Malcolm Pike

Summary

Affiliation: University of Southern California
Country: USA

Publications

  1. ncbi request reprint A common 8q24 variant in prostate and breast cancer from a large nested case-control study
    Fredrick R Schumacher
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Cancer Res 67:2951-6. 2007
  2. pmc Polymorphisms in genes involved in estrogen and progesterone metabolism and mammographic density changes in women randomized to postmenopausal hormone therapy: results from a pilot study
    Sarah J Lord
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Breast Cancer Res 7:R336-44. 2005
  3. pmc Dense breast stromal tissue shows greatly increased concentration of breast epithelium but no increase in its proliferative activity
    Debra Hawes
    Department of Pathology, Keck School of Medicine, University of Southern California, 2011 Zonal Avenue, Los Angeles, CA 90089, USA
    Breast Cancer Res 8:R24. 2006
  4. pmc Reproductive factors and breast cancer risk according to joint estrogen and progesterone receptor status: a meta-analysis of epidemiological studies
    Huiyan Ma
    Department of Preventive Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue 4407, Los Angeles, CA 90089, USA
    Breast Cancer Res 8:R43. 2006
  5. pmc Greatly increased occurrence of breast cancers in areas of mammographically dense tissue
    Giske Ursin
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA
    Breast Cancer Res 7:R605-8. 2005
  6. pmc A comprehensive analysis of the androgen receptor gene and risk of breast cancer: results from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3)
    David G Cox
    Program in Molecular and Genetic Epidemiology, Epidemiology Department, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Breast Cancer Res 8:R54. 2006
  7. pmc A comprehensive analysis of common genetic variation in prolactin (PRL) and PRL receptor (PRLR) genes in relation to plasma prolactin levels and breast cancer risk: the multiethnic cohort
    Sulggi A Lee
    Department of Preventive Medicine, University of Southern California Keck School of Medicine, Norris Comprehensive Cancer Center, Los Angeles, CA, USA
    BMC Med Genet 8:72. 2007
  8. ncbi request reprint Prevention of cancers of the breast, endometrium and ovary
    Malcolm C Pike
    USC Norris Cancer Center, Los Angeles, CA, USA
    Oncogene 23:6379-91. 2004
  9. ncbi request reprint Hormonal factors and the risk of invasive ovarian cancer: a population-based case-control study
    Malcolm C Pike
    USC Norris Comprehensive Cancer Center, Keck School of Medicine, Department of Preventive Medicine, University of Southern California, Los Angeles, California 90033, USA
    Fertil Steril 82:186-95. 2004
  10. ncbi request reprint Breast cancer in a multiethnic cohort in Hawaii and Los Angeles: risk factor-adjusted incidence in Japanese equals and in Hawaiians exceeds that in whites
    Malcolm C Pike
    Department of Preventive Medicine, University of Southern California Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Cancer Epidemiol Biomarkers Prev 11:795-800. 2002

Detail Information

Publications79

  1. ncbi request reprint A common 8q24 variant in prostate and breast cancer from a large nested case-control study
    Fredrick R Schumacher
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Cancer Res 67:2951-6. 2007
    ..590). Although the gene responsible has yet to be identified, the validation of this marker in this large sample of prostate cancer cases leaves little room for the possibility of a false-positive result...
  2. pmc Polymorphisms in genes involved in estrogen and progesterone metabolism and mammographic density changes in women randomized to postmenopausal hormone therapy: results from a pilot study
    Sarah J Lord
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Breast Cancer Res 7:R336-44. 2005
    ..Identifying genetic variants that determine increases in mammographic density in hormone users may be important in understanding hormonal carcinogenesis of the breast...
  3. pmc Dense breast stromal tissue shows greatly increased concentration of breast epithelium but no increase in its proliferative activity
    Debra Hawes
    Department of Pathology, Keck School of Medicine, University of Southern California, 2011 Zonal Avenue, Los Angeles, CA 90089, USA
    Breast Cancer Res 8:R24. 2006
    ....
  4. pmc Reproductive factors and breast cancer risk according to joint estrogen and progesterone receptor status: a meta-analysis of epidemiological studies
    Huiyan Ma
    Department of Preventive Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue 4407, Los Angeles, CA 90089, USA
    Breast Cancer Res 8:R43. 2006
    ..This report presents the first meta-analysis of results from epidemiological studies that have investigated parity, age at first birth, breastfeeding, and age at menarche in relation to ER+PR+ and ER-PR- cancer risk...
