Michael E Pichichero

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. ncbi request reprint Use of selected cephalosporins in penicillin-allergic patients: a paradigm shift
    Michael E Pichichero
    University of Rochester Medical Center, Elmwood Pediatric Group, Rochester, NY 14642, USA
    Diagn Microbiol Infect Dis 57:13S-18S. 2007
  2. pmc CD4+ T-cell responses among adults and young children in response to Streptococcus pneumoniae and Haemophilus influenzae vaccine candidate protein antigens
    Sharad K Sharma
    Center for Infectious Disease and Immunology, Research Institute, Rochester General Hospital, 1425 Portland Avenue, Rochester, NY 14621, USA
    Vaccine 31:3090-7. 2013
  3. doi request reprint Bactericidal antibody response against P6, protein D, and OMP26 of nontypeable Haemophilus influenzae after acute otitis media in otitis-prone children
    M Nadeem Khan
    Center for Infectious Diseases and Immunology, Rochester General Hospital Research Institute, Rochester, NY, USA
    FEMS Immunol Med Microbiol 65:439-47. 2012
  4. pmc Mercury levels in premature and low birth weight newborn infants after receipt of thimerosal-containing vaccines
    Michael E Pichichero
    University of Rochester, Rochester, NY, USA
    J Pediatr 155:495-9. 2009
  5. pmc Identification of Streptococcus pneumoniae and Haemophilus influenzae in culture-negative middle ear fluids from children with acute otitis media by combination of multiplex PCR and multi-locus sequencing typing
    Qingfu Xu
    Rochester General Hospital Research Institute, 1425 Portland Avenue, Rochester, NY 14621, USA
    Int J Pediatr Otorhinolaryngol 75:239-44. 2011
  6. pmc Higher serum levels of interleukin 10 occur at onset of acute otitis media caused by Streptococcus pneumoniae compared to Haemophilus influenzae and Moraxella catarrhalis
    Keyi Liu
    Rochester General Hospital Research Institute, Rochester, New York 14621, USA
    Laryngoscope 123:1500-5. 2013
  7. ncbi request reprint Frequency of symptomatic relapses of group A beta-hemolytic streptococcal tonsillopharyngitis in children from 4 pediatric practices following penicillin, amoxicillin, and cephalosporin antibiotic treatment
    Janet R Casey
    Legacy Pediatrics, University of Rochester, Rochester, New York, USA
    Clin Pediatr (Phila) 47:549-54. 2008
  8. pmc Antibody response to Haemophilus influenzae outer membrane protein D, P6, and OMP26 after nasopharyngeal colonization and acute otitis media in children
    Michael E Pichichero
    Rochester General Hospital Research Institue, 1425 Portland Avenue, Rochester, NY 14621, USA
    Vaccine 28:7184-92. 2010
  9. doi request reprint Otitis media
    Michael E Pichichero
    Center for Infectious Diseases and Immunology, Rochester General Hospital Research Institute, Rochester General Hospital, Rochester, NY 14621, USA
    Pediatr Clin North Am 60:391-407. 2013
  10. pmc Antibody response to Streptococcus pneumoniae proteins PhtD, LytB, PcpA, PhtE and Ply after nasopharyngeal colonization and acute otitis media in children
    Michael E Pichichero
    Rochester General Hospital Research Institute, Rochester, NY, USA
    Hum Vaccin Immunother 8:799-805. 2012

Collaborators

Detail Information

Publications100

  1. ncbi request reprint Use of selected cephalosporins in penicillin-allergic patients: a paradigm shift
    Michael E Pichichero
    University of Rochester Medical Center, Elmwood Pediatric Group, Rochester, NY 14642, USA
    Diagn Microbiol Infect Dis 57:13S-18S. 2007
    ..Particular emphasis is placed on the role of chemical structure in determining the risk of cross-reactivity between specific agents...
  2. pmc CD4+ T-cell responses among adults and young children in response to Streptococcus pneumoniae and Haemophilus influenzae vaccine candidate protein antigens
    Sharad K Sharma
    Center for Infectious Disease and Immunology, Research Institute, Rochester General Hospital, 1425 Portland Avenue, Rochester, NY 14621, USA
    Vaccine 31:3090-7. 2013
    ..We conclude that adults have circulating memory CD4(+) T cells (CD45RA(-)) that can be stimulated by all the tested Spn and NTHi protein vaccine candidate antigens, whereas young children have a more limited response...
  3. doi request reprint Bactericidal antibody response against P6, protein D, and OMP26 of nontypeable Haemophilus influenzae after acute otitis media in otitis-prone children
    M Nadeem Khan
    Center for Infectious Diseases and Immunology, Rochester General Hospital Research Institute, Rochester, NY, USA
    FEMS Immunol Med Microbiol 65:439-47. 2012
    ..Future studies of protein D, P6, OMP26, and other potential NTHi vaccine antigens should include studies of bactericidal antibody in children who are otitis prone as a possible correlate of protection...
  4. pmc Mercury levels in premature and low birth weight newborn infants after receipt of thimerosal-containing vaccines
    Michael E Pichichero
    University of Rochester, Rochester, NY, USA
    J Pediatr 155:495-9. 2009
    ....
  5. pmc Identification of Streptococcus pneumoniae and Haemophilus influenzae in culture-negative middle ear fluids from children with acute otitis media by combination of multiplex PCR and multi-locus sequencing typing
    Qingfu Xu
    Rochester General Hospital Research Institute, 1425 Portland Avenue, Rochester, NY 14621, USA
    Int J Pediatr Otorhinolaryngol 75:239-44. 2011
    ..This study aimed to develop a combined molecular method to accurately detect these otopathogens...
