment on gait biomechanics in peripheral arterial disease patients
    Jessie M Huisinga
    Nebraska Biomechanics Core Facility, University of Nebraska at Omaha, 6001 Dodge Street Omaha, NE, 68182, USA
    J Neuroeng Rehabil 7:25. 2010
    ..However, the effect of pharmacological treatment on gait biomechanics in PAD patients has not been objectively evaluated as is common with other gait abnormalities...
  4. doi request reprint The myopathy of peripheral arterial occlusive disease: part 1. Functional and histomorphological changes and evidence for mitochondrial dysfunction
    Iraklis I Pipinos
    Department of Surgery, University of Nebraska Medical Center, Omaha, NE 68198 3280, USA
    Vasc Endovascular Surg 41:481-9. 2007
    ..Important new findings of a possible neuropathy and a shift in muscle fiber type are also reviewed. Learning more about these mechanisms will enhance our understanding of the degree to which they are preventable and treatable...
  5. doi request reprint The myopathy of peripheral arterial occlusive disease: Part 2. Oxidative stress, neuropathy, and shift in muscle fiber type
    Iraklis I Pipinos
    Department of Surgery, University of Nebraska Medical Center and Nebraska Western Iowa Veterans Affairs Medical Center, Omaha, Nebraska 68193 3280, USA
    Vasc Endovascular Surg 42:101-12. 2008
    ..Important new findings of a possible neuropathy and a shift in muscle fiber type are also reviewed. Learning more about these mechanisms will enhance our understanding of the degree to which they are preventable and treatable...
  6. ncbi request reprint Mitochondrial defects and oxidative damage in patients with peripheral arterial disease
    Iraklis I Pipinos
    Department of Surgery, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Free Radic Biol Med 41:262-9. 2006
    ..Peripheral arterial disease is associated with abnormal mitochondrial function and evidence of significant oxidative stress...
  7. pmc Chronically ischemic mouse skeletal muscle exhibits myopathy in association with mitochondrial dysfunction and oxidative damage
    Iraklis I Pipinos
    Department of Surgery, University of Nebraska Medical Center, Omaha, Nebraska 68198 3280, USA
    Am J Physiol Regul Integr Comp Physiol 295:R290-6. 2008
    ..e., in the absence of other comorbid conditions, causes myopathy with mitochondrial dysfunction and increased oxidative stress, recapitulating the muscle pathology of PAD patients...
  8. doi request reprint One patent intracranial collateral predicts tolerance of flow reversal during carotid angioplasty and stenting
    Iraklis I Pipinos
    Department of Surgery, University of Nebraska Medical Center, Omaha, NE 68198 3280, USA
    Ann Vasc Surg 23:32-8. 2009
    ..Continued progress in noninvasive imaging modalities is becoming increasingly helpful in our understanding of cerebral physiology and selection of patients for invasive carotid procedures...
  9. ncbi request reprint Transcervical approach with protective flow reversal for carotid angioplasty and stenting
    Iraklis I Pipinos
    Department of Surgery, University of Nebraska Medical Center, Omaha, Nebraska 68198 3280, USA
    J Endovasc Ther 12:446-53. 2005
    ..To report our initial experience using a transcervical approach for carotid angioplasty/stenting (CAS) that employs internal carotid artery (ICA) flow reversal for neuroprotection...
  10. ncbi request reprint Abnormal mitochondrial respiration in skeletal muscle in patients with peripheral arterial disease
    Iraklis I Pipinos
    Department of Surgery, University of Nebraska Medical Center, 983280 Nebraska Medical Center, Omaha, NE 68198 3280, USA
    J Vasc Surg 38:827-32. 2003
    ..We examined mitochondrial respiration in the gastrocnemius muscle of nine patients (10 legs) with advanced PAD and in nine control patients (nine legs) without evidence of PAD...
  11. doi request reprint Claudication distances and the Walking Impairment Questionnaire best describe the ambulatory limitations in patients with symptomatic peripheral arterial disease
    Sara A Myers
    Heath, Physical Education, and Recreation HPER Biomechanics Laboratory, University of Nebraska Medical Center, Omaha 68198 3280, USA
    J Vasc Surg 47:550-555. 2008
    ..The current study provides data on the relationship between quantitative and qualitative measures of symptomatic peripheral arterial disease...
