Research Topics
| P J PickhardtSummaryAffiliation: University of Wisconsin Country: USA Publications
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Publications
Primary neoplasms of peritoneal and sub-peritoneal origin: CT findingsPerry J Pickhardt
Department of Radiology, University of Wisconsin Medical School, E3 311 Clinical Science Center, 600 Highland Ave, Madison, WI 53792, USA
Radiographics 25:983-95. 2005..CT is useful not only for the detection, characterization, and staging of primary neoplasms of peritoneal and subperitoneal origin, but also for guiding biopsy for tissue diagnosis...
Unusual nonneoplastic peritoneal and subperitoneal conditions: CT findingsPerry J Pickhardt
Department of Radiology, University of Wisconsin Medical School, Madison, WI 53792, USA
Radiographics 25:719-30. 2005..CT is an excellent imaging modality for detection and characterization of peritoneal involvement from these unusual diseases...
CT colonography (virtual colonoscopy) for primary colorectal screening: challenges facing clinical implementationP J Pickhardt
Department of Radiology, University of Wisconsin Medical School, E3/311 Clinical Science Center, 600 Highland Avenue, Madison, WI 53792-3252, USA
Abdom Imaging 30:1-4. 2005
Differential diagnosis of polypoid lesions seen at CT colonography (virtual colonoscopy)Perry J Pickhardt
Department of Radiology, University of Wisconsin Medical School, E3 311 Clinical Science Center, 600 Highland Ave, Madison, WI 53792, USA
Radiographics 24:1535-56; discussion 1557-9. 2004..A variety of useful techniques and observations can be used to increase the specificity of CT colonography for distinguishing false polyps from true polyps...
Location of adenomas missed by optical colonoscopyPerry J Pickhardt
Department of Radiology, University of Wisconsin Medical School, E3 311 Clinical Science Center, 600 Highland Avenue, Madison, WI 53792 3252, USA
Ann Intern Med 141:352-9. 2004..Previous estimates of the adenoma miss rate with optical colonoscopy (OC) are hindered by the use of OC as its own reference standard...
Translucency rendering in 3D endoluminal CT colonography: a useful tool for increasing polyp specificity and decreasing interpretation timePerry J Pickhardt
Department of Radiology, University of Wisconsin Medical School, Clinical Science Center, 600 Highland Ave, E3/311, Madison, WI 53792-3252, USA
AJR Am J Roentgenol 183:429-36. 2004
Nonadenomatous polyps at CT colonography: prevalence, size distribution, and detection ratesPerry J Pickhardt
Department of Radiology, University of Wisconsin Medical School, E3 311 Clinical Science Center, 600 Highland Ave, Madison, WI 53792 3252, USA
Radiology 232:784-90. 2004..To prospectively investigate with computed tomographic (CT) colonography the prevalence and size distribution of nonadenomatous polyps in asymptomatic adults and to compare the detection rates of adenomatous and nonadenomatous polyps...
Computed tomographic virtual colonoscopy to screen for colorectal neoplasia in asymptomatic adultsPerry J Pickhardt
Department of Radiology, National Naval Medical Center, Bethesda, MD, USA
N Engl J Med 349:2191-200. 2003..We evaluated the performance characteristics of computed tomographic (CT) virtual colonoscopy for the detection of colorectal neoplasia in an average-risk screening population...
Computed tomographic colonography for colorectal screeningD H Kim
Department of Radiology, University of Wisconsin Medical School, Madison, Wisconsin 53792 3525, USA
Endoscopy 39:545-9. 2007..This article describes the approach used at the University of Wisconsin, which has been validated in a large multicenter screening trial and which is currently used for an active CTC-based colorectal cancer screening program...
Virtual colonoscopy for primary screening. The future is nowP J Pickhardt
Department of Radiology, University of Wisconsin, Medical School, E3 311 Clinical Science Center, Madison, WI 53792, USA
Minerva Chir 60:139-50. 2005..This review will cover current VC technique, compare the existing multi-center VC trials, discuss issues related to primary VC screening, and briefly update the progress of our VC screening program...
