M Pichichero

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. ncbi Probability of achieving requisite pharmacodynamic exposure for oral beta-lactam regimens against Haemophilus influenzae in children
    Michael E Pichichero
    Department of Microbiology and Immunology, University of Rochester, Rochester, New York 14642, USA
    Paediatr Drugs 10:391-7. 2008
  2. ncbi Acellular pertussis vaccine boosters combined with diphtheria and tetanus toxoid boosters for adolescents: safety and immunogenicity assessment when preceded by different 5-dose DTaP/DTwP schedules
    Michael E Pichichero
    Microbiology and Immunology, Pediatrics and Medicine, University of Rochester Medical Center, 601 Elmwood Avenue, Box 672, Rochester, NY 14642, USA
    Clin Pediatr (Phila) 45:613-20. 2006
  3. ncbi The new meningococcal conjugate vaccine. A profile of its safety, efficacy, and indications for use
    Michael E Pichichero
    Department of Microbiology, University of Rochester Medical Center, NY 14642, USA
    Postgrad Med 119:47-54, 64. 2006
  4. ncbi Comparison of European and U.S. results for cephalosporin versus penicillin treatment of group A streptococcal tonsillopharyngitis
    M Pichichero
    University of Rochester Medical Center, Elmwood Pediatric Group, 601 Elmwood Avenue, PO Box 672, Rochester, NY 14642, USA
    Eur J Clin Microbiol Infect Dis 25:354-64. 2006
  5. ncbi An adolescent and adult formulation combined tetanus, diphtheria and five-component pertussis vaccine
    Michael E Pichichero
    University of Rochester Medical Center, Elmwood Pediatric Group, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Expert Rev Vaccines 5:175-87. 2006
  6. ncbi Acellular pertussis vaccine booster combined with diphtheria and tetanus toxoids for adolescents
    Michael E Pichichero
    University of Rochester Medical Center, Rochester, NY 14642, USA
    Pediatrics 117:1084-93. 2006
  7. ncbi Cephalosporins can be prescribed safely for penicillin-allergic patients
    Michael E Pichichero
    University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    J Fam Pract 55:106-12. 2006
  8. ncbi Meningococcal conjugate vaccines
    Michael E Pichichero
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York 14642, USA
    Expert Opin Biol Ther 5:1475-89. 2005
  9. ncbi Safety and efficacy of gatifloxacin therapy for children with recurrent acute otitis media (AOM) and/or AOM treatment failure
    Michael E Pichichero
    Elmwood Pediatric Group, University of Rochester Medical Center, Rochester, New York 14642, USA
    Clin Infect Dis 41:470-8. 2005
  10. ncbi Combined tetanus, diphtheria, and 5-component pertussis vaccine for use in adolescents and adults
    Michael E Pichichero
    University of Rochester Medical Center, Rochester, NY 14642, USA
    JAMA 293:3003-11. 2005

