M R Pinsky

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. doi Heart lung interactions during mechanical ventilation
    Michael R Pinsky
    Department of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15261, USA
    Curr Opin Crit Care 18:256-60. 2012
  2. pmc Cross-comparison of cardiac output trending accuracy of LiDCO, PiCCO, FloTrac and pulmonary artery catheters
    Mehrnaz Hadian
    Department of Critical Care Medicine, University of Pittsburgh Medical Center, 230 Lothrop Street, Pittsburgh, PA 15261, USA
    Crit Care 14:R212. 2010
  3. pmc Searching for non-invasive markers of tissue hypoxia
    Juan Carlos Puyana
    Applied Research IMITs Center, Innovative Medical and Information Technology Center, UPMC, F1265 Presbyterian, Pittsburgh, PA 15213 2536, USA
    Crit Care 11:116. 2007
  4. pmc Characterization of tissue oxygen saturation and the vascular occlusion test: influence of measurement sites, probe sizes and deflation thresholds
    Hernando Gomez
    Department of Critical Care Medicine, University of Pittsburgh, 606 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Crit Care 13:S3. 2009
  5. pmc Second International Conference on Rapid Response System and Medical Emergency Team, 28-30 June 2006, Pittsburgh, PA, USA
    Francesca Rubulotta
    Department of Intensive Care, Policlinico Hospital University of Catania, Italy
    Crit Care 10:319. 2006
  6. doi Complexity modeling: identify instability early
    Michael R Pinsky
    Department of Critical Care Medicine, University of Pittsburgh, Pittsburg, PA, USA
    Crit Care Med 38:S649-55. 2010
  7. pmc Clinical applicability of functional hemodynamic monitoring
    Xaime García
    Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh PA 15261, USA
    Ann Intensive Care 1:35. 2011
  8. ncbi Heart-lung interactions
    Michael R Pinsky
    Department of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Curr Opin Crit Care 13:528-31. 2007
  9. ncbi Hemodynamic evaluation and monitoring in the ICU
    Michael R Pinsky
    Department of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Chest 132:2020-9. 2007
  10. pmc Defining the boundaries of bedside pulse contour analysis: dynamic arterial elastance
    Michael R Pinsky
    Department of Critical Care Medicine, University of Pittsburgh, 606 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Crit Care 15:120. 2011

Research Grants

Collaborators

Detail Information

Publications106 found, 100 shown here

  1. doi Heart lung interactions during mechanical ventilation
    Michael R Pinsky
    Department of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15261, USA
    Curr Opin Crit Care 18:256-60. 2012
    ..To survey the recent medical literature examining studies of the hemodynamic effects of mechanical ventilation...
  2. pmc Cross-comparison of cardiac output trending accuracy of LiDCO, PiCCO, FloTrac and pulmonary artery catheters
    Mehrnaz Hadian
    Department of Critical Care Medicine, University of Pittsburgh Medical Center, 230 Lothrop Street, Pittsburgh, PA 15261, USA
    Crit Care 14:R212. 2010
    ....
  3. pmc Searching for non-invasive markers of tissue hypoxia
    Juan Carlos Puyana
    Applied Research IMITs Center, Innovative Medical and Information Technology Center, UPMC, F1265 Presbyterian, Pittsburgh, PA 15213 2536, USA
    Crit Care 11:116. 2007
    ..Thus, the use of StO2 alone to define the endpoint of resuscitation may be misleading...
  4. pmc Characterization of tissue oxygen saturation and the vascular occlusion test: influence of measurement sites, probe sizes and deflation thresholds
    Hernando Gomez
    Department of Critical Care Medicine, University of Pittsburgh, 606 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Crit Care 13:S3. 2009
    ..We hypothesized that baseline and VOT StO2 would be different in the forearm (F) and thenar eminence (TH) and that different minimal StO2 values during the VOT would result in different reoxygenation rates (ReO2)...
  5. pmc Second International Conference on Rapid Response System and Medical Emergency Team, 28-30 June 2006, Pittsburgh, PA, USA
    Francesca Rubulotta
    Department of Intensive Care, Policlinico Hospital University of Catania, Italy
    Crit Care 10:319. 2006
  6. doi Complexity modeling: identify instability early
    Michael R Pinsky
    Department of Critical Care Medicine, University of Pittsburgh, Pittsburg, PA, USA
    Crit Care Med 38:S649-55. 2010
    ....
  7. pmc Clinical applicability of functional hemodynamic monitoring
    Xaime García
    Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh PA 15261, USA
    Ann Intensive Care 1:35. 2011
    ..Furthermore, these measures can be made increasingly more sensitive and specific if coupled to other "traditional" measures of organ perfusion, such as blood lactate levels...
  8. ncbi Heart-lung interactions
    Michael R Pinsky
    Department of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Curr Opin Crit Care 13:528-31. 2007
    ..Thus, it is important to understand the determinants of these complex heart-lung interactions...