  5. pmc Greatly increased occurrence of breast cancers in areas of mammographically dense tissue
    Giske Ursin
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA
    Breast Cancer Res 7:R605-8. 2005
    ..We addressed this question by studying ductal carcinoma in situ (DCIS), as revealed by microcalcifications...
  6. pmc A comprehensive analysis of the androgen receptor gene and risk of breast cancer: results from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3)
    David G Cox
    Program in Molecular and Genetic Epidemiology, Epidemiology Department, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Breast Cancer Res 8:R54. 2006
    ..Here, we report on the results of a large and comprehensive study of the association between genetic variation in the AR gene and risk of breast cancer in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3)...
  7. pmc A comprehensive analysis of common genetic variation in prolactin (PRL) and PRL receptor (PRLR) genes in relation to plasma prolactin levels and breast cancer risk: the multiethnic cohort
    Sulggi A Lee
    Department of Preventive Medicine, University of Southern California Keck School of Medicine, Norris Comprehensive Cancer Center, Los Angeles, CA, USA
    BMC Med Genet 8:72. 2007
    ..Prospective epidemiological studies have also shown that women with higher circulating PRL levels have an increase in risk of breast cancer, suggesting that variability in PRL may also be important in determining a woman's risk...
  8. ncbi request reprint Prevention of cancers of the breast, endometrium and ovary
    Malcolm C Pike
    USC Norris Cancer Center, Los Angeles, CA, USA
    Oncogene 23:6379-91. 2004
    ..Some recent epidemiological findings in endometrial and ovarian cancer suggest new avenues for possible chemoprevention of these cancers...
  9. ncbi request reprint Hormonal factors and the risk of invasive ovarian cancer: a population-based case-control study
    Malcolm C Pike
    USC Norris Comprehensive Cancer Center, Keck School of Medicine, Department of Preventive Medicine, University of Southern California, Los Angeles, California 90033, USA
    Fertil Steril 82:186-95. 2004
    ..To examine the influence of hormone-related factors on the risk of invasive epithelial ovarian cancer (ovarian cancer)...
  10. ncbi request reprint Breast cancer in a multiethnic cohort in Hawaii and Los Angeles: risk factor-adjusted incidence in Japanese equals and in Hawaiians exceeds that in whites
    Malcolm C Pike
    Department of Preventive Medicine, University of Southern California Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Cancer Epidemiol Biomarkers Prev 11:795-800. 2002
    ..The adjusted RR of NHs is 65% greater than that of Ws, and that of migrant Latinas is 16% lower than that of Ws. Elucidating the causes of the high rates in NHs is now a major focus of our efforts...
  11. pmc Estrogen-progestin replacement therapy: regulatory action needed
    Malcolm C Pike
    Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California 90033, USA
    Breast Cancer Res 4:222-3. 2002
    ..We should then act as if the effect on the marker is a quantitative guide to the probable effect on breast cancer risk. Regulatory authorities need to require such studies on all current regimens...
  12. ncbi request reprint Mammographic density and breast cancer in three ethnic groups
    Giske Ursin
    Department of Preventive Medicine, University of California Keck School of Medicine, Los Angeles, California 90089, USA
    Cancer Epidemiol Biomarkers Prev 12:332-8. 2003
    ..Furthermore, our findings suggest that mammographic density is as strong a predictor of risk for African-American and Asian-American women as for white women...
  13. ncbi request reprint Does mammographic density reflect ethnic differences in breast cancer incidence rates?
    Zhengjia Chen
    Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA, USA
    Am J Epidemiol 159:140-7. 2004
    ..This study suggests that absolute but not percent mammographic density reflects the lower breast cancer incidence rates of Asian Americans in relation to those of African Americans and Whites...
  14. ncbi request reprint Common genetic variation in IGF1 and prostate cancer risk in the Multiethnic Cohort
    Iona Cheng
    Department of Preventive Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    J Natl Cancer Inst 98:123-34. 2006
    ..Insulin-like growth factor I (IGF-I) appears to play a role in prostate development and carcinogenesis. We investigated whether genetic variation at the IGF1 locus is associated with prostate cancer risk...
  15. pmc Multiple regions within 8q24 independently affect risk for prostate cancer
    Christopher A Haiman
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA
    Nat Genet 39:638-44. 2007
    ..None of the prostate cancer risk variants aligns to a known gene or alters the coding sequence of an encoded protein...