  6. pmc Higher serum levels of interleukin 10 occur at onset of acute otitis media caused by Streptococcus pneumoniae compared to Haemophilus influenzae and Moraxella catarrhalis
    Keyi Liu
    Rochester General Hospital Research Institute, Rochester, New York 14621, USA
    Laryngoscope 123:1500-5. 2013
    ..We sought to determine if IL-10 could serve as a biomarker to distinguish AOM caused by Spn versus NTHi and Mcat...
  7. ncbi request reprint Frequency of symptomatic relapses of group A beta-hemolytic streptococcal tonsillopharyngitis in children from 4 pediatric practices following penicillin, amoxicillin, and cephalosporin antibiotic treatment
    Janet R Casey
    Legacy Pediatrics, University of Rochester, Rochester, New York, USA
    Clin Pediatr (Phila) 47:549-54. 2008
    ....
  8. pmc Antibody response to Haemophilus influenzae outer membrane protein D, P6, and OMP26 after nasopharyngeal colonization and acute otitis media in children
    Michael E Pichichero
    Rochester General Hospital Research Institue, 1425 Portland Avenue, Rochester, NY 14621, USA
    Vaccine 28:7184-92. 2010
    ..For all 3 proteins serum antibody levels in the convalescent phase of AOM infection were not as high as after NP colonization. Antibodies to protein D and P6 but not OMP26 were bactericidal...
  9. doi request reprint Otitis media
    Michael E Pichichero
    Center for Infectious Diseases and Immunology, Rochester General Hospital Research Institute, Rochester General Hospital, Rochester, NY 14621, USA
    Pediatr Clin North Am 60:391-407. 2013
    ..Antibiotic prophylaxis has fallen into disfavor as a preventative strategy for AOM recurrences...
  10. pmc Antibody response to Streptococcus pneumoniae proteins PhtD, LytB, PcpA, PhtE and Ply after nasopharyngeal colonization and acute otitis media in children
    Michael E Pichichero
    Rochester General Hospital Research Institute, Rochester, NY, USA
    Hum Vaccin Immunother 8:799-805. 2012
    ....
  11. pmc When co-colonizing the nasopharynx haemophilus influenzae predominates over Streptococcus pneumoniae except serotype 19A strains to cause acute otitis media
    Qingfu Xu
    Center for Infectious Diseases and Immunology, Rochester General Hospital Research Institute, Rochester, NY, USA
    Pediatr Infect Dis J 31:638-40. 2012
    ..Haemophilus influenzae and Streptococcus pneumoniae both predominated over Moraxella catarrhalis to cause AOM...
  12. ncbi request reprint Symptomatic relapse of group A beta-hemolytic streptococcal tonsillopharyngitis in children
    Janet R Casey
    University of Rochester School of Medicine, Elmwood Pediatric Group, Rochester, New York, USA
    Clin Pediatr (Phila) 46:307-10. 2007
    ..02). Clinicians should be aware that the rate of symptomatic failures after antibiotic therapy for group A beta-hemolytic streptococcal tonsillopharyngitis differs by drug and is not an uncommon event...
  13. ncbi request reprint Acellular pertussis vaccine boosters combined with diphtheria and tetanus toxoid boosters for adolescents: safety and immunogenicity assessment when preceded by different 5-dose DTaP/DTwP schedules
    Michael E Pichichero
    Microbiology and Immunology, Pediatrics and Medicine, University of Rochester Medical Center, 601 Elmwood Avenue, Box 672, Rochester, NY 14642, USA
    Clin Pediatr (Phila) 45:613-20. 2006
    ..Seroprotective levels and antibody concentrations were comparable regardless of prior DTaP/DTwP vaccine history. A sixth sequential dose of Tdap after 5 doses of DTaP appears safe and immunogenic...
  14. pmc Novel type of Streptococcus pneumoniae causing multidrug-resistant acute otitis media in children
    Qingfu Xu
    University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    Emerg Infect Dis 15:547-51. 2009
    ..pneumoniae in which all strains had 6 of the same alleles as ST-156. The multidrug-resistant strains related to ST-156 expressed different capsular serotypes: 9V, 14, 11A, 15C, and 19F...
  15. doi request reprint Mucosal vaccination with a multicomponent adenovirus-vectored vaccine protects against Streptococcus pneumoniae infection in the lung
    Maria T Arévalo
    Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    FEMS Immunol Med Microbiol 55:346-51. 2009
    ..pneumoniae strain D39 colonization in mouse lungs. Taken together, these data demonstrate the feasibility of developing a mucosal vaccine against S. pneumoniae using recombinant adenoviruses for antigen delivery...
  16. pmc Phylogenetic relatedness and diversity of non-typable Haemophilus influenzae in the nasopharynx and middle ear fluid of children with acute otitis media
    Ravinder Kaur
    Rochester General Hospital, Research Institute, Center for Infectious Diseases and Immunology, Rochester, NY, USA
    J Med Microbiol 60:1841-8. 2011
    ..In this first study of its type to our knowledge, we could not identify predominant MLST types among strains colonizing the NP versus those causing AOM or expressing a β-lactamase enzyme conferring penicillin resistance in children...
  17. pmc Nontypeable Streptococcus pneumoniae as an otopathogen
    Qingfu Xu
    Rochester General Hospital Research Institute, Rochester, NY 14621, USA
    Diagn Microbiol Infect Dis 69:200-4. 2011
    ..pneumoniae (NT-Spn) in a child with acute otitis media (AOM). The strain was pneumolysin PCR positive and capsule gene PCR negative. Virulence of the NT-Spn was confirmed in a chinchilla model of AOM...