  9. ncbi Hemodynamic evaluation and monitoring in the ICU
    Michael R Pinsky
    Department of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Chest 132:2020-9. 2007
    ..Multicenter trials are needed of early goal-directed therapies for all patients presenting in shock of various etiologies and when the protocol and not the monitoring device is the primary variable...
  10. pmc Defining the boundaries of bedside pulse contour analysis: dynamic arterial elastance
    Michael R Pinsky
    Department of Critical Care Medicine, University of Pittsburgh, 606 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Crit Care 15:120. 2011
    ..The use of dynamic Ea for clinical decision-making thus needs to be validated separately for different devices and types of patients...
  11. ncbi Fluid and volume monitoring
    M R Pinsky
    Critical Care Medicine, Bioengineering, Cardiovascular Diseases and Anesthesiology, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
    Int J Artif Organs 31:111-26. 2008
    ..Thus, compensated shock with a normal blood pressure is a major cause of AKI or exacerbations of AKI during ultrafiltration...
  12. ncbi The effect of tracheal gas insufflation on gas exchange efficiency
    Michael R Pinsky
    Cardiopulmonary Research Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Anesth Analg 103:1213-8. 2006
    ....
  13. ncbi Sepsis and multiple organ failure
    Michael R Pinsky
    Department of Critical Care Medicine, Bioengineering and Anesthesiology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Contrib Nephrol 156:47-63. 2007
    ..Sepsis and multiple organ failure are complex processes that result from dysregulation of the immune response and its associated hematological, hemodynamic and metabolic disturbances...
  14. ncbi Practical issues of hemodynamic monitoring at the bedside
    Patricio M Polanco
    Division of Trauma, Department of Surgery, University of Pittsburgh School of Medicine, F1275 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Surg Clin North Am 86:1431-56. 2006
    ..The current clinical data relevant to hemodynamic monitoring are reviewed and discussed...
  15. ncbi Influence of alterations in loading on mitral annular velocity by tissue Doppler echocardiography and its associated ability to predict filling pressures
    Didier C Jacques
    Division of Cardiology, University of Pittsburgh, 200 Lothrop St, Pittsburgh, PA 15213, USA
    Chest 126:1910-8. 2004
    ..Changes in preload and afterload were induced by vena caval and partial aortic occlusions, respectively. Data were collected during control phase and during infusions of dobutamine and esmolol to alter contractility...
  16. ncbi Short-term and long-term outcome prediction with the Acute Physiology and Chronic Health Evaluation II system after orthotopic liver transplantation
    D C Angus
    Department of Anesthesiology and Critical Care Medicine, Center for Research on Health Care, University of Pittsburgh, PA 15213, USA
    Crit Care Med 28:150-6. 2000
    ..To evaluate the relationship between the postoperative Acute Physiology and Chronic Health Evaluation (APACHE) II score and mortality at hospital discharge and at 1 yr in liver transplant recipients...
  17. ncbi Esmolol-induced regional wall motion abnormalities do not affect regional ventricular elastances
    D P Strum
    Cardiopulmonary Research Laboratory, Department of Anesthesiology and Critical Care Medicine, University of Pittsburgh, PA, USA
    Anesth Analg 90:252-61. 2000
    ..05), but apical regional stroke work decreased. Thus, esmolol-induced RWMA were associated with cardiac dilation but not with decreased regional or global elastances...
  18. ncbi Principals of hemodynamic monitoring
    Patricio M Polanco
    Division of Trauma, Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Contrib Nephrol 156:133-57. 2007
    ..However, to be used effectively its applications and limitations need to be defined and its values applied within the context of proven therapeutic approaches...
  19. pmc Effect of tidal volume, sampling duration, and cardiac contractility on pulse pressure and stroke volume variation during positive-pressure ventilation
    Hyung Kook Kim
    Cardiopulmonary Research Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Crit Care Med 36:2858-62. 2008
    ..We hypothesized that the magnitude of pulse pressure variation would increase with sampling duration, and that both tidal volume and contractility would independently alter pulse pressure variation and stroke volume variation...
  20. ncbi Effects of continuous, expiratory, reverse, and bi-directional tracheal gas insufflation in conjunction with a flow relief valve on delivered tidal volume, total positive end-expiratory pressure, and carbon dioxide elimination: a bench study
    E Delgado
    Respiratory Care Department, University of Pittsburgh Medical Center, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Respir Care 46:577-85. 2001
    ..When TGI is delivered throughout the respiratory cycle, additional adjustments are needed to maintain tidal volume (V(T)) constant...
  21. ncbi Effects of modulation of left ventricular contractile state and loading conditions on tissue Doppler myocardial performance index
    Maxime Cannesson
    Cardiovascular Institute, University of Pittsburgh, Pittsburgh, PA 15213 2582, USA
    Am J Physiol Heart Circ Physiol 290:H1952-9. 2006
    ..All the above increases and decreases and r values were significant (P < 0.05 vs. baseline). In conclusion, TD MPI can rapidly quantify alterations in LV contractile state but is affected by acute alterations in preload and afterload...
