D Piomelli

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint The endogenous cannabinoid system and the treatment of marijuana dependence
    Daniele Piomelli
    Department of Pharmacology, University of California, Irvine, Irvine, CA 92697 4625, USA
    Neuropharmacology 47:359-67. 2004
  2. doi request reprint The element of surprise
    Daniele Piomelli
    Department of Pharmacology, MedSurge II, University of California, Irvine, California 92697 4625, USA
    Nat Med 14:720-1. 2008
  3. pmc Deficient liver biosynthesis of docosahexaenoic acid correlates with cognitive impairment in Alzheimer's disease
    Giuseppe Astarita
    Department of Pharmacology, University of California Irvine, Irvine, California, United States of America
    PLoS ONE 5:e12538. 2010
  4. pmc Elevated stearoyl-CoA desaturase in brains of patients with Alzheimer's disease
    Giuseppe Astarita
    Department of Pharmacology, University of California Irvine, Irvine, California, United States of America
    PLoS ONE 6:e24777. 2011
  5. pmc More surprises lying ahead. The endocannabinoids keep us guessing
    Daniele Piomelli
    Department of Anatomy and Neurobiology, University of California, Irvine, CA 92697 1275, USA Department of Pharmacology, University of California, Irvine, CA 92697 1275, USA Department of Drug Discovery and Development, Istituto Italiano di Tecnologia, Genoa 16163, Italy Department of Biological Chemistry, University of California, Irvine, CA 92697 1275, USA Electronic address
    Neuropharmacology 76:228-34. 2014
  6. pmc A fatty gut feeling
    Daniele Piomelli
    Department of Anatomy and Neurobiology, University of California, Irvine, CA 92612, USA
    Trends Endocrinol Metab 24:332-41. 2013
  7. pmc Endocannabinoid signaling in the gut mediates preference for dietary unsaturated fats
    Nicholas V DiPatrizio
    Department of Anatomy and Neurobiology, University of California Irvine School of Medicine, Irvine, CA 92697 1275, USA
    FASEB J 27:2513-20. 2013
  8. ncbi request reprint The endocannabinoid system: a drug discovery perspective
    Daniele Piomelli
    Department of Pharmacology, University of California, Irvine, CA 92697 4625, USA
    Curr Opin Investig Drugs 6:672-9. 2005
  9. pmc The fat-induced satiety factor oleoylethanolamide suppresses feeding through central release of oxytocin
    Silvana Gaetani
    Department of Physiology and Pharmacology V Erspamer, Sapienza University of Rome, 00185 Rome, Italy
    J Neurosci 30:8096-101. 2010
  10. ncbi request reprint The molecular logic of endocannabinoid signalling
    Daniele Piomelli
    Department of Pharmacology, University of California, Irvine 92697 4625, USA
    Nat Rev Neurosci 4:873-84. 2003

Research Grants

Detail Information

Publications110 found, 100 shown here

  1. ncbi request reprint The endogenous cannabinoid system and the treatment of marijuana dependence
    Daniele Piomelli
    Department of Pharmacology, University of California, Irvine, Irvine, CA 92697 4625, USA
    Neuropharmacology 47:359-67. 2004
    ....
  2. doi request reprint The element of surprise
    Daniele Piomelli
    Department of Pharmacology, MedSurge II, University of California, Irvine, California 92697 4625, USA
    Nat Med 14:720-1. 2008
  3. pmc Deficient liver biosynthesis of docosahexaenoic acid correlates with cognitive impairment in Alzheimer's disease
    Giuseppe Astarita
    Department of Pharmacology, University of California Irvine, Irvine, California, United States of America
    PLoS ONE 5:e12538. 2010
    ..The results indicate that a deficit in d-bifunctional protein activity impairs docosahexaenoic acid biosynthesis in liver of Alzheimer's disease patients, lessening the flux of this neuroprotective fatty acid to the brain...
  4. pmc Elevated stearoyl-CoA desaturase in brains of patients with Alzheimer's disease
    Giuseppe Astarita
    Department of Pharmacology, University of California Irvine, Irvine, California, United States of America
    PLoS ONE 6:e24777. 2011
    ..80; P = 0.0001) and the Boston Naming test (r = -0.57; P = 0.0071). Our results reveal a previously unrecognized role for the lipogenic enzyme SCD in AD...
  5. pmc More surprises lying ahead. The endocannabinoids keep us guessing
    Daniele Piomelli
    Department of Anatomy and Neurobiology, University of California, Irvine, CA 92697 1275, USA Department of Pharmacology, University of California, Irvine, CA 92697 1275, USA Department of Drug Discovery and Development, Istituto Italiano di Tecnologia, Genoa 16163, Italy Department of Biological Chemistry, University of California, Irvine, CA 92697 1275, USA Electronic address
    Neuropharmacology 76:228-34. 2014
    ..This article is part of a Special Issue entitled 'NIDA 40th Anniversary Issue'...
  6. pmc A fatty gut feeling
    Daniele Piomelli
    Department of Anatomy and Neurobiology, University of California, Irvine, CA 92612, USA
    Trends Endocrinol Metab 24:332-41. 2013
    ..OEA signaling may be a key component of the physiological system devoted to the monitoring of dietary fat intake, and its dysfunction might contribute to overweight and obesity. ..
  7. pmc Endocannabinoid signaling in the gut mediates preference for dietary unsaturated fats
    Nicholas V DiPatrizio
    Department of Anatomy and Neurobiology, University of California Irvine School of Medicine, Irvine, CA 92697 1275, USA
    FASEB J 27:2513-20. 2013
    ..Our results suggest that oral exposure to the monoenoic and dienoic fatty acid component of dietary fat selectively initiates endocannabinoid mobilization in the gut, and that this local signaling event is essential for fat preference...
  8. ncbi request reprint The endocannabinoid system: a drug discovery perspective
    Daniele Piomelli
    Department of Pharmacology, University of California, Irvine, CA 92697 4625, USA
    Curr Opin Investig Drugs 6:672-9. 2005
    ....
  9. pmc The fat-induced satiety factor oleoylethanolamide suppresses feeding through central release of oxytocin
    Silvana Gaetani
    Department of Physiology and Pharmacology V Erspamer, Sapienza University of Rome, 00185 Rome, Italy
    J Neurosci 30:8096-101. 2010
    ..The results suggest that OEA suppresses feeding by activating central oxytocin transmission...
