Robert Pignolo

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc Fibrodysplasia ossificans progressiva: clinical and genetic aspects
    Robert J Pignolo
    Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Orphanet J Rare Dis 6:80. 2011
  2. pmc Circulating osteogenic precursor cells
    Robert J Pignolo
    Department of Medicine, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104 6081, USA
    Crit Rev Eukaryot Gene Expr 20:171-80. 2010
  3. pmc Heterozygous inactivation of Gnas in adipose-derived mesenchymal progenitor cells enhances osteoblast differentiation and promotes heterotopic ossification
    Robert J Pignolo
    Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA
    J Bone Miner Res 26:2647-55. 2011
  4. doi request reprint Circulating osteogenic cells: implications for injury, repair, and regeneration
    Robert J Pignolo
    Department of Medicine and Orthopaedic Surgery, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6081, USA
    J Bone Miner Res 26:1685-93. 2011
  5. pmc Defects in telomere maintenance molecules impair osteoblast differentiation and promote osteoporosis
    Robert J Pignolo
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Aging Cell 7:23-31. 2008
  6. pmc Role for circulating osteogenic precursor cells in aortic valvular disease
    Kevin P Egan
    Department of Medicine, University of Pennsylvania School of Medicine, 36th St and Hamilton Walk, Philadelphia, PA 19104 6081, USA
    Arterioscler Thromb Vasc Biol 31:2965-71. 2011
  7. ncbi request reprint Morphogen receptor genes and metamorphogenes: skeleton keys to metamorphosis
    Frederick S Kaplan
    Department of Orthopaedic Surgery and Medicine, The University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Ann N Y Acad Sci 1116:113-33. 2007
  8. ncbi request reprint A new era for fibrodysplasia ossificans progressiva: a druggable target for the second skeleton
    Frederick S Kaplan
    University of Pennsylvania School of Medicine, Department of Orthopaedic Surgery, Hospital of the University of Pennsylvania, Silverstein Two, 34th and Spruce Street, Philadelphia, PA 19104, USA
    Expert Opin Biol Ther 7:705-12. 2007
  9. ncbi request reprint Hematopoietic stem-cell contribution to ectopic skeletogenesis
    Frederick S Kaplan
    Center for Research in Fibrodyplasia Ossificans Progressiva and Related Disorders, Department of Orthopaedic Surgery, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6081, USA
    J Bone Joint Surg Am 89:347-57. 2007
  10. pmc Skeletal metamorphosis in fibrodysplasia ossificans progressiva (FOP)
    Frederick S Kaplan
    Departments of Orthopaedic Surgery and Medicine, c o Department of Orthopaedic Surgery, Hospital of the University of Pennsylvania, Silverstein 2, 3400 Spruce Street, Philadelphia, PA, 19104, USA
    J Bone Miner Metab 26:521-30. 2008