  12. ncbi request reprint Mitochondriopathy of peripheral arterial disease
    Konstantinos I Makris
    Department of Surgery, Creighton University Medical Center, Omaha, NE 68198 3280, USA
    Vascular 15:336-43. 2007
    ..In this review, we present the current histomorphologic, physiologic, and biochemical evidence defining the nature of this mitochondriopathy and discuss its contribution to the pathogenesis and clinical manifestations of PAD...
  13. ncbi request reprint Pentoxifylline reverses oxidative mitochondrial defect in claudicating skeletal muscle
    Iraklis I Pipinos
    Department of Surgery, University of Nebraska Medical Center, Omaha, Nebraska 68198 3280, USA
    J Surg Res 102:126-32. 2002
    ..Previous morphologic studies and phosphorus nuclear magnetic resonance spectroscopy (31P MRS) have suggested a primary mitochondrial defect in claudicating skeletal muscle. We hypothesized that pentoxifylline may alleviate this defect...
  14. ncbi request reprint Concomitant arterial and venous reconstruction with resection of lower extremity sarcomas
    B Timothy Baxter
    Department of General and Orthopedic Surgery, The University of Nebraska Medical Center, Omaha, NE, USA
    Ann Vasc Surg 21:272-9. 2007
    ..We present our experience with a consecutive series of patients undergoing resection of lower extremity sarcomas en block with the artery and vein, focusing on the mid- and long-term outcomes of their vascular reconstruction...
  15. ncbi request reprint Transcervical carotid stenting with flow reversal for neuroprotection: technique, results, advantages, and limitations
    Iraklis I Pipinos
    Department of Surgery, University of Nebraska Medical Center, Omaha, NE 68198 3280, USA
    Vascular 14:245-55. 2006
    ..The purpose of this review is to describe our method of transcervical carotid artery stenting, review the accumulating outcomes data, and discuss the clinical advantages of and indications for this increasingly popular technique...
  16. ncbi request reprint Regarding "Can carotid endarterectomy improve metabolic status in patients with asymptomatic internal carotid artery flow lesion? Studies with localized in vivo proton magnetic resonance spectroscopy"
    Thomas G Lynch
    Department of Surgery, University of Nebraska Medical Center, Omaha, 68198 3280, USA
    J Vasc Surg 36:646-8. 2002
  17. doi request reprint Peripheral arterial disease affects kinematics during walking
    Rolando Celis
    University of Nebraska Medical Center, Omaha, Nebraska 68198 3280, USA
    J Vasc Surg 49:127-32. 2009
    ..We hypothesized that compared with control subjects, claudicating patients have altered kinematic gait patterns that can be fully characterized utilizing advanced biomechanical analysis...
  18. doi request reprint Chronic mesenteric ischemia: endovascular versus open revascularization
    Prateek K Gupta
    Department of Surgery, Creighton University, Omaha, Nebraska, USA
    J Endovasc Ther 17:540-9. 2010
    ..To review 20 years of literature on chronic mesenteric ischemia (CMI), examining its complex clinical presentation and comparing open and endovascular treatment options...
  19. doi request reprint Cerebral protection devices reduce periprocedural strokes during carotid angioplasty and stenting: a systematic review of the current literature
    Nitin Garg
    Creighton University Medical Center, Omaha, Nebraska, USA
    J Endovasc Ther 16:412-27. 2009
    ..To compare through a systematic review of published literature the stroke outcomes in protected and unprotected carotid artery stenting (CAS)...
  20. ncbi request reprint Duplex ultrasound criteria for defining the severity of carotid stenosis
    Konstantinos A Filis
    Division of Vascular Surgery, Department of Surgery, Stanford University Hospital, Stanford, CA 94305 5642, USA
    Ann Vasc Surg 16:413-21. 2002
    ..Clinical management of patients with carotid stenosis can be based solely on carotid DUS in 97% of patients considered for treatment of carotid artery disease...
  21. doi request reprint Gait variability is altered in patients with peripheral arterial disease
    Sara A Myers
    Nebraska Biomechanics Core Facility, University of Nebraska Medical Center, Omaha, Neb, USA
    J Vasc Surg 49:924-931.e1. 2009
    ..Increase in the variability of the locomotor system makes the gait more noisy and unstable. The purpose of this study is to investigate gait variability in patients with PAD...
