Gary L Pierce

Summary

Affiliation: University of Colorado
Country: USA

Publications

  1. pmc Reduced vascular tetrahydrobiopterin (BH4) and endothelial function with ageing: is it time for a chronic BH4 supplementation trial in middle-aged and older adults?
    Gary L Pierce
    Department of Integrative Physiology, University of Colorado, Boulder, CO, USA
    J Physiol 586:2673-4. 2008
  2. pmc Nuclear factor-{kappa}B activation contributes to vascular endothelial dysfunction via oxidative stress in overweight/obese middle-aged and older humans
    Gary L Pierce
    Department of Integrative Physiology, University of Colorado at Boulder, 80309, USA
    Circulation 119:1284-92. 2009
  3. ncbi request reprint Effect of heart transplantation on skeletal muscle metabolic enzyme reserve and fiber type in end-stage heart failure patients
    Gary L Pierce
    Department of Applied Physiology and Kinesiology, Center for Exercise Science, College of Health and Human Performance, University of Florida, Gainesville, FL, USA
    Clin Transplant 21:94-100. 2007
  4. pmc Weight loss alone improves conduit and resistance artery endothelial function in young and older overweight/obese adults
    Gary L Pierce
    Department of Integrative Physiology, UCB 354, University of Colorado, Boulder, CO 80309, USA
    Hypertension 52:72-9. 2008
  5. doi request reprint Effects of exercise training on forearm and calf vasodilation and proinflammatory markers in recent heart transplant recipients: a pilot study
    Gary L Pierce
    Department of Applied Physiology and Kinesiology, College of Health and Human Performance, University of Florida, Gainesville, Florida, USA
    Eur J Cardiovasc Prev Rehabil 15:10-8. 2008
  6. ncbi request reprint Role of heart failure etiology on arterial wave reflection in heart transplant recipients: relation with C-reactive protein
    Gary L Pierce
    Department of Applied Physiology and Kinesiology, USA
    J Hypertens 25:2273-9. 2007
  7. pmc Habitually exercising older men do not demonstrate age-associated vascular endothelial oxidative stress
    Gary L Pierce
    Department of Integrative Physiology, University of Colorado, Boulder, CO 80309, USA
    Aging Cell 10:1032-7. 2011
  8. pmc Vascular endothelial function is related to white blood cell count and myeloperoxidase among healthy middle-aged and older adults
    Ashley E Walker
    Department of Integrative Physiology, University of Colorado, Boulder, Colo 80309, USA
    Hypertension 55:363-9. 2010
  9. pmc Regular aerobic exercise protects against impaired fasting plasma glucose-associated vascular endothelial dysfunction with aging
    Allison E DeVan
    Department of Integrative Physiology, University of Colorado, Boulder, CO 80309, USA
    Clin Sci (Lond) 124:325-31. 2013
  10. pmc Cytochrome P-450 2C9 signaling does not contribute to age-associated vascular endothelial dysfunction in humans
    Anthony J Donato
    Department of Integrative Physiology, Universty of Colorado at Boulder, 354 UCB, Boulder, CO 80309, USA
    J Appl Physiol (1985) 105:1359-63. 2008

