Christian Pike

Summary

Affiliation: University of Southern California
Country: USA

Publications

  1. pmc 17β-estradiol and progesterone regulate expression of β-amyloid clearance factors in primary neuron cultures and female rat brain
    Anusha Jayaraman
    Neuroscience Graduate Program, University of Southern California, Los Angeles, California 90089, USA
    Endocrinology 153:5467-79. 2012
  2. pmc Androgen cell signaling pathways involved in neuroprotective actions
    Christian J Pike
    Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA
    Horm Behav 53:693-705. 2008
  3. pmc Protective actions of sex steroid hormones in Alzheimer's disease
    Christian J Pike
    Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA
    Front Neuroendocrinol 30:239-58. 2009
  4. pmc Continuous and cyclic progesterone differentially interact with estradiol in the regulation of Alzheimer-like pathology in female 3xTransgenic-Alzheimer's disease mice
    Jenna C Carroll
    University of Southern California, 3715 McClintock Avenue, Los Angeles, California 90089 0191
    Endocrinology 151:2713-22. 2010
  5. ncbi request reprint Testosterone attenuates beta-amyloid toxicity in cultured hippocampal neurons
    C J Pike
    Andrus Gerontology Center, University of Southern California, 3715 McClintock Avenue, Los Angeles, CA 90089 0191, USA
    Brain Res 919:160-5. 2001
  6. ncbi request reprint Androgens, aging, and Alzheimer's disease
    Christian J Pike
    Andrus Gerontology Center, University of Southern California, Los Angeles, CA 90089 0191, USA
    Endocrine 29:233-41. 2006
  7. pmc Progesterone inhibits estrogen-mediated neuroprotection against excitotoxicity by down-regulating estrogen receptor-β
    Claudia Aguirre
    Neuroscience Program, University of Southern California, Los Angeles, CA 90089 2520, USA
    J Neurochem 115:1277-87. 2010
  8. pmc Androgens selectively protect against apoptosis in hippocampal neurones
    T V Nguyen
    Neuroscience Graduate Programme and Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089 0191, USA
    J Neuroendocrinol 22:1013-22. 2010
  9. ncbi request reprint Estrogen regulates bcl-x expression in rat hippocampus
    S E Stoltzner
    Andrus Gerontology Center, University of Southern California, 3715 McClintock Avenue, Los Angeles, CA 90089-0191, USA
    Neuroreport 12:2797-800. 2001
  10. ncbi request reprint Norepinephrine induces BDNF and activates the PI-3K and MAPK cascades in embryonic hippocampal neurons
    M J Chen
    California State University, Los Angeles, Department of Biological Sciences, 5151 State University Dr, Los Angeles, CA 90032, USA
    Cell Signal 19:114-28. 2007

Research Grants

  1. MECHANISM OF ESTROGEN NEUROPROTECTION IN ALZHEIMERS DISE
    Christian Pike; Fiscal Year: 2000
  2. MECHANISM OF ESTROGEN NEUROPROTECTION IN ALZHEIMERS DISE
    Christian Pike; Fiscal Year: 2003
  3. Androgens and Alzheimer's Disease
    Christian Pike; Fiscal Year: 2007
  4. Androgens and Alzheimer's Disease
    Christian Pike; Fiscal Year: 2009

