Christopher D Pilcher

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. ncbi request reprint Brief but efficient: acute HIV infection and the sexual transmission of HIV
    Christopher D Pilcher
    Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    J Infect Dis 189:1785-92. 2004
  2. ncbi request reprint Detection of acute infections during HIV testing in North Carolina
    Christopher D Pilcher
    Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, USA
    N Engl J Med 352:1873-83. 2005
  3. ncbi request reprint Real-time, universal screening for acute HIV infection in a routine HIV counseling and testing population
    Christopher D Pilcher
    Department of Medicien, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7030, USA
    JAMA 288:216-21. 2002
  4. pmc Acute HIV revisited: new opportunities for treatment and prevention
    Christopher D Pilcher
    Department of Medicine, University of North Carolina at Chapel Hill, 27599 7215, USA
    J Clin Invest 113:937-45. 2004
  5. pmc Amplified transmission of HIV-1: comparison of HIV-1 concentrations in semen and blood during acute and chronic infection
    Christopher D Pilcher
    Center for Infectious Diseases, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7030, USA
    AIDS 21:1723-30. 2007
  6. pmc Improved detection of acute HIV-1 infection in sub-Saharan Africa: development of a risk score algorithm
    Kimberly A Powers
    Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina 27599 7435, USA
    AIDS 21:2237-42. 2007
  7. ncbi request reprint Frequent detection of acute HIV infection in pregnant women
    Kristine B Patterson
    School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    AIDS 21:2303-8. 2007
  8. ncbi request reprint Detection of acute HIV infections in an urban HIV counseling and testing population in the United States
    Frances H Priddy
    Department of Medicine, Emory University, Atlanta, GA, USA
    J Acquir Immune Defic Syndr 44:196-202. 2007
  9. pmc Targeted testing for acute HIV infection in North Carolina
    William C Miller
    Division of Infectious Diseases, Department of Medicine, School of Medicine, University of North Carolina at Chapel Hill, CB 7030, 130 Manning Drive, Chapel Hill, North Carolina 27599 7435, USA
    AIDS 23:835-43. 2009
  10. pmc Multiple V1/V2 env variants are frequently present during primary infection with human immunodeficiency virus type 1
    Kimberly Ritola
    University of North Carolina at Chapel Hill, 22 062 Lineberger Cancer Center, CB 7295, Chapel Hill, NC 27599 7295, USA
    J Virol 78:11208-18. 2004

Detail Information

Publications33

  1. ncbi request reprint Brief but efficient: acute HIV infection and the sexual transmission of HIV
    Christopher D Pilcher
    Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    J Infect Dis 189:1785-92. 2004
    ..We examined whether viral dynamics in the genital tract during the natural history of acute human immunodeficiency virus type 1 (HIV-1) infection could explain efficient heterosexual transmission of HIV...
  2. ncbi request reprint Detection of acute infections during HIV testing in North Carolina
    Christopher D Pilcher
    Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, USA
    N Engl J Med 352:1873-83. 2005
    ..North Carolina has added nucleic acid amplification testing for the human immunodeficiency virus (HIV) to standard HIV antibody tests to detect persons with acute HIV infection who are viremic but antibody-negative...
  3. ncbi request reprint Real-time, universal screening for acute HIV infection in a routine HIV counseling and testing population
    Christopher D Pilcher
    Department of Medicien, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7030, USA
    JAMA 288:216-21. 2002
    ..However, HIV nucleic acid-based testing is widely used to screen for antibody-negative acute infection among low-risk blood donors...
  4. pmc Acute HIV revisited: new opportunities for treatment and prevention
    Christopher D Pilcher
    Department of Medicine, University of North Carolina at Chapel Hill, 27599 7215, USA
    J Clin Invest 113:937-45. 2004
    ..In this review article, we will highlight critical opportunities for HIV treatment and prevention that are presented by these diagnostic strategies...
  5. pmc Amplified transmission of HIV-1: comparison of HIV-1 concentrations in semen and blood during acute and chronic infection
    Christopher D Pilcher
    Center for Infectious Diseases, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7030, USA
    AIDS 21:1723-30. 2007
    ..This study was conducted to compare viral dynamics in blood and semen between subjects with antibody negative, acute HIV-1 infection and other subjects with later stages of infection...
  6. pmc Improved detection of acute HIV-1 infection in sub-Saharan Africa: development of a risk score algorithm
    Kimberly A Powers
    Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina 27599 7435, USA
    AIDS 21:2237-42. 2007
    ..To facilitate the efficient use of these tests, we sought to develop a risk score algorithm for identifying likely AHI cases and targeting the tests towards those individuals...