  10. ncbi request reprint The molecular logic of endocannabinoid signalling
    Daniele Piomelli
    Department of Pharmacology, University of California, Irvine 92697 4625, USA
    Nat Rev Neurosci 4:873-84. 2003
  11. ncbi request reprint Stimulation of endocannabinoid formation in brain slice cultures through activation of group I metabotropic glutamate receptors
    Kwang Mook Jung
    Department of Pharmacology, 3101 Gillespie NRF, University of California, Irvine, CA 92697 4625
    Mol Pharmacol 68:1196-202. 2005
    ..The results suggest that 2-AG is a primary endocannabinoid mediator of mGlu receptor-dependent neuronal plasticity...
  12. ncbi request reprint The challenge of brain lipidomics
    Daniele Piomelli
    Department of Pharmacology, Center for the Neurobiology of Learning and Memory, University of California, Irvine, CA 92697 4625, USA
    Prostaglandins Other Lipid Mediat 77:23-34. 2005
    ..In this review, I outline several key features of brain lipid signaling and discuss the opportunities and challenges that such features impose on future lipidomic approaches...
  13. ncbi request reprint A neuroscientist's guide to lipidomics
    Daniele Piomelli
    Department of Pharmacology, University of California, Irvine, California 92697, USA
    Nat Rev Neurosci 8:743-54. 2007
    ..The objective of neural lipidomics is to understand how these molecules work together; this difficult task will greatly benefit from technical advances that might enable the testing of emerging hypotheses...
  14. ncbi request reprint Pharmacological profile of the selective FAAH inhibitor KDS-4103 (URB597)
    Daniele Piomelli
    Kadmus Pharmaceuticals, Inc Irvine, California 92697 4625, USA
    CNS Drug Rev 12:21-38. 2006
    ..The results suggest that KDS-4103 will offer a novel approach with a favorable therapeutic window for the treatment of anxiety, depression and pain...
  15. ncbi request reprint The ligand that came from within
    D Piomelli
    Department of Pharmacology, 360 MSRII, University of California, Irvine, CA 92697 4625, USA
    Trends Pharmacol Sci 22:17-9. 2001
    ..Are these lipid-like second messengers the long-sought endogenous vanilloids?..
  16. ncbi request reprint The endocannabinoid system as a target for therapeutic drugs
    D Piomelli
    University of California, Irvine, 92697 4625, USA
    Trends Pharmacol Sci 21:218-24. 2000
    ..Recent advances in the biochemistry and pharmacology of the endocannabinoid system in relation to the opportunities that this system offers for the development of novel therapeutic agents will be discussed...
  17. pmc Structural determinants for recognition and translocation by the anandamide transporter
    D Piomelli
    The Neurosciences Institute, San Diego, CA 92121, USA
    Proc Natl Acad Sci U S A 96:5802-7. 1999
    ..These results outline the general structural requisites for anandamide transport and may assist in the development of selective inhibitors with potential clinical applications...
  18. ncbi request reprint Mechanisms of endocannabinoid inactivation: biochemistry and pharmacology
    A Giuffrida
    Department of Pharmacology, University of California, Irvine, California 92697 4625, USA
    J Pharmacol Exp Ther 298:7-14. 2001
    ..A more thorough characterization of the roles of endocannabinoids in health and disease will be necessary to define the significance of endocannabinoid inactivation mechanisms as targets for therapeutic drugs...
  19. pmc Anandamide suppresses pain initiation through a peripheral endocannabinoid mechanism
    Jason R Clapper
    Department of Pharmacology, University of California Irvine, Irvine, California, USA
    Nat Neurosci 13:1265-70. 2010
    ..Brain-impenetrant FAAH inhibitors, which strengthen this gating mechanism, might offer a new approach to pain therapy...
  20. pmc Anandamide transport is independent of fatty-acid amide hydrolase activity and is blocked by the hydrolysis-resistant inhibitor AM1172
    D Fegley
    Department of Pharmacology and Center for the Neurobiology of Learning and Memory, University of California, Irvine, CA 92697 4625, USA
    Proc Natl Acad Sci U S A 101:8756-61. 2004
    ..AM1172 may serve as a prototype for novel anandamide transport inhibitors with increased metabolic stability...
  21. ncbi request reprint Receptor-dependent formation of endogenous cannabinoids in cortical neurons
    N Stella
    Department of Pharmacology, 360 Med Surge II, University of California, Irvine 92697-4625, USA
    Eur J Pharmacol 425:189-96. 2001
    ....
  22. pmc Pharmacological characterization of the peripheral FAAH inhibitor URB937 in female rodents: interaction with the Abcg2 transporter in the blood-placenta barrier
    G Moreno-Sanz
    Departments of Pharmacology and Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA
    Br J Pharmacol 167:1620-8. 2012
    ..In the present study, we investigated the tissue distribution and antinociceptive properties of URB937 in female mice and rats...
  23. ncbi request reprint Characterization of the fatty acid amide hydrolase inhibitor cyclohexyl carbamic acid 3'-carbamoyl-biphenyl-3-yl ester (URB597): effects on anandamide and oleoylethanolamide deactivation
    Darren Fegley
    Department of Pharmacology, University of California, Irvine CA 92697 4625, USA
    J Pharmacol Exp Ther 313:352-8. 2005
    ..The results also suggest that an enzyme distinct from FAAH catalyzes OEA hydrolysis in the duodenum, where this lipid substance acts as a local satiety factor...
  24. ncbi request reprint Modulation of anxiety through blockade of anandamide hydrolysis
    Satish Kathuria
    Department of Pharmacology, University of California, Irvine, California, USA
    Nat Med 9:76-81. 2003
    ..Our results indicate that anandamide participates in the modulation of emotional states and point to fatty acid amide hydrolase inhibition as an innovative approach to anti-anxiety therapy...
  25. ncbi request reprint Antidepressant-like activity of the fatty acid amide hydrolase inhibitor URB597 in a rat model of chronic mild stress
    Marco Bortolato
    Department of Pharmacology, University of California, Irvine, California 92697 4260, USA
    Biol Psychiatry 62:1103-10. 2007
    ....
  26. ncbi request reprint Oleoylethanolamide stimulates lipolysis by activating the nuclear receptor peroxisome proliferator-activated receptor alpha (PPAR-alpha)
    Manuel Guzman
    Department of Pharmacology, University of California, Irvine, CA 92697 4260, USA
    J Biol Chem 279:27849-54. 2004
    ..The results suggest that OEA stimulates fat utilization through activation of PPAR-alpha and that this effect may contribute to its anti-obesity actions...
