Affiliation: University of California
- Performance of rapid point-of-care and laboratory tests for acute and established HIV infection in San FranciscoChristopher D Pilcher
HIV AIDS Division, University of California San Francisco, San Francisco, California, United States of America
PLoS ONE 8:e80629. 2013..Current laboratory and point-of-care tests for HIV detect different analytes and use different sample types. Some have fast turnaround times (<1 hour). We investigated how HIV test choice could impact case finding by testing programs...
- Adjusting for sampling variability in sparse data: geostatistical approaches to disease mappingKristen H Hampton
Department of Environmental Sciences and Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
Int J Health Geogr 10:54. 2011..The aim is to produce more reliable maps of disease rates in small areas to improve identification of spatial trends at the local level...
- Approaching "HIV elimination": interventions for acute HIV infectionChristopher D Pilcher
University of California San Francisco Health Program, San Francisco General Hospital, Ward 84, 995 Potrero Avenue, San Francisco, CA 94110, USA
Curr HIV/AIDS Rep 3:160-8. 2006....
- Public health rationale for rapid nucleic acid or p24 antigen tests for HIVChristopher D Pilcher
HIV AIDS Division, University of California, San Francisco, San Francisco, CA 94110, USA
J Infect Dis 201:S7-15. 2010..Finally, we suggest priorities in operations research that must be achieved to pave the way for the future introduction of direct rapid viral testing technologies in the HIV testing marketplace...
- Inferring HIV transmission dynamics from phylogenetic sequence relationshipsChristopher D Pilcher
University of California San Francisco, San Francisco, California, United States of America
PLoS Med 5:e69. 2008
- Challenges in detecting HIV persistence during potentially curative interventions: a study of the Berlin patientSteven A Yukl
San Francisco VA Medical Center and University of California, San Francisco, San Francisco, California, United States of America
PLoS Pathog 9:e1003347. 2013..The absence of recrudescent HIV replication and waning HIV-specific immune responses five years after withdrawal of treatment provide proof of a clinical cure...
- Amplified transmission of HIV-1: comparison of HIV-1 concentrations in semen and blood during acute and chronic infectionChristopher D Pilcher
Center for Infectious Diseases, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7030, USA
AIDS 21:1723-30. 2007..This study was conducted to compare viral dynamics in blood and semen between subjects with antibody negative, acute HIV-1 infection and other subjects with later stages of infection...
- Diagnosis and management of acute HIV infectionNicola M Zetola
Division of Infectious Diseases, University of California San Francisco, San Francisco, CA 94103, USA
Infect Dis Clin North Am 21:19-48, vii. 2007....
- Detection of acute infections during HIV testing in North CarolinaChristopher D Pilcher
Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, USA
N Engl J Med 352:1873-83. 2005..North Carolina has added nucleic acid amplification testing for the human immunodeficiency virus (HIV) to standard HIV antibody tests to detect persons with acute HIV infection who are viremic but antibody-negative...
- Comparison of group testing algorithms for case identification in the presence of test errorHae Young Kim
Department of Biostatistics, School of Public Health, University of North Carolina at Chapel Hill, 3107 E McGavran Greenberg Hall, Chapel Hill, North Carolina 27599, USA
Biometrics 63:1152-63. 2007..The methodology is illustrated by comparing different pooling algorithms for the detection of individuals recently infected with HIV in North Carolina and Malawi...
- Multiple V1/V2 env variants are frequently present during primary infection with human immunodeficiency virus type 1Kimberly Ritola
University of North Carolina at Chapel Hill, 22 062 Lineberger Cancer Center, CB 7295, Chapel Hill, NC 27599 7295, USA
J Virol 78:11208-18. 2004..Alternatively, the inefficient transfer of a multiply infected cell could account for both the low probability of transmission and the transfer of multiple variants...
- Improved detection of acute HIV-1 infection in sub-Saharan Africa: development of a risk score algorithmKimberly A Powers
Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina 27599 7435, USA
AIDS 21:2237-42. 2007..To facilitate the efficient use of these tests, we sought to develop a risk score algorithm for identifying likely AHI cases and targeting the tests towards those individuals...
- Frequent detection of acute HIV infection in pregnant womenKristine B Patterson
School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
AIDS 21:2303-8. 2007..Universal prenatal HIV antibody testing, which does not detect acute HIV, is standard for pregnant women in the United States. Unrecognized HIV acquisition during pregnancy may result in higher rates of perinatal transmission...
- Frequent detection of acute primary HIV infection in men in MalawiChristopher D Pilcher
Departments of Medicine and Epidemiology at the University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
AIDS 18:517-24. 2004..Acute (antibody-negative) HIV infection is associated with high transmission potential but is rarely recognized...
- Optimizing screening for acute human immunodeficiency virus infection with pooled nucleic acid amplification testsDaniel J Westreich
Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
J Clin Microbiol 46:1785-92. 2008..Used selectively and carefully, the simple models developed here can guide the selection of a pooling algorithm for the detection of AHI cases in a wide variety of settings...
- Real-time, universal screening for acute HIV infection in a routine HIV counseling and testing populationChristopher D Pilcher
Department of Medicien, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7030, USA
JAMA 288:216-21. 2002..However, HIV nucleic acid-based testing is widely used to screen for antibody-negative acute infection among low-risk blood donors...
- Rapid, real-time detection of acute HIV infection in patients in AfricaSusan A Fiscus
Department of Microbiology and Immunology, University of North Carolina UNC at Chapel Hill, Chapel Hill, NC 27599 7290, USA
J Infect Dis 195:416-24. 2007..We conducted a prospective study to evaluate methods of detecting clients with sexually transmitted diseases (STDs) who were acutely coinfected with human immunodeficiency virus (HIV) in Lilongwe, Malawi...