  22. ncbi request reprint Peripheral arterial disease affects ground reaction forces during walking
    Melissa M Scott-Pandorf
    University of Nebraska at Omaha, Omaha, Nebraska, USA
    J Vasc Surg 46:491-9. 2007
    ..We hypothesized that the claudicating legs of PAD patients have an altered kinetic gait pattern compared with normal legs from control subjects...
  23. doi request reprint Gait variability patterns are altered in healthy young individuals during the acute reperfusion phase of ischemia-reperfusion
    Sara A Myers
    Nebraska Biomechanics Core Facility, University of Nebraska at Omaha, Omaha, Nebraska 68198 3280, USA
    J Surg Res 164:6-12. 2010
    ..Therefore, the purpose of this study is to isolate and determine the specific effect of the acute reperfusion phase of ischemia-reperfusion on gait variability in young individuals with no vascular disease...
  24. ncbi request reprint Treatment with pharmacological agents in peripheral arterial disease patients does not result in biomechanical gait changes
    Jessie M Huisinga
    Nebraska Biomechanics Core Facility, Department of Health, Physical Education, and Recreation, University of Nebraska at Omaha, Omaha, NE, USA
    J Appl Biomech 26:341-8. 2010
    ..Walking speed was unchanged, in either treatment group, as a result of the medication. These results suggest that to improve biomechanical walking parameters of PAD patients, clinicians cannot rely on drug therapies alone...
  25. ncbi request reprint Inferior vena cava filter placement for pulmonary embolism risk reduction in super morbidly obese undergoing bariatric surgery
    Christa M Trigilio-Black
    Department of Surgery, University of Nebraska Medical Center, Omaha, Nebraska 68198 3280, USA
    Surg Obes Relat Dis 3:461-4. 2007
    ..Pulmonary embolism (PE) is a leading cause of mortality after bariatric surgery. We evaluated inferior vena cava (IVC) filter use for PE risk reduction in high-risk super morbidly obese bariatric surgery patients...
  26. doi request reprint Direct and indirect measurement of patient radiation exposure during endovascular aortic aneurysm repair
    Dustin J Weiss
    University of Nebraska Medical Center, Nebraska Western Iowa Veterans Administration Hospital, Omaha, NE 68198 3280, USA
    Ann Vasc Surg 22:723-9. 2008
    ..Despite the complexity and duration of endovascular AAA repair, the procedure can be performed safely without excessive radiation exposure...
  27. doi request reprint Current evidence and clinical implications of aspirin resistance
    George Kasotakis
    Department Surgery, Creighton University Medical Center, Omaha, Neb, USA
    J Vasc Surg 50:1500-10. 2009
    ..Suggestions are advanced for the direction of future trials evaluating aspirin resistance in patients with vascular disease...
  28. ncbi request reprint Isolated iliac artery aneurysms
    Rajdeep S Sandhu
    Department of Surgery, University of Nebraska Medical Center, Omaha, 68198, USA
    Semin Vasc Surg 18:209-15. 2005
    ..Results of open and endovascular strategies are summarized and follow-up recommendations are proposed...
  29. ncbi request reprint Giant-cell temporal arteritis in a 17-year-old male
    Iraklis I Pipinos
    Department of Surgery, University of Nebraska Medical Center, Omaha, USA
    J Vasc Surg 43:1053-5. 2006
    ..Postoperatively, the patient was treated with prednisone for 3 months. Three years after surgery, the patient remains well and reports no recurrence of temporal artery disease...
  30. ncbi request reprint Detachable coils for repair of extraparenchymal renal artery aneurysms: an alternative to surgical therapy
    Nitin Garg
    Department of Surgery, University of Nebraska Medical Center, Omaha, NE 68193 3280, USA
    Ann Vasc Surg 21:97-110. 2007

Research Grants3

  1. Mitochondriopathy of Chronically Ischemic Muscle
    Iraklis Pipinos; Fiscal Year: 2007
    ..Aim 3: Correlate mitochondrial dysfunction with muscle contractile properties. Aim 4: Correlate mitochondrial dysfunction with oxidative damage in the ischemic skeletal muscle. ..
  2. Mitochondrial dysfunction, oxidative damage and inflammation in claudication
    IRAKLIS ILIAS PIPINOS; Fiscal Year: 2010
    ....