  27. ncbi request reprint The fatty-acid amide hydrolase inhibitor URB597 does not affect triacylglycerol hydrolysis in rat tissues
    Jason R Clapper
    Center for Drug Discovery, University of California, Irvine, CA 92697, USA
    Pharmacol Res 54:341-4. 2006
    ..The results indicate that URB597, while potent at inhibiting FAAH, does not affect TGH and TGL activities in rat tissues...
  28. ncbi request reprint Long-term plasticity of endocannabinoid signaling induced by developmental febrile seizures
    Kang Chen
    Department of Anatomy and Neurobiology, University of California, Irvine, Irvine, CA 92697, USA
    Neuron 39:599-611. 2003
    ..These results demonstrate a selective, long-term increase in the gain of endocannabinoid-mediated retrograde signaling at GABAergic synapses in a model of a human neurological disease...
  29. ncbi request reprint Regulation of food intake by oleoylethanolamide
    J Lo Verme
    Department of Pharmacology, University of California, Irvine, California, 92697 4260, USA
    Cell Mol Life Sci 62:708-16. 2005
    ..Finally, we discuss the possible role of OEA as a peripheral satiety hormone...
  30. ncbi request reprint Elevated circulating levels of anandamide after administration of the transport inhibitor, AM404
    A Giuffrida
    Department of Pharmacology, University of California, 360 Med Surge II, Irvine, CA 92697 4625, USA
    Eur J Pharmacol 408:161-8. 2000
    ..hydrochloride (SR141716A, 0.5 mg kg(-1), i.p). These results are consistent with the hypothesis that AM404 inhibits anandamide inactivation in vivo...
  31. pmc A critical cysteine residue in monoacylglycerol lipase is targeted by a new class of isothiazolinone-based enzyme inhibitors
    A R King
    Department of Pharmacology, University of California Irvine, Irvine, CA 92697 4625, USA
    Br J Pharmacol 157:974-83. 2009
    ..In the present study, we characterize the role of cysteines in MGL function and identify a series of cysteine-reactive agents that inhibit MGL activity with nanomolar potencies by interacting with cysteine residue 208...
  32. pmc Brain monoglyceride lipase participating in endocannabinoid inactivation
    T P Dinh
    Department of Pharmacology, University of California, Irvine, CA 92697 4625, USA
    Proc Natl Acad Sci U S A 99:10819-24. 2002
    ..No such effect was observed on the accumulation of anandamide, another endocannabinoid lipid. The results suggest that hydrolysis by means of MGL is a primary mechanism for 2-AG inactivation in intact neurons...
  33. ncbi request reprint Anxiolytic-like properties of the anandamide transport inhibitor AM404
    Marco Bortolato
    Department of Psychiatry and Human Behavior, Center for Drug Discovery, University of California, Irvine, CA 92697 4625, USA
    Neuropsychopharmacology 31:2652-9. 2006
    ..These results support a role of anandamide in the regulation of emotion and point to the anandamide transport system as a potential target for anxiolytic drugs...
  34. doi request reprint The endocannabinoid system as a target for novel anxiolytic and antidepressant drugs
    Silvana Gaetani
    Department of Physiology and Pharmacology, Sapienza University of Rome, P le Aldo Moro 5, 00185 Rome, Italy
    Int Rev Neurobiol 85:57-72. 2009
    ....
  35. pmc Selective N-acylethanolamine-hydrolyzing acid amidase inhibition reveals a key role for endogenous palmitoylethanolamide in inflammation
    Carlos Solorzano
    Department of Pharmacology, University of California, Irvine, CA 92697 4624, USA
    Proc Natl Acad Sci U S A 106:20966-71. 2009
    ..The PEA-hydrolyzing amidase NAAA may provide a previously undescribed target for antiinflammatory medicines...
  36. ncbi request reprint Modulation of neuropathic and inflammatory pain by the endocannabinoid transport inhibitor AM404 [N-(4-hydroxyphenyl)-eicosa-5,8,11,14-tetraenamide]
    G La Rana
    Department of Experimental Pharmacology, 3101 Gillespie NRF, University of California, Irvine, CA 92697 4625, USA
    J Pharmacol Exp Ther 317:1365-71. 2006
    ..The results provide new evidence for a role of the endocannabinoid system in pain modulation and point to anandamide transport as a potential target for analgesic drug development...
  37. ncbi request reprint Endogenous cannabinoid signaling and psychomotor disorders
    A Giuffrida
    Department of Pharmacology, University of California, 360 Med Surge II, Irvine, CA, USA
    Prostaglandins Other Lipid Mediat 61:63-70. 2000
    ..This mini-review discusses the participation of the endogenous cannabinoid system in the regulation of motor behaviors, pointing out its possible involvement in the pathophysiology of psychomotor disorders...
  38. pmc Cannabinoid CB1 receptors and ligands in vertebrate retina: localization and function of an endogenous signaling system
    A Straiker
    Department of Neurosciences, University of California School of Medicine, San Diego, CA 92093, USA
    Proc Natl Acad Sci U S A 96:14565-70. 1999
    ....
  39. pmc Discovery of potent and reversible monoacylglycerol lipase inhibitors
    Alvin R King
    Department of Pharmacology, University of California Irvine, Irvine, CA 92697, USA
    Chem Biol 16:1045-52. 2009
    ..This previously unrecognized regulatory region might offer a molecular target for potent and reversible inhibitors of MGL...
  40. pmc Fat-induced satiety factor oleoylethanolamide enhances memory consolidation
    Patrizia Campolongo
    Department of Pharmacology, University of California, Irvine, CA 92697 4625, USA
    Proc Natl Acad Sci U S A 106:8027-31. 2009
    ..The results indicate that OEA, acting as a PPAR-alpha agonist, facilitates memory consolidation through noradrenergic activation of the BLA, a mechanism that is also critically involved in memory enhancement induced by emotional arousal...
  41. pmc Synthesis and characterization of a peripherally restricted CB1 cannabinoid antagonist, URB447, that reduces feeding and body-weight gain in mice
    Jesse LoVerme
    Department of Pharmacology, 360 MedScience II, University of California, Irvine, CA 92697 4625, USA
    Bioorg Med Chem Lett 19:639-43. 2009
    ..URB447 may provide a useful pharmacological tool for investigating the cannabinoid system, and might serve as a starting point for developing clinically viable CB(1) antagonists devoid of central side effects...