  16. ncbi request reprint The association of endogenous sex steroids and sex steroid binding proteins with mammographic density: results from the Postmenopausal Estrogen/Progestin Interventions Mammographic Density Study
    Gail A Greendale
    Division of Geriatrics, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA 90095 1687, USA
    Am J Epidemiol 162:826-34. 2005
    ..These results suggest that some sex steroids may increase the risk of breast cancer by stimulating breast epithelial or stromal proliferation, which appears on a mammogram as higher density...
  17. ncbi request reprint Postmenopausal hormone therapy and change in mammographic density
    Gail A Greendale
    Division of Geriatric Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    J Natl Cancer Inst 95:30-7. 2003
    ..Mammographic density is an independent risk factor for breast cancer. Postmenopausal hormone use is associated with an increase in mammographic density, but the magnitude of the density increase is unknown...
  18. ncbi request reprint Steroid 5-alpha reductase type II V89L substitution is not associated with risk of prostate cancer in a multiethnic population study
    Celeste L Pearce
    Department of Preventive Medicine and USC Norris Comprehensive Cancer Center and Hospital, University of Southern California Keck School of Medicine, Los Angeles, California 90089 9176, USA
    Cancer Epidemiol Biomarkers Prev 11:417-8. 2002
  19. ncbi request reprint Galactose-1-phosphate uridyl transferase (GALT) genotype and phenotype, galactose consumption, and the risk of borderline and invasive ovarian cancer (United States)
    Wendy Cozen
    Department of Preventive Medicine, USC Keck School of Medicine, USC Norris Cancer Center, Los Angeles, CA 90033, USA
    Cancer Causes Control 13:113-20. 2002
    ..We examined these issues as part of a large case-control study of ovarian cancer conducted in Los Angeles between 1992 and 1998...
  20. ncbi request reprint Effect of reproductive hormones on ovarian epithelial tumors: I. Effect on cell cycle activity
    Hong Zhou
    Department of Pathology, USC Norris Comprehensive Cancer Center, Keck School of Medicine of University of Southern California, Los Angeles, California 90033, USA
    Cancer Biol Ther 1:300-6. 2002
    ..We conclude that P4 inhibits cell cycle activity in ovarian epithelial tumors, in part via down-regulation of the cdkl/cyclin B complex. This inhibitory effect may have therapeutic utility against ovarian epithelial tumors...
  21. pmc Long-term postmenopausal hormone therapy and endometrial cancer
    Pedram Razavi
    University of Southern California, Department of Preventive Medicine, Norris Comprehensive Cancer Center, Los Angeles, California, USA
    Cancer Epidemiol Biomarkers Prev 19:475-83. 2010
    ..These findings confirm that long-term use of ET, sequential EPT, or, among normal weight women, continuous-combined EPT is associated with increased risk of endometrial cancer...
  22. ncbi request reprint Postmenopausal hormone therapy and breast cancer risk: the Multiethnic Cohort
    Sulggi Lee
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Norris Comprehensive Cancer Center, 1441 Eastlake Avenue, Los Angeles, CA 90033 0800, USA
    Int J Cancer 118:1285-91. 2006
    ..There was little difference in risk by stage of disease or histologic subtype. The increase with EPT use was clearly seen in all 5 ethnic groups; and the increase with ET in 4 of the 5 groups...
  23. ncbi request reprint Body size, hormone therapy and risk of breast cancer in Asian-American women
    Anna H Wu
    Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA, USA
    Int J Cancer 120:844-52. 2007
    ..017). The increased risk associated with high body weight was observed irrespective of HT use. Use of HT and high body size might have contributed to the rapid increase of breast cancer in Asian-Americans...
  24. pmc Established risk factors account for most of the racial differences in cardiovascular disease mortality
    Sean O Henderson
    Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, California, United States of America
    PLoS ONE 2:e377. 2007
    ..Cardiovascular disease (CVD) mortality varies across racial and ethnic groups in the U.S., and the extent that known risk factors can explain the differences has not been extensively explored...
  25. ncbi request reprint A systematic assessment of common genetic variation in CYP11A and risk of breast cancer
    Veronica Wendy Setiawan
    Departments of Preventive Medicine and Urology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Cancer Res 66:12019-25. 2006
    ..Based on these findings, CYP11A deserves further consideration as a candidate breast cancer susceptibility gene...
  26. ncbi request reprint Genetic variation at the CYP19A1 locus predicts circulating estrogen levels but not breast cancer risk in postmenopausal women
    Christopher A Haiman
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90033, USA
    Cancer Res 67:1893-7. 2007
    ..Thus, although genetic variation in CYP19A1 produces measurable differences in estrogen levels among postmenopausal women, the magnitude of the change was insufficient to contribute detectably to breast cancer...
