Research Topics
| Christian PikeSummaryAffiliation: University of Southern California Country: USA Publications
Research Grants
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Detail Information
Publications
17β-estradiol and progesterone regulate expression of β-amyloid clearance factors in primary neuron cultures and female rat brainAnusha Jayaraman
Neuroscience Graduate Program, University of Southern California, Los Angeles, California 90089, USA
Endocrinology 153:5467-79. 2012..These findings further define sex steroid hormone actions involved in regulation of Aβ, a relationship potentially important to therapeutic approaches aimed at reducing risk of Alzheimer's disease...- Androgen cell signaling pathways involved in neuroprotective actionsChristian J Pike
Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA
Horm Behav 53:693-705. 2008..Continued elucidation of cell signaling pathways that contribute to protective actions of androgens should facilitate the development of targeted therapeutic strategies to combat AD and other age-related neurodegenerative diseases... - Protective actions of sex steroid hormones in Alzheimer's diseaseChristian J Pike
Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA
Front Neuroendocrinol 30:239-58. 2009.... - Continuous and cyclic progesterone differentially interact with estradiol in the regulation of Alzheimer-like pathology in female 3xTransgenic-Alzheimer's disease miceJenna C Carroll
University of Southern California, 3715 McClintock Avenue, Los Angeles, California 90089 0191
Endocrinology 151:2713-22. 2010..These results provide new insight into the neural interactions between E(2) and progesterone that may prove valuable in optimizing HT regimens in postmenopausal women... 
Testosterone attenuates beta-amyloid toxicity in cultured hippocampal neuronsC J Pike
Andrus Gerontology Center, University of Southern California, 3715 McClintock Avenue, Los Angeles, CA 90089 0191, USA
Brain Res 919:160-5. 2001..beta-Amyloid neurotoxicity was significantly reduced by testosterone via a rapid, estrogen-independent mechanism. These data may provide additional insight into the treatment of age-related neurodegenerative disorders...- Androgens, aging, and Alzheimer's diseaseChristian J Pike
Andrus Gerontology Center, University of Southern California, Los Angeles, CA 90089 0191, USA
Endocrine 29:233-41. 2006..These new findings support the clinical evaluation of androgen-based therapies for the prevention and treatment of AD... - Progesterone inhibits estrogen-mediated neuroprotection against excitotoxicity by down-regulating estrogen receptor-βClaudia Aguirre
Neuroscience Program, University of Southern California, Los Angeles, CA 90089 2520, USA
J Neurochem 115:1277-87. 2010.... - Androgens selectively protect against apoptosis in hippocampal neuronesT V Nguyen
Neuroscience Graduate Programme and Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089 0191, USA
J Neuroendocrinol 22:1013-22. 2010..Determining the specificity of androgen neuroprotection may enable the development of androgen compounds for the treatment of neurodegenerative disorders... - Estrogen regulates bcl-x expression in rat hippocampusS E Stoltzner
Andrus Gerontology Center, University of Southern California, 3715 McClintock Avenue, Los Angeles, CA 90089-0191, USA
Neuroreport 12:2797-800. 2001..Estrogen-mediated regulation of bcl-x may be relevant to the maintenance of neuronal viability and may contribute to the mechanism of estrogen neuroprotection... - Norepinephrine induces BDNF and activates the PI-3K and MAPK cascades in embryonic hippocampal neuronsM J Chen
California State University, Los Angeles, Department of Biological Sciences, 5151 State University Dr, Los Angeles, CA 90032, USA
Cell Signal 19:114-28. 2007.... - Androgens modulate neuronal vulnerability to kainate lesionM Ramsden
Andrus Gerontology Center, University of Southern California, 3715 McClintock Avenue, Los Angeles, CA 90089-0191, USA