Detail Information

Publications30

  1. pmc Reduced vascular tetrahydrobiopterin (BH4) and endothelial function with ageing: is it time for a chronic BH4 supplementation trial in middle-aged and older adults?
    Gary L Pierce
    Department of Integrative Physiology, University of Colorado, Boulder, CO, USA
    J Physiol 586:2673-4. 2008
  2. pmc Nuclear factor-{kappa}B activation contributes to vascular endothelial dysfunction via oxidative stress in overweight/obese middle-aged and older humans
    Gary L Pierce
    Department of Integrative Physiology, University of Colorado at Boulder, 80309, USA
    Circulation 119:1284-92. 2009
    ..We tested the hypothesis that nuclear factor-kappaB (NF-kappaB) activity contributes to vascular endothelial dysfunction with aging and obesity in humans...
  3. ncbi request reprint Effect of heart transplantation on skeletal muscle metabolic enzyme reserve and fiber type in end-stage heart failure patients
    Gary L Pierce
    Department of Applied Physiology and Kinesiology, Center for Exercise Science, College of Health and Human Performance, University of Florida, Gainesville, FL, USA
    Clin Transplant 21:94-100. 2007
    ..The purpose of this study was to determine the effect of heart transplantation on skeletal muscle metabolic enzyme reserve and MHC fiber type in end-stage HF patients...
  4. pmc Weight loss alone improves conduit and resistance artery endothelial function in young and older overweight/obese adults
    Gary L Pierce
    Department of Integrative Physiology, UCB 354, University of Colorado, Boulder, CO 80309, USA
    Hypertension 52:72-9. 2008
    ..The improvements in resistance artery function are mediated by an increase in NO bioavailability and are related to reductions in abdominal visceral fat...
  5. doi request reprint Effects of exercise training on forearm and calf vasodilation and proinflammatory markers in recent heart transplant recipients: a pilot study
    Gary L Pierce
    Department of Applied Physiology and Kinesiology, College of Health and Human Performance, University of Florida, Gainesville, Florida, USA
    Eur J Cardiovasc Prev Rehabil 15:10-8. 2008
    ..It is, however, currently unknown whether aerobic exercise has a similar effect in heart transplant recipients (HTR)...
  6. ncbi request reprint Role of heart failure etiology on arterial wave reflection in heart transplant recipients: relation with C-reactive protein
    Gary L Pierce
    Department of Applied Physiology and Kinesiology, USA
    J Hypertens 25:2273-9. 2007
    ....
  7. pmc Habitually exercising older men do not demonstrate age-associated vascular endothelial oxidative stress
    Gary L Pierce
    Department of Integrative Physiology, University of Colorado, Boulder, CO 80309, USA
    Aging Cell 10:1032-7. 2011
    ..Older men who exercise regularly do not demonstrate vascular endothelial oxidative stress, and this may be a key molecular mechanism underlying their reduced risk of cardiovascular diseases...
  8. pmc Vascular endothelial function is related to white blood cell count and myeloperoxidase among healthy middle-aged and older adults
    Ashley E Walker
    Department of Integrative Physiology, University of Colorado, Boulder, Colo 80309, USA
    Hypertension 55:363-9. 2010
    ....
  9. pmc Regular aerobic exercise protects against impaired fasting plasma glucose-associated vascular endothelial dysfunction with aging
    Allison E DeVan
    Department of Integrative Physiology, University of Colorado, Boulder, CO 80309, USA
    Clin Sci (Lond) 124:325-31. 2013
    ..e. endothelium-independent dilation). IFG exacerbates age-associated vascular endothelial dysfunction and this adverse effect is completely prevented in MA/O adults who regularly perform aerobic exercise...
  10. pmc Cytochrome P-450 2C9 signaling does not contribute to age-associated vascular endothelial dysfunction in humans
    Anthony J Donato
    Department of Integrative Physiology, Universty of Colorado at Boulder, 354 UCB, Boulder, CO 80309, USA
    J Appl Physiol (1985) 105:1359-63. 2008
    ..These results provide the first support for the concept that increased CYP 2C9 signaling does not contribute to impairments in EDD with aging in healthy adults...
  11. pmc Translational evidence that impaired autophagy contributes to arterial ageing
    Thomas J Larocca