Screening CT colonography: how I do itPerry J Pickhardt
Department of Radiology, University of Wisconsin Medical School, E3 311 Clinical Science Center, 600 Highland Ave, Madison, WI 53792 3252, USA
AJR Am J Roentgenol 189:290-8. 2007..CT colonography is ideally suited for widespread screening of asymptomatic adults and has become an integral component of the screening efforts at my institution since local third-party coverage was initiated...
Incidence of colonic perforation at CT colonography: review of existing data and implications for screening of asymptomatic adultsPerry J Pickhardt
Department of Radiology, University of Wisconsin Medical School, E3/311 Clinical Science Center, 600 Highland Ave, Madison, WI 53792-3252, USA
Radiology 239:313-6. 2006
Evaluation of submucosal lesions of the large intestine: part 2. Nonneoplastic causesPerry J Pickhardt
Department of Radiology, University of Wisconsin Medical School, 600 Highland Ave, E3 311 Clinical Science Center, Madison, WI 53792 3252, USA
Radiographics 27:1693-703. 2007....
Evaluation of submucosal lesions of the large intestine: part 1. NeoplasmsPerry J Pickhardt
Department of Radiology, University of Wisconsin Medical School, 600 Highland Ave, E3 311 Clinical Science Center, Madison, WI 53792 3252, USA
Radiographics 27:1681-92. 2007..It is important that radiologists be familiar with the multimodality imaging appearances of such entities so that neoplasms--especially those that are malignant--can be accurately identified and characterized and effectively managed...
Impact of a CT colonography screening program on endoscopic colonoscopy in clinical practiceDarren C Schwartz
Department of Medicine, Section of Gastroenterology and Hepatology, University of Wisconsin Medical School Madison, Madison, WI 53792 5124, USA
Am J Gastroenterol 103:346-51. 2008..The potential effect of CT colonography (CTC) on endoscopic colonoscopy (EC) has been the topic of much speculation. The aim of this study was to evaluate the impact of a CTC screening program on colonoscopy in clinical practice...
CT colonography versus colonoscopy for the detection of advanced neoplasiaDavid H Kim
Department of Radiology, University of Wisconsin Medical School, Madison 53792 3252, USA
N Engl J Med 357:1403-12. 2007..Advanced neoplasia represents the primary target for colorectal-cancer screening and prevention. We compared the diagnostic yield from parallel computed tomographic colonography (CTC) and optical colonoscopy (OC) screening programs...
Anatomic factors predictive of incomplete colonoscopy based on findings at CT colonographyMeghan E Hanson
Department of Radiology, University of Wisconsin Medical School, E3 311 Clinical Science Center, 600 Highland Ave, Madison, WI 53792 3252, USA
AJR Am J Roentgenol 189:774-9. 2007..Reasons for failure to reach the cecum at optical colonoscopy are multifactorial. The purpose of this study was to compare CT colonography (CTC) findings in patients with complete versus those with incomplete optical colonoscopy...
Polyp detection at CT colonography: inadequate primary 3D endoluminal reference standard precludes meaningful comparisonPerry J Pickhardt
Radiology 244:316-7. 2007
Teniae coli-based circumferential localization system for CT colonography: feasibility studyAdam Huang
Diagnostic Radiology Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892 1182, USA
Radiology 243:551-60. 2007..The teniae coli are extractable landmarks, and the teniae coli-based circumferential localization system helps guide virtual navigation and polyp registration at CT colonography...
Effect of colonic distention on superiority of supine versus prone views in screening computed tomographic colonographySteven J Michel
Department of Radiology, University of Wisconsin Medical School, Madison, WI, USA
Clin Imaging 31:325-8. 2007..The purpose of this study was to evaluate the effect of colonic distention in computed tomographic colonography (CTC)...