  18. pmc Reduced serum IgG responses to pneumococcal antigens in otitis-prone children may be due to poor memory B-cell generation
    Sharad K Sharma
    Center for Infectious Diseases and Vaccine Immunology, Research Institute, Rochester General Hospital, Rochester, NY, USA
    J Infect Dis 205:1225-9. 2012
    ....
  19. pmc New patterns in the otopathogens causing acute otitis media six to eight years after introduction of pneumococcal conjugate vaccine
    Janet R Casey
    Department of Pediatrics, University of Rochester, Rochester, NY, USA
    Pediatr Infect Dis J 29:304-9. 2010
    ....
  20. ncbi request reprint Metaanalysis of short course antibiotic treatment for group a streptococcal tonsillopharyngitis
    Janet R Casey
    Department of Pediatrics, Elmwood Pediatric Group, University of Rochester Medical Center, NY, USA
    Pediatr Infect Dis J 24:909-17. 2005
    ..To compare bacterial and clinical cure rates in patients with group A streptococcal (GAS) tonsillopharyngitis treated with oral beta-lactam or macrolide antibiotics for 4-5 days versus 10-day comparators...
  21. ncbi request reprint Pathogen shifts and changing cure rates for otitis media and tonsillopharyngitis
    Michael E Pichichero
    Department of Microbiology and Immunology, Pediatrics and Medicine, University of Rochester Medical Center, Elmwood Pediatric Group, Rochester, New York 14642, USA
    Clin Pediatr (Phila) 45:493-502. 2006
    ..Recent results with amoxicillin suggest its efficacy is also waning. Cephalosporins have the highest bacteriologic and clinical efficacy. This has implications for optimal antibiotic therapy...
  22. ncbi request reprint Bacterial eradication rates with shortened courses of 2nd- and 3rd-generation cephalosporins versus 10 days of penicillin for treatment of group A streptococcal tonsillopharyngitis in adults
    Michael E Pichichero
    University of Rochester, and Elmwood Pediatric Group, Rochester, NY 14642, USA
    Diagn Microbiol Infect Dis 59:127-30. 2007
    ..46; 95% confidence interval, 0.96-2.22, P = 0.08)...
  23. pmc Impact of respiratory viral infections on α-hemolytic streptococci and otopathogens in the nasopharynx of young children
    Victoria Friedel
    Center for Infectious Diseases and Immunology, Rochester General Hospital Research Institute and Department of Clinical Microbiology, Rochester, NY 14621, USA
    Pediatr Infect Dis J 32:27-31. 2013
    ....
  24. pmc Dual orientation of the outer membrane lipoprotein P6 of nontypeable haemophilus influenzae
    Lea Vacca Michel
    School of Chemistry and Materials Science, Rochester Institute of Technology, Rochester, NY, USA
    J Bacteriol 195:3252-9. 2013
    ..We conclude that P6 of NTHi is likely inserted into the OM in two distinct orientations, with the predominant orientation facing in toward the periplasm. ..
  25. ncbi request reprint Systematic review of factors contributing to penicillin treatment failure in Streptococcus pyogenes pharyngitis
    Michael E Pichichero
    University of Rochester Medical Center, Rochester, NY 14642, USA
    Otolaryngol Head Neck Surg 137:851-857. 2007
    ..Review the evidence for various explanations for microbiologic treatment failure following use of penicillin in group A streptococcal (GAS) tonsillopharyngitis...
  26. pmc Serum antibody response to three non-typeable Haemophilus influenzae outer membrane proteins during acute otitis media and nasopharyngeal colonization in otitis prone and non-otitis prone children
    Ravinder Kaur
    Rochester General Hospital Research Institute, 1425 Portland Avenue, Rochester, NY 14621, USA
    Vaccine 29:1023-8. 2011
    ..Moreover, the data suggest that otitis prone children should be evaluated for their responses to Protein D, P6 and OMP26 vaccine antigens of NTHi...
  27. pmc Protection against anthrax by needle-free mucosal immunization with human anthrax vaccine
    Mingtao Zeng
    Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box 672, Rochester, New York 14642, USA
    Vaccine 25:3588-94. 2007
    ..anthracis Sterne spores. The data suggests that intranasal administration may be an effective immunization modality for an improved immunization program against anthrax...
  28. ncbi request reprint Safe use of selected cephalosporins in penicillin-allergic patients: a meta-analysis
    Michael E Pichichero
    Department of Microbiology and Immunology, University of Rochester, Elmwood Pediatric Group, Otolaryngology, University of Rochester Medical Center, Rochester, NY, USA
    Otolaryngol Head Neck Surg 136:340-7. 2007
    ....
  29. ncbi request reprint Meta-analysis of cephalosporins versus penicillin for treatment of group A streptococcal tonsillopharyngitis in adults
    Janet R Casey
    University of Rochester, Elmwood Pediatric Group, Rochester, New York 14620, USA
    Clin Infect Dis 38:1526-34. 2004
    ..This meta-analysis indicates that the likelihood of bacteriologic and clinical failure in the treatment of GABHS tonsillopharyngitis is 2 times higher for oral penicillin than for oral cephalosporins...
  30. doi request reprint Pathogens causing recurrent and difficult-to-treat acute otitis media, 2003-2006
    Michael E Pichichero
    University of Rochester Medical Center and Legacy Pediatrics, Rochester, New York 14642, USA
    Clin Pediatr (Phila) 47:901-6. 2008
    ..influenzae produced beta-lactamase, respectively. Although H. influenzae remains the most frequently isolated pathogen in children with AOMTF or recurrent AOM, S. pneumoniae that are PNSP are reemerging as important organisms...