  22. ncbi Dynamic effects of positive-pressure ventilation on canine left ventricular pressure-volume relations
    A Y Denault
    Cardiopulmonary Research Laboratory, Department of Anesthesiology and Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15261, USA
    J Appl Physiol 91:298-308. 2001
    ..The decreases in LV ESV exceed the amount explained solely by a reduction in LV ejection pressure...
  23. ncbi Cardiac contractility is not depressed in early canine endotoxic shock
    M R Pinsky
    Cardiopulmonary Research Laboratory and Department of Anesthesiology and Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Am J Respir Crit Care Med 161:1087-93. 2000
    ..The cardiovascular collapse seen during the first 4 h of endotoxemia is therefore not due even partly to alterations in LV contractility...
  24. ncbi Modeling of asynchronous myocardial contraction by effective stroke volume analysis
    D P Strum
    Cardiopulmonary Research Laboratory, Department of Anesthesiology and Critical Care Medicine, University of Pittsburgh, PA, USA
    Anesth Analg 90:243-51. 2000
    ..We conclude that effective SV and phase angle analysis are more sensitive measures of regional myocardial dysfunction when RWMA exist than are measures of maximal regional SV...
  25. ncbi Leukocyte activation in the peripheral blood of patients with cirrhosis of the liver and SIRS. Correlation with serum interleukin-6 levels and organ dysfunction
    A J Rosenbloom
    Department of Anesthesiology, University of Pittsburgh Medical Center, PA 15213, USA
    JAMA 274:58-65. 1995
    ..CONCLUSIONS--In human SIRS, the circulating monocyte and PMN pools undergo alterations suggestive of leukocyte activation, including up-regulation of PMN CD11b in correlation with the serum IL-6 level and severity of organ dysfunction...
  26. pmc Ability of pulse power, esophageal Doppler, and arterial pulse pressure to estimate rapid changes in stroke volume in humans
    Jose Marquez
    Departments of Anesthesiology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Crit Care Med 36:3001-7. 2008
    ..However, the accuracy of commercially available devices to report dynamic left ventricular stroke volume variation has never been validated...
  27. ncbi Differential effects of left ventricular pacing sites in an acute canine model of contraction dyssynchrony
    Lauren Johnson
    Cardiovascular Systems Laboratory, Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA
    Am J Physiol Heart Circ Physiol 293:H3046-55. 2007
    ..The dissociation between changes in synchrony and global LV performance with CRTf suggests that regional analysis from a single plane may not be sufficient to adequately characterize contraction synchrony...
  28. ncbi Color-coded tissue Doppler assessment of the effects of acute ischemia on regional left ventricular function: comparison with sonomicrometry
    J Gorcsan
    Division of Cardiology, University of Pittsburgh, Pennsylvania, USA
    J Am Soc Echocardiogr 14:335-42. 2001
    ..The delay in time to peak systolic velocity by TD and sonomicrometry were correlated (r = 0.75, P < .001). In conclusion, color-coded TD echocardiography has the potential to quantify regional LV function during coronary ischemia...
  29. ncbi Controlled observations in critical care medicine: the therapeutic trial
    M R Pinsky
    Department of Anesthesiology and Critical Care Medicine, University of Pittsburgh, PA, USA
    Ann Acad Med Singapore 27:387-96. 1998
    ..This review will focus on the exploratory aspect of clinical trials wherein a specific manoeuvre is performed to determine either the aetiology or severity of a pathophysiologic problem...
  30. ncbi Quality-adjusted survival in the first year after the acute respiratory distress syndrome
    D C Angus
    Critical Care Medicine Division, Department of Anesthesiology and Critical Care Medicine, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Am J Respir Crit Care Med 163:1389-94. 2001
    ..We conclude that ARDS developing in previously healthy patients is associated with poor quality-adjusted survival. These data are important for cost-effectiveness analyses and long-term care...
  31. ncbi Quantitative assessment of alterations in regional left ventricular contractility with color-coded tissue Doppler echocardiography. Comparison with sonomicrometry and pressure-volume relations
    J Gorcsan
    Division of Cardiology, University of Pittsburgh PA, USA
    Circulation 95:2423-33. 1997
    ..The objective of the present study was to evaluate endocardial velocity with TDI as a method of objectively quantifying alterations in regional contractility over a wide range induced by inotropic modulation...
  32. ncbi Monitoring and humidification during tracheal gas insufflation
    E Delgado
    Respiratory Care Department, University of Pittsburgh Medical Center, 200 Lothrop Street, Pittsburgh PA 15213
    Respir Care 46:185-92. 2001
    ..Finally, patients must be closely monitored for increases in peak inspiratory pressure from obstruction of the tracheal tube and should have the TGI catheter removed and inspected every 8-12 hours to assess for plugs...