    Department of Integrative Physiology, University of Colorado at Boulder, 354 UCB, Boulder, CO 80309, USA
    J Physiol 590:3305-16. 2012
    ..Autophagy-enhancing strategies may therefore have therapeutic efficacy for ameliorating age-associated arterial dysfunction and preventing CVD...
  12. pmc Sex-specific effects of habitual aerobic exercise on brachial artery flow-mediated dilation in middle-aged and older adults
    Gary L Pierce
    Department of Integrative Physiology, University of Colorado, Boulder, CO 80309, U S A
    Clin Sci (Lond) 120:13-23. 2011
    ..Some post-menopausal women without CVD may be less responsive to habitual aerobic exercise than MA/O men...
  13. pmc Low dietary sodium intake is associated with enhanced vascular endothelial function in middle-aged and older adults with elevated systolic blood pressure
    Kristen L Jablonski
    Department of Integrative Physiology, University of Colorado, Boulder, Colorado, USA
    Ther Adv Cardiovasc Dis 3:347-56. 2009
    ..We tested the hypothesis that vascular endothelial function is related to dietary sodium intake among middle-aged and older adults (MA and O) with elevated systolic BP...
  14. ncbi request reprint Effect of resistance exercise on skeletal muscle myopathy in heart transplant recipients
    Randy W Braith
    Center for Exercise Science, College of Health and Human Performance, University of Florida, Gainesville, Florida 32611, USA
    Am J Cardiol 95:1192-8. 2005
    ..Resistance exercise initiated early in the post-transplant period is efficacious in changing skeletal muscle phenotype through increases in enzymatic reserve and shifts in fiber morphology...
  15. doi request reprint Exercise training attenuates progressive decline in brachial artery reactivity in heart transplant recipients
    Randy W Braith
    Center for Exercise Science, Department of Applied Physiology and Kinesiology, College of Health and Human Performance, University of Florida, Gainesville, Florida 32611, USA
    J Heart Lung Transplant 27:52-9. 2008
    ..Heart transplantation normalizes central hemodynamics, but endothelial dysfunction persists after transplantation...
  16. doi request reprint Changes in central artery blood pressure and wave reflection during a cold pressor test in young adults
    Darren P Casey
    Department of Applied Physiology and Kinesiology, College of Health and Human Performance, University of Florida, Gainesville, FL, USA
    Eur J Appl Physiol 103:539-43. 2008
    ....
  17. ncbi request reprint Direct evidence of endothelial oxidative stress with aging in humans: relation to impaired endothelium-dependent dilation and upregulation of nuclear factor-kappaB
    Anthony J Donato
    Department of Integrative Physiology, University of Colorado at Boulder, Boulder, CO 80309, USA
    Circ Res 100:1659-66. 2007
    ..Increased expression of NAD(P)H oxidase and nuclear factor-kappaB may contribute to endothelial oxidative stress with aging in humans...
  18. ncbi request reprint Arterial-wave reflections are increased in heart failure patients with a left-ventricular assist device
    Richard S Schofield
    Department of Veterans Affairs Medical Center, Gainesville, Florida, USA
    Am J Hypertens 20:622-8. 2007
    ..Although the treatment of HF via left-ventricular assist device (LVAD) placement has recently become widespread, the effects of LVAD therapy on central arterial pulse-wave reflections are unknown...
  19. pmc Vascular smooth muscle responsiveness to nitric oxide is reduced in healthy adults with increased adiposity
    Demetra D Christou
    Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, USA
    Am J Physiol Heart Circ Physiol 303:H743-50. 2012
    ..Adiposity may influence NID in part via other cardiovascular risk factors...
  20. pmc 25-Hydroxyvitamin D deficiency is associated with inflammation-linked vascular endothelial dysfunction in middle-aged and older adults
    Kristen L Jablonski
    Department of Integrative Physiology, University of Colorado, Boulder, Colo 80309, USA
    Hypertension 57:63-9. 2011
    ..Reduced vitamin D receptor and 1-α hydroxylase may be molecular mechanisms linking vitamin D insufficiency to endothelial dysfunction...
  21. ncbi request reprint Effect of resistance training on arterial wave reflection and brachial artery reactivity in normotensive postmenopausal women
    Darren P Casey