  42. ncbi request reprint A key role for diacylglycerol lipase-alpha in metabotropic glutamate receptor-dependent endocannabinoid mobilization
    Kwang Mook Jung
    Department of Pharmacology, University of California, Irvine, CA 92697 4625, USA
    Mol Pharmacol 72:612-21. 2007
    ..The findings indicate that DGL-alpha mediates group I mGlu receptor-induced 2-AG mobilization. They further suggest that the interaction of CC-Homer with DGL-alpha is necessary for appropriate function of this lipase...
  43. pmc CD36 gene deletion decreases oleoylethanolamide levels in small intestine of free-feeding mice
    Ana Guijarro
    Department of Pharmacology, University of California, Irvine, CA 92697 4625, USA
    Pharmacol Res 61:27-33. 2010
    ..The results underscore the important role of CD36 in jejunal OEA production linked to feeding...
  44. ncbi request reprint Pharmacological characterization of hydrolysis-resistant analogs of oleoylethanolamide with potent anorexiant properties
    Giuseppe Astarita
    Department of Pharmacology, 360 MSRII, University of California, Irvine, CA 92697 4625, USA
    J Pharmacol Exp Ther 318:563-70. 2006
    ..These results suggest that the endogenous high-affinity PPAR-alpha agonist OEA may provide a scaffold for the discovery of novel orally active PPAR-alpha ligands...
  45. ncbi request reprint A role for endocannabinoids in viral-induced dyskinetic and convulsive phenomena
    Marylou V Solbrig
    Department of Neurology, 3226 Gillespie Neuroscience Research Bldg, University of California Irvine, Irvine, CA 92697 4292, USA
    Exp Neurol 194:355-62. 2005
    ....
  46. ncbi request reprint Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-alpha
    Jin Fu
    Department of Pharmacology, University of California, Irvine, California 92697 4625, USA
    Nature 425:90-3. 2003
    ..Our results, which show that OEA induces satiety by activating PPAR-alpha, identify an unexpected role for this nuclear receptor in regulating behaviour, and raise possibilities for the treatment of eating disorders...
  47. ncbi request reprint Oleoylethanolamide, an endogenous PPAR-alpha agonist, lowers body weight and hyperlipidemia in obese rats
    Jin Fu
    Department of Psychiatry, University of California, Irvine, CA 92697 4625, USA
    Neuropharmacology 48:1147-53. 2005
    ..The results suggest that OEA regulates lipid metabolism and that this effect may contribute to its anti-obesity properties...
  48. ncbi request reprint A role for monoglyceride lipase in 2-arachidonoylglycerol inactivation
    Thien P Dinh
    Department of Pharmacology, University of California, 360 Med Surge II, Irvine, CA 92697 4625, USA
    Chem Phys Lipids 121:149-58. 2002
    ..These results indicate that hydrolysis via MGL may be a primary route of 2-AG inactivation in intact neuronal cells...
  49. pmc Effects of diet and behavioral enrichment on free fatty acids in the aged canine brain
    S Snigdha
    Institute for Memory Impairments and Neurological Disorders, University of California Irvine, Irvine, CA, USA
    Neuroscience 202:326-33. 2012
    ..Together with data showing increased palmitoleic acid levels in AD patients, our data suggest that reducing palmitoleic acid levels and desaturation index in the brain may be associated with improved cognitive performance...
  50. ncbi request reprint The endocannabinoid system: a physiological perspective on its role in psychomotor control
    A Giuffrida
    Department of Pharmacology, University of California, 360 Med Surge II, Irvine, CA 92697 4625, USA
    Chem Phys Lipids 108:151-8. 2000
    ..The role of the endocannabinoids as modulators of psychomotor behaviors and the potential therapeutic perspectives deriving from the pharmacological manipulation of the endogenous cannabinoid system are also discussed...
  51. ncbi request reprint Rapid broad-spectrum analgesia through activation of peroxisome proliferator-activated receptor-alpha
    Jesse LoVerme
    Department of Pharmacology, Center for Drug Discovery, University of California, Irvine, CA 92697 4625, USA
    J Pharmacol Exp Ther 319:1051-61. 2006
    ..Our results suggest that PPAR-alpha agonists may represent a novel class of analgesics...
  52. pmc URB602 inhibits monoacylglycerol lipase and selectively blocks 2-arachidonoylglycerol degradation in intact brain slices
    Alvin R King
    Department of Pharmacology, University of California, Irvine, Irvine, CA 92697, USA
    Chem Biol 14:1357-65. 2007
    ..Thus, URB602 may provide a useful tool by which to investigate the physiological roles of 2-AG and explore the potential interest of MGL as a therapeutic target...
  53. ncbi request reprint Oleoylethanolamide inhibits food intake in free-feeding rats after oral administration
    Fariba Oveisi
    Department of Pharmacology, University of California, Irvine, CA 92697 4625, USA
    Pharmacol Res 49:461-6. 2004
    ..This effect is accompanied by a marked elevation in OEA levels in the small intestine, but not in brain or muscle...
  54. ncbi request reprint Anandamide hydrolysis: a new target for anti-anxiety drugs?
    Silvana Gaetani
    Department of Psychiatry, University of California, Irvine, CA 92697 4625, USA
    Trends Mol Med 9:474-8. 2003
    ..These findings suggest that anandamide contributes to the regulation of emotion and anxiety, and that FAAH might be the target for a novel class of anxiolytic drugs...
  55. doi request reprint Targeted lipidomics as a tool to investigate endocannabinoid function
    Giuseppe Astarita
    Department of Pharmacology, University of California, Irvine, California 92967, USA
    Int Rev Neurobiol 85:35-55. 2009
    ..Targeted lipidomics provides new opportunities for understanding endocannabinoid metabolism...
  56. pmc A second generation of carbamate-based fatty acid amide hydrolase inhibitors with improved activity in vivo
    Jason R Clapper
    Departments of Pharmacology and Biological Chemistry, 360 MSRII, University of California, Irvine, Irvine, CA 92697, USA
    ChemMedChem 4:1505-13. 2009
    ..The results suggest that an approach balancing inhibitor reactivity with target recognition produces FAAH inhibitors that display significantly improved drug-likeness...