Collaborators

Detail Information

Publications28

  1. pmc 17β-estradiol and progesterone regulate expression of β-amyloid clearance factors in primary neuron cultures and female rat brain
    Anusha Jayaraman
    Neuroscience Graduate Program, University of Southern California, Los Angeles, California 90089, USA
    Endocrinology 153:5467-79. 2012
    ..These findings further define sex steroid hormone actions involved in regulation of Aβ, a relationship potentially important to therapeutic approaches aimed at reducing risk of Alzheimer's disease...
  2. pmc Androgen cell signaling pathways involved in neuroprotective actions
    Christian J Pike
    Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA
    Horm Behav 53:693-705. 2008
    ..Continued elucidation of cell signaling pathways that contribute to protective actions of androgens should facilitate the development of targeted therapeutic strategies to combat AD and other age-related neurodegenerative diseases...
  3. pmc Protective actions of sex steroid hormones in Alzheimer's disease
    Christian J Pike
    Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA
    Front Neuroendocrinol 30:239-58. 2009
    ....
  4. pmc Continuous and cyclic progesterone differentially interact with estradiol in the regulation of Alzheimer-like pathology in female 3xTransgenic-Alzheimer's disease mice
    Jenna C Carroll
    University of Southern California, 3715 McClintock Avenue, Los Angeles, California 90089 0191
    Endocrinology 151:2713-22. 2010
    ..These results provide new insight into the neural interactions between E(2) and progesterone that may prove valuable in optimizing HT regimens in postmenopausal women...
  5. ncbi request reprint Testosterone attenuates beta-amyloid toxicity in cultured hippocampal neurons
    C J Pike
    Andrus Gerontology Center, University of Southern California, 3715 McClintock Avenue, Los Angeles, CA 90089 0191, USA
    Brain Res 919:160-5. 2001
    ..beta-Amyloid neurotoxicity was significantly reduced by testosterone via a rapid, estrogen-independent mechanism. These data may provide additional insight into the treatment of age-related neurodegenerative disorders...
  6. ncbi request reprint Androgens, aging, and Alzheimer's disease
    Christian J Pike
    Andrus Gerontology Center, University of Southern California, Los Angeles, CA 90089 0191, USA
    Endocrine 29:233-41. 2006
    ..These new findings support the clinical evaluation of androgen-based therapies for the prevention and treatment of AD...
  7. pmc Progesterone inhibits estrogen-mediated neuroprotection against excitotoxicity by down-regulating estrogen receptor-β
    Claudia Aguirre
    Neuroscience Program, University of Southern California, Los Angeles, CA 90089 2520, USA
    J Neurochem 115:1277-87. 2010
    ....
  8. pmc Androgens selectively protect against apoptosis in hippocampal neurones
    T V Nguyen
    Neuroscience Graduate Programme and Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089 0191, USA
    J Neuroendocrinol 22:1013-22. 2010
    ..Determining the specificity of androgen neuroprotection may enable the development of androgen compounds for the treatment of neurodegenerative disorders...
  9. ncbi request reprint Estrogen regulates bcl-x expression in rat hippocampus
    S E Stoltzner
    Andrus Gerontology Center, University of Southern California, 3715 McClintock Avenue, Los Angeles, CA 90089-0191, USA
    Neuroreport 12:2797-800. 2001
    ..Estrogen-mediated regulation of bcl-x may be relevant to the maintenance of neuronal viability and may contribute to the mechanism of estrogen neuroprotection...
  10. ncbi request reprint Norepinephrine induces BDNF and activates the PI-3K and MAPK cascades in embryonic hippocampal neurons
    M J Chen
    California State University, Los Angeles, Department of Biological Sciences, 5151 State University Dr, Los Angeles, CA 90032, USA
    Cell Signal 19:114-28. 2007
    ....
  11. ncbi request reprint Androgens modulate neuronal vulnerability to kainate lesion
    M Ramsden
    Andrus Gerontology Center, University of Southern California, 3715 McClintock Avenue, Los Angeles, CA 90089 0191, USA
    Neuroscience 122:573-8. 2003
    ..These results demonstrate that androgens act as endogenous modulators of neuron viability, a function that may be compromised in aging men as a consequence of normal, age-related androgen depletion...