Research Grants

  1. NTHi Immunity in Young Children
    Michael Pichichero; Fiscal Year: 2007

Detail Information

Publications75

  1. ncbi Probability of achieving requisite pharmacodynamic exposure for oral beta-lactam regimens against Haemophilus influenzae in children
    Michael E Pichichero
    Department of Microbiology and Immunology, University of Rochester, Rochester, New York 14642, USA
    Paediatr Drugs 10:391-7. 2008
    ..influenzae isolates using Monte Carlo simulation...
  2. ncbi Acellular pertussis vaccine boosters combined with diphtheria and tetanus toxoid boosters for adolescents: safety and immunogenicity assessment when preceded by different 5-dose DTaP/DTwP schedules
    Michael E Pichichero
    Microbiology and Immunology, Pediatrics and Medicine, University of Rochester Medical Center, 601 Elmwood Avenue, Box 672, Rochester, NY 14642, USA
    Clin Pediatr (Phila) 45:613-20. 2006
    ..Seroprotective levels and antibody concentrations were comparable regardless of prior DTaP/DTwP vaccine history. A sixth sequential dose of Tdap after 5 doses of DTaP appears safe and immunogenic...
  3. ncbi The new meningococcal conjugate vaccine. A profile of its safety, efficacy, and indications for use
    Michael E Pichichero
    Department of Microbiology, University of Rochester Medical Center, NY 14642, USA
    Postgrad Med 119:47-54, 64. 2006
    ..In this article, Dr. Pichichero discusses these advantages, current recommendations for administration, and prospects for broader vaccine coverage...
  4. ncbi Comparison of European and U.S. results for cephalosporin versus penicillin treatment of group A streptococcal tonsillopharyngitis
    M Pichichero
    University of Rochester Medical Center, Elmwood Pediatric Group, 601 Elmwood Avenue, PO Box 672, Rochester, NY 14642, USA
    Eur J Clin Microbiol Infect Dis 25:354-64. 2006
    ..patients is significantly less if a 10-day course of oral cephalosporin is prescribed, and is at least similar, if not significantly less, with a 4- to 5-day course of oral cephalosporin compared with a 10-day course of oral penicillin...
  5. ncbi An adolescent and adult formulation combined tetanus, diphtheria and five-component pertussis vaccine
    Michael E Pichichero
    University of Rochester Medical Center, Elmwood Pediatric Group, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Expert Rev Vaccines 5:175-87. 2006
    ..Surveillance data from Canada, where ADACEL vaccine has been used in adolescents and adults in conjunction with ongoing childhood vaccination for several years, indicate an enhanced overall reduction in pertussis disease...
  6. ncbi Acellular pertussis vaccine booster combined with diphtheria and tetanus toxoids for adolescents
    Michael E Pichichero
    University of Rochester Medical Center, Rochester, NY 14642, USA
    Pediatrics 117:1084-93. 2006
    ..Recently licensed in the United States for use in adolescents, acellular pertussis vaccines will provide an immunogenic and safe option for booster immunization against pertussis...
  7. ncbi Cephalosporins can be prescribed safely for penicillin-allergic patients
    Michael E Pichichero
    University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    J Fam Pract 55:106-12. 2006
    ..Cefprozil, cefuroxime, cefpodoxime, ceftazidime, and ceftriaxone do not increase risk of an allergic reaction...
  8. ncbi Meningococcal conjugate vaccines
    Michael E Pichichero
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York 14642, USA
    Expert Opin Biol Ther 5:1475-89. 2005
    ..meningitidis, and herd immunity. Large, randomised, double-blind studies in adults, adolescents, children and infants have demonstrated the immunogenicity and safety of the new meningococcal conjugate vaccine formulations...
  9. ncbi Safety and efficacy of gatifloxacin therapy for children with recurrent acute otitis media (AOM) and/or AOM treatment failure
    Michael E Pichichero
    Elmwood Pediatric Group, University of Rochester Medical Center, Rochester, New York 14642, USA
    Clin Infect Dis 41:470-8. 2005
    ..This study describes the safety and efficacy of gatifloxacin when used for treatment of children with recurrent acute otitis media (ROM) or acute otitis media (AOM) treatment failure (AOMTF)...
  10. ncbi Combined tetanus, diphtheria, and 5-component pertussis vaccine for use in adolescents and adults
    Michael E Pichichero
    University of Rochester Medical Center, Rochester, NY 14642, USA
    JAMA 293:3003-11. 2005
    ..Increasing reports of pertussis among US adolescents, adults, and their infant contacts have stimulated vaccine development for older age groups...
  11. ncbi Acellular pertussis vaccines for adolescents
    Michael E Pichichero
    Elmwood Pediatric Group, University of Rochester, Rochester, NY 14642, USA
    Pediatr Infect Dis J 24:S117-26. 2005
    ..This development has spurred studies and anticipated licensure of safer diphtheria, tetanus, acellular pertussis combined (Tdap) vaccines for this older population...
  12. ncbi Safe use of selected cephalosporins in penicillin-allergic patients: a meta-analysis
    Michael E Pichichero
    Department of Microbiology and Immunology, University of Rochester, Elmwood Pediatric Group, Otolaryngology, University of Rochester Medical Center, Rochester, NY, USA
    Otolaryngol Head Neck Surg 136:340-7. 2007
    ....
  13. ncbi Who should get the HPV vaccine?
