Raphael Pinaud

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. doi request reprint Detection of two mRNA species at single-cell resolution by double-fluorescence in situ hybridization
    Raphael Pinaud
    Department of Brain and Cognitive Sciences, University of Rochester, Rochester, New York 14627, USA
    Nat Protoc 3:1370-9. 2008
  2. pmc Genome of a songbird unveiled
    Raphael Pinaud
    Department of Brain and Cognitive Sciences, 117 Meliora Hall, River Campus, University of Rochester, Rochester, NY 14627, USA
    J Biol 9:19. 2010
  3. pmc Inhibitory network interactions shape the auditory processing of natural communication signals in the songbird auditory forebrain
    Raphael Pinaud
    Department of Brain and Cognitive Sciences, University of Rochester, Rochester, New York 14627, USA
    J Neurophysiol 100:441-55. 2008
  4. ncbi request reprint A songbird forebrain area potentially involved in auditory discrimination and memory formation
    Raphael Pinaud
    Department of Brain and Cognitive Sciences, University of Rochester, Rochester, NY 14627, USA
    J Biosci 33:145-55. 2008
  5. pmc Profiling of experience-regulated proteins in the songbird auditory forebrain using quantitative proteomics
    Raphael Pinaud
    Department of Brain and Cognitive Sciences, University of Rochester, Rochester, NY 14627, USA
    Eur J Neurosci 27:1409-22. 2008
  6. pmc GABA immunoreactivity in auditory and song control brain areas of zebra finches
    Raphael Pinaud
    Laboratory of Auditory and Vocal Learning, Neurological Sciences Institute, Oregon Health and Sciences University, Portland, OR, USA
    J Chem Neuroanat 34:1-21. 2007
  7. doi request reprint Estradiol shapes auditory processing in the adult brain by regulating inhibitory transmission and plasticity-associated gene expression
    Liisa A Tremere
    Department of Brain and Cognitive Sciences, University of Rochester, Rochester, New York 14627, USA
    J Neurosci 29:5949-63. 2009
  8. ncbi request reprint GABAergic neurons participate in the brain's response to birdsong auditory stimulation
    Raphael Pinaud
    Neurological Sciences Institute, Oregon Health and Science University, Portland 94006, USA
    Eur J Neurosci 20:1318-30. 2004
  9. ncbi request reprint Co-induction of activity-dependent genes in songbirds
    Tarciso A F Velho
    Neurological Sciences Institute, Oregon Health and Science University West Campus, 505 NW 185th Avenue, Beaverton, OR 97006, USA
    Eur J Neurosci 22:1667-78. 2005
  10. ncbi request reprint The excitatory thalamo-"cortical" projection within the song control system of zebra finches is formed by calbindin-expressing neurons
    Raphael Pinaud
    Neurological Sciences Institute, Oregon Health and Science University, Beaverton, Oregon 97006, USA
    J Comp Neurol 504:601-18. 2007