  27. ncbi request reprint Diabetes and risk of breast cancer in Asian-American women
    Anna H Wu
    Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA 90089, USA
    Carcinogenesis 28:1561-6. 2007
    ..08) than women without such a history after adjusting for BMI and WHR. Our results support the hypothesis that diabetes may have a role in the development of breast cancer, influencing risk via both sex hormone and insulin pathways...
  28. ncbi request reprint Tamoxifen, soy, and lifestyle factors in Asian American women with breast cancer
    Anna H Wu
    Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
    J Clin Oncol 25:3024-30. 2007
    ....
  29. ncbi request reprint Dietary fiber intake and endogenous serum hormone levels in naturally postmenopausal Mexican American women: the Multiethnic Cohort Study
    Kristine R Monroe
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA
    Nutr Cancer 58:127-35. 2007
    ..The suggestive findings relating increased estrogen levels to avocado and grapefruit intakes need confirmation...
  30. pmc Alcohol consumption and endometrial cancer risk: the multiethnic cohort
    Veronica Wendy Setiawan
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Int J Cancer 122:634-8. 2008
    ..Our results suggest that only alcohol consumption equivalent to 2 or more drinks per day increases risk of endometrial cancer in postmenopausal women...
  31. pmc Risk of urinary bladder cancer is associated with 8q24 variant rs9642880[T] in multiple racial/ethnic groups: results from the Los Angeles-Shanghai case-control study
    Victoria K Cortessis
    Department of Preventive Medicine, Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, 1441 Eastlake Ave, MC 9175, Los Angeles, CA 90089, USA
    Cancer Epidemiol Biomarkers Prev 19:3150-6. 2010
    ..Recent genome-wide association studies of urinary bladder cancer report risk to be associated with the T allele of rs9642880 on 8q24 among individuals of European descent...
  32. pmc Hypertension, diuretics and antihypertensives in relation to bladder cancer
    Xuejuan Jiang
    Department of Preventive Medicine, Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90089, USA
    Carcinogenesis 31:1964-71. 2010
    ..7 pg/g Hb) compared with individuals without hypertension (79.8 pg/g Hb) (P = 0.009). In conclusion, untreated hypertension was associated with a reduced risk of bladder cancer...
  33. pmc Sequence variant on 3q28 and urinary bladder cancer risk: findings from the Los Angeles-Shanghai bladder case-control study
    Mariana C Stern
    Department of Preventive Medicine, Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California 90089, USA
    Cancer Epidemiol Biomarkers Prev 18:3057-61. 2009
    ..045). Our results suggest that a TP63 gene variant may increase susceptibility for the development of urinary bladder tumors with low risk of progression...
  34. pmc Breast cancer risk factors defined by estrogen and progesterone receptor status: the multiethnic cohort study
    Veronica Wendy Setiawan
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Am J Epidemiol 169:1251-9. 2009
    ..0001). African Americans are more likely to be diagnosed with ER-/PR- tumors independently of stage at diagnosis, and there are disparate risk factor profiles across the ER/PR subtypes of breast cancer...
  35. doi request reprint Dietary patterns and breast cancer risk in Asian American women
    Anna H Wu
    Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA 90089, USA
    Am J Clin Nutr 89:1145-54. 2009
    ..The role of diet as a cause of breast cancer in Asian Americans has not been adequately studied...
  36. ncbi request reprint Progesterone and estrogen receptors in pregnant and premenopausal non-pregnant normal human breast
    DeShawn Taylor
    Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA
    Breast Cancer Res Treat 118:161-8. 2009
    ..Short-term changes in PRA expression while the chemoprevention is being administered may be a more useful marker...
  37. doi request reprint Increased ovarian cancer risk associated with menopausal estrogen therapy is reduced by adding a progestin
    Celeste Leigh Pearce
    Department of Preventive Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA
    Cancer 115:531-9. 2009
    ....
  38. doi request reprint Markers of inflammation and risk of ovarian cancer in Los Angeles County
    Anna H Wu
    Department of Preventive Medicine, University of Southern California, Keck School of Medicine, Los Angeles, CA 90089 9175, USA
    Int J Cancer 124:1409-15. 2009
    ..The NSAID finding was unexpected and suggests that factors associated with inflammation are associated with ovarian cancer risk. This result needs confirmation with careful attention to the reasons for NSAID use...