CT colonography (virtual colonoscopy): a practical approach for population screeningPerry J Pickhardt
Department of Radiology, University of Wisconsin Medical School, E3 311 Clinical Science Center, 600 Highland Ave, Madison, WI 53792 3252, USA
Radiol Clin North Am 45:361-75. 2007..It discusses the entire spectrum from program set-up through patient disposition following CTC examination. The authors hope this article will provide a roadmap for radiologists who wish to institute a CTC screening program...
Primary 2D versus primary 3D polyp detection at screening CT colonographyPerry J Pickhardt
Department of Radiology, University of Wisconsin Medical School, E3 311 Clinical Science Center, 600 Highland Ave, Madison, WI 53792 3252, USA
AJR Am J Roentgenol 189:1451-6. 2007..Our goal was to assess the sensitivity of primary 2D polyp detection with cases from the Department of Defense CTC screening trial and compare results with the primary 3D evaluation and previous 2D CTC trials...
Quality assessment for CT colonography: validation of automated measurement of colonic distention and residual fluidKeshav K Deshpande
Diagnostic Radiology Department, Clinical Center, National Institutes of Health, Bldg 10, Room 1C368X, Bethesda, MD 20892 1182, USA
AJR Am J Roentgenol 189:1457-63. 2007....
Small and diminutive polyps detected at screening CT colonography: a decision analysis for referral to colonoscopyPerry J Pickhardt
Department of Radiology, University of Wisconsin Medical School, E3 311 Clinical Science Center, 600 Highland Ave, Madison, WI 53792 3252, USA
AJR Am J Roentgenol 190:136-44. 2008..The objective of this study was to assess the clinical and economic impact of colonoscopic referral for small and diminutive polyps detected at CT colonography (CTC) screening...
Revised colorectal screening guidelines: joint effort of the American Cancer Society, U.S. Multisociety Task Force on Colorectal Cancer, and American College of RadiologyElizabeth G McFarland
Radiology 248:717-20. 2008
Imaging of primary malignant tumors of peritoneal and retroperitoneal originJ Louis Hinshaw
Department of Radiology, University of Wisconsin Medical School, Madison, WI, 53792, USA
Cancer Treat Res 143:281-97. 2008....
Findings on optical colonoscopy after positive CT colonography examDaniel Cornett
Section of Gastroenterology and Hepatology, Department of Medicine, University of Wisconsin Madison School of Medicine and Public Health, Madison, Wisconsin 53792 5124, USA
Am J Gastroenterol 103:2068-74. 2008..The aim of this study is to evaluate the findings on optical colonoscopy (OC) after a positive CT colonography (CTC) exam and characterize the type of polyps seen on OC but not reported by CTC...
Performance of a previously validated CT colonography computer-aided detection system in a new patient populationRonald M Summers
Diagnostic Radiology Department, National Institutes of Health Clinical Center, Bldg 10, Rm 1C368X MSC 1182, Bethesda, MD 20892 1182, USA
AJR Am J Roentgenol 191:168-74. 2008....
Screening for nonpolypoid colorectal neoplasmsPerry J Pickhardt
JAMA 299:2743; author reply 2743-4. 2008
Imaging evaluation of complications at optical colonoscopyDavid H Kim
Department of Radiology, University of Wisconsin Medical School, Madison, WI 53792 3252, USA
Curr Probl Diagn Radiol 37:165-77. 2008..Emphasis will be placed on cross-sectional imaging given the improved sensitivity and specificity over conventional radiography...
Computerized tomography colonography: a primer for gastroenterologistsPerry J Pickhardt
Department of Radiology, University of Wisconsin Medical School, Madison, Wisconsin 53792-3252, USA
Clin Gastroenterol Hepatol 6:497-502. 2008
Is there sufficient MDCT capacity to provide colorectal cancer screening with CT colonography for the U.S. population?Perry J Pickhardt
Department of Radiology, University of Wisconsin Medical School, E3 311 Clinical Science Center, 600 Highland Ave, Madison, WI 53792 3252, USA
AJR Am J Roentgenol 190:1044-9. 2008..Our aim was to assess the ability of the available MDCT capacity in the United States to provide population screening with CTC...
