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Genomes and GenesSpecies | Malcolm PikeSummaryAffiliation: University of Southern California Country: USA Publications
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Publications
A common 8q24 variant in prostate and breast cancer from a large nested case-control studyFredrick R Schumacher
Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
Cancer Res 67:2951-6. 2007..590). Although the gene responsible has yet to be identified, the validation of this marker in this large sample of prostate cancer cases leaves little room for the possibility of a false-positive result...
Polymorphisms in genes involved in estrogen and progesterone metabolism and mammographic density changes in women randomized to postmenopausal hormone therapy: results from a pilot studySarah J Lord
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
Breast Cancer Res 7:R336-44. 2005..Identifying genetic variants that determine increases in mammographic density in hormone users may be important in understanding hormonal carcinogenesis of the breast...- Dense breast stromal tissue shows greatly increased concentration of breast epithelium but no increase in its proliferative activityDebra Hawes
Department of Pathology, Keck School of Medicine, University of Southern California, 2011 Zonal Avenue, Los Angeles, CA 90089, USA
Breast Cancer Res 8:R24. 2006..The increased breast cancer risk associated with increased mammographic densities may simply be a reflection of increased epithelial cell numbers. Why epithelium is concentrated in high CT density areas remains to be explained... - Reproductive factors and breast cancer risk according to joint estrogen and progesterone receptor status: a meta-analysis of epidemiological studiesHuiyan Ma
Department of Preventive Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue 4407, Los Angeles, CA 90089, USA
Breast Cancer Res 8:R43. 2006..This report presents the first meta-analysis of results from epidemiological studies that have investigated parity, age at first birth, breastfeeding, and age at menarche in relation to ER+PR+ and ER-PR- cancer risk... - Greatly increased occurrence of breast cancers in areas of mammographically dense tissueGiske Ursin
Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA
Breast Cancer Res 7:R605-8. 2005..We addressed this question by studying ductal carcinoma in situ (DCIS), as revealed by microcalcifications... - A comprehensive analysis of the androgen receptor gene and risk of breast cancer: results from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3)David G Cox
Program in Molecular and Genetic Epidemiology, Epidemiology Department, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
Breast Cancer Res 8:R54. 2006..Here, we report on the results of a large and comprehensive study of the association between genetic variation in the AR gene and risk of breast cancer in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3)... - A comprehensive analysis of common genetic variation in prolactin (PRL) and PRL receptor (PRLR) genes in relation to plasma prolactin levels and breast cancer risk: the multiethnic cohortSulggi A Lee
Department of Preventive Medicine, University of Southern California Keck School of Medicine, Norris Comprehensive Cancer Center, Los Angeles, CA, USA
BMC Med Genet 8:72. 2007..Prospective epidemiological studies have also shown that women with higher circulating PRL levels have an increase in risk of breast cancer, suggesting that variability in PRL may also be important in determining a woman's risk... - Prevention of cancers of the breast, endometrium and ovaryMalcolm C Pike
USC Norris Cancer Center, Los Angeles, CA, USA
Oncogene 23:6379-91. 2004..Some recent epidemiological findings in endometrial and ovarian cancer suggest new avenues for possible chemoprevention of these cancers... - Hormonal factors and the risk of invasive ovarian cancer: a population-based case-control studyMalcolm C Pike
USC Norris Comprehensive Cancer Center, Keck School of Medicine, Department of Preventive Medicine, University of Southern California, Los Angeles, California 90033, USA
Fertil Steril 82:186-95. 2004..To examine the influence of hormone-related factors on the risk of invasive epithelial ovarian cancer (ovarian cancer)... - Breast cancer in a multiethnic cohort in Hawaii and Los Angeles: risk factor-adjusted incidence in Japanese equals and in Hawaiians exceeds that in whitesMalcolm C Pike
Department of Preventive Medicine, University of Southern California Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
Cancer Epidemiol Biomarkers Prev 11:795-800. 2002..The adjusted RR of NHs is 65% greater than that of Ws, and that of migrant Latinas is 16% lower than that of Ws. Elucidating the causes of the high rates in NHs is now a major focus of our efforts... - Estrogen-progestin replacement therapy: regulatory action neededMalcolm C Pike
Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California 90033, USA
Breast Cancer Res 4:222-3. 2002..We should then act as if the effect on the marker is a quantitative guide to the probable effect on breast cancer risk. Regulatory authorities need to require such studies on all current regimens... - Mammographic density and breast cancer in three ethnic groupsGiske Ursin
Department of Preventive Medicine, University of California Keck School of Medicine, Los Angeles, California 90089, USA
Cancer Epidemiol Biomarkers Prev 12:332-8. 2003..Furthermore, our findings suggest that mammographic density is as strong a predictor of risk for African-American and Asian-American women as for white women... - Does mammographic density reflect ethnic differences in breast cancer incidence rates?Zhengjia Chen
Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA, USA
Am J Epidemiol 159:140-7. 2004..This study suggests that absolute but not percent mammographic density reflects the lower breast cancer incidence rates of Asian Americans in relation to those of African Americans and Whites... - Common genetic variation in IGF1 and prostate cancer risk in the Multiethnic CohortIona Cheng
Department of Preventive Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
J Natl Cancer Inst 98:123-34. 2006..Insulin-like growth factor I (IGF-I) appears to play a role in prostate development and carcinogenesis. We investigated whether genetic variation at the IGF1 locus is associated with prostate cancer risk... - Multiple regions within 8q24 independently affect risk for prostate cancerChristopher A Haiman
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA
Nat Genet 39:638-44. 2007..None of the prostate cancer risk variants aligns to a known gene or alters the coding sequence of an encoded protein... - The association of endogenous sex steroids and sex steroid binding proteins with mammographic density: results from the Postmenopausal Estrogen/Progestin Interventions Mammographic Density StudyGail A Greendale
Division of Geriatrics, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA 90095 1687, USA
Am J Epidemiol 162:826-34. 2005..These results suggest that some sex steroids may increase the risk of breast cancer by stimulating breast epithelial or stromal proliferation, which appears on a mammogram as higher density... - Postmenopausal hormone therapy and change in mammographic densityGail A Greendale
Division of Geriatric Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
J Natl Cancer Inst 95:30-7. 2003..Mammographic density is an independent risk factor for breast cancer. Postmenopausal hormone use is associated with an increase in mammographic density, but the magnitude of the density increase is unknown... - Steroid 5-alpha reductase type II V89L substitution is not associated with risk of prostate cancer in a multiethnic population studyCeleste L Pearce
Department of Preventive Medicine and USC/Norris Comprehensive Cancer Center and Hospital, University of Southern California Keck School of Medicine, Los Angeles, California 90089-9176, USA
Cancer Epidemiol Biomarkers Prev 11:417-8. 2002 - Galactose-1-phosphate uridyl transferase (GALT) genotype and phenotype, galactose consumption, and the risk of borderline and invasive ovarian cancer (United States)Wendy Cozen
Department of Preventive Medicine, USC Keck School of Medicine, USC Norris Cancer Center, Los Angeles, CA 90033, USA
Cancer Causes Control 13:113-20. 2002..We examined these issues as part of a large case-control study of ovarian cancer conducted in Los Angeles between 1992 and 1998... - Effect of reproductive hormones on ovarian epithelial tumors: I. Effect on cell cycle activityHong Zhou
Department of Pathology, USC/Norris Comprehensive Cancer Center, Keck School of Medicine of University of Southern California, Los Angeles, California 90033, USA
Cancer Biol Ther 1:300-6. 2002..We conclude that P4 inhibits cell cycle activity in ovarian epithelial tumors, in part via down-regulation of the cdkl/cyclin B complex. This inhibitory effect may have therapeutic utility against ovarian epithelial tumors... - Long-term postmenopausal hormone therapy and endometrial cancerPedram Razavi
University of Southern California, Department of Preventive Medicine, Norris Comprehensive Cancer Center, Los Angeles, California, USA
Cancer Epidemiol Biomarkers Prev 19:475-83. 2010..These findings confirm that long-term use of ET, sequential EPT, or, among normal weight women, continuous-combined EPT is associated with increased risk of endometrial cancer... - Postmenopausal hormone therapy and breast cancer risk: the Multiethnic CohortSulggi Lee
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Norris Comprehensive Cancer Center, 1441 Eastlake Avenue, Los Angeles, CA 90033-0800, USA