  57. pmc Food intake regulates oleoylethanolamide formation and degradation in the proximal small intestine
    Jin Fu
    Department of Pharmacology and Center for Drug Discovery, University of California, Irvine, California 92697, USA
    J Biol Chem 282:1518-28. 2007
    ..Collectively, these results indicate that nutrient availability controls OEA mobilization in the mucosa of the proximal intestine through a concerted regulation of OEA biosynthesis and degradation...
  58. ncbi request reprint The nuclear receptor peroxisome proliferator-activated receptor-alpha mediates the anti-inflammatory actions of palmitoylethanolamide
    Jesse Lo Verme
    Department of Pharmacology, 360 MSRII, University of California, Irvine, CA 92697 4625, USA
    Mol Pharmacol 67:15-9. 2005
    ..These findings indicate that PPAR-alpha mediates the anti-inflammatory effects of PEA and suggest that this fatty-acid ethanolamide may serve, like its analog OEA, as an endogenous ligand of PPAR-alpha...
  59. ncbi request reprint RNA interference suggests a primary role for monoacylglycerol lipase in the degradation of the endocannabinoid 2-arachidonoylglycerol
    Thien P Dinh
    Department of Pharmacology, University of California, Irvine, 360 Med Surge II, Irvine, CA 92697, USA
    Mol Pharmacol 66:1260-4. 2004
    ....
  60. ncbi request reprint The search for the palmitoylethanolamide receptor
    Jesse LoVerme
    Center for Drug Discovery, University of California, Irvine, CA 92697 4260, USA
    Life Sci 77:1685-98. 2005
    ..Here we outline the history of PEA, starting with its initial discovery in the 1950s, and discuss the pharmacological properties of this compound, particularly in regards to its ability to activate PPAR-alpha...
  61. ncbi request reprint Modulation of meal pattern in the rat by the anorexic lipid mediator oleoylethanolamide
    Silvana Gaetani
    Department of Pharmacology, University of California, Irvine, CA 92697 4625, USA
    Neuropsychopharmacology 28:1311-6. 2003
    ..These results suggest that OEA may participate in the regulation of satiety and may provide a chemical scaffold for the design of novel appetite-suppressing medications...
  62. ncbi request reprint Identification of biosynthetic precursors for the endocannabinoid anandamide in the rat brain
    Giuseppe Astarita
    Department of Pharmacology and Center for Drug Discovery, University of California, Irvine, CA 92967, USA
    J Lipid Res 49:48-57. 2008
    ..These results reveal a previously unrecognized preference of brain N-acyl transferase activity for polyunsaturated NArPE and provide new insights on the physiological regulation of anandamide biosynthesis...
  63. pmc The endocannabinoid system as a target for the treatment of cannabis dependence
    Jason R Clapper
    Department of Pharmacology, University of California, Irvine 3101 Gillespie NRF, Irvine, CA 92697, USA
    Neuropharmacology 56:235-43. 2009
    ..In this article, we review evidence suggesting that (i) cannabis influences brain endocannabinoid signaling and (ii) FAAH inhibitors such as URB597 might offer a possible therapeutic avenue for the treatment of cannabis withdrawal...
  64. pmc Targeted enhancement of oleoylethanolamide production in proximal small intestine induces across-meal satiety in rats
    Jin Fu
    Department of Pharmacology and Center for Drug Discovery, University of California, Irvine, California, USA
    Am J Physiol Regul Integr Comp Physiol 295:R45-50. 2008
    ....
  65. ncbi request reprint Oleylethanolamide activates Ras-Erk pathway and improves myocardial function in doxorubicin-induced heart failure
    Hou Fen Su
    Department of Medicine, University of California, Irvine, 92697, USA
    Endocrinology 147:827-34. 2006
    ..These findings suggest OEA is a novel cardioprotective compound that may be used to develop new strategies for the management of cardiomyopathy...
  66. ncbi request reprint Cold exposure stimulates synthesis of the bioactive lipid oleoylethanolamide in rat adipose tissue
    Jesse LoVerme
    Center for Drug Discovery, and Department of Pharmacology, University of California, Irvine, California 92697, USA
    J Biol Chem 281:22815-8. 2006
    ..Collectively, these results identify cold exposure as a natural stimulus for OEA formation in white fat and suggest a role for the sympathetic nervous system in regulating OEA biosynthesis...
  67. ncbi request reprint Cerebrospinal anandamide levels are elevated in acute schizophrenia and are inversely correlated with psychotic symptoms
    Andrea Giuffrida
    Department of Pharmacology, University of California, Irvine, CA, USA
    Neuropsychopharmacology 29:2108-14. 2004
    ..452, P = 0.001). The results suggest that anandamide elevation in acute paranoid schizophrenia may reflect a compensatory adaptation to the disease state...
  68. pmc Lipidomic analysis of endocannabinoid metabolism in biological samples
    Giuseppe Astarita
    Department of Pharmacology, University of California, Irvine, CA 92967 4625, United States
    J Chromatogr B Analyt Technol Biomed Life Sci 877:2755-67. 2009
    ..Here, we review these new developments from the perspective of our laboratory's experience in the field...
  69. pmc Enhancement of endocannabinoid signaling and the pharmacotherapy of depression
    Regina A Mangieri
    Department of Pharmacology and Center for Drug Discovery, The University of California, Irvine, CA 92697, USA
    Pharmacol Res 56:360-6. 2007
    ..This article will review these areas of research, highlighting the potential of endocannabinoid metabolism modulators as therapeutics for the treatment of depression...
  70. pmc An endocannabinoid signal associated with desire for alcohol is suppressed in recently abstinent alcoholics
    Regina A Mangieri
    Department of Pharmacology, University of California, Irvine, 3101 Gillespie NRF, Irvine, CA 92697, USA
    Psychopharmacology (Berl) 205:63-72. 2009
    ..Alcoholics report persistent alcohol craving that is heightened by cognitive cues, stressful situations, and abstinence. The role of endogenous cannabinoids in human alcohol craving--though long suspected--remains elusive...
  71. pmc Diacylglycerol lipase-alpha and -beta control neurite outgrowth in neuro-2a cells through distinct molecular mechanisms
    Kwang Mook Jung
    Department of Pharmacology, University of California, Irvine, California 92697 4625, USA
    Mol Pharmacol 80:60-7. 2011
    ..The findings further suggest that DGL-α and -β may regulate neurite outgrowth by engaging temporally and spatially distinct molecular pathways...