  12. ncbi request reprint Androgens modulate beta-amyloid levels in male rat brain
    M Ramsden
    Andrus Gerontology Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089 0191, USA
    J Neurochem 87:1052-5. 2003
    ..These findings suggest that age-related androgen depletion may result in accumulation of Abeta in the male brain and thereby act as a risk factor for the development of AD...
  13. pmc Progesterone attenuates oestrogen neuroprotection via downregulation of oestrogen receptor expression in cultured neurones
    A Jayaraman
    Neuroscience Graduate Programme and Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089 0191, USA
    J Neuroendocrinol 21:77-81. 2009
    ..These results identify a potential mechanism by which progesterone antagonises neural oestrogen actions, a finding that may have important implications for hormone therapy in postmenopausal women...
  14. ncbi request reprint Androgens activate mitogen-activated protein kinase signaling: role in neuroprotection
    Thuy Vi V Nguyen
    Neuroscience Graduate Program, University of Southern California, Los Angeles, California 90089 0191, USA
    J Neurochem 94:1639-51. 2005
    ....
  15. ncbi request reprint Estrogen activates protein kinase C in neurons: role in neuroprotection
    Myriam Cordey
    Neuroscience Graduate Program, Keck School of Medicine, Department of Cell and Neurobiology, Andrus Gerontology Center, University of Southern California, Los Angeles, California 90089 0191, USA
    J Neurochem 84:1340-8. 2003
    ..These data provide new understanding into the mechanism(s) underlying estrogen neuroprotection, an action with therapeutic relevance to Alzheimer's disease and other age-related neurodegenerative disorders...
  16. pmc Progesterone receptors: form and function in brain
    Roberta Diaz Brinton
    Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, School of Pharmacy, 1985 Zonal Avenue, Los Angeles, CA 90089, USA
    Front Neuroendocrinol 29:313-39. 2008
    ....
  17. ncbi request reprint Age-related testosterone depletion and the development of Alzheimer disease
    Emily R Rosario
    JAMA 292:1431-2. 2004
  18. pmc Androgen regulation of beta-amyloid protein and the risk of Alzheimer's disease
    Emily R Rosario
    Davis School of Gerontology, University of Southern California, 3715 McClintock Avenue, Los Angeles, CA 90089 0191, USA
    Brain Res Rev 57:444-53. 2008
    ..Emerging data suggest that the regulatory actions of androgens on both Abeta and the development of AD support consideration of androgen therapy for the prevention and treatment of AD...
  19. ncbi request reprint Androgens regulate the development of neuropathology in a triple transgenic mouse model of Alzheimer's disease
    Emily R Rosario
    Neuroscience Graduate Program, University of Southern California, Los Angeles, California 90089, USA
    J Neurosci 26:13384-9. 2006
    ..In addition, our finding that DHT protects against acceleration of AD-like neuropathology predicts that androgen-based hormone therapy may be a useful strategy for the prevention and treatment of AD in aging men...
  20. ncbi request reprint Flutamide and cyproterone acetate exert agonist effects: induction of androgen receptor-dependent neuroprotection
    Thuy Vi V Nguyen
    University of Southern California, Davis School of Gerontology, 3715 McClintock Avenue, Los Angeles, CA 90089 0191, USA
    Endocrinology 148:2936-43. 2007
    ..These findings provide new insight into the agonist vs. antagonist properties of antiandrogens, information that will be crucial to understanding the neural implications of clinically used AR-modulating drugs...
  21. ncbi request reprint Estrogen regulates Bcl-w and Bim expression: role in protection against beta-amyloid peptide-induced neuronal death
    Mingzhong Yao
    Davis School of Gerontology, University of Southern California, Los Angeles, California 90089, USA
    J Neurosci 27:1422-33. 2007
    ..These data provide new understanding into the mechanisms contributing to estrogen neuroprotection, a neural function with potential therapeutic relevance to Alzheimer's disease...
  22. ncbi request reprint Beta-amyloid-induced neuronal apoptosis involves c-Jun N-terminal kinase-dependent downregulation of Bcl-w
    Mingzhong Yao
    Andrus Gerontology Center, University of Southern California, Los Angeles, California 90089 0191, USA
    J Neurosci 25:1149-58. 2005