Int J Cancer 118:1285-91. 2006..There was little difference in risk by stage of disease or histologic subtype. The increase with EPT use was clearly seen in all 5 ethnic groups; and the increase with ET in 4 of the 5 groups... - Body size, hormone therapy and risk of breast cancer in Asian-American womenAnna H Wu
Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA, USA
Int J Cancer 120:844-52. 2007..017). The increased risk associated with high body weight was observed irrespective of HT use. Use of HT and high body size might have contributed to the rapid increase of breast cancer in Asian-Americans... - Established risk factors account for most of the racial differences in cardiovascular disease mortalitySean O Henderson
Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, California, United States of America
PLoS ONE 2:e377. 2007..Cardiovascular disease (CVD) mortality varies across racial and ethnic groups in the U.S., and the extent that known risk factors can explain the differences has not been extensively explored... - A systematic assessment of common genetic variation in CYP11A and risk of breast cancerVeronica Wendy Setiawan
Departments of Preventive Medicine and Urology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
Cancer Res 66:12019-25. 2006..Based on these findings, CYP11A deserves further consideration as a candidate breast cancer susceptibility gene... - Genetic variation at the CYP19A1 locus predicts circulating estrogen levels but not breast cancer risk in postmenopausal womenChristopher A Haiman
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90033, USA
Cancer Res 67:1893-7. 2007..Thus, although genetic variation in CYP19A1 produces measurable differences in estrogen levels among postmenopausal women, the magnitude of the change was insufficient to contribute detectably to breast cancer... - Diabetes and risk of breast cancer in Asian-American womenAnna H Wu
Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA 90089, USA
Carcinogenesis 28:1561-6. 2007..08) than women without such a history after adjusting for BMI and WHR. Our results support the hypothesis that diabetes may have a role in the development of breast cancer, influencing risk via both sex hormone and insulin pathways... - Tamoxifen, soy, and lifestyle factors in Asian American women with breast cancerAnna H Wu
Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
J Clin Oncol 25:3024-30. 2007.... - Dietary fiber intake and endogenous serum hormone levels in naturally postmenopausal Mexican American women: the Multiethnic Cohort StudyKristine R Monroe
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA
Nutr Cancer 58:127-35. 2007..The suggestive findings relating increased estrogen levels to avocado and grapefruit intakes need confirmation... - Alcohol consumption and endometrial cancer risk: the multiethnic cohortVeronica Wendy Setiawan
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
Int J Cancer 122:634-8. 2008..Our results suggest that only alcohol consumption equivalent to 2 or more drinks per day increases risk of endometrial cancer in postmenopausal women... - Risk of urinary bladder cancer is associated with 8q24 variant rs9642880[T] in multiple racial/ethnic groups: results from the Los Angeles-Shanghai case-control studyVictoria K Cortessis
Department of Preventive Medicine, Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, 1441 Eastlake Ave, MC 9175, Los Angeles, CA 90089, USA
Cancer Epidemiol Biomarkers Prev 19:3150-6. 2010..Recent genome-wide association studies of urinary bladder cancer report risk to be associated with the T allele of rs9642880 on 8q24 among individuals of European descent... - Hypertension, diuretics and antihypertensives in relation to bladder cancerXuejuan Jiang
Department of Preventive Medicine, Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90089, USA
Carcinogenesis 31:1964-71. 2010..7 pg/g Hb) compared with individuals without hypertension (79.8 pg/g Hb) (P = 0.009). In conclusion, untreated hypertension was associated with a reduced risk of bladder cancer... - Sequence variant on 3q28 and urinary bladder cancer risk: findings from the Los Angeles-Shanghai bladder case-control studyMariana C Stern
Department of Preventive Medicine, Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California 90089, USA
Cancer Epidemiol Biomarkers Prev 18:3057-61. 2009..045). Our results suggest that a TP63 gene variant may increase susceptibility for the development of urinary bladder tumors with low risk of progression... - Breast cancer risk factors defined by estrogen and progesterone receptor status: the multiethnic cohort studyVeronica Wendy Setiawan
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
Am J Epidemiol 169:1251-9. 2009..0001). African Americans are more likely to be diagnosed with ER-/PR- tumors independently of stage at diagnosis, and there are disparate risk factor profiles across the ER/PR subtypes of breast cancer... 
