Michael R Pinsky

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi request reprint Clinical significance of pulmonary artery occlusion pressure
    Michael R Pinsky
    Division of Coibical Care Medicine, 604 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Intensive Care Med 29:175-8. 2003
  2. ncbi request reprint Modeling ischemia-induced dyssynchronous myocardial contraction
    David P Strum
    Cardiopulmonary Research Laboratory, Department of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15261, USA
    Anesth Analg 103:846-53. 2006
  3. pmc Searching for non-invasive markers of tissue hypoxia
    Juan Carlos Puyana
    Applied Research IMITs Center, Innovative Medical and Information Technology Center, UPMC, F1265 Presbyterian, Pittsburgh, PA 15213 2536, USA
    Crit Care 11:116. 2007
  4. ncbi request reprint On the future of critical care medicine
    Michael R Pinsky
    J Crit Care 22:265-6. 2007
  5. doi request reprint Is myocardial adrenergic responsiveness depressed in human septic shock?
    Alain Cariou
    Cochin Saint Vincent de Paul Hospital and Paris Descartes University, Paris, France
    Intensive Care Med 34:917-22. 2008
  6. pmc Early or late parenteral nutrition: ASPEN vs. ESPEN
    Matthew E Cove
    Department of Critical Care Medicine, 606 Scaife Hall 3550 Terrace Street, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Crit Care 15:317. 2011
  7. pmc Clinical review: Update on hemodynamic monitoring--a consensus of 16
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, 808 Route de Lennik, 1070 Brussels, Belgium
    Crit Care 15:229. 2011
  8. pmc Thirty years of critical care medicine
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Route de Lennik 808, 1070 Bruxelles, Belgium
    Crit Care 14:311. 2010
  9. ncbi request reprint Pathophysiology of sepsis and multiple organ failure: pro- versus anti-inflammatory aspects
    Michael R Pinsky
    Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Contrib Nephrol 144:31-43. 2004
  10. ncbi request reprint Rationale for cardiovascular monitoring
    Michael R Pinsky
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Curr Opin Crit Care 9:222-4. 2003

Research Grants

  1. Heart-Lung Interactions & Cardiovascular Insufficiency
    Michael Pinsky; Fiscal Year: 2007
  2. EXPERIMENTAL THERAPEUTICS IN CRITICAL ILLNESS
    Michael Pinsky; Fiscal Year: 2007

Detail Information

Publications91

  1. ncbi request reprint Clinical significance of pulmonary artery occlusion pressure
    Michael R Pinsky
    Division of Coibical Care Medicine, 604 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Intensive Care Med 29:175-8. 2003
    ..Regrettably, under many common clinically relevant conditions, even when Ppao values are measured accurately, Ppao values at baseline and in response to therapy often reflect an inaccurate measure of cardiovascular status...
  2. ncbi request reprint Modeling ischemia-induced dyssynchronous myocardial contraction
    David P Strum
    Cardiopulmonary Research Laboratory, Department of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15261, USA
    Anesth Analg 103:846-53. 2006
    ..Potentially, phase angle and regional amplitude analyses may prove to be effective measures to identify and quantify the beneficial effects of resynchronization therapies on myocardial function...
  3. pmc Searching for non-invasive markers of tissue hypoxia
    Juan Carlos Puyana
    Applied Research IMITs Center, Innovative Medical and Information Technology Center, UPMC, F1265 Presbyterian, Pittsburgh, PA 15213 2536, USA
    Crit Care 11:116. 2007
    ..Thus, the use of StO2 alone to define the endpoint of resuscitation may be misleading...
  4. ncbi request reprint On the future of critical care medicine
    Michael R Pinsky
    J Crit Care 22:265-6. 2007
  5. doi request reprint Is myocardial adrenergic responsiveness depressed in human septic shock?
    Alain Cariou
    Cochin Saint Vincent de Paul Hospital and Paris Descartes University, Paris, France
    Intensive Care Med 34:917-22. 2008
    ..To assess left ventricular (LV) contractile function and adrenergic responsiveness in septic patients...
  6. pmc Early or late parenteral nutrition: ASPEN vs. ESPEN
    Matthew E Cove
    Department of Critical Care Medicine, 606 Scaife Hall 3550 Terrace Street, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Crit Care 15:317. 2011
    ..CITATION: Casaer MP, Mesotten D, Hermans G et al. Early versus late parenteral nutrition in critically ill adults. N Engl J Med. 2011;365: 506-517...
