J Richard Pilsner
Affiliation: University of Massachusetts
Wu H, Huffman A, Whitcomb B, Josyula S, Labrie S, Tougias E, et al
. Sperm mitochondrial DNA measures and semen parameters among men undergoing fertility treatment. Reprod Biomed Online. 2018;: pubmed publisher
..91), whereas sperm mtDNAdel had moderate predictive accuracy (C-statistic: 0.75). Sperm mtDNAcn is a measure of consecutive abnormal semen parameters and has promise as a diagnostic test. ..
Wu H, Hauser R, Krawetz S, Pilsner J. Environmental Susceptibility of the Sperm Epigenome During Windows of Male Germ Cell Development. Curr Environ Health Rep. 2015;2:356-66 pubmed publisher
..Moving forward, the nascent field of sperm epigenetics research is likely to advance our understanding of paternal environmental determinants of offspring health and development. ..
Huffman A, Wu H, Rosati A, Rahil T, Sites C, Whitcomb B, et al
. Associations of urinary phthalate metabolites and lipid peroxidation with sperm mitochondrial DNA copy number and deletions. Environ Res. 2018;163:10-15 pubmed publisher
..Given our relatively small sample size, our results should be interpreted with caution. Future research is needed to replicate the findings in larger studies and among sperm samples obtained from the general population. ..
Pilsner J, Shershebnev A, Medvedeva Y, Suvorov A, Wu H, Goltsov A, et al
. Peripubertal serum dioxin concentrations and subsequent sperm methylome profiles of young Russian adults. Reprod Toxicol. 2018;78:40-49 pubmed publisher
..Findings from our limited sample size suggest that peripubertal environmental exposures are associated with sperm DNA methylation in young adults. ..
Wu H, Olmsted A, Cantonwine D, Shahsavari S, Rahil T, Sites C, et al
. Urinary phthalate and phthalate alternative metabolites and isoprostane among couples undergoing fertility treatment. Environ Res. 2017;153:1-7 pubmed publisher
..Additional studies are needed to replicate our findings and to examine the potential health implications of the use of phthalates and alternative phthalates in consumer end products. ..
Wu H, Ashcraft L, Whitcomb B, Rahil T, Tougias E, Sites C, et al
. Parental contributions to early embryo development: influences of urinary phthalate and phthalate alternatives among couples undergoing IVF treatment. Hum Reprod. 2017;32:65-75 pubmed
..This work was generously supported by grant K22-ES023085 from the National Institute of Environmental Health Sciences. The authors declare no competing interests. N/A. ..
Pilsner J, Parker M, Sergeyev O, Suvorov A. Spermatogenesis disruption by dioxins: Epigenetic reprograming and windows of susceptibility. Reprod Toxicol. 2017;69:221-229 pubmed publisher
..This is supported by recent animal data that show that environmental conditions can cause epigenetic dysregulation in sperm in the context of specific windows of epigenetic reprogramming during spermatogenesis. ..
Suvorov A, Shershebnev A, Wu H, Medvedeva Y, Sergeyev O, Pilsner J. Perinatal exposure to low dose 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) alters sperm DNA methylation in adult rats. Reprod Toxicol. 2018;75:136-143 pubmed publisher
..Two DMRs overlapped between the two time-points. This is the first study to demonstrate that environmentally-relevant perinatal exposure to PBDE results in long-lasting changes in sperm DNA methylation. ..