  72. pmc Proinflammatory stimuli control N-acylphosphatidylethanolamine-specific phospholipase D expression in macrophages
    Chenggang Zhu
    Department of Biological Chemistry, University of California, Irvine, California, USA
    Mol Pharmacol 79:786-92. 2011
    ..Our findings suggest that proinflammatory stimuli suppress NAPE-PLD expression and PEA biosynthesis in macrophages and that this effect might contribute to the inflammatory response...
  73. ncbi request reprint Postprandial increase of oleoylethanolamide mobilization in small intestine of the Burmese python (Python molurus)
    Giuseppe Astarita
    Dept of Psychiatry and Human Behavior, Univ of California, Irvine, CA, USA
    Am J Physiol Regul Integr Comp Physiol 290:R1407-12. 2006
    ....
  74. pmc Synthesis and structure-activity relationships of N-(2-oxo-3-oxetanyl)amides as N-acylethanolamine-hydrolyzing acid amidase inhibitors
    Carlos Solorzano
    Department of Pharmacology, University of California, Irvine, 360 MSRII, Irvine, California 92697 4625, USA
    J Med Chem 53:5770-81. 2010
    ....
  75. pmc Actions of the FAAH inhibitor URB597 in neuropathic and inflammatory chronic pain models
    Angelo Jayamanne
    Pain Management Research Institute, Northern Clinical School, The University of Sydney, NSW, Australia
    Br J Pharmacol 147:281-8. 2006
    ..These findings suggest that the FAAH inhibitor URB597 produces cannabinoid CB1 and CB2 receptor-mediated analgesia in inflammatory pain states, without causing the undesirable side effects associated with cannabinoid receptor activation...
  76. ncbi request reprint Tandem mass spectrometric data-FAAH inhibitory activity relationships of some carbamic acid O-aryl esters
    Elisa Basso
    CNR, Istituto di Scienze e Tecnologie Molecolari, Corso Stati Uniti 4, 35127 Padova, Italy
    J Mass Spectrom 39:1450-5. 2004
    ..797) with their FAAH-inhibitory activity. This indicates that the energetics of the C(O)--O bond cleavage may be relevant in explaining FAAH inhibition...
  77. ncbi request reprint Effects of levodopa on endocannabinoid levels in rat basal ganglia: implications for the treatment of levodopa-induced dyskinesias
    Belen Ferrer
    Fundacion Hospital Carlos Haya, 29010 Malaga, Spain
    Eur J Neurosci 18:1607-14. 2003
    ..These results indicate that a deficiency in endocannabinoid transmission may contribute to levodopa-induced dyskinesias and that these complications may be alleviated by activation of CB1 receptors...
  78. ncbi request reprint Endocannabinoids at the spinal level regulate, but do not mediate, nonopioid stress-induced analgesia
    Richard L Suplita
    Neuroscience and Behavior Program, Department of Psychology, University of Georgia, Baldwin Street, Athens, GA 30602 3013, USA
    Neuropharmacology 50:372-9. 2006
    ..Our results suggest that endocannabinoids in the spinal cord regulate, but do not mediate, nonopioid SIA...
  79. ncbi request reprint Role of endogenous cannabinoids in synaptic signaling
    Tamas F Freund
    Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest 8, Szigony u 43, H 1083 Hungary
    Physiol Rev 83:1017-66. 2003
    ..Finally, the possible functions of endocannabinoids as retrograde synaptic signal molecules are discussed in relation to synaptic plasticity and network activity patterns...
  80. pmc Molecular composition of the endocannabinoid system at glutamatergic synapses
    Istvan Katona
    Institute of Experimental Medicine, Hungarian Academy of Sciences, H 1083 Budapest, Hungary
    J Neurosci 26:5628-37. 2006
    ....
  81. ncbi request reprint Design, synthesis, and structure-activity relationships of alkylcarbamic acid aryl esters, a new class of fatty acid amide hydrolase inhibitors
    Giorgio Tarzia
    Istituto di Chimica Farmaceutica e Tossicologica, Universita degli Studi di Urbino Carlo Bo, Piazza del Rinascimento 6, Italy
    J Med Chem 46:2352-60. 2003
    ..URB524 (N-cyclohexylcarbamic acid biphenyl-3-yl ester, 9g) is the most potent compound of the series (IC(50) = 63 nM) and was therefore selected for further optimization...
  82. ncbi request reprint A peripheral mechanism for CB1 cannabinoid receptor-dependent modulation of feeding
    Raquel Gomez
    University Institute of Drug Dependencies, Department of Psychobiology, University Complutense of Madrid, Madrid 28223, Spain
    J Neurosci 22:9612-7. 2002
    ..Pretreatment with SR141716A enhanced the inhibition of feeding induced by intraperitoneal administration of oleoylethanolamide. The results reveal an unexpected role for peripheral CB1 receptors in the regulation of feeding...
  83. ncbi request reprint Identification and functional characterization of brainstem cannabinoid CB2 receptors
    Marja D Van Sickle
    Institute of Infection, Immunity, and Inflammation and Hotchkiss Brain Institute, Department of Physiology and Biophysics, University of Calgary, Calgary, AB, Canada T2N 4N1
    Science 310:329-32. 2005
    ..CB2 receptors represent an alternative site of action of endocannabinoids that opens the possibility of nonpsychotropic therapeutic interventions using enhanced endocannabinoid levels in localized brain areas...
  84. ncbi request reprint Attenuation of spontaneous opiate withdrawal in mice by the anandamide transport inhibitor AM404
    Ignacio del Arco
    Fundacion Hospital Carlos Haya, Avda Carlos Haya 82 7 Planta, Pabellon A, Malaga 29010, Spain
    Eur J Pharmacol 454:103-4. 2002
    ..p.). These results suggest that spontaneous but not opioid antagonist-precipitated withdrawal is associated with dynamic changes in endogenous cannabinoid signaling...
  85. ncbi request reprint Selective inhibition of 2-AG hydrolysis enhances endocannabinoid signaling in hippocampus
    Judit K Makara
    Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, 8 Szigony u 43, Budapest, H 1083 Hungary
    Nat Neurosci 8:1139-41. 2005
    ..These results establish a role for 2-AG in synaptic plasticity and point to monoacylglycerol lipase as a possible drug target...
  86. pmc Inhibition of anandamide hydrolysis by cyclohexyl carbamic acid 3'-carbamoyl-3-yl ester (URB597) reverses abuse-related behavioral and neurochemical effects of nicotine in rats
    Maria Scherma
    Preclinical Pharmacology Section, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, MD 21224, USA
    J Pharmacol Exp Ther 327:482-90. 2008
    ..These findings suggest that FAAH inhibition can counteract the addictive properties of nicotine and that FAAH may serve as a new target for development of medications for treatment of tobacco dependence...