  7. pmc Clinical review: Update on hemodynamic monitoring--a consensus of 16
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, 808 Route de Lennik, 1070 Brussels, Belgium
    Crit Care 15:229. 2011
    ....
  8. pmc Thirty years of critical care medicine
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Route de Lennik 808, 1070 Bruxelles, Belgium
    Crit Care 14:311. 2010
    ..We then look at the process of care and realize that, here, huge progress has been made. Lastly, we suggest how critical care medicine will continue to evolve for the better over the next 30 years...
  9. ncbi request reprint Pathophysiology of sepsis and multiple organ failure: pro- versus anti-inflammatory aspects
    Michael R Pinsky
    Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Contrib Nephrol 144:31-43. 2004
  10. ncbi request reprint Rationale for cardiovascular monitoring
    Michael R Pinsky
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Curr Opin Crit Care 9:222-4. 2003
    ..Thus, their use in the management of the critically ill patient cannot be vigorously defended, except under specific conditions...
  11. ncbi request reprint Probing chaos in search of health
    Michael R Pinsky
    Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Crit Care 18:163-5. 2003
  12. ncbi request reprint Hemodynamic monitoring in the intensive care unit
    Michael R Pinsky
    Department of Critical Care Medicine, Bioengineering and Anesthesiology, University of Pittsburgh School of Medicine, 606 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Clin Chest Med 24:549-60. 2003
    ....
  13. ncbi request reprint Goals of resuscitation from circulatory shock
    Michael R Pinsky
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Contrib Nephrol 144:94-104. 2004
  14. ncbi request reprint Dysregulation of the immune response in severe sepsis
    Michael R Pinsky
    Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Am J Med Sci 328:220-9. 2004
    ..Successful clinical trials of novel treatments for the management of severe sepsis share a common ability to down-regulate this overall response, restoring normal proinflammatory responsiveness and mitochondrial energetic function...
  15. ncbi request reprint Assessment of indices of preload and volume responsiveness
    Michael R Pinsky
    Department of Critical Care Medicine, University of Pittsburgh, Pennsylvania 15261, USA
    Curr Opin Crit Care 11:235-9. 2005
    ..To summarize the relevant peer-reviewed publications over the past year that addressed issues of when to give (or not give) fluid to the critically ill patient...
  16. ncbi request reprint Cardiovascular issues in respiratory care
    Michael R Pinsky
    Bioengineering and Anesthesiology, Department of Critical Care Medicine, University of Pittsburgh Medical Center, 606 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15213, USA
    Chest 128:592S-597S. 2005
    ..In patients with hypervolemic heart failure, this afterload reducing effect can result in improved LV ejection, increased cardiac output, and reduced myocardial oxygen demand...
  17. pmc Why measure cardiac output?
    Michael R Pinsky
    Department of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Crit Care 7:114-6. 2003
  18. pmc Functional hemodynamic monitoring
    Michael R Pinsky
    Department of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Crit Care 9:566-72. 2005
    ..Potentially, as these and newer, less invasive hemodynamic measures are validated, they could be incorporated into such protocolized care in a cost-effective manner...
  19. pmc Physiologic responses to severe hemorrhagic shock and the genesis of cardiovascular collapse: can irreversibility be anticipated?
    Hernando Gomez
    Department of Critical Care Medicine, University of Pittsburgh, 3550 Terrace Street, Scaife Hall, Pittsburgh, PA 15261, USA
    J Surg Res 178:358-69. 2012
    ..We hypothesized that vascular tone loss characterizes CC, and that arterial pulse pressure/stroke volume index ratio or vascular tone index (VTI) would identify CC...
  20. pmc Cardiorespiratory instability before and after implementing an integrated monitoring system
    Marilyn Hravnak
    School of Nursing, School of Medicine, University of Pittsburgh, USA
    Crit Care Med 39:65-72. 2011
    ....
  21. ncbi request reprint Long-term mortality and quality of life after prolonged mechanical ventilation
    Lakshmipathi Chelluri
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, PA, USA
    Crit Care Med 32:61-9. 2004
    ..To describe and identify factors associated with mortality rate and quality of life 1 yr after prolonged mechanical ventilation...