    ..Complete elucidation of the mechanism of Abeta-induced apoptosis promises to accelerate development of neuroprotective interventions for the treatment of AD...
  23. ncbi request reprint Neuroprotective properties of selective estrogen receptor agonists in cultured neurons
    Myriam Cordey
    Neuroscience Graduate Program and Andrus Gerontology Center, University of Southern California, 3715 McClintock Avenue, Los Angeles, CA 90089 0191, USA
    Brain Res 1045:217-23. 2005
    ..These data indicate that estrogen-mediated neuroprotection likely involves a variety of mechanisms and that protection due to PKC activation is more likely due to ERalpha compared to ERbeta...
  24. ncbi request reprint Conventional protein kinase C isoforms mediate neuroprotection induced by phorbol ester and estrogen
    Myriam Cordey
    Neuroscience Graduate Program and Andrus Gerontology Center, University of Southern California, Los Angeles, California 90089 0191, USA
    J Neurochem 96:204-17. 2006
    ..Taken together, these data provide evidence that conventional PKC isoforms mediate phorbol ester and estrogen neuroprotection of cultured neurons challenged by Abeta toxicity...
  25. ncbi request reprint Exercise increases the vulnerability of rat hippocampal neurons to kainate lesion
    Martin Ramsden
    Andrus Gerontology Center, University of Southern California, 3715 McClintock Avenue, Los Angeles, CA 90089 0191, USA
    Brain Res 971:239-44. 2003
    ....
  26. ncbi request reprint The synthetic estrogen 4-estren-3 alpha,17 beta-diol (estren) induces estrogen-like neuroprotection
    Myriam Cordey
    Neuroscience Graduate Program, University of Southern California, Los Angeles, CA 90089 0191, USA
    Neurobiol Dis 19:331-9. 2005
    ..In contrast, the estrogen receptor antagonist ICI 182,780 blocked E2, but not estren neuroprotection. Our results indicate that estren-induced activation of rapid cell signaling pathways protects cultured neurons from A beta toxicity...
  27. pmc Selective estrogen receptor modulators differentially regulate Alzheimer-like changes in female 3xTg-AD mice
    Jenna C Carroll
    Neuroscience Graduate Program and Davis School of Gerontology, University of Southern California, 3715 McClintock Avenue, Los Angeles, California 90089 0191, USA
    Endocrinology 149:2607-11. 2008
    ..These findings provide initial evidence of beneficial actions of SERMs in a mouse model of AD and support continued investigation of SERMs as an alternative to estrogen-based HT in reducing the risk of AD in postmenopausal women...
  28. ncbi request reprint Progesterone and estrogen regulate Alzheimer-like neuropathology in female 3xTg-AD mice
    Jenna C Carroll
    Neuroscience Graduate Program, Davis School of Gerontology, University of Southern California, Los Angeles, California 90089, USA
    J Neurosci 27:13357-65. 2007
    ..These results demonstrate that estrogen and progesterone independently and interactively regulate AD-like neuropathology and suggest that an optimized hormone therapy may be useful in reducing the risk of AD in postmenopausal women...

Research Grants8

  1. MECHANISM OF ESTROGEN NEUROPROTECTION IN ALZHEIMERS DISE
    Christian Pike; Fiscal Year: 2000
    ..We anticipate that our proposed studies will generate new insight into the ability of estrogen to modulate neuronal viability throughout life, from neural development through age-related neurodegenerative disorders. ..
  2. MECHANISM OF ESTROGEN NEUROPROTECTION IN ALZHEIMERS DISE
    Christian Pike; Fiscal Year: 2003
    ..The applicants anticipate that their novel hypotheses will generate new insight into the ability of estrogen to modulate neuronal viability throughout life, from neural development through age-related neurodegenerative disorders. ..
  3. Androgens and Alzheimer's Disease
    Christian Pike; Fiscal Year: 2007
    ..Together, we believe these novel and timely studies will begin an important evaluation of interactions between normal male aging events, neuroprotection, A-beta regulation, and the risk of developing Alzheimer's disease. ..
  4. Androgens and Alzheimer's Disease
    Christian Pike; Fiscal Year: 2009
    ..Together, we believe these novel and timely studies will begin an important evaluation of interactions between normal male aging events, neuroprotection, A-beta regulation, and the risk of developing Alzheimer's disease. ..