  39. pmc No association between the SRD5A2 gene A49T missense variant and prostate cancer risk: lessons learned
    C Leigh Pearce
    1Department of Preventive Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Hum Mol Genet 17:2456-61. 2008
    ..Overall, this report highlights the importance of rigorous genotyping quality control measures and replication efforts in genetic association studies...
  40. doi request reprint Comprehensive evaluation of ESR2 variation and ovarian cancer risk
    Celeste Leigh Pearce
    USC Norris Comprehensive Cancer Center and Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90089, USA
    Cancer Epidemiol Biomarkers Prev 17:393-6. 2008
    ..28-11.73; P = 0.016). Haplotype D was also reported by the BPC3 to be associated with increased risk of breast cancer. This haplotype warrants further investigation to rule out any effect with invasive ovarian cancer risk...
  41. pmc Interleukin-2, interleukin-12, and interferon-gamma levels and risk of young adult Hodgkin lymphoma
    Wendy Cozen
    Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles 90089 9175, USA
    Blood 111:3377-82. 2008
    ..8-fold (P=.03) increase in YAHL risk. Thus, both case-twins and their unaffected cotwins had a decreased ability to produce IL-12, which may contribute to YAHL susceptibility...
  42. ncbi request reprint CYP17 genetic variation and risk of breast and prostate cancer from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3)
    Veronica Wendy Setiawan
    Department of Preventive Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Cancer Epidemiol Biomarkers Prev 16:2237-46. 2007
    ..Our findings do not support the hypothesis that common germ line variation in CYP17 makes a substantial contribution to postmenopausal breast or prostate cancer susceptibility...
  43. pmc Genetic variations on chromosomes 5p15 and 15q25 and bladder cancer risk: findings from the Los Angeles-Shanghai bladder case-control study
    Manuela Gago-Dominguez
    Department of Preventive Medicine, Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90089 9175, USA
    Carcinogenesis 32:197-202. 2011
    ..26; 95% CI, 1.04-1.54; P = 0.017). Our results support 5p15 and 15q25 as susceptibility regions for bladder cancer risk...
  44. ncbi request reprint Racial/ethnic differences in endometrial cancer risk: the multiethnic cohort study
    Veronica Wendy Setiawan
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Am J Epidemiol 165:262-70. 2007
    ..92) for Latinas. Results from this study show that the interethnic differences in endometrial cancer risk do not appear to be explained by differences in the distribution of known risk factors among women of different races/ethnicities...
  45. ncbi request reprint Ethnic differences in neuroendocrine cell expression in normal human prostatic tissue
    Siamak Daneshmand
    Department of Urology, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA
    Urology 65:1008-12. 2005
    ..To determine whether any differences exist in neuroendocrine (NE) cell differentiation in normal prostates among various ethnic groups because the incidence and mortality from prostate cancer vary across racial groups...
  46. ncbi request reprint Urinary 2-hydroxyestrone/16alpha-hydroxyestrone ratio and family history of breast cancer in premenopausal women
    Giske Ursin
    Department of Preventive Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles 90089, USA
    Breast Cancer Res Treat 72:139-43. 2002
    ..Our data suggest that among premenopausal women, family history is not associated with higher urinary estrogen levels or a lower ratio of urinary 2-OHE1/16alpha-OHE1...
  47. ncbi request reprint Clarifying the PROGINS allele association in ovarian and breast cancer risk: a haplotype-based analysis
    Celeste Leigh Pearce
    Department of Preventive Medicine, Norris Comprehensive Cancer Center, University of Southern California, Keck School of Medicine, Los Angeles, CA 90089, USA
    J Natl Cancer Inst 97:51-9. 2005
    ..We set out to refine the association between common variation at the PGR gene locus and these two diseases...
  48. ncbi request reprint Post-treatment change in serum estrone predicts mammographic percent density changes in women who received combination estrogen and progestin in the Postmenopausal Estrogen/Progestin Interventions (PEPI) Trial
    Giske Ursin
    Department of Preventive Medicine, Norris Comprehensive Cancer Center, Room 4407, USC Keck School of Medicine, 1441 Eastlake Avenue, Los Angeles, CA 90089, USA
    J Clin Oncol 22:2842-8. 2004
    ..We determined whether increases in serum estrone as a function of treatment predict increases in mammographic percent density...