  33. ncbi Clinical applications of cardiopulmonary interactions
    M R Pinsky
    Department of Anesthesiology and Critical Care Medicine, University of Pittsburgh and Oakland VA Medical Center, USA
    J Physiol Pharmacol 48:587-603. 1997
    ..In that regard, the initiation and withdrawal of ventilatory support can be seen as a ventilatory probe into the determinants of cardiovascular homeostasis in the ventilatory-dependent patient...
  34. ncbi Dysregulation of the immune response in severe sepsis
    Michael R Pinsky
    Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Am J Med Sci 328:220-9. 2004
    ..Successful clinical trials of novel treatments for the management of severe sepsis share a common ability to down-regulate this overall response, restoring normal proinflammatory responsiveness and mitochondrial energetic function...
  35. ncbi Assessment of indices of preload and volume responsiveness
    Michael R Pinsky
    Department of Critical Care Medicine, University of Pittsburgh, Pennsylvania 15261, USA
    Curr Opin Crit Care 11:235-9. 2005
    ..To summarize the relevant peer-reviewed publications over the past year that addressed issues of when to give (or not give) fluid to the critically ill patient...
  36. pmc Defining the incidence of cardiorespiratory instability in patients in step-down units using an electronic integrated monitoring system
    Marilyn Hravnak
    School of Nursing, University of Pittsburgh, 336 Victoria Bldg, 3500 Victoria St, Pittsburgh, PA 15261, USA
    Arch Intern Med 168:1300-8. 2008
    ..We undertook this study to characterize respiratory status in an SDU population, to define features of cardiorespiratory instability, and to evaluate an IMS index value that should trigger medical emergency team (MET) activation...
  37. ncbi Long-term mortality and quality of life after prolonged mechanical ventilation
    Lakshmipathi Chelluri
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, PA, USA
    Crit Care Med 32:61-9. 2004
    ..To describe and identify factors associated with mortality rate and quality of life 1 yr after prolonged mechanical ventilation...
  38. ncbi Goals of resuscitation from circulatory shock
    Michael R Pinsky
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Contrib Nephrol 144:94-104. 2004
  39. ncbi Cardiovascular issues in respiratory care
    Michael R Pinsky
    Bioengineering and Anesthesiology, Department of Critical Care Medicine, University of Pittsburgh Medical Center, 606 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15213, USA
    Chest 128:592S-597S. 2005
    ..In patients with hypervolemic heart failure, this afterload reducing effect can result in improved LV ejection, increased cardiac output, and reduced myocardial oxygen demand...
  40. pmc Functional hemodynamic monitoring
    Michael R Pinsky
    Department of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Crit Care 9:566-72. 2005
    ..Potentially, as these and newer, less invasive hemodynamic measures are validated, they could be incorporated into such protocolized care in a cost-effective manner...
  41. ncbi Ability of pulse contour and esophageal Doppler to estimate rapid changes in stroke volume
    Scott R Gunn
    Medical Center, Department of Critical Care Medicine, University of Pittsburgh, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Intensive Care Med 32:1537-46. 2006
    ..We tested these relationships in the setting of rapidly changing stroke volumes and different cardiovascular states over a period of 10-15 cardiac cycles...
  42. ncbi Estimating left ventricular contractility using inspiratory-hold maneuvers
    Hyung Kook Kim
    Cardiopulmonary Research Laboratory, Department of Critical Care Medicine, School of Medicine, University of Pittsburgh, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Intensive Care Med 33:181-9. 2007
    ..To compare estimates of left ventricular (LV) end-systolic elastance created by inferior vena caval (IVC) occlusion with those by apneic continuous positive airway pressure (CPAP)...
  43. ncbi Modeling ischemia-induced dyssynchronous myocardial contraction
    David P Strum
    Cardiopulmonary Research Laboratory, Department of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15261, USA
    Anesth Analg 103:846-53. 2006
    ..Potentially, phase angle and regional amplitude analyses may prove to be effective measures to identify and quantify the beneficial effects of resynchronization therapies on myocardial function...
  44. ncbi Pathophysiology of sepsis and multiple organ failure: pro- versus anti-inflammatory aspects
    Michael R Pinsky
    Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Contrib Nephrol 144:31-43. 2004
  45. pmc Tissue Doppler imaging of right ventricular decompensation in pulmonary hypertension
    Marc A Simon
    Cardiovascular Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Congest Heart Fail 15:271-6. 2009
    ..0001). RV free wall strain decreases in PH without hemodynamically decompensated RV function suggesting it may be a preceding step in the development of RV failure. This may be of particular use in following patients sequentially...
  46. ncbi Effect of tracheal gas insufflation during weaning from prolonged mechanical ventilation: a preliminary study
    Leslie A Hoffman
    Department of Acute Tertiary Care, University of Pittsburgh School of Nursing, Pittsburgh, PA, USA
    Am J Crit Care 12:31-9. 2003
    ..Tracheal gas insufflation reduces inspired tidal volume and minute ventilation in spontaneously breathing patients and may facilitate weaning from mechanical ventilation...