Research Grants

  1. Estrogen Modulation of Auditory Processing
    Raphael Pinaud; Fiscal Year: 2010

Collaborators

Detail Information

Publications25

  1. doi request reprint Detection of two mRNA species at single-cell resolution by double-fluorescence in situ hybridization
    Raphael Pinaud
    Department of Brain and Cognitive Sciences, University of Rochester, Rochester, New York 14627, USA
    Nat Protoc 3:1370-9. 2008
    ..Required controls, representative results and troubleshooting of important steps of this procedure are presented. After tissue sections are obtained, the total length of the procedure is 2-3 d...
  2. pmc Genome of a songbird unveiled
    Raphael Pinaud
    Department of Brain and Cognitive Sciences, 117 Meliora Hall, River Campus, University of Rochester, Rochester, NY 14627, USA
    J Biol 9:19. 2010
    ..An international collaborative effort has recently uncovered the genome of the zebra finch, a songbird model that has provided unique insights into an array of biological phenomena...
  3. pmc Inhibitory network interactions shape the auditory processing of natural communication signals in the songbird auditory forebrain
    Raphael Pinaud
    Department of Brain and Cognitive Sciences, University of Rochester, Rochester, New York 14627, USA
    J Neurophysiol 100:441-55. 2008
    ..Thus processing of learned natural communication sounds in songbirds, and possibly other vocal learners, may depend on complex interactions of inhibitory networks...
  4. ncbi request reprint A songbird forebrain area potentially involved in auditory discrimination and memory formation
    Raphael Pinaud
    Department of Brain and Cognitive Sciences, University of Rochester, Rochester, NY 14627, USA
    J Biosci 33:145-55. 2008
    ..We end this review by discussing evidence that suggests that NCM may be a site of auditory memory formation and/or storage...
  5. pmc Profiling of experience-regulated proteins in the songbird auditory forebrain using quantitative proteomics
    Raphael Pinaud
    Department of Brain and Cognitive Sciences, University of Rochester, Rochester, NY 14627, USA
    Eur J Neurosci 27:1409-22. 2008
    ....
  6. pmc GABA immunoreactivity in auditory and song control brain areas of zebra finches
    Raphael Pinaud
    Laboratory of Auditory and Vocal Learning, Neurological Sciences Institute, Oregon Health and Sciences University, Portland, OR, USA
    J Chem Neuroanat 34:1-21. 2007
    ..Our data are in accordance with a prominent role of GABAergic mechanisms in regulating the neural circuits involved in song perceptual processing, motor production, and vocal learning in songbirds...
  7. doi request reprint Estradiol shapes auditory processing in the adult brain by regulating inhibitory transmission and plasticity-associated gene expression
    Liisa A Tremere
    Department of Brain and Cognitive Sciences, University of Rochester, Rochester, New York 14627, USA
    J Neurosci 29:5949-63. 2009
    ..Our results reveal acute and rapid nongenomic functions for estradiol in central auditory physiology and suggest that such roles may be ubiquitously expressed across sensory systems...
  8. ncbi request reprint GABAergic neurons participate in the brain's response to birdsong auditory stimulation
    Raphael Pinaud
    Neurological Sciences Institute, Oregon Health and Science University, Portland 94006, USA
    Eur J Neurosci 20:1318-30. 2004
    ..Altogether, our results suggest that GABAergic mechanisms participate in auditory processing and perception, and might contribute to the memorization of birdsong...
  9. ncbi request reprint Co-induction of activity-dependent genes in songbirds
    Tarciso A F Velho
    Neurological Sciences Institute, Oregon Health and Science University West Campus, 505 NW 185th Avenue, Beaverton, OR 97006, USA
    Eur J Neurosci 22:1667-78. 2005
    ..They also demonstrate that genes representing distinct genomic and cellular regulatory programs, namely early effectors and transcription factors, are co-activated in the same neuronal cells by a naturally learned stimulus...
  10. ncbi request reprint The excitatory thalamo-"cortical" projection within the song control system of zebra finches is formed by calbindin-expressing neurons
    Raphael Pinaud
    Neurological Sciences Institute, Oregon Health and Science University, Beaverton, Oregon 97006, USA
    J Comp Neurol 504:601-18. 2007
    ..Our findings provide a clear-cut neurochemical signature for a critical projection in the songbird vocal control pathways that enable song learning...
  11. ncbi request reprint Disparity for disinhibitory and excitatory effects during cortical reorganization
    Liisa A Tremere
    CROET, OHSU, Portland, Oregon 97201, USA
    Int J Neurosci 116:547-64. 2006
    ..These findings suggest that recruitment of inhibition in reorganizing cells relies on activity-dependent mechanisms, with reinstatement of GABAergic transmission being secondary to the formation of novel glutamatergic drives...
  12. ncbi request reprint Song-induced gene expression: a window on song auditory processing and perception
    Claudio V Mello
    Laboratory of Vocal and Auditory Learning, Neurological Sciences Institute, Oregon Health and Science University, 505 NW 185th Avenue, West Campus, Bldg 1, Beaverton, OR 97006, USA
    Ann N Y Acad Sci 1016:263-81. 2004
    ....
  13. doi request reprint Postinhibitory rebound spikes are modulated by the history of membrane hyperpolarization in the SCN
    Liisa A Tremere
    CROET, OHSU, Portland, OR, USA
    Eur J Neurosci 28:1127-35. 2008