Dietary patterns and breast cancer risk in Asian American womenAnna H Wu
Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA 90089, USA
Am J Clin Nutr 89:1145-54. 2009..The role of diet as a cause of breast cancer in Asian Americans has not been adequately studied...- Progesterone and estrogen receptors in pregnant and premenopausal non-pregnant normal human breastDeShawn Taylor
Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA
Breast Cancer Res Treat 118:161-8. 2009..Short-term changes in PRA expression while the chemoprevention is being administered may be a more useful marker... - Increased ovarian cancer risk associated with menopausal estrogen therapy is reduced by adding a progestinCeleste Leigh Pearce
Department of Preventive Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA
Cancer 115:531-9. 2009.... - Markers of inflammation and risk of ovarian cancer in Los Angeles CountyAnna H Wu
Department of Preventive Medicine, University of Southern California, Keck School of Medicine, Los Angeles, CA 90089 9175, USA
Int J Cancer 124:1409-15. 2009..The NSAID finding was unexpected and suggests that factors associated with inflammation are associated with ovarian cancer risk. This result needs confirmation with careful attention to the reasons for NSAID use... - No association between the SRD5A2 gene A49T missense variant and prostate cancer risk: lessons learnedC Leigh Pearce
1Department of Preventive Medicine, University of Southern California, Los Angeles, CA 90033, USA
Hum Mol Genet 17:2456-61. 2008..Overall, this report highlights the importance of rigorous genotyping quality control measures and replication efforts in genetic association studies... - Comprehensive evaluation of ESR2 variation and ovarian cancer riskCeleste Leigh Pearce
USC Norris Comprehensive Cancer Center and Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90089, USA
Cancer Epidemiol Biomarkers Prev 17:393-6. 2008..28-11.73; P = 0.016). Haplotype D was also reported by the BPC3 to be associated with increased risk of breast cancer. This haplotype warrants further investigation to rule out any effect with invasive ovarian cancer risk... - Interleukin-2, interleukin-12, and interferon-gamma levels and risk of young adult Hodgkin lymphomaWendy Cozen
Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles 90089 9175, USA
Blood 111:3377-82. 2008..8-fold (P=.03) increase in YAHL risk. Thus, both case-twins and their unaffected cotwins had a decreased ability to produce IL-12, which may contribute to YAHL susceptibility... - CYP17 genetic variation and risk of breast and prostate cancer from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3)Veronica Wendy Setiawan
Department of Preventive Medicine, University of Southern California, Los Angeles, CA 90033, USA
Cancer Epidemiol Biomarkers Prev 16:2237-46. 2007..Our findings do not support the hypothesis that common germ line variation in CYP17 makes a substantial contribution to postmenopausal breast or prostate cancer susceptibility... - Genetic variations on chromosomes 5p15 and 15q25 and bladder cancer risk: findings from the Los Angeles-Shanghai bladder case-control studyManuela Gago-Dominguez
Department of Preventive Medicine, Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90089 9175, USA
Carcinogenesis 32:197-202. 2011..26; 95% CI, 1.04-1.54; P = 0.017). Our results support 5p15 and 15q25 as susceptibility regions for bladder cancer risk... - Racial/ethnic differences in endometrial cancer risk: the multiethnic cohort studyVeronica Wendy Setiawan
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
Am J Epidemiol 165:262-70. 2007..92) for Latinas. Results from this study show that the interethnic differences in endometrial cancer risk do not appear to be explained by differences in the distribution of known risk factors among women of different races/ethnicities... - Ethnic differences in neuroendocrine cell expression in normal human prostatic tissueSiamak Daneshmand
Department of Urology, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, California, USA
Urology 65:1008-12. 2005..The comparatively low NE cell expression in African-American men may play a role in the greater rate of prostate carcinogenesis seen in this ethnic group... - Urinary 2-hydroxyestrone/16alpha-hydroxyestrone ratio and family history of breast cancer in premenopausal womenGiske Ursin
Department of Preventive Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles 90089, USA