Collaborators

Detail Information

Publications17

  1. pmc Fibrodysplasia ossificans progressiva: clinical and genetic aspects
    Robert J Pignolo
    Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Orphanet J Rare Dis 6:80. 2011
    ..The median lifespan is approximately 40 years of age. Most patients are wheelchair-bound by the end of the second decade of life and commonly die of complications of thoracic insufficiency syndrome...
  2. pmc Circulating osteogenic precursor cells
    Robert J Pignolo
    Department of Medicine, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104 6081, USA
    Crit Rev Eukaryot Gene Expr 20:171-80. 2010
    ..The role of COP cells in physiologic and pathophysiologic conditions of de novo bone formation suggests that they may serve as future targets for diagnostic measurements and therapeutic interventions...
  3. pmc Heterozygous inactivation of Gnas in adipose-derived mesenchymal progenitor cells enhances osteoblast differentiation and promotes heterotopic ossification
    Robert J Pignolo
    Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA
    J Bone Miner Res 26:2647-55. 2011
    ..Taken together, these data suggest that Gnas is a key regulator of fate decisions in adipose-derived mesenchymal progenitor cells, specifically those which are involved in bone formation...
  4. doi request reprint Circulating osteogenic cells: implications for injury, repair, and regeneration
    Robert J Pignolo
    Department of Medicine and Orthopaedic Surgery, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6081, USA
    J Bone Miner Res 26:1685-93. 2011
    ..We present evidence for their existence, methods used for their isolation and identification, possible physiological and pathophysiological roles, cellular origins, and possible mechanisms for their migration to target tissues...
  5. pmc Defects in telomere maintenance molecules impair osteoblast differentiation and promote osteoporosis
    Robert J Pignolo
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Aging Cell 7:23-31. 2008
    ..These data provide evidence that replicative aging of osteoblast precursors is an important mechanism of senile osteoporosis...
  6. pmc Role for circulating osteogenic precursor cells in aortic valvular disease
    Kevin P Egan
    Department of Medicine, University of Pennsylvania School of Medicine, 36th St and Hamilton Walk, Philadelphia, PA 19104 6081, USA
    Arterioscler Thromb Vasc Biol 31:2965-71. 2011
    ..These cells are identified by coexpression of the osteogenic marker type 1 collagen or osteoclacin and the hematopoietic marker CD45. We tested the hypothesis that these cells may contribute to heart valve stenosis...
  7. ncbi request reprint Morphogen receptor genes and metamorphogenes: skeleton keys to metamorphosis
    Frederick S Kaplan
    Department of Orthopaedic Surgery and Medicine, The University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Ann N Y Acad Sci 1116:113-33. 2007
    ..Such insight is applicable to a broad range of human afflictions...
  8. ncbi request reprint A new era for fibrodysplasia ossificans progressiva: a druggable target for the second skeleton
    Frederick S Kaplan
    University of Pennsylvania School of Medicine, Department of Orthopaedic Surgery, Hospital of the University of Pennsylvania, Silverstein Two, 34th and Spruce Street, Philadelphia, PA 19104, USA
    Expert Opin Biol Ther 7:705-12. 2007
    ..Effective therapies for FOP, and possibly for a vast array of more common conditions of heterotopic ossification, will be based on blocking activin-like kinase-2, a critical node in the BMP signaling pathway...
  9. ncbi request reprint Hematopoietic stem-cell contribution to ectopic skeletogenesis
    Frederick S Kaplan
    Center for Research in Fibrodyplasia Ossificans Progressiva and Related Disorders, Department of Orthopaedic Surgery, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6081, USA
    J Bone Joint Surg Am 89:347-57. 2007
    ..However, the definitive contribution of hematopoietic cells to the pathogenesis of ectopic skeletogenesis remains obscure...
  10. pmc Skeletal metamorphosis in fibrodysplasia ossificans progressiva (FOP)
    Frederick S Kaplan
    Departments of Orthopaedic Surgery and Medicine, c o Department of Orthopaedic Surgery, Hospital of the University of Pennsylvania, Silverstein 2, 3400 Spruce Street, Philadelphia, PA, 19104, USA
    J Bone Miner Metab 26:521-30. 2008
    ....
  11. pmc Circulating osteogenic precursor cells in heterotopic bone formation
    Robin K Suda
    Department of Medicine, University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania 19104 6160, USA
    Stem Cells 27:2209-19. 2009
    ..Thus, bone formation is not limited to cells of the mesenchymal lineage, and circulating cells of hematopoietic origin can also serve as osteogenic precursors at remote sites of tissue inflammation...
  12. pmc The FOP metamorphogene encodes a novel type I receptor that dysregulates BMP signaling
    Frederick S Kaplan
    Department of Orthopaedic Surgery, The Center for Research in FOP and Related Disorders, The University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Cytokine Growth Factor Rev 20:399-407. 2009
    ....
  13. pmc Fibrodysplasia ossificans progressiva
    Frederick S Kaplan
    Departments of Orthopedic Surgery and Medicine, The University of Pennsylvania School of Medicine, c o Hospital of The University of Pennsylvania, Philadelphia, PA, USA
    Best Pract Res Clin Rheumatol 22:191-205. 2008
    ..Effective therapies for FOP, and possibly for other common conditions of HO, may potentially be based on future interventions that block ACVR1/ALK2 signalling...
  14. ncbi request reprint v-ATPase V0 subunit d2-deficient mice exhibit impaired osteoclast fusion and increased bone formation
    Seoung Hoon Lee
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Nat Med 12:1403-9. 2006
    ....
  15. pmc Exploring human/animal intersections: converging lines of evidence in comparative models of aging
    John Q Trojanowski
    School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Alzheimers Dement 4:1-5. 2008
    ..Instead, an optimal translational research model supports a bidirectional flow of information from animal models to clinical research...
  16. pmc Telomere shortening exposes functions for the mouse Werner and Bloom syndrome genes
    Xiaobing Du
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Mol Cell Biol 24:8437-46. 2004
    ..These findings indicate that telomere dysfunction may contribute to the pathogenesis of Werner syndrome and Bloom syndrome...
  17. ncbi request reprint Putative role for EPC-1/PEDF in the G0 growth arrest of human diploid fibroblasts
    Robert J Pignolo
    Center for Gerontological Research, Medical College of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Cell Physiol 195:12-20. 2003
    ..Taken together, these results suggest that EPC-1 may play a role in the entry of early passage fibroblasts into a G(0) state or the maintenance of such a state once reached...

Research Grants5

  1. Circulating osteogenic cells in aging and disease
    Robert Pignolo; Fiscal Year: 2007
    ..LONG-TERM OBJECTIVES: To define the role of BdACs as osteogenic cells with potential for use in diagnostic testing, cell replacement therapy, or as a target population for gene therapy. ..
  2. Osteoporosis and osteoblast differentiation in mouse models of accelerated aging
    Robert Pignolo; Fiscal Year: 2007
    ..The Wrn-/-Terc -/- mutant mouse recapitulates senile osteoporosis characterized by decreased bone-forming capacity and provides a system to test stem cell replacement for amelioration of age-related osteoporosis. ..
  3. Osteoporosis and osteoblast differentiation in mouse models of accelerated aging
    ROBERT JOHN PIGNOLO; Fiscal Year: 2010
    ..The Wrn-/-Terc -/- mutant mouse recapitulates senile osteoporosis characterized by decreased bone-forming capacity and provides a system to test stem cell replacement for amelioration of age-related osteoporosis. ..