  22. ncbi request reprint Practical issues of hemodynamic monitoring at the bedside
    Patricio M Polanco
    Division of Trauma, Department of Surgery, University of Pittsburgh School of Medicine, F1275 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Surg Clin North Am 86:1431-56. 2006
    ..The current clinical data relevant to hemodynamic monitoring are reviewed and discussed...
  23. pmc Quantifying the role of regional dyssynchrony on global left ventricular performance
    Bouchra Lamia
    Department of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    JACC Cardiovasc Imaging 2:1350-6. 2009
    ....
  24. pmc Dynamic and site-specific impact of ventricular pacing on left ventricular ejection fraction
    David Schwartzman
    Cardiovascular Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Heart Rhythm 7:813-9. 2010
    ..Interactions between pacing site and LVEF remain unclear...
  25. pmc Effect of tidal volume, sampling duration, and cardiac contractility on pulse pressure and stroke volume variation during positive-pressure ventilation
    Hyung Kook Kim
    Cardiopulmonary Research Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Crit Care Med 36:2858-62. 2008
    ..We hypothesized that the magnitude of pulse pressure variation would increase with sampling duration, and that both tidal volume and contractility would independently alter pulse pressure variation and stroke volume variation...
  26. ncbi request reprint Differential effects of left ventricular pacing sites in an acute canine model of contraction dyssynchrony
    Lauren Johnson
    Cardiovascular Systems Laboratory, Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA
    Am J Physiol Heart Circ Physiol 293:H3046-55. 2007
    ..The dissociation between changes in synchrony and global LV performance with CRTf suggests that regional analysis from a single plane may not be sufficient to adequately characterize contraction synchrony...
  27. pmc Physiological relevance of quantifying segmental contraction synchrony
    Lauren Johnson
    Cardiovascular Systems Laboratory, Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Pacing Clin Electrophysiol 35:174-87. 2012
    ..We report the development and physiological relevance of a novel method to quantify LV segmental contraction synchrony...
  28. ncbi request reprint Principals of hemodynamic monitoring
    Patricio M Polanco
    Division of Trauma, Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Contrib Nephrol 156:133-57. 2007
    ..However, to be used effectively its applications and limitations need to be defined and its values applied within the context of proven therapeutic approaches...
  29. pmc Inflammatory markers at hospital discharge predict subsequent mortality after pneumonia and sepsis
    Sachin Yende
    The Clinical Research, Investigation, and Systems Modeling of Acute Illness CRISMA Laboratory, Department of Critical Care Medicine, Graduate School of Pubic Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Am J Respir Crit Care Med 177:1242-7. 2008
    ..Survivors of hospitalization for community-acquired pneumonia (CAP) are at increased risk of cardiovascular events, repeat infections, and death in the following months but the cause is unknown...
  30. pmc Left ventricular systolic torsion correlates global cardiac performance during dyssynchrony and cardiac resynchronization therapy
    Bouchra Lamia
    Department of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, USA
    Am J Physiol Heart Circ Physiol 300:H853-8. 2011
    ..12, P = 0.61 and r = 0.08, P = 0.73, respectively). Thus, we conclude that LV torsion is primarily altered by dyssynchrony, and CRT that restores LV performance also restores torsion...
  31. pmc Prehospital dynamic tissue oxygen saturation response predicts in-hospital lifesaving interventions in trauma patients
    Francis X Guyette
    Department of Emergency Medicine, University of Pittsburgh, Iroquois Building, Suite 400A, 3600 Forbes Avenue, Pittsburgh, PA 15261, USA
    J Trauma Acute Care Surg 72:930-5. 2012
    ..We hypothesize that prehospital tissue oximetric values and vascular occlusion test response can predict the need for in-hospital lifesaving interventions (LSI)...
  32. ncbi request reprint Effects of radial left ventricular dyssynchrony on cardiac performance using quantitative tissue Doppler radial strain imaging
    Kaoru Dohi
    Division of Cardiovascular Disease, Critical Care Medicine Department, University of Pittsburgh, Pittsburgh, Pennsylvania 15213 2582, USA
    J Am Soc Echocardiogr 19:475-82. 2006
    ..05 individually, r = 0.80 overall) and stroke work (r = -0.88 +/- 0.12 individually, r = -0.82 overall). Angle-corrected radial strain imaging has clinical potential to quantify mechanical dyssynchrony and effects of biventricular pacing...