Neuroscience 122:573-8. 2003..These results demonstrate that androgens act as endogenous modulators of neuron viability, a function that may be compromised in aging men as a consequence of normal, age-related androgen depletion... - Androgens modulate beta-amyloid levels in male rat brainM Ramsden
Andrus Gerontology Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089 0191, USA
J Neurochem 87:1052-5. 2003..These findings suggest that age-related androgen depletion may result in accumulation of Abeta in the male brain and thereby act as a risk factor for the development of AD... - Progesterone attenuates oestrogen neuroprotection via downregulation of oestrogen receptor expression in cultured neuronesA Jayaraman
Neuroscience Graduate Programme and Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089 0191, USA
J Neuroendocrinol 21:77-81. 2009..These results identify a potential mechanism by which progesterone antagonises neural oestrogen actions, a finding that may have important implications for hormone therapy in postmenopausal women... - Androgens activate mitogen-activated protein kinase signaling: role in neuroprotectionThuy Vi V Nguyen
Neuroscience Graduate Program, University of Southern California, Los Angeles, California 90089 0191, USA
J Neurochem 94:1639-51. 2005.... - Estrogen activates protein kinase C in neurons: role in neuroprotectionMyriam Cordey
Neuroscience Graduate Program, Keck School of Medicine, Department of Cell and Neurobiology, Andrus Gerontology Center, University of Southern California, Los Angeles, California 90089-0191, USA
J Neurochem 84:1340-8. 2003..These data provide new understanding into the mechanism(s) underlying estrogen neuroprotection, an action with therapeutic relevance to Alzheimer's disease and other age-related neurodegenerative disorders... - Progesterone receptors: form and function in brainRoberta Diaz Brinton
Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, School of Pharmacy, 1985 Zonal Avenue, Los Angeles, CA 90089, USA
Front Neuroendocrinol 29:313-39. 2008.... - Age-related testosterone depletion and the development of Alzheimer diseaseEmily R Rosario
JAMA 292:1431-2. 2004 - Androgen regulation of beta-amyloid protein and the risk of Alzheimer's diseaseEmily R Rosario
Davis School of Gerontology, University of Southern California, 3715 McClintock Avenue, Los Angeles, CA 90089 0191, USA
Brain Res Rev 57:444-53. 2008..Emerging data suggest that the regulatory actions of androgens on both Abeta and the development of AD support consideration of androgen therapy for the prevention and treatment of AD... - Androgens regulate the development of neuropathology in a triple transgenic mouse model of Alzheimer's diseaseEmily R Rosario
Neuroscience Graduate Program, University of Southern California, Los Angeles, California 90089, USA
J Neurosci 26:13384-9. 2006..In addition, our finding that DHT protects against acceleration of AD-like neuropathology predicts that androgen-based hormone therapy may be a useful strategy for the prevention and treatment of AD in aging men... - Flutamide and cyproterone acetate exert agonist effects: induction of androgen receptor-dependent neuroprotectionThuy Vi V Nguyen
University of Southern California, Davis School of Gerontology, 3715 McClintock Avenue, Los Angeles, CA 90089 0191, USA
Endocrinology 148:2936-43. 2007..These findings provide new insight into the agonist vs. antagonist properties of antiandrogens, information that will be crucial to understanding the neural implications of clinically used AR-modulating drugs... - Estrogen regulates Bcl-w and Bim expression: role in protection against beta-amyloid peptide-induced neuronal deathMingzhong Yao
Davis School of Gerontology, University of Southern California, Los Angeles, California 90089, USA
J Neurosci 27:1422-33. 2007..These data provide new understanding into the mechanisms contributing to estrogen neuroprotection, a neural function with potential therapeutic relevance to Alzheimer's disease... - Beta-amyloid-induced neuronal apoptosis involves c-Jun N-terminal kinase-dependent downregulation of Bcl-wMingzhong Yao
Andrus Gerontology Center, University of Southern California, Los Angeles, California 90089 0191, USA