  47. ncbi Pulmonary artery occlusion pressure
    Michael R Pinsky
    Department of Critical Care Medicine, University of Pittsburgh Medical Center, 604 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Intensive Care Med 29:19-22. 2003
  48. ncbi Clinical significance of pulmonary artery occlusion pressure
    Michael R Pinsky
    Division of Coibical Care Medicine, 604 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Intensive Care Med 29:175-8. 2003
    ..Regrettably, under many common clinically relevant conditions, even when Ppao values are measured accurately, Ppao values at baseline and in response to therapy often reflect an inaccurate measure of cardiovascular status...
  49. pmc Why measure cardiac output?
    Michael R Pinsky
    Department of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Crit Care 7:114-6. 2003
  50. ncbi Rationale for cardiovascular monitoring
    Michael R Pinsky
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Curr Opin Crit Care 9:222-4. 2003
    ..Thus, their use in the management of the critically ill patient cannot be vigorously defended, except under specific conditions...
  51. ncbi Use of vasopressor agents in critically ill patients
    John A Kellum
    Department of Anesthesiology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Curr Opin Crit Care 8:236-41. 2002
    ..When used at doses necessary to reverse distributive shock, less potent vasoconstrictors (eg, dopamine) do not appear to be safer than more potent ones (eg, norepinephrine) and do not appear to be as effective...
  52. ncbi Hospital costs in patients receiving prolonged mechanical ventilation: does age have an impact?
    Lakshmipathi Chelluri
    Department of Critical Care Medicine, Room 637, 6th Floor Scaife, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
    Crit Care Med 31:1746-51. 2003
    ..The aging of the population is one of the causes of the increase in healthcare costs in the past few decades. It is controversial whether chronological age alone should be used in making healthcare decisions...
  53. ncbi Recent advances in the clinical application of heart-lung interactions
    Michael R Pinsky
    Department of Critical Care Medicine, University of Pittsburgh Medical Center, Pennsylvania, USA
    Curr Opin Crit Care 8:26-31. 2002
    ..This review illustrates several of these studies within the context of known cardiopulmonary physiology...
  54. pmc Phenotyping the right ventricle in patients with pulmonary hypertension
    Marc A Simon
    Cardiovascular Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Clin Transl Sci 2:294-9. 2009
    ..In PH, there are significant phenotypic abnormalities in the RV even in the absence of overt hemodynamic RV decompensation. Regional changes in RV structure and function may be early markers of patients at risk for developing RV failure...
  55. ncbi Probing chaos in search of health
    Michael R Pinsky
    Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Crit Care 18:163-5. 2003
  56. pmc Dynamic and site-specific impact of ventricular pacing on left ventricular ejection fraction
    David Schwartzman
    Cardiovascular Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Heart Rhythm 7:813-9. 2010
    ..Interactions between pacing site and LVEF remain unclear...
  57. ncbi Hemodynamic monitoring in the intensive care unit
    Michael R Pinsky
    Department of Critical Care Medicine, Bioengineering and Anesthesiology, University of Pittsburgh School of Medicine, 606 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Clin Chest Med 24:549-60. 2003
    ....
  58. pmc Quantifying the role of regional dyssynchrony on global left ventricular performance
    Bouchra Lamia
    Department of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    JACC Cardiovasc Imaging 2:1350-6. 2009
    ....
  59. ncbi Left ventricular pressure-volume relations with transesophageal echocardiographic automated border detection: comparison with conductance-catheter technique
    J Gorcsan
    Division of Cardiology, University of Pittsburgh Medical Center, Pennsylvania 15213-2582, USA
    Am Heart J 131:544-52. 1996
    ..92 mm Hg/ml versus 2.70 +/- 1.15 mm Hg/ml and 6.63 +/- 1.66 mm Hg/ml versus 3.20 +/- 1.37 mm Hg/ml (p<0.05), respectively. However, the direction and relative magnitude of changes in elastance with inotropic modulation were similar...
  60. ncbi Implications of arterial pressure variation in patients in the intensive care unit
    S R Gunn
    Department of Anesthesiology and Critical Care Medicine, University of Pittsburgh Medical Center, 605 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Curr Opin Crit Care 7:212-7. 2001
    ....
  61. pmc Evidence-based review of the use of the pulmonary artery catheter: impact data and complications
    Mehrnaz Hadian
    Department of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Crit Care 10:S8. 2006
    ....
  62. ncbi Thresholded area over the curve of spectrometric tissue oxygen saturation as an indicator of volume resuscitability in porcine hemorrhagic shock
    Sven Zenker
    Center for Inflammation and Regenerative Modeling CIRM, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Trauma 63:573-8; discussion 578-80. 2007
    ..We therefore explored the value of peripheral muscle Sto2 in predicting systemic responsiveness to colloid volume resuscitation in a porcine model of hemorrhagic shock...