  7. ncbi request reprint Frequent detection of acute HIV infection in pregnant women
    Kristine B Patterson
    School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    AIDS 21:2303-8. 2007
    ..Universal prenatal HIV antibody testing, which does not detect acute HIV, is standard for pregnant women in the United States. Unrecognized HIV acquisition during pregnancy may result in higher rates of perinatal transmission...
  8. ncbi request reprint Detection of acute HIV infections in an urban HIV counseling and testing population in the United States
    Frances H Priddy
    Department of Medicine, Emory University, Atlanta, GA, USA
    J Acquir Immune Defic Syndr 44:196-202. 2007
    ..Antibody tests alone are insufficient for public health practice in high-risk urban HIV testing settings...
  9. pmc Targeted testing for acute HIV infection in North Carolina
    William C Miller
    Division of Infectious Diseases, Department of Medicine, School of Medicine, University of North Carolina at Chapel Hill, CB 7030, 130 Manning Drive, Chapel Hill, North Carolina 27599 7435, USA
    AIDS 23:835-43. 2009
    ..The identification of these persons is a critical public health challenge. We developed targeted approaches for detecting HIV RNA in persons with negative serological tests...
  10. pmc Multiple V1/V2 env variants are frequently present during primary infection with human immunodeficiency virus type 1
    Kimberly Ritola
    University of North Carolina at Chapel Hill, 22 062 Lineberger Cancer Center, CB 7295, Chapel Hill, NC 27599 7295, USA
    J Virol 78:11208-18. 2004
    ..Alternatively, the inefficient transfer of a multiply infected cell could account for both the low probability of transmission and the transfer of multiple variants...
  11. ncbi request reprint Rapid, real-time detection of acute HIV infection in patients in Africa
    Susan A Fiscus
    Department of Microbiology and Immunology, University of North Carolina UNC at Chapel Hill, Chapel Hill, NC 27599 7290, USA
    J Infect Dis 195:416-24. 2007
    ..We conducted a prospective study to evaluate methods of detecting clients with sexually transmitted diseases (STDs) who were acutely coinfected with human immunodeficiency virus (HIV) in Lilongwe, Malawi...
  12. ncbi request reprint Frequent detection of acute primary HIV infection in men in Malawi
    Christopher D Pilcher
    Departments of Medicine and Epidemiology at the University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    AIDS 18:517-24. 2004
    ..Acute (antibody-negative) HIV infection is associated with high transmission potential but is rarely recognized...
  13. pmc Sexual partnership patterns in malawi: implications for HIV/STI transmission
    Kimberly A Powers
    Department s of Epidemiology, The University of North Carolina, Chapel Hill, NC 27599 7030, USA
    Sex Transm Dis 38:657-66. 2011
    ..To contribute to the understanding of sexual partnership patterns in this region, we estimated partnership lengths, temporal gaps between partners, and periods of overlap across partners at an STI clinic in Lilongwe, Malawi...
  14. pmc Optimizing screening for acute human immunodeficiency virus infection with pooled nucleic acid amplification tests
    Daniel J Westreich
    Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Clin Microbiol 46:1785-92. 2008
    ..Used selectively and carefully, the simple models developed here can guide the selection of a pooling algorithm for the detection of AHI cases in a wide variety of settings...
  15. ncbi request reprint The unexpected movement of the HIV epidemic in the Southeastern United States: transmission among college students
    Lisa B Hightow
    Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Acquir Immune Defic Syndr 38:531-7. 2005
    ..In early 2003, acute HIV infection was diagnosed in 2 men attending college in North Carolina. We describe an epidemiologic investigation of newly diagnosed HIV infection in men attending college in North Carolina...
  16. ncbi request reprint Comparison of group testing algorithms for case identification in the presence of test error
    Hae Young Kim
    Department of Biostatistics, School of Public Health, University of North Carolina at Chapel Hill, 3107 E McGavran Greenberg Hall, Chapel Hill, North Carolina 27599, USA
    Biometrics 63:1152-63. 2007
    ..The methodology is illustrated by comparing different pooling algorithms for the detection of individuals recently infected with HIV in North Carolina and Malawi...
  17. ncbi request reprint Envelope diversity, coreceptor usage and syncytium-inducing phenotype of HIV-1 variants in saliva and blood during primary infection
    Stephanie A Freel
    School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    AIDS 17:2025-33. 2003
    ....
  18. pmc Adjusting for sampling variability in sparse data: geostatistical approaches to disease mapping
    Kristen H Hampton
    Department of Environmental Sciences and Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Int J Health Geogr 10:54. 2011
    ..The aim is to produce more reliable maps of disease rates in small areas to improve identification of spatial trends at the local level...