Breast Cancer Res Treat 72:139-43. 2002..Our data suggest that among premenopausal women, family history is not associated with higher urinary estrogen levels or a lower ratio of urinary 2-OHE1/16alpha-OHE1... - Clarifying the PROGINS allele association in ovarian and breast cancer risk: a haplotype-based analysisCeleste Leigh Pearce
Department of Preventive Medicine, Norris Comprehensive Cancer Center, University of Southern California, Keck School of Medicine, Los Angeles, CA 90089, USA
J Natl Cancer Inst 97:51-9. 2005..We set out to refine the association between common variation at the PGR gene locus and these two diseases... - Post-treatment change in serum estrone predicts mammographic percent density changes in women who received combination estrogen and progestin in the Postmenopausal Estrogen/Progestin Interventions (PEPI) TrialGiske Ursin
Department of Preventive Medicine, Norris Comprehensive Cancer Center, Room 4407, USC Keck School of Medicine, 1441 Eastlake Avenue, Los Angeles, CA 90089, USA
J Clin Oncol 22:2842-8. 2004..We determined whether increases in serum estrone as a function of treatment predict increases in mammographic percent density... - IL-6 levels and genotype are associated with risk of young adult Hodgkin lymphomaWendy Cozen
Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA, USA
Blood 103:3216-21. 2004..29; P =.03). Risk was decreased for both nodular sclerosis and other subtypes. Persons with genetically determined lower IL-6 levels may be less susceptible to young adult Hodgkin lymphoma... - A comprehensive haplotype analysis of CYP19 and breast cancer risk: the Multiethnic CohortChristopher A Haiman
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, USC Norris Comprehensive Cancer Center, 1441 Eastlake Ave, Rm 4441, Los Angeles, CA 90089 9175, USA
Hum Mol Genet 12:2679-92. 2003..31; 95% CI, 1.11-1.54). Our findings suggest the hypothesis that women with the long-range CYP19 haplotype 2b-3c may be carriers of a predisposing breast cancer susceptibility allele... - Choosing haplotype-tagging SNPS based on unphased genotype data using a preliminary sample of unrelated subjects with an example from the Multiethnic Cohort StudyDaniel O Stram
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, Calif 90033, USA
Hum Hered 55:27-36. 2003..A candidate set of htSNPS of a given size is chosen so as to maximize the minimum value of R2h over the common haplotypes, h... - Correlation of dietary intake and colorectal cancer incidence among Mexican-American migrants: the multiethnic cohort studyKristine R Monroe
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA
Nutr Cancer 45:133-47. 2003.... - Green tea and risk of breast cancer in Asian AmericansAnna H Wu
Department of Preventive Medicine, University of Southern California, Keck School of Medicine, Los Angeles, CA, USA
Int J Cancer 106:574-9. 2003..In summary, our results point to an important role of both green tea and soy intake in relation to breast cancer risk in Asian-American women... - Does menopausal hormone replacement therapy interact with known factors to increase risk of breast cancer?Giske Ursin
Department of Preventive Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA 90089, USA
J Clin Oncol 20:699-706. 2002.... - Adolescent and adult soy intake and risk of breast cancer in Asian-AmericansAnna H Wu
Department of Preventive Medicine, University of Southern California, Keck School of Medicine, Los Angeles, CA, USA
Carcinogenesis 23:1491-6. 2002..These results show that high soy intake in childhood in Asian-Americans is associated with reduced breast cancer risk. Risk may be further reduced by intake as an adult... - A controlled 2-mo dietary fat reduction and soy food supplementation study in postmenopausal womenAnna H Wu
Department of Preventive Medicine, University of Southern California Norris Comprehensive Cancer Center, Keck School of Medicine, Los Angeles, CA 90089 9175, USA
Am J Clin Nutr 81:1133-41. 2005..Low intake of dietary fat and high intake of soy foods have been suggested to partly explain the lower breast cancer rates in Asia, perhaps because of lower endogenous estrogens... - Comparison of prostate-specific antigen and hormone levels among men in Singapore and the United StatesIona Cheng
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, USC Norris Comprehensive Cancer Center, 1441 Eastlake Avenue, Los Angeles, CA, 90089 9175, USA