  31. ncbi request reprint Emergence of a multiresistant serotype 19A pneumococcal strain not included in the 7-valent conjugate vaccine as an otopathogen in children
    Michael E Pichichero
    University of Rochester and Legacy Pediatrics, Rochester, New York, USA
    JAMA 298:1772-8. 2007
    ..Concern has been raised about the possible emergence of a bacterial strain that is untreatable by US Food and Drug Administration (FDA)-approved antibiotics and that causes acute otitis media (AOM) in children...
  32. pmc Breast-feeding is associated with a reduced frequency of acute otitis media and high serum antibody levels against NTHi and outer membrane protein vaccine antigen candidate P6
    Albert Sabirov
    Department of Microbiology Immunology, University of Rochester, Rochester, New York 14627, USA
    Pediatr Res 66:565-70. 2009
    ..Higher serum IgG might facilitate protection against AOM and NP colonization in breast-fed children...
  33. pmc Acute otitis media otopathogens during 2008 to 2010 in Rochester, New York
    Janet R Casey
    Legacy Pediatrics, Rochester, NY, USA
    Pediatr Infect Dis J 32:805-9. 2013
    ..The otopathogen distribution colonizing the nasopharynx (NP) and causing acute otitis media (AOM) is in flux following the introduction of pneumococcal conjugate vaccine 7 (PCV7) and will continue to change...
  34. pmc Comparison of amoxicillin/clavulanic acid high dose with cefdinir in the treatment of acute otitis media
    Janet R Casey
    Legacy Pediatrics, Rochester, NY, USA
    Drugs 72:1991-7. 2012
    ....
  35. pmc Clinical significance of serum S100A12 in acute otitis media in young children
    Keyi Liu
    Center for Infectious Diseases and Immunology, Rochester General Research Institute, Rochester General Hospital, Rochester, NY 14621, USA
    Pediatr Infect Dis J 31:e56-8. 2012
    ..Acute otitis media (AOM) is a local infection mainly caused by Streptococcus pneumoniae (Spn), nontypeable Haemophilus influenzae (NTHi), and/or Moraxella catarrhalis (Mcat)...
  36. doi request reprint Probability of achieving requisite pharmacodynamic exposure for oral beta-lactam regimens against Haemophilus influenzae in children
    Michael E Pichichero
    Department of Microbiology and Immunology, University of Rochester, Rochester, New York 14642, USA
    Paediatr Drugs 10:391-7. 2008
    ..influenzae isolates using Monte Carlo simulation...
  37. doi request reprint Diagnostic inaccuracy and subject exclusions render placebo and observational studies of acute otitis media inconclusive
    Michael E Pichichero
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Pediatr Infect Dis J 27:958-62. 2008
    ..Diagnostic accuracy and appropriate inclusion/exclusion criteria representative of children at greatest risk is of paramount importance in trials to evaluate placebo or observation as an option for acute otitis media (AOM) management...
  38. pmc Simultaneous assay for four bacterial species including Alloiococcus otitidis using multiplex-PCR in children with culture negative acute otitis media
    Ravinder Kaur
    Center for Infectious Diseases and Immunology, Rochester General Hospital Research Institute, University of Rochester School of Medicine, Rochester, NY, USA
    Pediatr Infect Dis J 29:741-5. 2010
    ..Conventional culture methods detect these pathogens in only 60% to 70% of cases of AOM. Alloiococcus otitidis, another potential pathogen, has often been ignored...
  39. pmc Serum antibody response to five Streptococcus pneumoniae proteins during acute otitis media in otitis-prone and non-otitis-prone children
    Ravinder Kaur
    Rochester General Hospital Research Institute, Center for Infectious Diseases and Immunology, Rochester, NY 14621, USA
    Pediatr Infect Dis J 30:645-50. 2011
    ..Streptococcus pneumoniae (Spn) is one of the common bacteria responsible for episodic acute otitis media (AOM; non-otitis-prone), recurrent AOM (otitis-prone), and AOM treatment failure (AOMTF) in children...
  40. ncbi request reprint The evidence base for cephalosporin superiority over penicillin in streptococcal pharyngitis
    Janet R Casey
    Elmwood Pediatric Group, University of Rochester, Rochester, NY 14642, USA
    Diagn Microbiol Infect Dis 57:39S-45S. 2007
    ..This review examines the evidence supporting the use of cephalosporins as a first choice of treatment for many patients with GABHS pharyngitis...
  41. ncbi request reprint Acellular pertussis vaccine booster combined with diphtheria and tetanus toxoids for adolescents
    Michael E Pichichero
    University of Rochester Medical Center, Rochester, NY 14642, USA
    Pediatrics 117:1084-93. 2006
    ..Recently licensed in the United States for use in adolescents, acellular pertussis vaccines will provide an immunogenic and safe option for booster immunization against pertussis...
  42. ncbi request reprint Higher dosages of azithromycin are more effective in treatment of group A streptococcal tonsillopharyngitis
    Janet R Casey
    Department of Pediatrics, Elmwood Pediatric Group, University of Rochester Medical Center, New York, USA
    Clin Infect Dis 40:1748-55. 2005
    ..In this study, our objective was to determine the optimal dose of azithromycin for treatment of GAS tonsillopharyngitis in children and adults by analyzing trials that used different dose regimens...
  43. pmc Reduced memory CD4+ T-cell generation in the circulation of young children may contribute to the otitis-prone condition
    Sharad K Sharma
    Center for Infectious Disease and Vaccine Immunology, Research Institute, Rochester General Hospital, Rochester, New York 14621, USA
    J Infect Dis 204:645-53. 2011
    ..Poor antibody response has been associated with the otitis-prone condition; however, there is no precise mechanistic explanation for this condition...