  63. pmc Inflammatory markers at hospital discharge predict subsequent mortality after pneumonia and sepsis
    Sachin Yende
    The Clinical Research, Investigation, and Systems Modeling of Acute Illness CRISMA Laboratory, Department of Critical Care Medicine, Graduate School of Pubic Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Am J Respir Crit Care Med 177:1242-7. 2008
    ..Survivors of hospitalization for community-acquired pneumonia (CAP) are at increased risk of cardiovascular events, repeat infections, and death in the following months but the cause is unknown...
  64. ncbi Minimally invasive real time monitoring of mitochondrial NADH and tissue blood flow in the urethral wall during hemorrhage and resuscitation
    Julio A Clavijo
    Department of Critical Care Medicine and Surgery, University of Pittsburgh Medical Center, Presbyterian Hospital, Pittsburgh, PA, USA
    Med Sci Monit 14:BR175-82. 2008
    ..We hypothesized that changes in mitochondrial NADH and TBF are associated with impaired energy metabolism in the urethra and that these changes correlate with impaired tissue perfusion in the bladder during shock and resuscitation...
  65. doi Evolution of the intensive care unit as a clinical center and critical care medicine as a discipline
    Ake Grenvik
    Department of Critical Care Medicine, University of Pittsburgh, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Crit Care Clin 25:239-50, x. 2009
    ....
  66. ncbi Patients' recollections of stressful experiences while receiving prolonged mechanical ventilation in an intensive care unit
    Armando J Rotondi
    University of Pittsburgh, Pittsburgh, PA
    Crit Care Med 30:746-52. 2002
    ..To describe stressful experiences of adult patients who received mechanical ventilation for > or =48 hrs in an intensive care unit...
  67. ncbi Renal failure in the ICU: comparison of the impact of acute renal failure and end-stage renal disease on ICU outcomes
    Gilles Clermont
    Department of Critical Care Medicine and Renal Electrolyte Division, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Kidney Int 62:986-96. 2002
    ..We sought to determine the impact of renal dysfunction and/or loss of organ function on outcome...
  68. ncbi Effect of granulocyte-monocyte colony-stimulating factor therapy on leukocyte function and clearance of serious infection in nonneutropenic patients
    Alan J Rosenbloom
    Department of Critical Care Medicine, University of Pittsburgh Medical Center, 642 Scaife Hall, 3550 Terrace St, Pittsburgh, PA 15261
    Chest 127:2139-50. 2005
    ..We performed a clinical trial of GM-CSF in septic, hemodynamically stable patients to see whether GM-CSF treatment improved leukocyte function and mortality...
  69. pmc Effects of the components of positive airway pressure on work of breathing during bronchospasm
    Adelaida M Miro
    Cardiopulmonary Research Laboratory, Department of Anesthesiology Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Crit Care 8:R72-81. 2004
    ..Theoretically, expiratory positive airway pressure (EPAP), by reducing expiratory breaking, may be as important as inspiratory positive airway pressure (IPAP) in reducing work of breathing during acute bronchospasm...
  70. ncbi Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care
    D C Angus
    Critical Care Medicine Division, Department of Anesthesiology and Critical Care Medicine, and the Center for Research on Health Care, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 29:1303-10. 2001
    ..To determine the incidence, cost, and outcome of severe sepsis in the United States...
  71. ncbi Immune balance in critically ill patients
    M R Pinsky
    Department of Anesthesiology and Critical Care Medicine, University of Pittsburgh School of Medicine, PA, USA
    Arch Immunol Ther Exp (Warsz) 48:439-42. 2000
    ..Rather, there is a combined low grade pro-inflammatory state associated with an immune hyporesponsiveness that defines the usual immunologic state of the patient with severe sepsis...
  72. ncbi Quantifying learning in medical students during a critical care medicine elective: a comparison of three evaluation instruments
    P L Rogers
    Department of Anesthesiology and Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Crit Care Med 29:1268-73. 2001
    ..To compare three different evaluative instruments and determine which is able to measure different aspects of medical student learning...
  73. ncbi Suppression of cytokine-mediated beta2-integrin activation on circulating neutrophils in critically ill patients
    A J Rosenbloom
    Department of Anesthesiology and Critical Care Medicine, University of Pittsburgh School of Medicine, Pennsylvania, USA
    J Leukoc Biol 66:83-9. 1999
    ..We speculate that reduced CD11b responsiveness in SIRS contributes to the high risk of recurrent infection, but that it may also be protective against excessive PMN activation within the vascular space...
  74. ncbi Targets for resuscitation from shock
    M R Pinsky
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine Pittsburgh, PA 15261, USA
    Minerva Anestesiol 69:237-44. 2003
    ..Indirect signposts of adequate perfusion, such as venous O2 saturation, mentation, urine output and local measures of tissue blood flow are useful in monitoring this response...