  33. ncbi request reprint Thresholded area over the curve of spectrometric tissue oxygen saturation as an indicator of volume resuscitability in porcine hemorrhagic shock
    Sven Zenker
    Center for Inflammation and Regenerative Modeling CIRM, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Trauma 63:573-8; discussion 578-80. 2007
    ..We therefore explored the value of peripheral muscle Sto2 in predicting systemic responsiveness to colloid volume resuscitation in a porcine model of hemorrhagic shock...
  34. pmc Echocardiographic speckle tracking radial strain imaging to assess ventricular dyssynchrony in a pacing model of resynchronization therapy
    Masaki Tanabe
    The Cardiovascular Institute and Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Am Soc Echocardiogr 21:1382-8. 2008
    ..Our aim was to assess a new speckle tracking regional strain algorithm by comparison with angle-corrected tissue Doppler (TD) in an animal model of left bundle branch block and cardiac resynchronization therapy...
  35. pmc An adequately robust early TNF-alpha response is a hallmark of survival following trauma/hemorrhage
    Rajaie Namas
    Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    PLoS ONE 4:e8406. 2009
    ..Trauma/hemorrhagic shock (T/HS) results in cytokine-mediated acute inflammation that is generally considered detrimental...
  36. pmc Tissue Doppler imaging of right ventricular decompensation in pulmonary hypertension
    Marc A Simon
    Cardiovascular Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Congest Heart Fail 15:271-6. 2009
    ..0001). RV free wall strain decreases in PH without hemodynamically decompensated RV function suggesting it may be a preceding step in the development of RV failure. This may be of particular use in following patients sequentially...
  37. pmc Phenotyping the right ventricle in patients with pulmonary hypertension
    Marc A Simon
    Cardiovascular Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Clin Transl Sci 2:294-9. 2009
    ..In PH, there are significant phenotypic abnormalities in the RV even in the absence of overt hemodynamic RV decompensation. Regional changes in RV structure and function may be early markers of patients at risk for developing RV failure...
  38. ncbi request reprint Effects of modulation of left ventricular contractile state and loading conditions on tissue Doppler myocardial performance index
    Maxime Cannesson
    Cardiovascular Institute, University of Pittsburgh, Pittsburgh, PA 15213 2582, USA
    Am J Physiol Heart Circ Physiol 290:H1952-9. 2006
    ..All the above increases and decreases and r values were significant (P < 0.05 vs. baseline). In conclusion, TD MPI can rapidly quantify alterations in LV contractile state but is affected by acute alterations in preload and afterload...
  39. pmc Characteristics of patients with cardiorespiratory instability in a step-down unit
    Khalil Yousef
    School of Nursing, University of Pittsburgh, Pennsylvania 15261, USA
    Am J Crit Care 21:344-50. 2012
    ..Patients in step-down units are at higher risk for developing cardiorespiratory instability than are patients in general care areas. A triage tool is needed to identify at-risk patients who therefore require increased surveillance...
  40. pmc Cross-comparison of cardiac output trending accuracy of LiDCO, PiCCO, FloTrac and pulmonary artery catheters
    Mehrnaz Hadian
    Department of Critical Care Medicine, University of Pittsburgh Medical Center, 230 Lothrop Street, Pittsburgh, PA 15261, USA
    Crit Care 14:R212. 2010
    ....
  41. ncbi request reprint Understanding the inflammatory cytokine response in pneumonia and sepsis: results of the Genetic and Inflammatory Markers of Sepsis (GenIMS) Study
    John A Kellum
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, 604 Scaife Hall, 3550 Terrace St, Pittsburgh, PA15261, USA
    Arch Intern Med 167:1655-63. 2007
    ..In this study we describe the systemic cytokine response to pneumonia and determine if specific patterns, including the balance of proinflammatory and anti-inflammatory markers, are associated with severe sepsis and death...
  42. ncbi request reprint Hospital costs in patients receiving prolonged mechanical ventilation: does age have an impact?
    Lakshmipathi Chelluri
    Department of Critical Care Medicine, Room 637, 6th Floor Scaife, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
    Crit Care Med 31:1746-51. 2003
    ..The aging of the population is one of the causes of the increase in healthcare costs in the past few decades. It is controversial whether chronological age alone should be used in making healthcare decisions...