  44. ncbi request reprint Efficacy of cephalexin two vs. three times daily vs. cefadroxil once daily for streptococcal tonsillopharyngitis
    Correne D Curtin
    Elmwood Pediatric Group, Rochester, New York 14642, USA
    Clin Pediatr (Phila) 42:519-26. 2003
    ..Cephalexin dosed twice daily or three times daily and cefadroxil dosed once daily appear equivalent in bacteriologic and clinical cure of GABHS tonsillopharyngitis...
  45. pmc Lower nasopharyngeal epithelial cell repair and diminished innate inflammation responses contribute to the onset of acute otitis media in otitis-prone children
    David Verhoeven
    Rochester General Hospital Research Institute, Rochester General Hospital, 1425 Portland Ave, Rochester, NY 14621, USA
    Med Microbiol Immunol 202:295-302. 2013
    ..We conclude that lower epithelial cell repair responses during viral infection in the NP combined with diminished innate inflammatory responses potentiate Spn pathogenesis in the sOP child. ..
  46. pmc PcpA of Streptococcus pneumoniae mediates adherence to nasopharyngeal and lung epithelial cells and elicits functional antibodies in humans
    M Nadeem Khan
    Center for Infectious Diseases and Vaccine Immunology, Research Institute, Rochester General Hospital, Rochester, NY 14621, USA
    Microbes Infect 14:1102-10. 2012
    ..028). We conclude that PcpA can mediate adherence of pneumococci to human NP and lung epithelial cells and PcpA mediated adherence can be inhibited by human anti-PcpA antibodies...
  47. pmc Protective immunity against botulism provided by a single dose vaccination with an adenovirus-vectored vaccine
    Mingtao Zeng
    Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Box 672, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Vaccine 25:7540-8. 2007
    ..The data suggest that an adenovirus-vectored genetic vaccine is a highly efficient prophylaxis candidate against botulism...
  48. ncbi request reprint A review of evidence supporting the American Academy of Pediatrics recommendation for prescribing cephalosporin antibiotics for penicillin-allergic patients
    Michael E Pichichero
    University of Rochester Medical Center, Elmwood Pediatric Group, 601 Elmwood Ave, Box 672, Rochester, NY 14642, USA
    Pediatrics 115:1048-57. 2005
    ..Specific recommendations for the treatment of patients on the basis of their responses to previously prescribed agents are summarized...
  49. ncbi request reprint Acute otitis media: making sense of recent guidelines on antimicrobial treatment
    Michael E Pichichero
    University of Rochester Medical Center, Elmwood Pediatric Group, 601 Elmwood Avenue, Box 672, Rochester, NY 14642, USA
    J Fam Pract 54:313-22. 2005
    ..Key factors for enhancing compliance are taste of suspension, dosing frequency, and duration of therapy...
  50. ncbi request reprint Prospective identification and treatment of children with pediatric autoimmune neuropsychiatric disorder associated with group A streptococcal infection (PANDAS)
    Marie Lynd Murphy
    Elmwood Pediatric Group, University of Rochester Medical Center, 601 Elmwood Ave, Box 672, Rochester, NY 14642, USA
    Arch Pediatr Adolesc Med 156:356-61. 2002
    ....
  51. pmc Antibody in middle ear fluid of children originates predominantly from sera and nasopharyngeal secretions
    Ravinder Kaur
    Rochester General Hospital Research Institute, Center for Infectious Diseases and Immunology, Rochester, New York, USA
    Clin Vaccine Immunol 19:1593-6. 2012
    ....
  52. doi request reprint A simple scoring system to improve clinical assessment of acute otitis media
    Janet R Casey
    Legacy Pediatrics, Rochester, NY, USA
    Clin Pediatr (Phila) 50:623-9. 2011
    ..Study design. Symptoms of AOM observed by validated otoscopists were tabulated and scored with a 10-point and a 30-point system at acute onset of illness and at the test-of-cure (TOC) 3 weeks later...
  53. ncbi request reprint Cephalosporins can be prescribed safely for penicillin-allergic patients
    Michael E Pichichero
    University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    J Fam Pract 55:106-12. 2006
    ..Cefprozil, cefuroxime, cefpodoxime, ceftazidime, and ceftriaxone do not increase risk of an allergic reaction...
  54. ncbi request reprint Preferred antibiotics for treatment of acute otitis media: comparison of practicing pediatricians, general practitioners, and otolaryngologists
    Michael E Pichichero
    Elmwood Pediatric Group, University of Rochester Medical Center, 601 Elmwood Avenue, Box 672, Rochester, NY 14642, USA
    Clin Pediatr (Phila) 44:575-8. 2005
    ..After instruction that provides the rationale for guideline-recommended agents based on pharmacokinetics/pharmacodynamics and double tympanocentesis trials, endorsement of recommended antibiotics significantly improved to >90%...
  55. ncbi request reprint Variations in amoxicillin pharmacokinetic/pharmacodynamic parameters may explain treatment failures in acute otitis media
    Michael E Pichichero
    Rochester General Research Institute, Legacy Pediatric Group, Rochester, New York, USA
    Paediatr Drugs 11:243-9. 2009
    ..These findings suggest that variability in PK/PD parameters may impact amoxicillin concentrations in serum and MEF, possibly explaining some AOM treatment failures...
  56. ncbi request reprint A review of recommended antibiotic therapies with impact on outcomes in acute otitis media and acute bacterial sinusitis
    Michael E Pichichero
    University of Rochester Medical Center, Elmwood Pediatric Group, 601 Elmwood Ave, Box 672, Rochester, NY 14642, USA
    Am J Manag Care 12:S292-302. 2006
  57. ncbi request reprint Immunogenicity and safety of a combination diphtheria, tetanus toxoid, acellular pertussis, hepatitis B, and inactivated poliovirus vaccine coadministered with a 7-valent pneumococcal conjugate vaccine and a Haemophilus influenzae type b conjugate vaccine
    Michael E Pichichero
    University of Rochester Medical Center, Rochester, New York 14642, USA
    J Pediatr 151:43-9, 49.e1-2. 2007
    ....