  75. ncbi Genetic testing: costs and access to intensive care unit care
    Michael R Pinsky
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, PA, USA
    Crit Care Med 31:S411-5. 2003
    ..the greatest chance of benefit?" Similarly, as with other genetic predispositions such as cystic fibrosis and congenital hypercholesterolemia, to what extent should these data be available outside the patient-doctor relationship?..
  76. ncbi Let us use the pulmonary artery catheter correctly and only when we need it
    Michael R Pinsky
    Department of Critical Care Medicine, Bioengineering and Anesthesiology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Crit Care Med 33:1119-22. 2005
    ..To clarify the issues related to the use of the pulmonary artery catheter within a rational clinical perspective...
  77. pmc Informal caregiver burden among survivors of prolonged mechanical ventilation
    David C Van Pelt
    CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, 606D Scaife Hall, Pittsburgh, PA 15261, USA
    Am J Respir Crit Care Med 175:167-73. 2007
    ..In existing studies, it is unclear whether the observed burden is a consequence of critical illness or of preexisting patient illness...
  78. doi Use of non-invasive NIRS during a vascular occlusion test to assess dynamic tissue O(2) saturation response
    Hernando Gomez
    Department of Critical Care Medicine, Cardiopulmonary Research Laboratory, University of Pittsburgh, 606 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA, 15261, USA
    Intensive Care Med 34:1600-7. 2008
    ..We assessed tissue O(2) saturation (StO(2)) and total hemoglobin (HbT) changes during a vascular occlusion test (VOT) as markers of O(2) consumption and cardiovascular reserve...
  79. ncbi Reassessing the value of short-term mortality in sepsis: comparing conventional approaches to modeling
    Gilles Clermont
    Department of Critical Care Medicine, University of Pittsburgh, PA, USA
    Crit Care Med 31:2627-33. 2003
    ..This may be partly due to the use of insensitive mortality end points. We explored whether modeling survival was more sensitive than traditional end points in detecting mortality differences in cohorts of patients with sepsis...
  80. ncbi Utility of echocardiographic radial strain imaging to quantify left ventricular dyssynchrony and predict acute response to cardiac resynchronization therapy
    Kaoru Dohi
    University of Pittsburgh, Pennsylvania, USA
    Am J Cardiol 96:112-6. 2005
    ....
  81. pmc Hemodynamic monitoring over the past 10 years
    Michael R Pinsky
    University of Pittsburgh School of Medicine, 606 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Crit Care 10:117. 2006
    ..Novel monitoring will be driven more by its role in improving outcomes than in the technical abilities of the manufacturers...
  82. ncbi Functional hemodynamic monitoring
    Mehrnaz Hadian
    Department of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    Curr Opin Crit Care 13:318-23. 2007
    ..To assess the recent literature on effective use of information received from hemodynamic monitoring...
  83. ncbi Understanding the inflammatory cytokine response in pneumonia and sepsis: results of the Genetic and Inflammatory Markers of Sepsis (GenIMS) Study
    John A Kellum
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, 604 Scaife Hall, 3550 Terrace St, Pittsburgh, PA15261, USA
    Arch Intern Med 167:1655-63. 2007
    ..In this study we describe the systemic cytokine response to pneumonia and determine if specific patterns, including the balance of proinflammatory and anti-inflammatory markers, are associated with severe sepsis and death...
  84. ncbi Effects of radial left ventricular dyssynchrony on cardiac performance using quantitative tissue Doppler radial strain imaging
    Kaoru Dohi
    Division of Cardiovascular Disease, Critical Care Medicine Department, University of Pittsburgh, Pittsburgh, Pennsylvania 15213 2582, USA
    J Am Soc Echocardiogr 19:475-82. 2006
    ..05 individually, r = 0.80 overall) and stroke work (r = -0.88 +/- 0.12 individually, r = -0.82 overall). Angle-corrected radial strain imaging has clinical potential to quantify mechanical dyssynchrony and effects of biventricular pacing...
  85. pmc Insights into the effects of contraction dyssynchrony on global left ventricular mechano-energetic function
    Lauren Johnson
    Department of Bioengineering, Cardiovascular Systems Laboratory, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Pacing Clin Electrophysiol 32:224-33. 2009
    ..The effects of dyssynchrony on global left ventricular (LV) mechanics have been well documented; however, its impact on LV energetics has received less attention...
  86. ncbi Does acute organ dysfunction predict patient-centered outcomes?
    Gilles Clermont
    Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Division of General Internal Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Chest 121:1963-71. 2002
    ..Long-term patient-centered outcomes after acute illness may be associated with baseline health status, the development of acute organ dysfunction (AOD), or both...
  87. pmc Echocardiographic speckle tracking radial strain imaging to assess ventricular dyssynchrony in a pacing model of resynchronization therapy
    Masaki Tanabe
    The Cardiovascular Institute and Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Am Soc Echocardiogr 21:1382-8. 2008
    ..Our aim was to assess a new speckle tracking regional strain algorithm by comparison with angle-corrected tissue Doppler (TD) in an animal model of left bundle branch block and cardiac resynchronization therapy...