  43. ncbi request reprint Ability of pulse contour and esophageal Doppler to estimate rapid changes in stroke volume
    Scott R Gunn
    Medical Center, Department of Critical Care Medicine, University of Pittsburgh, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Intensive Care Med 32:1537-46. 2006
    ..We tested these relationships in the setting of rapidly changing stroke volumes and different cardiovascular states over a period of 10-15 cardiac cycles...
  44. ncbi request reprint Minimally invasive real time monitoring of mitochondrial NADH and tissue blood flow in the urethral wall during hemorrhage and resuscitation
    Julio A Clavijo
    Department of Critical Care Medicine and Surgery, University of Pittsburgh Medical Center, Presbyterian Hospital, Pittsburgh, PA, USA
    Med Sci Monit 14:BR175-82. 2008
    ..We hypothesized that changes in mitochondrial NADH and TBF are associated with impaired energy metabolism in the urethra and that these changes correlate with impaired tissue perfusion in the bladder during shock and resuscitation...
  45. doi request reprint Use of non-invasive NIRS during a vascular occlusion test to assess dynamic tissue O(2) saturation response
    Hernando Gomez
    Department of Critical Care Medicine, Cardiopulmonary Research Laboratory, University of Pittsburgh, 606 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA, 15261, USA
    Intensive Care Med 34:1600-7. 2008
    ..We assessed tissue O(2) saturation (StO(2)) and total hemoglobin (HbT) changes during a vascular occlusion test (VOT) as markers of O(2) consumption and cardiovascular reserve...
  46. doi request reprint Effect of tidal volume, intrathoracic pressure, and cardiac contractility on variations in pulse pressure, stroke volume, and intrathoracic blood volume
    Jaume Mesquida
    Cardiopulmonary Research Laboratory, Department of Critical Care Medicine, University of Pittsburgh Medical Center, 606 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Intensive Care Med 37:1672-9. 2011
    ....
  47. ncbi request reprint Heart-lung interactions
    Michael R Pinsky
    Department of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Curr Opin Crit Care 13:528-31. 2007
    ..Thus, it is important to understand the determinants of these complex heart-lung interactions...
  48. ncbi request reprint Influence of alterations in loading on mitral annular velocity by tissue Doppler echocardiography and its associated ability to predict filling pressures
    Didier C Jacques
    Division of Cardiology, University of Pittsburgh, 200 Lothrop St, Pittsburgh, PA 15213, USA
    Chest 126:1910-8. 2004
    ..Changes in preload and afterload were induced by vena caval and partial aortic occlusions, respectively. Data were collected during control phase and during infusions of dobutamine and esmolol to alter contractility...
  49. pmc Defining the incidence of cardiorespiratory instability in patients in step-down units using an electronic integrated monitoring system
    Marilyn Hravnak
    School of Nursing, University of Pittsburgh, 336 Victoria Bldg, 3500 Victoria St, Pittsburgh, PA 15261, USA
    Arch Intern Med 168:1300-8. 2008
    ..We undertook this study to characterize respiratory status in an SDU population, to define features of cardiorespiratory instability, and to evaluate an IMS index value that should trigger medical emergency team (MET) activation...
  50. ncbi request reprint Estimating left ventricular contractility using inspiratory-hold maneuvers
    Hyung Kook Kim
    Cardiopulmonary Research Laboratory, Department of Critical Care Medicine, School of Medicine, University of Pittsburgh, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Intensive Care Med 33:181-9. 2007
    ..To compare estimates of left ventricular (LV) end-systolic elastance created by inferior vena caval (IVC) occlusion with those by apneic continuous positive airway pressure (CPAP)...
  51. pmc Ability of pulse power, esophageal Doppler, and arterial pulse pressure to estimate rapid changes in stroke volume in humans
    Jose Marquez
    Departments of Anesthesiology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Crit Care Med 36:3001-7. 2008
    ..However, the accuracy of commercially available devices to report dynamic left ventricular stroke volume variation has never been validated...
  52. ncbi request reprint Reassessing the value of short-term mortality in sepsis: comparing conventional approaches to modeling
    Gilles Clermont
    Department of Critical Care Medicine, University of Pittsburgh, PA, USA
    Crit Care Med 31:2627-33. 2003
    ..This may be partly due to the use of insensitive mortality end points. We explored whether modeling survival was more sensitive than traditional end points in detecting mortality differences in cohorts of patients with sepsis...
  53. ncbi request reprint The effect of tracheal gas insufflation on gas exchange efficiency
    Michael R Pinsky
    Cardiopulmonary Research Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Anesth Analg 103:1213-8. 2006
    ....