  58. doi request reprint Comparison of study designs for acute otitis media trials
    Michael E Pichichero
    University of Rochester, School of Medicine, Department of Microbiology Immunology, 601 Elmwood Avenue, Box 672, Rochester, NY 14642, United States
    Int J Pediatr Otorhinolaryngol 72:737-50. 2008
    ..A framework for evaluating the efficacy of antibiotics in development as well as those currently approved for acute otitis media (AOM) is needed...
  59. ncbi request reprint Efficacy of penicillin vs. amoxicillin in children with group A beta hemolytic streptococcal tonsillopharyngitis
    Correne Curtin-Wirt
    Elmwood Pediatric Group, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Clin Pediatr (Phila) 42:219-25. 2003
    ..84, 95% confidence interval 1.02-3.29); the same was true for dinical cure (OR = 1.99, 95% CI = 1.02-3.87). Amoxicillin may be superior to penicillin for bacteriologic and clinical cure of GABHS tonsillopharyngitis...
  60. ncbi request reprint White blood cell count can aid judicious antibiotic prescribing in acute upper respiratory infections in children
    Janet R Casey
    Elmwood Pediatric Group, Rochester, NY 14642, USA
    Clin Pediatr (Phila) 42:113-9. 2003
    ..With this approach, return office visits in the following 2 weeks were infrequent (13% of 737 patients), and no child had significant bacterial illness that was missed. With selective use of WBC count testing..
  61. ncbi request reprint Rethinking the total cost of care in AOM and ABS: The impact of improved diagnostic accuracy and antibiotic treatment where high efficacy and adherence are achievable
    Michael E Pichichero
    University of Rochester Medical Center, Elmwood Pediatric Group, 601 Elmwood Ave, Box 672, Rochester, NY 14642, USA
    Am J Manag Care 12:S283-91. 2006
  62. doi request reprint A comparison of 2 white blood cell count devices to aid judicious antibiotic prescribing
    Janet R Casey
    Legacy Pediatrics, Department of Pediatrics, University of Rochester, Rochester, New York, 14642, USA
    Clin Pediatr (Phila) 48:291-4. 2009
    ..A simple and quick point-of-care WBC count device produces similar results as achievable with a Cell-Dyn counter for total WBCs and may assist in judicious antibiotic prescribing...
  63. ncbi request reprint Acellular pertussis vaccine safety and efficacy in children, adolescents and adults
    Janet R Casey
    Elmwood Pediatric Group, University of Rochester, Rochester, New York 14620, USA
    Drugs 65:1367-89. 2005
    ..The economic impact of pertussis and transmission from adults to vulnerable infants provides a cost-benefit justification for widespread use of DTaP vaccines in all age groups with routine boosting every 10 years...
  64. ncbi request reprint Diagnostic accuracy, tympanocentesis training performance, and antibiotic selection by pediatric residents in management of otitis media
    Michael E Pichichero
    Elmwood Pediatric Group, University of Rochester Medical Center, Rochester, New York 14642, USA
    Pediatrics 110:1064-70. 2002
    ....
  65. ncbi request reprint Meningococcal conjugate vaccines
    Michael E Pichichero
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York 14642, USA
    Expert Opin Biol Ther 5:1475-89. 2005
    ..meningitidis, and herd immunity. Large, randomised, double-blind studies in adults, adolescents, children and infants have demonstrated the immunogenicity and safety of the new meningococcal conjugate vaccine formulations...
  66. ncbi request reprint Azithromycin for the treatment of pertussis
    Michael E Pichichero
    Department of Microbiology and Immunology, University of Rochester Medical Center, 601 Elmwood Avenue, Box 672, Rochester, NY 14642, USA
    Pediatr Infect Dis J 22:847-9. 2003
  67. ncbi request reprint Mercury concentrations and metabolism in infants receiving vaccines containing thiomersal: a descriptive study
    Michael E Pichichero
    Department of Microbiology Immunology, University of Rochester, Rochester, New York, NY, USA
    Lancet 360:1737-41. 2002
    ..We aimed to measure concentrations of mercury in blood, urine, and stools of infants who received such vaccines...
  68. ncbi request reprint Otitis media
    Michael E Pichichero
    Elmwood Pediatric Group, University of Rochester Medical Center, Rochester, NY 14642, USA
    Expert Opin Pharmacother 3:1073-90. 2002
    ..Best-practice for management of acute OM continues to advocate antibiotic therapy with careful, accurate diagnosis and consideration of the major pathogens and their mechanisms of resistance...
  69. ncbi request reprint Clinical evaluation of Pediarix: a new pediatric combination vaccine
    Michael E Pichichero
    University of Rochester Medical Center, Rochester, New York 14642, USA
    Clin Pediatr (Phila) 42:393-400. 2003
  70. ncbi request reprint Impact of a birth dose of hepatitis B vaccine on the reactogenicity and immunogenicity of diphtheria-tetanus-acellular pertussis-hepatitis B-inactivated poliovirus-Haemophilus influenzae type b combination vaccination
    Michael E Pichichero
    University of Rochester Medical Center, Rochester, NY 14642, USA
    Pediatr Infect Dis J 21:854-9. 2002
    ....
  71. ncbi request reprint Seven-year follow-up of vaccine response in extremely premature infants
    Khaver I Kirmani
    Department of Pediatrics, Strong Children s Research Center, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Pediatrics 109:498-504. 2002
    ..To assess the immune response of 7-year-old former extremely preterm (PT) infants to routine childhood immunizations...
