Research Topics
| Robert PignoloSummaryAffiliation: University of Pennsylvania Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Fibrodysplasia ossificans progressiva: clinical and genetic aspectsRobert J Pignolo
Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Orphanet J Rare Dis 6:80. 2011..The median lifespan is approximately 40 years of age. Most patients are wheelchair-bound by the end of the second decade of life and commonly die of complications of thoracic insufficiency syndrome...
Circulating osteogenic precursor cellsRobert J Pignolo
Department of Medicine, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104 6081, USA
Crit Rev Eukaryot Gene Expr 20:171-80. 2010..The role of COP cells in physiologic and pathophysiologic conditions of de novo bone formation suggests that they may serve as future targets for diagnostic measurements and therapeutic interventions...- Heterozygous inactivation of Gnas in adipose-derived mesenchymal progenitor cells enhances osteoblast differentiation and promotes heterotopic ossificationRobert J Pignolo
Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA
J Bone Miner Res 26:2647-55. 2011..Taken together, these data suggest that Gnas is a key regulator of fate decisions in adipose-derived mesenchymal progenitor cells, specifically those which are involved in bone formation... 
Circulating osteogenic cells: implications for injury, repair, and regenerationRobert J Pignolo
Department of Medicine and Orthopaedic Surgery, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6081, USA
J Bone Miner Res 26:1685-93. 2011..We present evidence for their existence, methods used for their isolation and identification, possible physiological and pathophysiological roles, cellular origins, and possible mechanisms for their migration to target tissues...- Defects in telomere maintenance molecules impair osteoblast differentiation and promote osteoporosisRobert J Pignolo
Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Aging Cell 7:23-31. 2008..These data provide evidence that replicative aging of osteoblast precursors is an important mechanism of senile osteoporosis... - Role for circulating osteogenic precursor cells in aortic valvular diseaseKevin P Egan
Department of Medicine, University of Pennsylvania School of Medicine, 36th St and Hamilton Walk, Philadelphia, PA 19104 6081, USA
Arterioscler Thromb Vasc Biol 31:2965-71. 2011..These cells are identified by coexpression of the osteogenic marker type 1 collagen or osteoclacin and the hematopoietic marker CD45. We tested the hypothesis that these cells may contribute to heart valve stenosis... - Morphogen receptor genes and metamorphogenes: skeleton keys to metamorphosisFrederick S Kaplan
Department of Orthopaedic Surgery and Medicine, The University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Ann N Y Acad Sci 1116:113-33. 2007..Such insight is applicable to a broad range of human afflictions... - A new era for fibrodysplasia ossificans progressiva: a druggable target for the second skeletonFrederick S Kaplan
University of Pennsylvania School of Medicine, Department of Orthopaedic Surgery, Hospital of the University of Pennsylvania, Silverstein Two, 34th and Spruce Street, Philadelphia, PA 19104, USA
Expert Opin Biol Ther 7:705-12. 2007..Effective therapies for FOP, and possibly for a vast array of more common conditions of heterotopic ossification, will be based on blocking activin-like kinase-2, a critical node in the BMP signaling pathway... - Hematopoietic stem-cell contribution to ectopic skeletogenesisFrederick S Kaplan
Center for Research in Fibrodyplasia Ossificans Progressiva and Related Disorders, Department of Orthopaedic Surgery, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6081, USA
J Bone Joint Surg Am 89:347-57. 2007..However, the definitive contribution of hematopoietic cells to the pathogenesis of ectopic skeletogenesis remains obscure... - Skeletal metamorphosis in fibrodysplasia ossificans progressiva (FOP)Frederick S Kaplan
Departments of Orthopaedic Surgery and Medicine, c o Department of Orthopaedic Surgery, Hospital of the University of Pennsylvania, Silverstein 2, 3400 Spruce Street, Philadelphia, PA, 19104, USA
J Bone Miner Metab 26:521-30. 2008.... - Circulating osteogenic precursor cells in heterotopic bone formationRobin K Suda
Department of Medicine, University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania 19104 6160, USA
Stem Cells 27:2209-19. 2009..Thus, bone formation is not limited to cells of the mesenchymal lineage, and circulating cells of hematopoietic origin can also serve as osteogenic precursors at remote sites of tissue inflammation... - The FOP metamorphogene encodes a novel type I receptor that dysregulates BMP signalingFrederick S Kaplan
Department of Orthopaedic Surgery, The Center for Research in FOP and Related Disorders, The University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Cytokine Growth Factor Rev 20:399-407. 2009.... - Fibrodysplasia ossificans progressivaFrederick S Kaplan
Departments of Orthopedic Surgery and Medicine, The University of Pennsylvania School of Medicine, c o Hospital of The University of Pennsylvania, Philadelphia, PA, USA
Best Pract Res Clin Rheumatol 22:191-205. 2008..Effective therapies for FOP, and possibly for other common conditions of HO, may potentially be based on future interventions that block ACVR1/ALK2 signalling... - v-ATPase V0 subunit d2-deficient mice exhibit impaired osteoclast fusion and increased bone formationSeoung Hoon Lee
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Nat Med 12:1403-9. 2006.... - Exploring human/animal intersections: converging lines of evidence in comparative models of agingJohn Q Trojanowski
School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
Alzheimers Dement 4:1-5. 2008..Instead, an optimal translational research model supports a bidirectional flow of information from animal models to clinical research... - Telomere shortening exposes functions for the mouse Werner and Bloom syndrome genesXiaobing Du
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Mol Cell Biol 24:8437-46. 2004..These findings indicate that telomere dysfunction may contribute to the pathogenesis of Werner syndrome and Bloom syndrome... - Putative role for EPC-1/PEDF in the G0 growth arrest of human diploid fibroblastsRobert J Pignolo
Center for Gerontological Research, Medical College of Pennsylvania, Philadelphia, Pennsylvania, USA
J Cell Physiol 195:12-20. 2003..Taken together, these results suggest that EPC-1 may play a role in the entry of early passage fibroblasts into a G(0) state or the maintenance of such a state once reached...
Research Grants
- Circulating osteogenic cells in aging and diseaseRobert Pignolo; Fiscal Year: 2007..LONG-TERM OBJECTIVES: To define the role of BdACs as osteogenic cells with potential for use in diagnostic testing, cell replacement therapy, or as a target population for gene therapy. ..
- Osteoporosis and osteoblast differentiation in mouse models of accelerated agingRobert Pignolo; Fiscal Year: 2007..The Wrn-/-Terc -/- mutant mouse recapitulates senile osteoporosis characterized by decreased bone-forming capacity and provides a system to test stem cell replacement for amelioration of age-related osteoporosis. ..
- Osteoporosis and osteoblast differentiation in mouse models of accelerated agingROBERT JOHN PIGNOLO; Fiscal Year: 2010..The Wrn-/-Terc -/- mutant mouse recapitulates senile osteoporosis characterized by decreased bone-forming capacity and provides a system to test stem cell replacement for amelioration of age-related osteoporosis. ..