  87. ncbi request reprint The effect of cannabidiol and URB597 on conditioned gaping (a model of nausea) elicited by a lithium-paired context in the rat
    Erin M Rock
    Department of Psychology, University of Guelph, Guelph, ON, Canada
    Psychopharmacology (Berl) 196:389-95. 2008
    ..In this study, the effect of manipulation of the endocannabinoid (EC) system on a rat model of nausea (conditioned gaping) was determined...
  88. ncbi request reprint Synthesis and structure-activity relationships of FAAH inhibitors: cyclohexylcarbamic acid biphenyl esters with chemical modulation at the proximal phenyl ring
    Giorgio Tarzia
    Istituto di Chimica Farmaceutica e Tossicologica, Universita degli Studi di Urbino Carlo Bo, Piazza del Rinascimento 6, 61029 Urbino, Italy
    ChemMedChem 1:130-9. 2006
    ..Derivatives with small polar groups at the para position of the proximal phenyl ring were slightly better FAAH inhibitors than the parent compound URB524...
  89. ncbi request reprint An endocannabinoid mechanism for stress-induced analgesia
    Andrea G Hohmann
    Neuroscience and Behavior Program, Department of Psychology, The University of Georgia, Athens, Georgia 30602 3013, USA
    Nature 435:1108-12. 2005
    ..These studies also identify monoacylglycerol lipase as a previously unrecognized therapeutic target...
  90. ncbi request reprint The endogenous cannabinoid anandamide produces delta-9-tetrahydrocannabinol-like discriminative and neurochemical effects that are enhanced by inhibition of fatty acid amide hydrolase but not by inhibition of anandamide transport
    Marcello Solinas
    Laboratoire de Biologie et Physiologie Cellulaires, CNRS 6187, Universite de Poitiers, Poitiers, France
    J Pharmacol Exp Ther 321:370-80. 2007
    ....
  91. pmc Regulation of brain anandamide by acute administration of ethanol
    Belen Ferrer
    Fundacion IMABIS, Hospital Carlos Haya, Malaga 29010, Spain
    Biochem J 404:97-104. 2007
    ..These results suggest that receptor-mediated release of acylethanolamide is inhibited by the acute administration of ethanol, and that this effect is not derived from increased fatty acid ethanolamide degradation...
  92. ncbi request reprint The fatty acid amide hydrolase inhibitor URB597 (cyclohexylcarbamic acid 3'-carbamoylbiphenyl-3-yl ester) reduces neuropathic pain after oral administration in mice
    Roberto Russo
    Department of Experimental Pharmacology, University of Naples, Italy
    J Pharmacol Exp Ther 322:236-42. 2007
    ..The results provide new evidence for a role of the endocannabinoid system in pain modulation and reinforce the proposed role of FAAH as a target for analgesic drug development...
  93. pmc Synergistic antinociception by the cannabinoid receptor agonist anandamide and the PPAR-alpha receptor agonist GW7647
    Roberto Russo
    Department of Experimental Pharmacology, University of Naples, Naples, Italy
    Eur J Pharmacol 566:117-9. 2007
    ..These findings reveal a synergistic interaction between the endocannabinoid and PPAR-alpha systems that might be exploited clinically and identify a new pharmacological effect of the BK channel activator isopimaric acid...
  94. ncbi request reprint Effects of the FAAH inhibitor, URB597, and anandamide on lithium-induced taste reactivity responses: a measure of nausea in the rat
    Shelley K Cross-Mellor
    Department of Psychology, University of Guelph, Guelph, ON, Canada
    Psychopharmacology (Berl) 190:135-43. 2007
    ..Because of the rapid breakdown and hydrolysis of endocannabinoids, such as anandamide, the therapeutic effects may be enhanced by prolonging their duration of action...
  95. ncbi request reprint The antinociceptive effects of local injections of propofol in rats are mediated in part by cannabinoid CB1 and CB2 receptors
    Josee Guindon
    Department of Pharmacology, Faculty of Medicine, Université de Montréal CHUM, Montreal, Quebec, Canada
    Anesth Analg 104:1563-9, table of contents. 2007
    ....
  96. ncbi request reprint Anandamide levels in cerebrospinal fluid of first-episode schizophrenic patients: impact of cannabis use
    F Markus Leweke
    Department of Psychiatry and Psychotherapy, University of Cologne, Kerpener Str 62, 50924 Cologne, Germany
    Schizophr Res 94:29-36. 2007
    ..In the present study we examined whether cannabis use may alter such a mechanism...
  97. ncbi request reprint Endocannabinoid transport tightly controls 2-arachidonoyl glycerol actions in the hippocampus: effects of low temperature and the transport inhibitor AM404
    Norbert Hajos
    Institute of Experimental Medicine, Hungarian Academy of Sciences, Szigony u 43, H 1083 Budapest, Hungary
    Eur J Neurosci 19:2991-6. 2004
    ....
  98. pmc The endogenous cannabinoid anandamide has effects on motivation and anxiety that are revealed by fatty acid amide hydrolase (FAAH) inhibition
    Maria Scherma
    Preclinical Pharmacology Section, Behavioral Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, NIH, DHHS, Baltimore, MD, USA
    Neuropharmacology 54:129-40. 2008
    ..Thus, additive interactions between the effects of anandamide on brain reward processes and on anxiety may account for its aversive effects when intravenously administered during FAAH inhibition with URB597...
  99. ncbi request reprint Correlation between energetics of collisionally activated decompositions, interaction energy and biological potency of carbamate FAAH inhibitors
    Giovanni Valitutti
    J Mass Spectrom 42:1624-7. 2007
  100. doi request reprint Endogenous cannabinoids in patients with schizophrenia and substance use disorder during quetiapine therapy
    Stephane Potvin
    Fernand Seguin Research Center, Louis H Lafontaine Hospital and Biomedical Sciences Program, Faculty of Medicine, University of Montreal, Montreal, Quebec, Canada
    J Psychopharmacol 22:262-9. 2008
    ..Lastly, baseline anandamide predicted endpoint SUD scores (alcohol/ cannabis). Anandamide is a potential target for medications aimed at relieving SUD in schizophrenia...
