Andrew A Pieper

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. ncbi Discovery of a proneurogenic, neuroprotective chemical
    Andrew A Pieper
    Department of Biochemistry, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9152, USA
    Cell 142:39-51. 2010
  2. ncbi Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of Parkinson disease
    Héctor De Jesús-Cortés
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 109:17010-5. 2012
  3. ncbi The neuronal PAS domain protein 3 transcription factor controls FGF-mediated adult hippocampal neurogenesis in mice
    Andrew A Pieper
    Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 102:14052-7. 2005
  4. ncbi Acid promoted cinnamyl ion mobility within peptide derived macrocycles
    Hongda Zhao
    Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9038, USA
    J Am Chem Soc 130:13864-6. 2008
  5. ncbi Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of amyotrophic lateral sclerosis
    Rachel Tesla
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 109:17016-21. 2012
  6. ncbi Development of proneurogenic, neuroprotective small molecules
    Karen S MacMillan
    Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9038, United States
    J Am Chem Soc 133:1428-37. 2011
  7. ncbi Unesterified cholesterol accumulation in late endosomes/lysosomes causes neurodegeneration and is prevented by driving cholesterol export from this compartment
    Amal Aqul
    Department of Pediatrics, The University of Texas Southwestern Medical School, Dallas, Texas 75390, USA
    J Neurosci 31:9404-13. 2011

Collaborators

  • Stephen D Turley
  • Jenny Hsieh
  • JEF DE BRABANDER
  • Sandi Jo Estill
  • Rachel Tesla
  • Lorraine Morlock
  • Joseph M Ready
  • Jacinth Naidoo
  • Noelle S Williams
  • Steven L McKnight
  • Pin Xu
  • Héctor De Jesús-Cortés
  • Paula Huntington
  • Jordan Drawbridge
  • Stephanie Tran
  • Amal Aqul
  • Karen S MacMillan
  • Hongda Zhao
  • Hamilton Parker Wolf
  • Jeremiah Britt
  • Aaron Burket
  • Latisha McDaniel
  • Ruth Starwalt
  • Gelin Wang
  • Whitney Knobbe
  • Lisa M Melito
  • Bing Liu
  • Ginger L Becker
  • Paula J Huntington
  • Benny Liu
  • Joyce J Repa
  • Jamie Longgood
  • Lisa Melito
  • Dennis K Burns
  • John M Dietschy
  • Jue Liang
  • Charina M Ramirez
  • Thomas G LaCour
  • Patrick G Harran
  • Emanuela Capota
  • Lidet Negash
  • Qi Wei

Detail Information

Publications7

  1. ncbi Discovery of a proneurogenic, neuroprotective chemical
    Andrew A Pieper
    Department of Biochemistry, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9152, USA
    Cell 142:39-51. 2010
    ..Prolonged administration of P7C3 to aged rats also enhanced neurogenesis in the dentate gyrus, impeded neuron death, and preserved cognitive capacity as a function of terminal aging. PAPERCLIP:..
  2. ncbi Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of Parkinson disease
    Héctor De Jesús-Cortés
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 109:17010-5. 2012
    ..We propose that the chemical scaffold represented by P7C3 and P7C3A20 provides a basis for optimizing and advancing pharmacologic agents for the treatment of patients with PD...
  3. ncbi The neuronal PAS domain protein 3 transcription factor controls FGF-mediated adult hippocampal neurogenesis in mice
    Andrew A Pieper
    Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 102:14052-7. 2005
    ..We propose that a deficiency in adult neurogenesis may cause the behavioral and neuroanatomical abnormalities seen in Npas3-/- mice, and we speculate that impaired neurogenesis may be involved in the pathophysiology of schizophrenia...
  4. ncbi Acid promoted cinnamyl ion mobility within peptide derived macrocycles
    Hongda Zhao
    Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9038, USA
    J Am Chem Soc 130:13864-6. 2008
    ..From a library of screening fractions generated in this way, we have identified a small molecule that selectively promotes hippocampal neurogenesis in the adult mouse brain...
  5. ncbi Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of amyotrophic lateral sclerosis
    Rachel Tesla
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 109:17016-21. 2012
    ..We propose that the chemical scaffold represented by P7C3 and P7C3A20 may provide a basis for the discovery and optimization of pharmacologic agents for the treatment of ALS...
  6. ncbi Development of proneurogenic, neuroprotective small molecules
    Karen S MacMillan
    Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9038, United States
    J Am Chem Soc 133:1428-37. 2011
    ..The most potent compounds are active at nanomolar concentrations. Finally, we have identified derivatives that may facilitate mode-of-action studies through affinity chromatography or photo-cross-linking...
  7. ncbi Unesterified cholesterol accumulation in late endosomes/lysosomes causes neurodegeneration and is prevented by driving cholesterol export from this compartment
    Amal Aqul
    Department of Pediatrics, The University of Texas Southwestern Medical School, Dallas, Texas 75390, USA
    J Neurosci 31:9404-13. 2011
    ..Inactivation of NPC1 leads to lysosomal C sequestration and neurodegeneration, but this is prevented by the continuous, direct administration of HP-β-CD into the CNS...