  54. pmc Characterization of tissue oxygen saturation and the vascular occlusion test: influence of measurement sites, probe sizes and deflation thresholds
    Hernando Gomez
    Department of Critical Care Medicine, University of Pittsburgh, 606 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Crit Care 13:S3. 2009
    ..We hypothesized that baseline and VOT StO2 would be different in the forearm (F) and thenar eminence (TH) and that different minimal StO2 values during the VOT would result in different reoxygenation rates (ReO2)...
  55. ncbi request reprint Effect of granulocyte-monocyte colony-stimulating factor therapy on leukocyte function and clearance of serious infection in nonneutropenic patients
    Alan J Rosenbloom
    Department of Critical Care Medicine, University of Pittsburgh Medical Center, 642 Scaife Hall, 3550 Terrace St, Pittsburgh, PA 15261
    Chest 127:2139-50. 2005
    ..We performed a clinical trial of GM-CSF in septic, hemodynamically stable patients to see whether GM-CSF treatment improved leukocyte function and mortality...
  56. pmc Insights into the effects of contraction dyssynchrony on global left ventricular mechano-energetic function
    Lauren Johnson
    Department of Bioengineering, Cardiovascular Systems Laboratory, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Pacing Clin Electrophysiol 32:224-33. 2009
    ..The effects of dyssynchrony on global left ventricular (LV) mechanics have been well documented; however, its impact on LV energetics has received less attention...
  57. ncbi request reprint Renal failure in the ICU: comparison of the impact of acute renal failure and end-stage renal disease on ICU outcomes
    Gilles Clermont
    Department of Critical Care Medicine and Renal Electrolyte Division, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Kidney Int 62:986-96. 2002
    ..We sought to determine the impact of renal dysfunction and/or loss of organ function on outcome...
  58. pmc Informal caregiver burden among survivors of prolonged mechanical ventilation
    David C Van Pelt
    CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, 606D Scaife Hall, Pittsburgh, PA 15261, USA
    Am J Respir Crit Care Med 175:167-73. 2007
    ..In existing studies, it is unclear whether the observed burden is a consequence of critical illness or of preexisting patient illness...
  59. ncbi request reprint Sepsis and multiple organ failure
    Michael R Pinsky
    Department of Critical Care Medicine, Bioengineering and Anesthesiology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Contrib Nephrol 156:47-63. 2007
    ..Sepsis and multiple organ failure are complex processes that result from dysregulation of the immune response and its associated hematological, hemodynamic and metabolic disturbances...
  60. pmc Robust model-based quantification of global ventricular torsion from spatially sparse three-dimensional time series data by orthogonal distance regression: evaluation in a canine animal model under different pacing regimes
    Sven Zenker
    Cardiopulmonary Research Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Pacing Clin Electrophysiol 36:13-23. 2013
    ..Current methods require specific positioning and numbers of myocardial markers and assumptions about temporal positional evolution that may be violated during dyssynchronous contraction...
  61. doi request reprint Evolution of the intensive care unit as a clinical center and critical care medicine as a discipline
    Ake Grenvik
    Department of Critical Care Medicine, University of Pittsburgh, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Crit Care Clin 25:239-50, x. 2009
    ....
  62. pmc The effects of vasoactive drugs on pulse pressure and stroke volume variation in postoperative ventilated patients
    Mehrnaz Hadian
    Department of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
    J Crit Care 26:328.e1-8. 2011
    ..Although pulse pressure variation (PPV) and stroke volume variation (SVV) during mechanical ventilation have been shown to predict preload responsiveness, the effect of vasoactive therapy on PPV and SVV is unknown...
  63. pmc Defining the boundaries of bedside pulse contour analysis: dynamic arterial elastance
    Michael R Pinsky
    Department of Critical Care Medicine, University of Pittsburgh, 606 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Crit Care 15:120. 2011
    ..The use of dynamic Ea for clinical decision-making thus needs to be validated separately for different devices and types of patients...
  64. doi request reprint Complexity modeling: identify instability early
    Michael R Pinsky
    Department of Critical Care Medicine, University of Pittsburgh, Pittsburg, PA, USA
    Crit Care Med 38:S649-55. 2010
    ....