CT colonography and computer-aided detection: effect of false-positive results on reader specificity and reading efficiency in a low-prevalence screening populationStuart A Taylor
Department of Specialist X Ray, University College Hospital, 2F Podium, 235 Euston Rd, London NW1 2BU, England
Radiology 247:133-40. 2008....
Reproducibility of tumor volume measurement at microCT colonography in living miceBenjamin Y Durkee
Department of Medical Physics, 1400 University Avenue, University of Wisconsin, Madison, WI 53706, USA
Acad Radiol 15:334-41. 2008..The precision and accuracy of volumetric measurements were determined to assess whether changes in tumor volume over time were readily detectable...
Missed lesions at primary 2D CT colonography: further support for 3D polyp detectionPerry J Pickhardt
Radiology 246:648; author reply 648-9. 2008
Asymptomatic pneumatosis at CT colonography: a benign self-limited imaging finding distinct from perforationPerry J Pickhardt
Department of Radiology, University of Wisconsin Medical School, E3 311 Clinical Science Center, 600 Highland Ave, Madison, WI 53792 3252, USA
AJR Am J Roentgenol 190:W112-7. 2008..The purpose of our study was to report the prevalence and clinical course of colonic pneumatosis at CT colonography (CTC)...
Cost-effectiveness of colorectal cancer screening with computed tomography colonography: the impact of not reporting diminutive lesionsPerry J Pickhardt
Department of Radiology, University of Wisconsin Medical School, Madison, Wisconsin 53792 3252, USA
Cancer 109:2213-21. 2007..The purpose of the current study was to assess the potential harms, benefits, and cost-effectiveness of CTC screening without the reporting of diminutive lesions compared with other screening strategies...
Characteristics of advanced adenomas detected at CT colonographic screening: implications for appropriate polyp size thresholds for polypectomy versus surveillanceDavid H Kim
Department of Radiology, University of Wisconsin Medical School, 600 Highland Ave, E3 311 Clinical Science Center, Madison, WI 53792 3252, USA
AJR Am J Roentgenol 188:940-4. 2007..These observations may be a basis for formulation of polypectomy thresholds and CTC surveillance strategies...
Inverted appendiceal stumps simulating large pedunculated polyps on screening CT colonographyTyler M Prout
Department of Radiology, University of Wisconsin Medical School, E3/311 Clinical Science Center, 600 Highland Ave, Madison, WI 53792-3252, USA
AJR Am J Roentgenol 186:535-8. 2006
Oral contrast adherence to polyps on CT colonographyRonald M Summers
Radiology Department, National Institutes of Health, Bethesda, MD and Uniformed Services University of the Health Sciences, Bethesda, MD 20892-1182, USA
J Comput Assist Tomogr 30:51-7. 2006..Polyps with villous histology show a higher rate of contrast adherence than nonvillous polyps...
Computed tomographic virtual colonoscopy computer-aided polyp detection in a screening populationRonald M Summers
Diagnostic Radiology Department, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland 20892 1182, USA
Gastroenterology 129:1832-44. 2005..Our objective was to determine whether a computer program is as sensitive as optical colonoscopy for the detection of adenomatous colonic polyps on CT virtual colonoscopy...
Linear polyp measurement at CT colonography: in vitro and in vivo comparison of two-dimensional and three-dimensional displaysPerry J Pickhardt
Department of Radiology, University of Wisconsin Medical School, E3 311 Clinical Science Center, 600 Highland Ave, Madison, WI 53792 3252, USA
Radiology 236:872-8. 2005....