Cancer Epidemiol Biomarkers Prev 14:1692-6. 2005..Given that the overall mortality rate of prostate cancer in Singapore is low, these undiagnosed cancers may be of nonaggressive type. Alternatively, PSA may be a poor marker of prostate cancer in this low-risk population... - Role of lipid peroxidation in the epidemiology and prevention of breast cancerManuela Gago-Dominguez
USC Norris Comprehensive Cancer Center, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90089 9181, USA
Cancer Epidemiol Biomarkers Prev 14:2829-39. 2005.... - BRCA1 and BRCA2 mutation carriers, oral contraceptive use, and breast cancer before age 50Robert W Haile
Department of Preventive Medicine, University of Southern California Keck School of Medicine, 1441 Eastlake Avenue, MS 9175, Los Angeles, CA 90089 9175, USA
Cancer Epidemiol Biomarkers Prev 15:1863-70. 2006..Understanding the effect of oral contraceptives on risk of breast cancer in BRCA1 or BRCA2 mutation carriers is important because oral contraceptive use is a common, modifiable practice... - Ethnic and racial differences in the smoking-related risk of lung cancerChristopher A Haiman
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Norris Comprehensive Cancer Center, Los Angeles, CA 90089 9175, USA
N Engl J Med 354:333-42. 2006..There is remarkable variation in the incidence of lung cancer among ethnic and racial groups in the United States... - Prostate cancer incidence and intake of fruits, vegetables and related micronutrients: the multiethnic cohort study* (United States)Daniel O Stram
Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
Cancer Causes Control 17:1193-207. 2006..To describe the relationship between the intake of fruits, vegetables, and related vitamins and antioxidants, and the risk of prostate cancer in male participants in a large multiethnic cohort study... - Ethnic differences in the use of regular mammography: the multiethnic cohortQuannetta T Edwards
Department of Clinical Cancer Genetics, City of Hope National Medical Center, Duarte, CA, USA
Breast Cancer Res Treat 115:163-70. 2009.... - Changes in the mouse estrus cycle in response to BRCA1 inactivation suggest a potential link between risk factors for familial and sporadic ovarian cancerHao Hong
Department of Pathology, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
Cancer Res 70:221-8. 2010.... - The role of mammographic density in evaluating changes in breast cancer riskMalcolm C Pike
USC/Norris Comprehensive Cancer Center, Los Angeles, CA 90033, USA
Gynecol Endocrinol 21:1-5. 2005.... - Cell-nonautonomous induction of ovarian and uterine serous cystadenomas in mice lacking a functional Brca1 in ovarian granulosa cellsRajas Chodankar
Department of Pathology, University of Southern California Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California 90033, USA
Curr Biol 15:561-5. 2005..These tumors carried normal Brca1 alleles, supporting the view that Brca1 may influence tumor development indirectly, possibly through an effector secreted by granulosa cells... - Reduced mammographic density with use of a gonadotropin-releasing hormone agonist-based chemoprevention regimen in BRCA1 carriersJeffrey N Weitzel
Department of Clinical Cancer Genetics, City of Hope Cancer Center, 1500 East Duarte Road, Duarte, CA 91010, USA
Clin Cancer Res 13:654-8. 2007..We evaluated the efficacy, safety, and tolerability of hormonal chemoprevention with a gonadotropin-releasing hormone agonist (GnRHA) with low-dose add-back steroids in BRCA1(mut) carriers... - Haplotype analysis of the HSD17B1 gene and risk of breast cancer: a comprehensive approach to multicenter analyses of prospective cohort studiesHeather Spencer Feigelson
Department of Epidemiology and Surveillance Research, American Cancer Society, National Home Office, Atlanta, Georgia 30329, USA
Cancer Res 66:2468-75. 2006..Although the probability that these ER-negative findings are false-positive results is high, these findings were consistent across each cohort examined and warrant further study... - Tagging single nucleotide polymorphisms in cell cycle control genes and susceptibility to invasive epithelial ovarian cancerSimon A Gayther
Translational Research Laboratories, University College London, London, United Kingdom
Cancer Res 67:3027-35. 2007..This study highlights the need for multicenter collaborations for genetic association studies... - Haplotypes of the estrogen receptor beta gene and breast cancer riskDavid G Cox
Program in Molecular and Genetic Epidemiology, Epidemiology Department, Harvard School of Public Health, Boston, MA, USA