  65. ncbi request reprint Functional hemodynamic monitoring
    Mehrnaz Hadian
    Department of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    Curr Opin Crit Care 13:318-23. 2007
    ..To assess the recent literature on effective use of information received from hemodynamic monitoring...
  66. pmc Evidence-based review of the use of the pulmonary artery catheter: impact data and complications
    Mehrnaz Hadian
    Department of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Crit Care 10:S8. 2006
    ....
  67. ncbi request reprint Hemodynamic evaluation and monitoring in the ICU
    Michael R Pinsky
    Department of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Chest 132:2020-9. 2007
    ..Multicenter trials are needed of early goal-directed therapies for all patients presenting in shock of various etiologies and when the protocol and not the monitoring device is the primary variable...
  68. pmc Hemodynamic monitoring over the past 10 years
    Michael R Pinsky
    University of Pittsburgh School of Medicine, 606 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Crit Care 10:117. 2006
    ..Novel monitoring will be driven more by its role in improving outcomes than in the technical abilities of the manufacturers...
  69. ncbi request reprint Pulmonary artery occlusion pressure
    Michael R Pinsky
    Department of Critical Care Medicine, University of Pittsburgh Medical Center, 604 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Intensive Care Med 29:19-22. 2003
  70. ncbi request reprint Genetic testing: costs and access to intensive care unit care
    Michael R Pinsky
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, PA, USA
    Crit Care Med 31:S411-5. 2003
    ..the greatest chance of benefit?" Similarly, as with other genetic predispositions such as cystic fibrosis and congenital hypercholesterolemia, to what extent should these data be available outside the patient-doctor relationship?..
  71. ncbi request reprint Use of vasopressor agents in critically ill patients
    John A Kellum
    Department of Anesthesiology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Curr Opin Crit Care 8:236-41. 2002
    ..When used at doses necessary to reverse distributive shock, less potent vasoconstrictors (eg, dopamine) do not appear to be safer than more potent ones (eg, norepinephrine) and do not appear to be as effective...
  72. ncbi request reprint Recent advances in the clinical application of heart-lung interactions
    Michael R Pinsky
    Department of Critical Care Medicine, University of Pittsburgh Medical Center, Pennsylvania, USA
    Curr Opin Crit Care 8:26-31. 2002
    ..This review illustrates several of these studies within the context of known cardiopulmonary physiology...
  73. ncbi request reprint Let us use the pulmonary artery catheter correctly and only when we need it
    Michael R Pinsky
    Department of Critical Care Medicine, Bioengineering and Anesthesiology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Crit Care Med 33:1119-22. 2005
    ..To clarify the issues related to the use of the pulmonary artery catheter within a rational clinical perspective...
  74. ncbi request reprint Effect of tracheal gas insufflation during weaning from prolonged mechanical ventilation: a preliminary study
    Leslie A Hoffman
    Department of Acute Tertiary Care, University of Pittsburgh School of Nursing, Pittsburgh, PA, USA
    Am J Crit Care 12:31-9. 2003
    ..Tracheal gas insufflation reduces inspired tidal volume and minute ventilation in spontaneously breathing patients and may facilitate weaning from mechanical ventilation...
  75. ncbi request reprint Utility of echocardiographic radial strain imaging to quantify left ventricular dyssynchrony and predict acute response to cardiac resynchronization therapy
    Kaoru Dohi
    University of Pittsburgh, Pennsylvania, USA
    Am J Cardiol 96:112-6. 2005
    ....
  76. pmc Effects of the components of positive airway pressure on work of breathing during bronchospasm
    Adelaida M Miro
    Cardiopulmonary Research Laboratory, Department of Anesthesiology Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Crit Care 8:R72-81. 2004
    ..Theoretically, expiratory positive airway pressure (EPAP), by reducing expiratory breaking, may be as important as inspiratory positive airway pressure (IPAP) in reducing work of breathing during acute bronchospasm...
  77. ncbi request reprint Patients' recollections of stressful experiences while receiving prolonged mechanical ventilation in an intensive care unit
    Armando J Rotondi
    University of Pittsburgh, Pittsburgh, PA
    Crit Care Med 30:746-52. 2002
    ..To describe stressful experiences of adult patients who received mechanical ventilation for > or =48 hrs in an intensive care unit...
  78. ncbi request reprint Does acute organ dysfunction predict patient-centered outcomes?