  49. ncbi request reprint IL-6 levels and genotype are associated with risk of young adult Hodgkin lymphoma
    Wendy Cozen
    Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA, USA
    Blood 103:3216-21. 2004
    ..29; P =.03). Risk was decreased for both nodular sclerosis and other subtypes. Persons with genetically determined lower IL-6 levels may be less susceptible to young adult Hodgkin lymphoma...
  50. ncbi request reprint A comprehensive haplotype analysis of CYP19 and breast cancer risk: the Multiethnic Cohort
    Christopher A Haiman
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, USC Norris Comprehensive Cancer Center, 1441 Eastlake Ave, Rm 4441, Los Angeles, CA 90089 9175, USA
    Hum Mol Genet 12:2679-92. 2003
    ..31; 95% CI, 1.11-1.54). Our findings suggest the hypothesis that women with the long-range CYP19 haplotype 2b-3c may be carriers of a predisposing breast cancer susceptibility allele...
  51. ncbi request reprint Choosing haplotype-tagging SNPS based on unphased genotype data using a preliminary sample of unrelated subjects with an example from the Multiethnic Cohort Study
    Daniel O Stram
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, Calif 90033, USA
    Hum Hered 55:27-36. 2003
    ..A candidate set of htSNPS of a given size is chosen so as to maximize the minimum value of R2h over the common haplotypes, h...
  52. ncbi request reprint Correlation of dietary intake and colorectal cancer incidence among Mexican-American migrants: the multiethnic cohort study
    Kristine R Monroe
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA
    Nutr Cancer 45:133-47. 2003
    ....
  53. ncbi request reprint Green tea and risk of breast cancer in Asian Americans
    Anna H Wu
    Department of Preventive Medicine, University of Southern California, Keck School of Medicine, Los Angeles, CA, USA
    Int J Cancer 106:574-9. 2003
    ..In summary, our results point to an important role of both green tea and soy intake in relation to breast cancer risk in Asian-American women...
  54. ncbi request reprint Does menopausal hormone replacement therapy interact with known factors to increase risk of breast cancer?
    Giske Ursin
    Department of Preventive Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA 90089, USA
    J Clin Oncol 20:699-706. 2002
    ....
  55. ncbi request reprint Adolescent and adult soy intake and risk of breast cancer in Asian-Americans
    Anna H Wu
    Department of Preventive Medicine, University of Southern California, Keck School of Medicine, Los Angeles, CA, USA
    Carcinogenesis 23:1491-6. 2002
    ..These results show that high soy intake in childhood in Asian-Americans is associated with reduced breast cancer risk. Risk may be further reduced by intake as an adult...
  56. ncbi request reprint A controlled 2-mo dietary fat reduction and soy food supplementation study in postmenopausal women
    Anna H Wu
    Department of Preventive Medicine, University of Southern California Norris Comprehensive Cancer Center, Keck School of Medicine, Los Angeles, CA 90089 9175, USA
    Am J Clin Nutr 81:1133-41. 2005
    ..Low intake of dietary fat and high intake of soy foods have been suggested to partly explain the lower breast cancer rates in Asia, perhaps because of lower endogenous estrogens...
  57. ncbi request reprint Comparison of prostate-specific antigen and hormone levels among men in Singapore and the United States
    Iona Cheng
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, USC Norris Comprehensive Cancer Center, 1441 Eastlake Avenue, Los Angeles, CA, 90089 9175, USA
    Cancer Epidemiol Biomarkers Prev 14:1692-6. 2005
    ..Given that the overall mortality rate of prostate cancer in Singapore is low, these undiagnosed cancers may be of nonaggressive type. Alternatively, PSA may be a poor marker of prostate cancer in this low-risk population...
  58. ncbi request reprint Role of lipid peroxidation in the epidemiology and prevention of breast cancer
    Manuela Gago-Dominguez
    USC Norris Comprehensive Cancer Center, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90089 9181, USA
    Cancer Epidemiol Biomarkers Prev 14:2829-39. 2005
    ....
  59. ncbi request reprint BRCA1 and BRCA2 mutation carriers, oral contraceptive use, and breast cancer before age 50
    Robert W Haile
    Department of Preventive Medicine, University of Southern California Keck School of Medicine, 1441 Eastlake Avenue, MS 9175, Los Angeles, CA 90089 9175, USA
    Cancer Epidemiol Biomarkers Prev 15:1863-70. 2006
    ..Understanding the effect of oral contraceptives on risk of breast cancer in BRCA1 or BRCA2 mutation carriers is important because oral contraceptive use is a common, modifiable practice...