Int J Cancer 122:387-92. 2008..These data suggest that inherited variants in ESR2 (while possibly conferring a small increased risk of breast cancer) are not associated with appreciable (OR > 1.2) changes in breast cancer risk among Caucasian women... - Urinary estrogen metabolites and their ratio among Asian American womenRoni T Falk
Environmental Epidemiology Branch, National Cancer Institute, 6120 Executive Boulevard, MSC 7234, Suite 7070, Bethesda, MD 20892, USA
Cancer Epidemiol Biomarkers Prev 14:221-6. 2005..Our study suggests that the ratio of 2-OHE(1):16alpha-OHE(1) may be a marker for lifestyle influences on estrogen metabolism associated with westernization... - Association of vegetable, fruit, and grain intakes with colorectal cancer: the Multiethnic Cohort StudyAbraham M Y Nomura
Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI 96813, USA
Am J Clin Nutr 88:730-7. 2008..It is uncertain whether or not vegetables, fruit, or grains protect against colorectal cancer... - IGF-1, IGFBP-1, and IGFBP-3 polymorphisms predict circulating IGF levels but not breast cancer risk: findings from the Breast and Prostate Cancer Cohort Consortium (BPC3)Alpa V Patel
Department of Epidemiology and Surveillance Research, American Cancer Society, Atlanta, Georgia, United States of America
PLoS ONE 3:e2578. 2008..In summary, the impact of genetic variation in IGF1 and IGFBP3 on circulating IGF levels does not appear to substantially influence breast cancer risk substantially among primarily Caucasian postmenopausal women... - Genetic variation in the HSD17B1 gene and risk of prostate cancerPeter Kraft
Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America
PLoS Genet 1:e68. 2005..These results suggest that the germline variants in HSD17B1 characterized by these htSNPs do not substantially influence the risk of prostate cancer in U.S. and European whites... - Consortium analysis of 7 candidate SNPs for ovarian cancerSusan J Ramus
Translational Research Laboratory, University College London EGA Institute for Women s Health, London, United Kingdom
Int J Cancer 123:380-8. 2008..These null results for SNPs identified from relatively large initial studies shows the importance of replicating associations by a consortium approach... - Nonsteroidal antiinflammatory drugs and breast cancer risk: the multiethnic cohortJasmeet K Gill
Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI, USA
Am J Epidemiol 166:1150-8. 2007..This study found duration of current other NSAID use to be protective against breast cancer risk... - Does breast size modify the association between mammographic density and breast cancer risk?Anne Stuedal
Department of Nutrition, University of Oslo, Oslo, Norway
Cancer Epidemiol Biomarkers Prev 17:621-7. 2008..S. women. Because African American women have a larger breast size, we assessed whether the association between mammographic density and breast cancer was less apparent in large than in small breasts... - Dietary fiber and colorectal cancer risk: the multiethnic cohort studyAbraham M Y Nomura
Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI 96813, USA
Cancer Causes Control 18:753-64. 2007..To investigate the association of dietary fiber with colorectal cancer.. - Predictors of the timing of natural menopause in the Multiethnic Cohort StudyKatherine Delellis Henderson
Department of Cancer Etiology, City of Hope National Medical Center, Duarte, CA 91010, USA
Am J Epidemiol 167:1287-94. 2008..21, 1.30) and later among Japanese Americans (HR = 0.93, 95% CI: 0.90, 0.95). These results support the hypothesis that the timing of natural menopause is driven by a combination of genetic, reproductive, and lifestyle factors... - Maternal risk factors for testicular cancer: a population-based case-control study (UK)Carol A C Coupland
Division of Primary Care, School of Community Health Sciences, University of Nottingham, UK
Cancer Causes Control 15:277-83. 2004..To investigate the role of a range of maternal and pre-natal characteristics as potential risk factors for testicular cancer...
Research Grants
- GENETIC & ENVIRONMENTAL RISK FACTORS FOR BLADDER CANCERMalcolm Pike; Fiscal Year: 2009..The ultimate goal of this research is to assess individual bladder cancer risk for the purpose of preventive interventions. ..
- GENETIC & ENVIRONMENTAL RISK FACTORS FOR BLADDER CANCERMalcolm Pike; Fiscal Year: 2009..The ultimate goal of this research is to assess individual bladder cancer risk for the purpose of preventive interventions. ..