    Gilles Clermont
    Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Division of General Internal Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Chest 121:1963-71. 2002
    ..Long-term patient-centered outcomes after acute illness may be associated with baseline health status, the development of acute organ dysfunction (AOD), or both...
  79. ncbi request reprint Passive leg raising predicts fluid responsiveness in the critically ill
    Xavier Monnet
    Service de Reanimation Medicale, Centre Hospitalier Universitaire de Bicetre, Assistance Publique Hopitaux de Paris, Université Paris 11, Le Kremlin Bicetre, France
    Crit Care Med 34:1402-7. 2006
    ..We hypothesized that the hemodynamic response to PLR predicts fluid responsiveness in mechanically ventilated patients...
  80. ncbi request reprint Does dobutamine improve ventricular function in dogs with regional myocardial dysfunction?
    David P Strum
    Department of Anesthesiology and Critical Care Medicine, Kingston General Hospital, Queen s University, 76 Stuart Street, Kingston, Ontario K7L 2V7, Canada
    Anesth Analg 95:19-25, table of contents. 2002
    ..We concluded that systemic dobutamine restored global LV function but failed to correct RWMA...
  81. ncbi request reprint Functional hemodynamic monitoring
    Michael R Pinsky
    Intensive Care Med 28:386-8. 2002
  82. ncbi request reprint Probing the limits of arterial pulse contour analysis to predict preload responsiveness
    Michael R Pinsky
    Anesth Analg 96:1245-7. 2003
  83. ncbi request reprint Monitoring skeletal muscle and subcutaneous tissue acid-base status and oxygenation during hemorrhagic shock and resuscitation
    Julio A Clavijo-Alvarez
    Harvard Center for Minimally Invasive Surgery, Harvard University, Boston, Massachusetts, USA
    Shock 24:270-5. 2005
    ..The response of these indicators as potential surrogates of impaired tissue metabolism varies among tissues and according to the phases of hemorrhage or resuscitation...
  84. ncbi request reprint The dynamic interface between hemodynamic variables and autonomic tone
    Michael R Pinsky
    Crit Care Med 33:2437-8. 2005
  85. ncbi request reprint Genetics of individualizing patient care
    Michael R Pinsky
    Crit Care Med 35:287-0. 2007
  86. ncbi request reprint Esophageal Doppler monitoring predicts fluid responsiveness in critically ill ventilated patients
    Xavier Monnet
    Service de Reanimation Medicale, Centre Hospitalo Universitaire de BicĂȘtre, Assistance Publique Hopitaux de Paris, Universite Paris XI, 78 rue du General Leclerc, 94270 Le Kremlin Bicetre, France
    Intensive Care Med 31:1195-201. 2005
    ..To test whether fluid responsiveness can be predicted by the respiratory variation in aortic blood flow and/or the flow time corrected for heart rate monitored with esophageal Doppler...
  87. ncbi request reprint Effect of positive pressure on venous return in volume-loaded cardiac surgical patients
    Paul C M van den Berg
    Department of Intensive Care, Leiden University Medical Centre, 2300 RC Leiden, The Netherlands
    J Appl Physiol 92:1223-31. 2002
    ....
  88. doi request reprint The pulmonary artery catheter: in medio virtus
    Jean Louis Vincent
    Department of Intensive Care Medicine, Erasme Hospital, Universite Libre de Bruxelles, Belgium
    Crit Care Med 36:3093-6. 2008
    ..To clarify the role of the pulmonary artery catheter in the intensive care unit...
  89. ncbi request reprint Using ventilation-induced aortic pressure and flow variation to diagnose preload responsiveness
    Michael R Pinsky
    Intensive Care Med 30:1008-10. 2004
  90. ncbi request reprint The classical Guyton view that mean systemic pressure, right atrial pressure, and venous resistance govern venous return is/is not correct
    Michael R Pinsky
    J Appl Physiol 101:1528. 2006
  91. ncbi request reprint At the threshold of noninvasive functional hemodynamic monitoring
    Michael R Pinsky
    Anesthesiology 106:1084-5. 2007

Research Grants2

  1. Heart-Lung Interactions & Cardiovascular Insufficiency
    Michael Pinsky; Fiscal Year: 2007
    ....
  2. EXPERIMENTAL THERAPEUTICS IN CRITICAL ILLNESS
    Michael Pinsky; Fiscal Year: 2007
    ..Furthermore, formal research presentations by the trainees will be given biannually to the local research community. ..