  72. ncbi request reprint Who should get the HPV vaccine?
    Michael E Pichichero
    Department of Microbiology and Immunology, Pediatrics, and Medicine, University of Rochester Medical Center, Elmood Pediatric Group, 601 Elmwood Avenue, Box 672, Rochester, NY 14642, USA
    J Fam Pract 56:197-202. 2007
  73. ncbi request reprint N-fragment of edema factor as a candidate antigen for immunization against anthrax
    Mingtao Zeng
    Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box 672, Rochester, NY 14642, USA
    Vaccine 24:662-70. 2006
    ..Our data suggest that EF plays a role in eliciting protective immunity against anthrax, and that it should be included in a new generation multi-component subunit vaccine...
  74. pmc Vaccine candidate P6 of nontypable Haemophilus influenzae is not a transmembrane protein based on protein structural analysis
    Lea Vacca Michel
    Department of Chemistry, Rochester Institute of Technology, Rochester, NY, USA
    Vaccine 29:1624-7. 2011
    ..We found that P6 cannot be a transmembrane protein, and therefore may not be surface exposed. We conclude that there may be another protein on the surface of NTHi that has epitopes similar if not identical to P6...
  75. ncbi request reprint Safety and efficacy of gatifloxacin therapy for children with recurrent acute otitis media (AOM) and/or AOM treatment failure
    Michael E Pichichero
    Elmwood Pediatric Group, University of Rochester Medical Center, Rochester, New York 14642, USA
    Clin Infect Dis 41:470-8. 2005
    ..This study describes the safety and efficacy of gatifloxacin when used for treatment of children with recurrent acute otitis media (ROM) or acute otitis media (AOM) treatment failure (AOMTF)...
  76. doi request reprint Efficacy and safety of besifloxacin ophthalmic suspension 0.6% in children and adolescents with bacterial conjunctivitis: a post hoc, subgroup analysis of three randomized, double-masked, parallel-group, multicenter clinical trials
    Timothy L Comstock
    Medical Affairs, Global Pharmaceutical, Bausch and Lomb, Inc, Rochester, New York 14609, USA
    Paediatr Drugs 12:105-12. 2010
    ..Besifloxacin is a new topical fluoroquinolone, the first chlorofluoroquinolone, for the treatment of bacterial conjunctivitis...
  77. ncbi request reprint Changes in frequency and pathogens causing acute otitis media in 1995-2003
    Janet R Casey
    Elmwood Pediatric Group, Department of Pediatrics, University of Rochester, Rochester, NY, USA
    Pediatr Infect Dis J 23:824-8. 2004
    ....
  78. ncbi request reprint Improving vaccine delivery using novel adjuvant systems
    Michael E Pichichero
    University of Rochester, School of Medicine, Department of Microbiology Immunology, Rochester, New York 14642, USA
    Hum Vaccin 4:262-70. 2008
    ..The vaccines including these adjuvants are highly relevant today, and are expected to reduce the disease burden of cervical cancer, hepatitis B and malaria...
  79. ncbi request reprint Comparison of performance by otolaryngologists, pediatricians, and general practioners on an otoendoscopic diagnostic video examination
    Michael E Pichichero
    Elmwood Pediatric Group, University of Rochester Medical Center, 601 Elmwood Avenue, Box 672, Rochester, NY 14642, USA
    Int J Pediatr Otorhinolaryngol 69:361-6. 2005
    ....
  80. doi request reprint Mercury levels in newborns and infants after receipt of thimerosal-containing vaccines
    Michael E Pichichero
    Department of Microbiology Immunology, Pediatrics, and Medicine, University of Rochester, Rochester, New York 14642, USA
    Pediatrics 121:e208-14. 2008
    ..We conducted a pharmacokinetic study to assess blood levels and elimination of ethyl mercury after vaccination of infants with thimerosal-containing vaccines...
  81. ncbi request reprint The new meningococcal conjugate vaccine. A profile of its safety, efficacy, and indications for use
    Michael E Pichichero
    Department of Microbiology, University of Rochester Medical Center, NY 14642, USA
    Postgrad Med 119:47-54, 64. 2006
    ..In this article, Dr. Pichichero discusses these advantages, current recommendations for administration, and prospects for broader vaccine coverage...
  82. ncbi request reprint Evolving shifts in otitis media pathogens: relevance to a managed care organization
    Michael E Pichichero
    University of Rochester Medical Center, Rochester, NY, USA
    Am J Manag Care 11:S192-201. 2005
    ....
  83. doi request reprint Booster vaccinations: can immunologic memory outpace disease pathogenesis?
    Michael E Pichichero
    Rochester General Research Institute, Rochester General Hospital, Rochester, New York 14621, USA
    Pediatrics 124:1633-41. 2009
    ..With infectious diseases for which the pace of pathogenesis is slow, immune memory should be sufficient to prevent disease...
  84. ncbi request reprint An adolescent and adult formulation combined tetanus, diphtheria and five-component pertussis vaccine
    Michael E Pichichero
    University of Rochester Medical Center, Elmwood Pediatric Group, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Expert Rev Vaccines 5:175-87. 2006
    ..Surveillance data from Canada, where ADACEL vaccine has been used in adolescents and adults in conjunction with ongoing childhood vaccination for several years, indicate an enhanced overall reduction in pertussis disease...
  85. ncbi request reprint Combined tetanus, diphtheria, and 5-component pertussis vaccine for use in adolescents and adults
    Michael E Pichichero
    University of Rochester Medical Center, Rochester, NY 14642, USA
    JAMA 293:3003-11. 2005
    ..Increasing reports of pertussis among US adolescents, adults, and their infant contacts have stimulated vaccine development for older age groups...