Electronic cleansing and stool tagging in CT colonography: advantages and pitfalls with primary three-dimensional evaluationPerry J Pickhardt
Department of Radiology, National Naval Medical Center, 8901 Wisconsin Ave, Bethesda, MD 20889-5600, USA
AJR Am J Roentgenol 181:799-805. 2003
CT colonography reporting and data system: a consensus proposalMichael E Zalis
Radiology 236:3-9. 2005
Automated seed placement for colon segmentation in computed tomography colonographyGheorghe Iordanescu
Department of Radiology, National Institutes of Health, Building 10, Room 1C660, 10 Center Drive MSC 1182, Bethesda, MD 20892-1182, USA
Acad Radiol 12:182-90. 2005..CONCLUSION: Fully automatic seed placement for colonic segmentation is feasible in the majority of cases without seeding of undesired extracolonic air...
Computer-aided detection of polyps on oral contrast-enhanced CT colonographyRonald M Summers
Radiology Department, National Institutes of Health, 10 Center Dr, Bldg. 10, Rm. 1C660, MSC 1182, Bethesda, MD 20892-1182, USA
AJR Am J Roentgenol 184:105-8. 2005
The effect of diagnostic confidence on the probability of optical colonoscopic confirmation of potential polyps detected on CT colonography: prospective assessment in 1,339 asymptomatic adultsPerry J Pickhardt
Department of Radiology, University of Wisconsin Medical School, E3/311 Clinical Science Center, 600 Highland Ave, Madison, WI 53792-3252, USA
AJR Am J Roentgenol 183:1661-5. 2004..Although polyp size represents the primary criterion for CTC screening algorithms, this data could help guide the decision to opt for noninvasive CTC surveillance versus optical colonoscopy for polypectomy...
Flat colorectal lesions in asymptomatic adults: implications for screening with CT virtual colonoscopyPerry J Pickhardt
Department of Radiology, University of Wisconsin Medical School, Madison, 600 Highland Ave, E3/311 Clinical Science Center, Madison, WI 53792-3252, USA
AJR Am J Roentgenol 183:1343-7. 2004..The sensitivity of virtual colonoscopy for detecting flat lesions was similar to that of polypoid lesions. These results indicate that flat lesions are not a significant drawback for virtual colonoscopy screening...
Three-dimensional endoluminal CT colonography (virtual colonoscopy): comparison of three commercially available systemsPerry J Pickhardt
Department of Radiology, National Naval Medical Center, 8901 Wisconsin Ave, Bethesda, MD 20889-5600, USA
AJR Am J Roentgenol 181:1599-606. 2003..Of the three, effective time-efficient primary 3D evaluation appears to be feasible only with the V3D-Colon system...
Virtual colonoscopy: issues related to primary screeningPerry J Pickhardt
Department of Radiology, University of Wisconsin Medical School, E3 311 Clinical Science Center, 600 Highland Avenue, Madison, WI 53792 3252, USA
Eur Radiol 15:D133-7. 2005....
Hybrid segmentation of colon filled with air and opacified fluid for CT colonographyMarek Franaszek
Diagnostic Radiology Department, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA
IEEE Trans Med Imaging 25:358-68. 2006..In addition, visual inspection of 24 CT colonography scans demonstrated good performance of our procedure: the reconstructed colonic wall appeared smooth even at the interface between air and fluid and there were no leaked regions...
Venous malformations mimicking multiple mucosal polyps on screening CT colonographyAndrew D Lee
Department of Radiology, University of Wisconsin Medical School, E3/311 Clinical Science Center, 600 Highland Ave, Madison, WI 53792-3252, USA
AJR Am J Roentgenol 186:1113-5. 2006
The natural history of colorectal polyps and masses: rediscovered truths from the barium enema eraPerry J Pickhardt
Department of Radiology, University of Wisconsin Medical School, E3/311 Clinical Science Center, 600 Highland Ave, Madison, WI 53792-3252, USA
AJR Am J Roentgenol 188:619-21. 2007
Prospective blinded trial comparing 45-mL and 90-mL doses of oral sodium phosphate for bowel preparation before computed tomographic colonographyDavid H Kim
Department of Radiology University of Wisconsin Medical School, Madison, WI 53792 3252, USA
J Comput Assist Tomogr 31:53-8. 2007..To compare the efficacy of computed tomographic colonography (CTC) bowel preparation using single- (45 mL) versus double-dose sodium phosphate...