J Neurosci 25:1149-58. 2005..Complete elucidation of the mechanism of Abeta-induced apoptosis promises to accelerate development of neuroprotective interventions for the treatment of AD... - Neuroprotective properties of selective estrogen receptor agonists in cultured neuronsMyriam Cordey
Neuroscience Graduate Program and Andrus Gerontology Center, University of Southern California, 3715 McClintock Avenue, Los Angeles, CA 90089-0191, USA
Brain Res 1045:217-23. 2005..These data indicate that estrogen-mediated neuroprotection likely involves a variety of mechanisms and that protection due to PKC activation is more likely due to ERalpha compared to ERbeta... - Conventional protein kinase C isoforms mediate neuroprotection induced by phorbol ester and estrogenMyriam Cordey
Neuroscience Graduate Program and Andrus Gerontology Center, University of Southern California, Los Angeles, California 90089-0191, USA
J Neurochem 96:204-17. 2006..Taken together, these data provide evidence that conventional PKC isoforms mediate phorbol ester and estrogen neuroprotection of cultured neurons challenged by Abeta toxicity... - Exercise increases the vulnerability of rat hippocampal neurons to kainate lesionMartin Ramsden
Andrus Gerontology Center, University of Southern California, 3715 McClintock Avenue, Los Angeles, CA 90089-0191, USA
Brain Res 971:239-44. 2003.... - The synthetic estrogen 4-estren-3 alpha,17 beta-diol (estren) induces estrogen-like neuroprotectionMyriam Cordey
Neuroscience Graduate Program, University of Southern California, Los Angeles, CA 90089-0191, USA
Neurobiol Dis 19:331-9. 2005..In contrast, the estrogen receptor antagonist ICI 182,780 blocked E2, but not estren neuroprotection. Our results indicate that estren-induced activation of rapid cell signaling pathways protects cultured neurons from A beta toxicity... - Selective estrogen receptor modulators differentially regulate Alzheimer-like changes in female 3xTg-AD miceJenna C Carroll
Neuroscience Graduate Program and Davis School of Gerontology, University of Southern California, 3715 McClintock Avenue, Los Angeles, California 90089 0191, USA
Endocrinology 149:2607-11. 2008..These findings provide initial evidence of beneficial actions of SERMs in a mouse model of AD and support continued investigation of SERMs as an alternative to estrogen-based HT in reducing the risk of AD in postmenopausal women... - Progesterone and estrogen regulate Alzheimer-like neuropathology in female 3xTg-AD miceJenna C Carroll
Neuroscience Graduate Program, Davis School of Gerontology, University of Southern California, Los Angeles, California 90089, USA
J Neurosci 27:13357-65. 2007..These results demonstrate that estrogen and progesterone independently and interactively regulate AD-like neuropathology and suggest that an optimized hormone therapy may be useful in reducing the risk of AD in postmenopausal women...
Research Grants
- MECHANISM OF ESTROGEN NEUROPROTECTION IN ALZHEIMERS DISEChristian Pike; Fiscal Year: 2000..We anticipate that our proposed studies will generate new insight into the ability of estrogen to modulate neuronal viability throughout life, from neural development through age-related neurodegenerative disorders. ..
- MECHANISM OF ESTROGEN NEUROPROTECTION IN ALZHEIMERS DISEChristian Pike; Fiscal Year: 2003..The applicants anticipate that their novel hypotheses will generate new insight into the ability of estrogen to modulate neuronal viability throughout life, from neural development through age-related neurodegenerative disorders. ..
- Androgens and Alzheimer's DiseaseChristian Pike; Fiscal Year: 2007..Together, we believe these novel and timely studies will begin an important evaluation of interactions between normal male aging events, neuroprotection, A-beta regulation, and the risk of developing Alzheimer's disease. ..
- Androgens and Alzheimer's DiseaseChristian Pike; Fiscal Year: 2009..Together, we believe these novel and timely studies will begin an important evaluation of interactions between normal male aging events, neuroprotection, A-beta regulation, and the risk of developing Alzheimer's disease. ..