  60. ncbi request reprint Ethnic and racial differences in the smoking-related risk of lung cancer
    Christopher A Haiman
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Norris Comprehensive Cancer Center, Los Angeles, CA 90089 9175, USA
    N Engl J Med 354:333-42. 2006
    ..There is remarkable variation in the incidence of lung cancer among ethnic and racial groups in the United States...
  61. ncbi request reprint Prostate cancer incidence and intake of fruits, vegetables and related micronutrients: the multiethnic cohort study* (United States)
    Daniel O Stram
    Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Cancer Causes Control 17:1193-207. 2006
    ..To describe the relationship between the intake of fruits, vegetables, and related vitamins and antioxidants, and the risk of prostate cancer in male participants in a large multiethnic cohort study...
  62. doi request reprint Ethnic differences in the use of regular mammography: the multiethnic cohort
    Quannetta T Edwards
    Department of Clinical Cancer Genetics, City of Hope National Medical Center, Duarte, CA, USA
    Breast Cancer Res Treat 115:163-70. 2009
    ....
  63. pmc Changes in the mouse estrus cycle in response to BRCA1 inactivation suggest a potential link between risk factors for familial and sporadic ovarian cancer
    Hao Hong
    Department of Pathology, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Cancer Res 70:221-8. 2010
    ....
  64. ncbi request reprint The role of mammographic density in evaluating changes in breast cancer risk
    Malcolm C Pike
    USC Norris Comprehensive Cancer Center, Los Angeles, CA 90033, USA
    Gynecol Endocrinol 21:1-5. 2005
    ....
  65. ncbi request reprint Cell-nonautonomous induction of ovarian and uterine serous cystadenomas in mice lacking a functional Brca1 in ovarian granulosa cells
    Rajas Chodankar
    Department of Pathology, University of Southern California Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California 90033, USA
    Curr Biol 15:561-5. 2005
    ..These tumors carried normal Brca1 alleles, supporting the view that Brca1 may influence tumor development indirectly, possibly through an effector secreted by granulosa cells...
  66. ncbi request reprint Reduced mammographic density with use of a gonadotropin-releasing hormone agonist-based chemoprevention regimen in BRCA1 carriers
    Jeffrey N Weitzel
    Department of Clinical Cancer Genetics, City of Hope Cancer Center, 1500 East Duarte Road, Duarte, CA 91010, USA
    Clin Cancer Res 13:654-8. 2007
    ..We evaluated the efficacy, safety, and tolerability of hormonal chemoprevention with a gonadotropin-releasing hormone agonist (GnRHA) with low-dose add-back steroids in BRCA1(mut) carriers...
  67. ncbi request reprint Haplotype analysis of the HSD17B1 gene and risk of breast cancer: a comprehensive approach to multicenter analyses of prospective cohort studies
    Heather Spencer Feigelson
    Department of Epidemiology and Surveillance Research, American Cancer Society, National Home Office, Atlanta, Georgia 30329, USA
    Cancer Res 66:2468-75. 2006
    ..Although the probability that these ER-negative findings are false-positive results is high, these findings were consistent across each cohort examined and warrant further study...
  68. ncbi request reprint Tagging single nucleotide polymorphisms in cell cycle control genes and susceptibility to invasive epithelial ovarian cancer
    Simon A Gayther
    Translational Research Laboratories, University College London, London, United Kingdom
    Cancer Res 67:3027-35. 2007
    ..This study highlights the need for multicenter collaborations for genetic association studies...
  69. pmc Haplotypes of the estrogen receptor beta gene and breast cancer risk
    David G Cox
    Program in Molecular and Genetic Epidemiology, Epidemiology Department, Harvard School of Public Health, Boston, MA, USA
    Int J Cancer 122:387-92. 2008
    ..These data suggest that inherited variants in ESR2 (while possibly conferring a small increased risk of breast cancer) are not associated with appreciable (OR > 1.2) changes in breast cancer risk among Caucasian women...
  70. ncbi request reprint Urinary estrogen metabolites and their ratio among Asian American women
    Roni T Falk
    Environmental Epidemiology Branch, National Cancer Institute, 6120 Executive Boulevard, MSC 7234, Suite 7070, Bethesda, MD 20892, USA
    Cancer Epidemiol Biomarkers Prev 14:221-6. 2005
    ..Our study suggests that the ratio of 2-OHE(1):16alpha-OHE(1) may be a marker for lifestyle influences on estrogen metabolism associated with westernization...