  86. ncbi request reprint Acellular pertussis vaccines for adolescents
    Michael E Pichichero
    Elmwood Pediatric Group, University of Rochester, Rochester, NY 14642, USA
    Pediatr Infect Dis J 24:S117-26. 2005
    ..This development has spurred studies and anticipated licensure of safer diphtheria, tetanus, acellular pertussis combined (Tdap) vaccines for this older population...
  87. ncbi request reprint Meta-analysis of cephalosporin versus penicillin treatment of group A streptococcal tonsillopharyngitis in children
    Janet R Casey
    Department of Pediatrics, Elmwood Pediatric Group, University of Rochester, Rochester, New York 14620, USA
    Pediatrics 113:866-82. 2004
    ..To conduct a meta-analysis of randomized, controlled trials of cephalosporin versus penicillin treatment of group A beta-hemolytic streptococcal (GABHS) tonsillopharyngitis in children...
  88. ncbi request reprint Meningococcal conjugate vaccine in adolescents and children
    Michael E Pichichero
    Department of Microbiology and Immunology, University of Rochester Medical Center, NY 14642, USA
    Clin Pediatr (Phila) 44:479-89. 2005
    ..Large randomized, double-blind studies in adolescents and 2- to 10-year olds have demonstrated the immunogenicity as well as the safety and tolerability of the new meningococcal conjugate vaccine formulation...
  89. pmc Quality of the Haemophilus influenzae type b (Hib) antibody response induced by diphtheria-tetanus-acellular pertussis/Hib combination vaccines
    Philippe A Denoel
    GlaxoSmithKline Biologicals, Rue de l Institut 89, 1330 Rixensart, Belgium
    Clin Vaccine Immunol 14:1362-9. 2007
    ..In conclusion, in vitro and in vivo data as well as postmarketing vaccine effectiveness data attest to the ability of DTPa-based/Hib combination vaccines to effectively prevent Hib-induced disease in children...
  90. ncbi request reprint Assessing diagnostic accuracy and tympanocentesis skills of South African physicians in management of otitis media
    Michael E Pichichero
    S Afr Med J 92:137-8. 2002
  91. ncbi request reprint Optimizing antibacterial therapy for community-acquired respiratory tract infections in children in an era of bacterial resistance
    Donald E Low
    Mount Sinai Hospital, Toronto, Canada
    Clin Pediatr (Phila) 43:135-51. 2004
    ..New antibacterials will continue to have a role in the treatment of RTIs in children, especially where resistance compromises existing therapies...
  92. ncbi request reprint Penicillin failures?!
    Michael E Pichichero
    Pediatrics 109:1189-90; author reply 1190-2. 2002
  93. ncbi request reprint Acute otitis media: influence of the PCV-7 vaccine on changes in the disease and its management
    Stephen Brunton
    Carbarrus Family Medicine Residency Program, Charlotte, North Carolina, USA
    J Fam Pract 54:961-8. 2005
    ..In these cases, watchful waiting may be appropriate. This publication addresses presumed bacterial causes of AOM for which antibiotic use may be efficacious...
  94. ncbi request reprint Does group A beta-hemolytic streptococcal infection increase risk for behavioral and neuropsychiatric symptoms in children?
    Eliana Miller Perrin
    Division of General Pediatrics and Adolescent Medicine, Department of Pediatrics, University of North Carolina at Chapel Hill, 200 Mason Farm Road, Chapel Hill, NC 27599 7220, USA
    Arch Pediatr Adolesc Med 158:848-56. 2004
    ..To determine whether group A beta-hemolytic streptococcal infections increase the risk of developing symptoms characteristic of the diagnosis pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS)...
  95. ncbi request reprint Verification of components of acellular pertussis vaccines that have been distributed solely, been in routine use for the last two decades and contributed greatly to control of pertussis in Japan
    Michael E Pichichero
    Biologicals 33:59. 2005
  96. ncbi request reprint Detection and characterization of pediatric serum antibody to the OMP P5-homologous adhesin of nontypeable Haemophilus influenzae during acute otitis media
    Laura A Novotny
    Department of Pediatrics, College of Medicine and Public Health, Children s Research Institute, The Ohio State University, Rm W302, 700 Children s Drive, Columbus, OH 43205 2696, USA
    Vaccine 20:3590-7. 2002
    ..The immune recognition we observed encourages us to further develop a P5-fimbrin based vaccine component...
  97. ncbi request reprint Evolving microbiology and molecular epidemiology of acute otitis media in the pneumococcal conjugate vaccine era
    Michael E Pichichero
    Department of Microbiology and Immunology, University of Rochester, Rochester, New York 14642, USA urmc rochester edu
    Pediatr Infect Dis J 26:S12-6. 2007
    ..Expansion of the number of serotypes included in pneumococcal conjugate vaccines is needed to sustain a long-term benefit from immunization against these bacteria...
  98. doi request reprint A randomized comparative study of levofloxacin versus amoxicillin/clavulanate for treatment of infants and young children with recurrent or persistent acute otitis media
    Gary J Noel
    Johnson and Johnson Pharmaceutical Research and Development, L L C, Raritan, NJ 08869, USA
    Pediatr Infect Dis J 27:483-9. 2008
    ..The need for alternative antimicrobial therapy for recurrent and persistent acute otitis media (AOM) in children has raised interest in assessing the efficacy and safety of fluoroquinolones for treatment of these infections...
  99. ncbi request reprint Gatifloxacin therapy for children: turn on the light
    Roger Echols
    Clin Infect Dis 41:1824-5. 2005
  100. ncbi request reprint Dynamics of antibiotic prescribing for children
    Michael E Pichichero
    JAMA 287:3133-5. 2002