    ..Our results suggest that SCN neurons may use rebound spikes as one means of producing output signals from a largely interconnected network of GABAergic neurons...
  14. doi request reprint Bilateral multielectrode neurophysiological recordings coupled to local pharmacology in awake songbirds
    Liisa A Tremere
    Department of Brain and Cognitive Sciences, University of Rochester, Rochester, New York, USA
    Nat Protoc 5:191-200. 2010
    ..Representative results and troubleshooting of key steps of this protocol are presented. Following the animal's recovery from head-post and recording chamber implantation surgery, the length of the procedure is 2 d...
  15. ncbi request reprint Calbindin-positive neurons reveal a sexual dimorphism within the songbird analogue of the mammalian auditory cortex
    Raphael Pinaud
    Laboratory of Auditory and Vocal Learning, Neurological Sciences Institute, Oregon Health and Science University, Portland, Oregon 97006, USA
    J Neurobiol 66:182-95. 2006
    ..Our results also suggest that local sex steroid hormones may play a local role in auditory processing in the songbird telencephalon...
  16. ncbi request reprint Incongruent restoration of inhibitory transmission and general metabolic activity during reorganization of somatosensory cortex
    Liisa A Tremere
    CROET, Oregon Health and Science University, Portland, Oregon 97239, USA
    Int J Neurosci 115:1003-15. 2005
    ..The remaining GAD activity suggests that the absence of electrical activity, characteristic of reorganizing cortex, is likely to depend in part on lateral inhibitory cortical connections...
  17. ncbi request reprint Experience-dependent immediate early gene expression in the adult central nervous system: evidence from enriched-environment studies
    Raphael Pinaud
    Neurological Sciences Institute, Oregon Health and Science University, Portland, Oregon 97006, USA
    Int J Neurosci 114:321-33. 2004
    ..The relationships between the altered expression profiles for both genes in response to an EE exposure, and their putative role in orchestrating network restructuring in response to enhanced environmental complexity are discussed...
  18. ncbi request reprint Presynaptic Na+ channels: locus, development, and recovery from inactivation at a high-fidelity synapse
    Ricardo M Leão
    The Vollum Institute, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    J Neurosci 25:3724-38. 2005
    ..We propose that the high density and polarized locus of Na+ channels on a long heminode are critical design features that allow the mature calyx of Held terminal to fire reliably at frequencies near 1 kHz...
  19. ncbi request reprint Ngfi-a immunoreactivity in the primate retina: implications for genetic regulation of plasticity
    Raphael Pinaud
    Neurological Sciences Institute and The Vollum Institute, OHSU, Portland, Oregon 97006, USA
    Int J Neurosci 113:1275-85. 2003
    ....
  20. ncbi request reprint Recovery from amblyopia in adults via decreased visual cortical inhibition caused by experience in an enriched environment
    Liisa A Tremere
    Department of Brain and Cognitive Sciences, University of Rochester, Rochester, NY 14627, USA
    J Biosci 33:157-8. 2008
  21. doi request reprint Duplex in situ hybridization in the study of gene co-regulation in the vertebrate brain
    Raphael Pinaud
    Department of Brain and Cognitive Sciences, Center for Visual Science and Center for Navigation and Communication Sciences, University of Rochester, Rochester, NY, USA
    Methods Mol Biol 611:115-29. 2010
    ..Although this method has been optimized for brain sections, it may be useful to detect two mRNA species in a variety of tissues...
  22. ncbi request reprint Light-induced Egr-1 expression in the striate cortex of the opossum
    Raphael Pinaud
    Neurological Sciences Institute, Oregon Health and Science University, Portland, OR, USA
    Brain Res Bull 61:139-46. 2003
    ....
  23. pmc Alteration of cingulate long-term plasticity and behavioral sensitization to inflammation by environmental enrichment
    Fanny W F Shum
    Department of Physiology, Faculty of Medicine, University of Toronto, University of Toronto Centre for the Study of Pain, 1 King s College Circle, University of Toronto, Toronto, Canada
    Learn Mem 14:304-12. 2007
    ..Our findings suggest that exposure to EE alters physiological properties within the ACC which results in enhanced responses to inflammation...
  24. pmc Presynaptic regulation of the inhibitory transmission by GluR5-containing kainate receptors in spinal substantia gelatinosa
    Hui Xu
    Department of Physiology, Faculty of Medicine, University of Toronto, University of Toronto Centre for the Study of Pain, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    Mol Pain 2:29. 2006
    ..GluR5-containing KARs are thus important for spinal sensory transmission/modulation in the spinal cord...
  25. ncbi request reprint Plasticity-driven gene expression in the rat retina
    Raphael Pinaud
    Department of Anatomy and Neurobiology, Laboratory of Molecular Neurobiology, Dalhousie University, Nova Scotia B3H 4H7, Halifax, Canada
    Brain Res Mol Brain Res 98:93-101. 2002
    ..Our results suggest that both NGFI-A and Arc may regulate mechanisms of plasticity that had been invoked by heightened complexity of the visual environment...

Research Grants1

  1. Estrogen Modulation of Auditory Processing
    Raphael Pinaud; Fiscal Year: 2010
    ..In addition, we aim to understand how this hormone engages sensory-regulated, plasticity-associated gene expression, and ultimately modulates higher-order behaviors such as auditory discrimination. ..