  101. doi request reprint Increase of brain endocannabinoid anandamide levels by FAAH inhibition and alcohol abuse behaviours in the rat
    Andrea Cippitelli
    Department of Experimental Medicine and Public Health, University of Camerino, Via Madonna delle Carceri, 62032 Camerino, Italy
    Psychopharmacology (Berl) 198:449-60. 2008
    ..As an alternative approach, CB1-receptor-mediated activity can be facilitated by increasing anandamide levels with the use of hydrolase fatty acid amide hydrolase (FAAH) inhibitors...

Research Grants40

  1. Role of oleoylethanolamide in the control of food intake
    Daniele Piomelli; Fiscal Year: 2010
    ....
  2. Role of oleoylethanolamide in the control of food intake
    Daniele Piomelli; Fiscal Year: 2009
    ....
  3. Characterization of anandamide transport in brain
    Daniele Piomelli; Fiscal Year: 2007
    ..abstract_text> ..
  4. Role of Endocannabinoids in the Behavioral Consequences of Social Isolation
    Daniele Piomelli; Fiscal Year: 2007
    ....
  5. Characterization of anandamide transport in brain
    Daniele Piomelli; Fiscal Year: 2007
    ..abstract_text> ..
  6. Role of oleoylethanolamide in the control of food intake
    Daniele Piomelli; Fiscal Year: 2007
    ....
  7. Characterization of a novel cannabinoid ligand
    Daniele Piomelli; Fiscal Year: 2007
    ..These studies will help reveal the roles played by the endocannabinoid system in the brain and may open innovative avenues for the treatment of neuropsychiatric and substance abuse disorders. ..
  8. Characterization of anandamide transport in brain
    Daniele Piomelli; Fiscal Year: 2006
    ..abstract_text> ..
  9. Characterization of a novel cannabinoid ligand
    Daniele Piomelli; Fiscal Year: 2006
    ..These studies will help reveal the roles played by the endocannabinoid system in the brain and may open innovative avenues for the treatment of neuropsychiatric and substance abuse disorders. ..
  10. Role of oleoylethanolamide in the control of food intake
    Daniele Piomelli; Fiscal Year: 2009
    ....
  11. Characterization of a novel brain cannabinoid ligand
    Daniele Piomelli; Fiscal Year: 2009
    ..The objective of our research is to understand how these transmitters are produced and eliminated, and discover innovative medicines that target these processes. ..
  12. Characterization of anandamide transport in brain
    Daniele Piomelli; Fiscal Year: 2005
    ..abstract_text> ..
  13. Oleylethanolamide derivatives as anti-obesity agents
    Daniele Piomelli; Fiscal Year: 2005
    ....
  14. CONTROL OF ENDOCANNABINOID RELEASE IN VIVO
    Daniele Piomelli; Fiscal Year: 2000
    ..Moreover, by uncovering the neurochemical interactions between cocaine and the endogenous cannabinoids, our studies will contribute to the general understanding of substance abuse and neuropsychiatric disorders. ..
  15. NOVEL BRAIN CANNABINOID LIGAND
    Daniele Piomelli; Fiscal Year: 2000
    ....
  16. ANANDAMIDE TRANSPORT IN BRAIN
    Daniele Piomelli; Fiscal Year: 2000
    ....
  17. ANANDAMIDE TRANSPORT IN BRAIN
    Daniele Piomelli; Fiscal Year: 1999
    ....
  18. NOVEL BRAIN CANNABINOID LIGAND
    Daniele Piomelli; Fiscal Year: 1999
    ....
  19. ANANDAMIDE TRANSPORT IN BRAIN
    Daniele Piomelli; Fiscal Year: 1999
    ....
  20. CONTROL OF ENDOCANNABINOID RELEASE IN VIVO
    Daniele Piomelli; Fiscal Year: 1999
    ..Moreover, by uncovering the neurochemical interactions between cocaine and the endogenous cannabinoids, our studies will contribute to the general understanding of substance abuse and neuropsychiatric disorders. ..
  21. ANANDAMIDE TRANSPORT IN BRAIN
    Daniele Piomelli; Fiscal Year: 2001
    ....
  22. NOVEL BRAIN CANNABINOID LIGAND
    Daniele Piomelli; Fiscal Year: 2001
    ....
  23. Characterization of a novel cannabinoid ligand
    Daniele Piomelli; Fiscal Year: 2005
    ..These studies will help reveal the roles played by the endocannabinoid system in the brain and may open innovative avenues for the treatment of neuropsychiatric and substance abuse disorders. ..
  24. CONTROL OF ENDOCANNABINOID RELEASE IN VIVO
    Daniele Piomelli; Fiscal Year: 2003
    ..Moreover, by uncovering the neurochemical interactions between cocaine and the endogenous cannabinoids, our studies will contribute to the general understanding of substance abuse and neuropsychiatric disorders. ..
  25. Characterization of anandamide transport in brain
    Daniele Piomelli; Fiscal Year: 2004
    ..abstract_text> ..
  26. CONTROL OF ENDOCANNABINOID RELEASE IN VIVO
    Daniele Piomelli; Fiscal Year: 2003
    ..Moreover, by uncovering the neurochemical interactions between cocaine and the endogenous cannabinoids, our studies will contribute to the general understanding of substance abuse and neuropsychiatric disorders. ..
  27. NOVEL BRAIN CANNABINOID LIGAND
    Daniele Piomelli; Fiscal Year: 2002
    ....
  28. ANANDAMIDE TRANSPORT IN BRAIN
    Daniele Piomelli; Fiscal Year: 2002
    ....
  29. CONTROL OF ENDOCANNABINOID RELEASE IN VIVO
    Daniele Piomelli; Fiscal Year: 2002
    ..Moreover, by uncovering the neurochemical interactions between cocaine and the endogenous cannabinoids, our studies will contribute to the general understanding of substance abuse and neuropsychiatric disorders. ..
  30. CONTROL OF ENDOCANNABINOID RELEASE IN VIVO
    Daniele Piomelli; Fiscal Year: 2001
    ..Moreover, by uncovering the neurochemical interactions between cocaine and the endogenous cannabinoids, our studies will contribute to the general understanding of substance abuse and neuropsychiatric disorders. ..
  31. Characterization of a novel brain cannabinoid ligand
    Daniele Piomelli; Fiscal Year: 2010
    ..The objective of our research is to understand how these transmitters are produced and eliminated, and discover innovative medicines that target these processes. ..