    Center for Exercise Science, Department of Applied Physiology and Kinesiology, College of Health and Human Performance, University of Florida, PO Box 118206, Gainesville, FL 32611, USA
    Eur J Appl Physiol 100:403-8. 2007
    ..This prospective, randomized study demonstrated that moderate intensity whole body RT in previously sedentary, normotensive postmenopausal women does not alter central aortic pressure wave reflection...
  22. pmc Habitual exercise and vascular ageing
    Douglas R Seals
    University of Colorado, 354 UCB, Boulder, CO 80309, USA
    J Physiol 587:5541-9. 2009
    ..Aerobic exercise also may protect arteries with ageing by increasing resistance to the effects of other CVD risk factors like LDL-cholesterol. Habitual aerobic exercise is an effective strategy to combat arterial ageing...
  23. pmc Increased proinflammatory and oxidant gene expression in circulating mononuclear cells in older adults: amelioration by habitual exercise
    Lindsey B Gano
    Department of Integrative Physiology, University of Colorado, Boulder, Colorado 80309, USA
    Physiol Genomics 43:895-902. 2011
    ..This proinflammatory/-oxidative gene signature may represent a therapeutic target for lifestyle and pharmacological prevention and treatment strategies...
  24. pmc Modulation of vascular endothelial function by low-density lipoprotein cholesterol with aging: influence of habitual exercise
    Ashley E Walker
    Department of Integrative Physiology, University of Colorado, Boulder, Colorado, USA
    Am J Hypertens 22:250-6. 2009
    ..The purpose of this study was to determine whether circulating LDL-C within the "normal" range modulates EDD in healthy older adults and whether young age or habitual aerobic exercise protects against this adverse effect...
  25. pmc Tetrahydrobiopterin supplementation enhances carotid artery compliance in healthy older men: a pilot study
    Gary L Pierce
    Department of Integrative Physiology, University of Colorado, Boulder, USA
    Am J Hypertens 25:1050-4. 2012
    ..We performed a pilot study to test the hypothesis that acute oral ingestion of tetrahydrobiopterin (BH(4)), a key cofactor modulating vascular nitric oxide (NO) synthase activity, improves large elastic artery stiffness with aging in men...
  26. pmc Leukocyte telomere length is preserved with aging in endurance exercise-trained adults and related to maximal aerobic capacity
    Thomas J Larocca
    Department of Integrative Physiology, University of Colorado, Boulder, CO 80309, USA
    Mech Ageing Dev 131:165-7. 2010
    ..This may represent a novel molecular mechanism underlying the "anti-aging" effects of maintaining high aerobic fitness...
  27. doi request reprint Pulse wave analysis of the aortic pressure waveform in severe left ventricular systolic dysfunction
    Scott J Denardo
    Division of Cardiovascular Medicine, University of Florida College of Medicine, Gainesville, FL 32610, USA
    Circ Heart Fail 3:149-56. 2010
    ..The effect of moderate left ventricular systolic dysfunction (LVSD) on ventricular/vascular coupling and the aortic pressure waveform (AoPW) has been well described, but the effect of severe LVSD has not...
  28. ncbi request reprint Radial artery tonometry demonstrates arterial stiffness in children with type 1 diabetes
    Michael J Haller
    Pediatric Endocrinology, P O Box 100296, Gainesville, FL 32610, USA
    Diabetes Care 27:2911-7. 2004
    ..To determine if children with type 1 diabetes have increased arterial stiffness by estimating augmentation index with the simple noninvasive technique of radial artery tonometry...
  29. ncbi request reprint Serum superoxide dismutase activity and nitric oxide do not correlate with arterial stiffness in children with type 1 diabetes mellitus
    Michael J Haller
    Division of Pediatric Endocrinology, Department of Pediatrics University of Florida, Gainesville 32610, USA
    J Pediatr Endocrinol Metab 19:267-9. 2006
  30. ncbi request reprint Effect of exercise training on endothelial function in men with coronary artery disease
    David G Edwards
    Department of Kinesiology, University of New Hampshire, Durham, New Hampshire 03824, USA
    Am J Cardiol 93:617-20. 2004
    ..9% at baseline vs 11.1% at 12 weeks). Exercise training resulted in increased plasma nitrite and nitrate levels, increased plasma superoxide dismutase activity, and decreased oxidative stress...