  88. pmc Peripheral vascular decoupling in porcine endotoxic shock
    Feras Hatib
    Edwards Lifesciences, Critical Care, Research and Development Department, Irvine, California, USA
    J Appl Physiol 111:853-60. 2011
    ....
  89. pmc Left ventricular systolic torsion correlates global cardiac performance during dyssynchrony and cardiac resynchronization therapy
    Bouchra Lamia
    Department of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, USA
    Am J Physiol Heart Circ Physiol 300:H853-8. 2011
    ..12, P = 0.61 and r = 0.08, P = 0.73, respectively). Thus, we conclude that LV torsion is primarily altered by dyssynchrony, and CRT that restores LV performance also restores torsion...
  90. pmc An adequately robust early TNF-alpha response is a hallmark of survival following trauma/hemorrhage
    Rajaie Namas
    Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    PLoS ONE 4:e8406. 2009
    ..Trauma/hemorrhagic shock (T/HS) results in cytokine-mediated acute inflammation that is generally considered detrimental...
  91. ncbi A new conceptual framework for ICU performance appraisal and improvement
    Armando J Rotondi
    Department of Critical Care Medicine, University of Pittsburgh, PA 15261, USA
    J Crit Care 17:16-28. 2002
    ..We reviewed the strengths and weaknesses of an outcomes-centered approach to intensive care unit (ICU) evaluation and present a more comprehensive conceptual framework for ICU evaluation and improvement...
  92. ncbi Physiologic endpoints (efficacy) for acute renal failure studies
    Patrick T Murray
    Department of Medicine, University of Chicago, Chicago, Illinois, USA
    Curr Opin Crit Care 8:519-25. 2002
    ..In this article, we present an approach to the choice of physiologic endpoints to determine the efficacy of interventions in acute renal failure...
  93. doi Is myocardial adrenergic responsiveness depressed in human septic shock?
    Alain Cariou
    Cochin Saint Vincent de Paul Hospital and Paris Descartes University, Paris, France
    Intensive Care Med 34:917-22. 2008
    ..To assess left ventricular (LV) contractile function and adrenergic responsiveness in septic patients...
  94. ncbi Probing the limits of arterial pulse contour analysis to predict preload responsiveness
    Michael R Pinsky
    Anesth Analg 96:1245-7. 2003
  95. ncbi The dynamic interface between hemodynamic variables and autonomic tone
    Michael R Pinsky
    Crit Care Med 33:2437-8. 2005
  96. ncbi Esophageal Doppler monitoring predicts fluid responsiveness in critically ill ventilated patients
    Xavier Monnet
    Service de Reanimation Medicale, Centre Hospitalo Universitaire de Bicêtre, Assistance Publique Hopitaux de Paris, Universite Paris XI, 78 rue du General Leclerc, 94270 Le Kremlin Bicetre, France
    Intensive Care Med 31:1195-201. 2005
    ..To test whether fluid responsiveness can be predicted by the respiratory variation in aortic blood flow and/or the flow time corrected for heart rate monitored with esophageal Doppler...
  97. ncbi Monitoring skeletal muscle and subcutaneous tissue acid-base status and oxygenation during hemorrhagic shock and resuscitation
    Julio A Clavijo-Alvarez
    Harvard Center for Minimally Invasive Surgery, Harvard University, Boston, Massachusetts, USA
    Shock 24:270-5. 2005
    ..The response of these indicators as potential surrogates of impaired tissue metabolism varies among tissues and according to the phases of hemorrhage or resuscitation...
  98. ncbi The classical Guyton view that mean systemic pressure, right atrial pressure, and venous resistance govern venous return is/is not correct
    Michael R Pinsky
    J Appl Physiol 101:1528. 2006
  99. ncbi Does dobutamine improve ventricular function in dogs with regional myocardial dysfunction?
    David P Strum
    Department of Anesthesiology and Critical Care Medicine, Kingston General Hospital, Queen s University, 76 Stuart Street, Kingston, Ontario K7L 2V7, Canada
    Anesth Analg 95:19-25, table of contents. 2002
    ..We concluded that systemic dobutamine restored global LV function but failed to correct RWMA...
  100. ncbi Using ventilation-induced aortic pressure and flow variation to diagnose preload responsiveness
    Michael R Pinsky
    Intensive Care Med 30:1008-10. 2004
  101. ncbi Effect of positive pressure on venous return in volume-loaded cardiac surgical patients
    Paul C M van den Berg
    Department of Intensive Care, Leiden University Medical Centre, 2300 RC Leiden, The Netherlands
    J Appl Physiol 92:1223-31. 2002
    ....

Research Grants6

  1. Quantifying Left Ventricular Ejection Effectiveness
    Michael Pinsky; Fiscal Year: 2007
    ..The ultimate goal of this proposal is to develop and validate an echocardiographic-based algorithm that quantifies LV ejection effectiveness by merging both power and synchrony of contraction into a common metric. ..