The cost-effectiveness of CT colonography in screening for colorectal neoplasiaSandeep Vijan
Veterans Affairs Health Services Research and Development Center for Practice Management and Outcomes Research, Ann Arbor, Michigan 48105, USA
Am J Gastroenterol 102:380-90. 2007..We examined the cost-effectiveness of 2- and 3-dimensional computerized tomography (CT) colonography as a screening test for colorectal neoplasia...
Extracolonic tumors of the gastrointestinal tract detected incidentally at screening CT colonographyPerry J Pickhardt
Department of Radiology, University of Wisconsin Medical School, E3 311 Clinical Science Center, 600 Highland Avenue, Madison, Wisconsin 53792 3252, USA
Dis Colon Rectum 50:56-63. 2007..The aim of this article is to report our experience with incidental detection of extracolonic tumors of the gastrointestinal tract identified prospectively at screening CT colonography...
Polyps: linear and volumetric measurement at CT colonographySrinath C Yeshwant
Diagnostic Radiology Department, Clinical Center, National Institutes of Health, Bldg 10, Room 1C351, 10 Center Dr, MSC 1182, Bethesda, MD 20892-1182, USA
Radiology 241:802-11. 2006..Linear diameter calculated from automated volume measurements showed the smallest variation between supine and prone scans while avoiding observer variability and may be best for assessing polyp size changes with serial examinations...
Utilization of the double-contrast barium enema in the early era of screening CT colonographyPerry J Pickhardt
AJR Am J Roentgenol 187:W661. 2006
CT colonography with computer-aided polyp detection: volume and attenuation thresholds to reduce false-positive findings owing to the ileocecal valveRonald M Summers
Department of Radiology, National Institutes of Health, 10 Center Dr, Bldg 10, Rm 1C351, MSC 1182, Bethesda, MD 20892-1182, USA
Radiology 241:426-32. 2006..Differences in sensitivity and specificity in the detection of polyps between the sets were not significant. CONCLUSION: Volume and average CT attenuation thresholds can help differentiate most ICVs from true polyps...
Screening for colorectal neoplasia with CT colonography: initial experience from the 1st year of coverage by third-party payersPerry J Pickhardt
Department of Radiology and Section of Gastroenterology and Hepatology, University of Wisconsin Medical School, E3 311 Clinical Science Center, 600 Highland Ave, Madison, WI 53792 3252, USA
Radiology 241:417-25. 2006..To evaluate our experience in the 1st year of computed tomographic (CT) colonography screening since the initiation of local third-party payer coverage...
Diagnostic performance of primary 3-dimensional computed tomography colonography in the setting of colonic diverticular diseaseMatthew F Sanford
Department of Radiology, University of Wisconsin Medical School, Madison, 53792, USA
Clin Gastroenterol Hepatol 4:1039-47. 2006..7% (61/72), respectively (not significant, P > or = .15). CONCLUSIONS: CDD was common in this asymptomatic screening population, but its presence did not degrade the diagnostic performance of primary 3D CTC for polyp detection...
Polyp volume versus linear size measurements at CT colonography: implications for noninvasive surveillance of unresected colorectal lesionsPerry J Pickhardt
Department of Radiology, University of Wisconsin Medical School, 600 Highland Ave, Madison, WI 53792, USA
AJR Am J Roentgenol 186:1605-10. 2006..CONCLUSION: Because changes in polyp volume are amplified compared with linear dimension, volume measurement rather than diameter measurement will better allow detection of small incremental changes in polyp size using CTC...
Surface visualization at 3D endoluminal CT colonography: degree of coverage and implications for polyp detectionPerry J Pickhardt
Department of Radiology, University of Wisconsin Medical School, Madison, Wisconsin, USA
Gastroenterology 130:1582-7. 2006....
By-patient performance characteristics of CT colonography: importance of polyp size threshold dataPerry J Pickhardt
Radiology 229:291-3; author reply 293; discussion 293. 2003