- The deadliest catch: fishing for HIV in new watersChristopher D Pilcher
Ann Intern Med 149:204-5. 2008
- Intensification of a triple-nucleoside regimen with tenofovir or efavirenz in HIV-1-infected patients with virological suppressionRoy M Gulick
Weill Medical College of Cornell University, 525 East 68th Street, New York, NY 10021, USA
AIDS 21:813-23. 2007..To compare a quadruple-nucleoside with an efavirenz-containing regimen for treatment of HIV-1 infection...
- Detection of acute HIV infections in an urban HIV counseling and testing population in the United StatesFrances H Priddy
Department of Medicine, Emory University, Atlanta, GA, USA
J Acquir Immune Defic Syndr 44:196-202. 2007..Antibody tests alone are insufficient for public health practice in high-risk urban HIV testing settings...
- Three- vs four-drug antiretroviral regimens for the initial treatment of HIV-1 infection: a randomized controlled trialRoy M Gulick
Cornell HIV Clinical Trials Unit, Division of International Medicine and Infectious Diseases, Weill Medical College of Cornell University, New York, NY, USA
JAMA 296:769-81. 2006..Three-drug antiretroviral regimens are standard of care for initial treatment of human immunodeficiency virus 1 (HIV-1) infection, but a 4-drug regimen could improve antiretroviral activity and be more effective than a 3-drug regimen...
- Diagnosing primary HIV infectionChristopher D Pilcher
Ann Intern Med 136:488-9; author reply 488-9. 2002
- Envelope diversity, coreceptor usage and syncytium-inducing phenotype of HIV-1 variants in saliva and blood during primary infectionStephanie A Freel
School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
AIDS 17:2025-33. 2003....
- Infrequent diagnosis of primary human immunodeficiency virus infection: missed opportunities in acute care settingsAmy C Weintrob
Department of Internal Medicine, Duke University Medical Center, Durham, NC 27710, USA
Arch Intern Med 163:2097-100. 2003..Human immunodeficiency virus is infrequently diagnosed during primary infection. More expeditious diagnosis of human immunodeficiency virus infection is a clinical and public health imperative...
- HIV infection: point-of-care testingBrian J Donovan
Infectious Diseases, Bristol Myers Squibb Company, Princeton, NJ 08543 4500, USA
Ann Pharmacother 38:670-6. 2004..To review the data regarding point-of-care testing for the diagnosis of HIV infection in the US...
- Acute HIV revisited: new opportunities for treatment and preventionChristopher D Pilcher
Department of Medicine, University of North Carolina at Chapel Hill, 27599 7215, USA
J Clin Invest 113:937-45. 2004..In this review article, we will highlight critical opportunities for HIV treatment and prevention that are presented by these diagnostic strategies...
- Absence of sustained hyperlactatemia in HIV-infected patients with risk factors for mitochondrial toxicityDavid A Wohl
Department of Medicine, University of North Carolina, Chapel Hill, USA
J Acquir Immune Defic Syndr 35:274-8. 2004..This variability may reflect differences in the definition of and risk factors for hyperlactatemia and/or techniques for venous lactate collection...
- Triple-nucleoside regimens versus efavirenz-containing regimens for the initial treatment of HIV-1 infectionRoy M Gulick
Weill Medical College of Cornell University, New York, USA
N Engl J Med 350:1850-61. 2004....
- Brief but efficient: acute HIV infection and the sexual transmission of HIVChristopher D Pilcher
Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
J Infect Dis 189:1785-92. 2004..We examined whether viral dynamics in the genital tract during the natural history of acute human immunodeficiency virus type 1 (HIV-1) infection could explain efficient heterosexual transmission of HIV...
- The unexpected movement of the HIV epidemic in the Southeastern United States: transmission among college studentsLisa B Hightow
Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
J Acquir Immune Defic Syndr 38:531-7. 2005..In early 2003, acute HIV infection was diagnosed in 2 men attending college in North Carolina. We describe an epidemiologic investigation of newly diagnosed HIV infection in men attending college in North Carolina...
- Amplified HIV transmission and new approaches to HIV preventionMyron S Cohen
J Infect Dis 191:1391-3. 2005
- Surveillance for HIV-1 incidence using tests for recent infection in resource-constrained countriesJ Steven McDougal
National Center for HIV AIDS, STD, TB Prevention, Centers for Disease Control and Prevention, US Public Health Service, Atlanta, GA 30333, USA
AIDS 19:S25-30. 2005....
- HIV antigens can induce TGF-beta(1)-producing immunoregulatory CD8+ T cellsMohammed L Garba
Department of Microbiology and Immunology, University of North Carolina, Chapel Hill NC 27599, USA
J Immunol 168:2247-54. 2002..This represents an important mechanism by which an HIV-specific response can nonspecifically suppress both HIV-specific and unrelated immune responses...
- CYTOREDUCTIVE CHEMOTHERAPY TARGETING HIV RESERVOIRSChristopher Pilcher; Fiscal Year: 2004..the PI with supervised laboratory experiences and didactic training in addition to a closely supervised clinical research experience, leading to R01 submission and establishment of the PI as an independent investigator ..
- Targeting Acute HIVChristopher Pilcher; Fiscal Year: 2007..Perform detailed cost effectiveness modeling in order to optimize acute HIV-centered efforts at HIV prevention. ..