  71. ncbi request reprint Association of vegetable, fruit, and grain intakes with colorectal cancer: the Multiethnic Cohort Study
    Abraham M Y Nomura
    Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI 96813, USA
    Am J Clin Nutr 88:730-7. 2008
    ..It is uncertain whether or not vegetables, fruit, or grains protect against colorectal cancer...
  72. pmc IGF-1, IGFBP-1, and IGFBP-3 polymorphisms predict circulating IGF levels but not breast cancer risk: findings from the Breast and Prostate Cancer Cohort Consortium (BPC3)
    Alpa V Patel
    Department of Epidemiology and Surveillance Research, American Cancer Society, Atlanta, Georgia, United States of America
    PLoS ONE 3:e2578. 2008
    ..In summary, the impact of genetic variation in IGF1 and IGFBP3 on circulating IGF levels does not appear to substantially influence breast cancer risk substantially among primarily Caucasian postmenopausal women...
  73. pmc Genetic variation in the HSD17B1 gene and risk of prostate cancer
    Peter Kraft
    Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America
    PLoS Genet 1:e68. 2005
    ..These results suggest that the germline variants in HSD17B1 characterized by these htSNPs do not substantially influence the risk of prostate cancer in U.S. and European whites...
  74. pmc Consortium analysis of 7 candidate SNPs for ovarian cancer
    Susan J Ramus
    Translational Research Laboratory, University College London EGA Institute for Women s Health, London, United Kingdom
    Int J Cancer 123:380-8. 2008
    ..These null results for SNPs identified from relatively large initial studies shows the importance of replicating associations by a consortium approach...
  75. ncbi request reprint Nonsteroidal antiinflammatory drugs and breast cancer risk: the multiethnic cohort
    Jasmeet K Gill
    Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI, USA
    Am J Epidemiol 166:1150-8. 2007
    ..This study found duration of current other NSAID use to be protective against breast cancer risk...
  76. doi request reprint Does breast size modify the association between mammographic density and breast cancer risk?
    Anne Stuedal
    Department of Nutrition, University of Oslo, Oslo, Norway
    Cancer Epidemiol Biomarkers Prev 17:621-7. 2008
    ..S. women. Because African American women have a larger breast size, we assessed whether the association between mammographic density and breast cancer was less apparent in large than in small breasts...
  77. ncbi request reprint Dietary fiber and colorectal cancer risk: the multiethnic cohort study
    Abraham M Y Nomura
    Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI 96813, USA
    Cancer Causes Control 18:753-64. 2007
    ..To investigate the association of dietary fiber with colorectal cancer..
  78. doi request reprint Predictors of the timing of natural menopause in the Multiethnic Cohort Study
    Katherine Delellis Henderson
    Department of Cancer Etiology, City of Hope National Medical Center, Duarte, CA 91010, USA
    Am J Epidemiol 167:1287-94. 2008
    ..21, 1.30) and later among Japanese Americans (HR = 0.93, 95% CI: 0.90, 0.95). These results support the hypothesis that the timing of natural menopause is driven by a combination of genetic, reproductive, and lifestyle factors...
  79. ncbi request reprint Maternal risk factors for testicular cancer: a population-based case-control study (UK)
    Carol A C Coupland
    Division of Primary Care, School of Community Health Sciences, University of Nottingham, UK
    Cancer Causes Control 15:277-83. 2004
    ..To investigate the role of a range of maternal and pre-natal characteristics as potential risk factors for testicular cancer...

Research Grants5

  1. GENETIC & ENVIRONMENTAL RISK FACTORS FOR BLADDER CANCER
    Malcolm Pike; Fiscal Year: 2009
    ..The ultimate goal of this research is to assess individual bladder cancer risk for the purpose of preventive interventions. ..
  2. GENETIC & ENVIRONMENTAL RISK FACTORS FOR BLADDER CANCER
    Malcolm Pike; Fiscal Year: 2006
    ..The ultimate goal of this research is to assess individual bladder cancer risk for the purpose of preventive interventions. ..
  3. GENETIC & ENVIRONMENTAL RISK FACTORS FOR BLADDER CANCER
    Malcolm Pike; Fiscal Year: 2007
    ..The ultimate goal of this research is to assess individual bladder cancer risk for the purpose of preventive interventions. ..
  4. GENETIC & ENVIRONMENTAL RISK FACTORS FOR BLADDER CANCER
    Malcolm Pike; Fiscal Year: 2009
    ..The ultimate goal of this research is to assess individual bladder cancer risk for the purpose of preventive interventions. ..