  19. pmc Leveraging a rapid, round-the-clock HIV testing system to screen for acute HIV infection in a large urban public medical center
    Katerina A Christopoulos
    HIV AIDS Division, Department of Medicine, San Francisco General Hospital, University of California, San Francisco, San Francisco, CA 94114, USA
    J Acquir Immune Defic Syndr 62:e30-8. 2013
    ..To describe the prevalence and location of new and acute HIV diagnoses in a large urban medical center. Secondary objectives were to evaluate rapid HIV test performance, the added yield of acute HIV screening, and linkage-to-care outcomes...
  20. ncbi request reprint Absence of sustained hyperlactatemia in HIV-infected patients with risk factors for mitochondrial toxicity
    David A Wohl
    Department of Medicine, University of North Carolina, Chapel Hill, USA
    J Acquir Immune Defic Syndr 35:274-8. 2004
    ..This variability may reflect differences in the definition of and risk factors for hyperlactatemia and/or techniques for venous lactate collection...
  21. ncbi request reprint Diagnosis and management of acute HIV infection
    Nicola M Zetola
    Division of Infectious Diseases, University of California San Francisco, San Francisco, CA 94103, USA
    Infect Dis Clin North Am 21:19-48, vii. 2007
    ....
  22. ncbi request reprint Intensification of a triple-nucleoside regimen with tenofovir or efavirenz in HIV-1-infected patients with virological suppression
    Roy M Gulick
    Weill Medical College of Cornell University, 525 East 68th Street, New York, NY 10021, USA
    AIDS 21:813-23. 2007
    ..To compare a quadruple-nucleoside with an efavirenz-containing regimen for treatment of HIV-1 infection...
  23. ncbi request reprint HIV infection: point-of-care testing
    Brian J Donovan
    Infectious Diseases, Bristol Myers Squibb Company, Princeton, NJ 08543 4500, USA
    Ann Pharmacother 38:670-6. 2004
    ..To review the data regarding point-of-care testing for the diagnosis of HIV infection in the US...
  24. ncbi request reprint Triple-nucleoside regimens versus efavirenz-containing regimens for the initial treatment of HIV-1 infection
    Roy M Gulick
    Weill Medical College of Cornell University, New York, USA
    N Engl J Med 350:1850-61. 2004
    ....
  25. ncbi request reprint Surveillance for HIV-1 incidence using tests for recent infection in resource-constrained countries
    J Steven McDougal
    National Center for HIV AIDS, STD, TB Prevention, Centers for Disease Control and Prevention, US Public Health Service, Atlanta, GA 30333, USA
    AIDS 19:S25-30. 2005
    ....
  26. ncbi request reprint Three- vs four-drug antiretroviral regimens for the initial treatment of HIV-1 infection: a randomized controlled trial
    Roy M Gulick
    Cornell HIV Clinical Trials Unit, Division of International Medicine and Infectious Diseases, Weill Medical College of Cornell University, New York, NY, USA
    JAMA 296:769-81. 2006
    ..Three-drug antiretroviral regimens are standard of care for initial treatment of human immunodeficiency virus 1 (HIV-1) infection, but a 4-drug regimen could improve antiretroviral activity and be more effective than a 3-drug regimen...
  27. ncbi request reprint Approaching "HIV elimination": interventions for acute HIV infection
    Christopher D Pilcher
    University of California San Francisco Health Program, San Francisco General Hospital, Ward 84, 995 Potrero Avenue, San Francisco, CA 94110, USA
    Curr HIV/AIDS Rep 3:160-8. 2006
    ....
  28. ncbi request reprint Amplified HIV transmission and new approaches to HIV prevention
    Myron S Cohen
    J Infect Dis 191:1391-3. 2005
  29. pmc Inferring HIV transmission dynamics from phylogenetic sequence relationships
    Christopher D Pilcher
    University of California San Francisco, San Francisco, California, United States of America
    PLoS Med 5:e69. 2008
  30. ncbi request reprint The deadliest catch: fishing for HIV in new waters
    Christopher D Pilcher
    Ann Intern Med 149:204-5. 2008
  31. ncbi request reprint Infrequent diagnosis of primary human immunodeficiency virus infection: missed opportunities in acute care settings
    Amy C Weintrob
    Department of Internal Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Arch Intern Med 163:2097-100. 2003
    ..Human immunodeficiency virus is infrequently diagnosed during primary infection. More expeditious diagnosis of human immunodeficiency virus infection is a clinical and public health imperative...
  32. ncbi request reprint Diagnosing primary HIV infection
    Christopher D Pilcher
    Ann Intern Med 136:488-9; author reply 488-9. 2002
  33. ncbi request reprint HIV antigens can induce TGF-beta(1)-producing immunoregulatory CD8+ T cells
    Mohammed L Garba
    Department of Microbiology and Immunology, University of North Carolina, Chapel Hill NC 27599, USA
    J Immunol 168:2247-54. 2002
    ..This represents an important mechanism by which an HIV-specific response can nonspecifically suppress both HIV-specific and unrelated immune responses...