Andrew A Pieper

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. pmc Discovery of a proneurogenic, neuroprotective chemical
    Andrew A Pieper
    Department of Biochemistry, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9152, USA
    Cell 142:39-51. 2010
  2. pmc Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of Parkinson disease
    Héctor De Jesús-Cortés
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 109:17010-5. 2012
  3. pmc The neuronal PAS domain protein 3 transcription factor controls FGF-mediated adult hippocampal neurogenesis in mice
    Andrew A Pieper
    Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 102:14052-7. 2005
  4. doi Acid promoted cinnamyl ion mobility within peptide derived macrocycles
    Hongda Zhao
    Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9038, USA
    J Am Chem Soc 130:13864-6. 2008
  5. pmc Double deletion of melanocortin 4 receptors and SAPAP3 corrects compulsive behavior and obesity in mice
    Pin Xu
    Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 110:10759-64. 2013
  6. pmc Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of amyotrophic lateral sclerosis
    Rachel Tesla
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 109:17016-21. 2012
  7. pmc Development of proneurogenic, neuroprotective small molecules
    Karen S MacMillan
    Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9038, United States
    J Am Chem Soc 133:1428-37. 2011
  8. pmc Unesterified cholesterol accumulation in late endosomes/lysosomes causes neurodegeneration and is prevented by driving cholesterol export from this compartment
    Amal Aqul
    Department of Pediatrics, The University of Texas Southwestern Medical School, Dallas, Texas 75390, USA
    J Neurosci 31:9404-13. 2011

Collaborators

  • Charina M Ramirez
  • Michael Lutter
  • Xinle Wu
  • Stephen D Turley
  • Jenny Hsieh
  • JEF DE BRABANDER
  • Sandi Jo Estill
  • Pin Xu
  • Stephanie Tran
  • Rachel Tesla
  • Noelle S Williams
  • Jacinth Naidoo
  • Steven L McKnight
  • Joseph M Ready
  • Lorraine Morlock
  • Latisha McDaniel
  • Paula J Huntington
  • Paula Huntington
  • Jordan Drawbridge
  • Héctor De Jesús-Cortés
  • Karen S MacMillan
  • Amal Aqul
  • Hongda Zhao
  • Brittany L Mason
  • Brad A Grueter
  • Charlotte Lee
  • Bradford B Lowell
  • Linh Vong
  • Robert C Malenka
  • Jeremiah K Britt
  • Rachel Hodge
  • Aaron Burket
  • Lisa M Melito
  • Hamilton Parker Wolf
  • Ruth Starwalt
  • Gelin Wang
  • Jeremiah Britt
  • Whitney Knobbe
  • Jamie Longgood
  • John M Dietschy
  • Bing Liu
  • Benny Liu
  • Jue Liang
  • Lisa Melito
  • Ginger L Becker
  • Dennis K Burns
  • Joyce J Repa
  • Patrick G Harran
  • Qi Wei
  • Thomas G LaCour
  • Emanuela Capota
  • Lidet Negash

Detail Information

Publications8

  1. pmc Discovery of a proneurogenic, neuroprotective chemical
    Andrew A Pieper
    Department of Biochemistry, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9152, USA
    Cell 142:39-51. 2010
    ..Prolonged administration of P7C3 to aged rats also enhanced neurogenesis in the dentate gyrus, impeded neuron death, and preserved cognitive capacity as a function of terminal aging. PAPERCLIP:..
  2. pmc Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of Parkinson disease
    Héctor De Jesús-Cortés
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 109:17010-5. 2012
    ..We propose that the chemical scaffold represented by P7C3 and P7C3A20 provides a basis for optimizing and advancing pharmacologic agents for the treatment of patients with PD...
  3. pmc The neuronal PAS domain protein 3 transcription factor controls FGF-mediated adult hippocampal neurogenesis in mice
    Andrew A Pieper
    Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 102:14052-7. 2005
    ..We propose that a deficiency in adult neurogenesis may cause the behavioral and neuroanatomical abnormalities seen in Npas3-/- mice, and we speculate that impaired neurogenesis may be involved in the pathophysiology of schizophrenia...
  4. doi Acid promoted cinnamyl ion mobility within peptide derived macrocycles
    Hongda Zhao
    Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9038, USA
    J Am Chem Soc 130:13864-6. 2008
    ..From a library of screening fractions generated in this way, we have identified a small molecule that selectively promotes hippocampal neurogenesis in the adult mouse brain...
  5. pmc Double deletion of melanocortin 4 receptors and SAPAP3 corrects compulsive behavior and obesity in mice
    Pin Xu
    Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 110:10759-64. 2013
    ..Our findings offer insights into the pathophysiology and treatment of both compulsive behavior and eating disorders. ..
  6. pmc Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of amyotrophic lateral sclerosis
    Rachel Tesla
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 109:17016-21. 2012
    ..We propose that the chemical scaffold represented by P7C3 and P7C3A20 may provide a basis for the discovery and optimization of pharmacologic agents for the treatment of ALS...
  7. pmc Development of proneurogenic, neuroprotective small molecules
    Karen S MacMillan
    Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9038, United States
    J Am Chem Soc 133:1428-37. 2011
    ..The most potent compounds are active at nanomolar concentrations. Finally, we have identified derivatives that may facilitate mode-of-action studies through affinity chromatography or photo-cross-linking...
  8. pmc Unesterified cholesterol accumulation in late endosomes/lysosomes causes neurodegeneration and is prevented by driving cholesterol export from this compartment
    Amal Aqul
    Department of Pediatrics, The University of Texas Southwestern Medical School, Dallas, Texas 75390, USA
    J Neurosci 31:9404-13. 2011
    ..Inactivation of NPC1 leads to lysosomal C sequestration and neurodegeneration, but this is prevented by the continuous, direct administration of HP-β-CD into the CNS...