    Michael E Pichichero
    Department of Microbiology and Immunology, Pediatrics, and Medicine, University of Rochester Medical Center, Elmood Pediatric Group, 601 Elmwood Avenue, Box 672, Rochester, NY 14642, USA
    J Fam Pract 56:197-202. 2007
  14. ncbi Diagnostic inaccuracy and subject exclusions render placebo and observational studies of acute otitis media inconclusive
    Michael E Pichichero
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Pediatr Infect Dis J 27:958-62. 2008
    ..Diagnostic accuracy and appropriate inclusion/exclusion criteria representative of children at greatest risk is of paramount importance in trials to evaluate placebo or observation as an option for acute otitis media (AOM) management...
  15. ncbi Pathogens causing recurrent and difficult-to-treat acute otitis media, 2003-2006
    Michael E Pichichero
    University of Rochester Medical Center and Legacy Pediatrics, Rochester, New York 14642, USA
    Clin Pediatr (Phila) 47:901-6. 2008
    ..influenzae produced beta-lactamase, respectively. Although H. influenzae remains the most frequently isolated pathogen in children with AOMTF or recurrent AOM, S. pneumoniae that are PNSP are reemerging as important organisms...
  16. ncbi Comparison of study designs for acute otitis media trials
    Michael E Pichichero
    University of Rochester, School of Medicine, Department of Microbiology Immunology, 601 Elmwood Avenue, Box 672, Rochester, NY 14642, United States
    Int J Pediatr Otorhinolaryngol 72:737-50. 2008
    ..A framework for evaluating the efficacy of antibiotics in development as well as those currently approved for acute otitis media (AOM) is needed...
  17. ncbi Improving vaccine delivery using novel adjuvant systems
    Michael E Pichichero
    University of Rochester, School of Medicine, Department of Microbiology Immunology, Rochester, New York 14642, USA
    Hum Vaccin 4:262-70. 2008
    ..The vaccines including these adjuvants are highly relevant today, and are expected to reduce the disease burden of cervical cancer, hepatitis B and malaria...
  18. ncbi Pharmacodynamic analysis and clinical trial of amoxicillin sprinkle administered once daily for 7 days compared to penicillin V potassium administered four times daily for 10 days in the treatment of tonsillopharyngitis due to Streptococcus pyogenes in ch
    M E Pichichero
    Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box 672, Rochester, NY 14642, USA
    Antimicrob Agents Chemother 52:2512-20. 2008
    ....
  19. ncbi Mercury levels in newborns and infants after receipt of thimerosal-containing vaccines
    Michael E Pichichero
    Department of Microbiology Immunology, Pediatrics, and Medicine, University of Rochester, Rochester, New York 14642, USA
    Pediatrics 121:e208-14. 2008
    ..We conducted a pharmacokinetic study to assess blood levels and elimination of ethyl mercury after vaccination of infants with thimerosal-containing vaccines...
  20. ncbi Systematic review of factors contributing to penicillin treatment failure in Streptococcus pyogenes pharyngitis
    Michael E Pichichero
    University of Rochester Medical Center, Rochester, NY 14642, USA
    Otolaryngol Head Neck Surg 137:851-857. 2007
    ..Review the evidence for various explanations for microbiologic treatment failure following use of penicillin in group A streptococcal (GAS) tonsillopharyngitis...
  21. ncbi Emergence of a multiresistant serotype 19A pneumococcal strain not included in the 7-valent conjugate vaccine as an otopathogen in children
    Michael E Pichichero
    University of Rochester and Legacy Pediatrics, Rochester, New York, USA
    JAMA 298:1772-8. 2007
    ..Concern has been raised about the possible emergence of a bacterial strain that is untreatable by US Food and Drug Administration (FDA)-approved antibiotics and that causes acute otitis media (AOM) in children...
  22. ncbi Bacterial eradication rates with shortened courses of 2nd- and 3rd-generation cephalosporins versus 10 days of penicillin for treatment of group A streptococcal tonsillopharyngitis in adults
    Michael E Pichichero
    University of Rochester, and Elmwood Pediatric Group, Rochester, NY 14642, USA
    Diagn Microbiol Infect Dis 59:127-30. 2007
    ..46; 95% confidence interval, 0.96-2.22, P = 0.08)...
  23. ncbi Immunogenicity and safety of a combination diphtheria, tetanus toxoid, acellular pertussis, hepatitis B, and inactivated poliovirus vaccine coadministered with a 7-valent pneumococcal conjugate vaccine and a Haemophilus influenzae type b conjugate vaccine
    Michael E Pichichero
    University of Rochester Medical Center, Rochester, New York 14642, USA
    J Pediatr 151:43-9, 49.e1-2. 2007
    ....
  24. ncbi Acute otitis media: making sense of recent guidelines on antimicrobial treatment
    Michael E Pichichero
    University of Rochester Medical Center, Elmwood Pediatric Group, 601 Elmwood Avenue, Box 672, Rochester, NY 14642, USA
    J Fam Pract 54:313-22. 2005
    ..Key factors for enhancing compliance are taste of suspension, dosing frequency, and duration of therapy...
  25. ncbi A review of evidence supporting the American Academy of Pediatrics recommendation for prescribing cephalosporin antibiotics for penicillin-allergic patients
    Michael E Pichichero
    University of Rochester Medical Center, Elmwood Pediatric Group, 601 Elmwood Ave, Box 672, Rochester, NY 14642, USA
    Pediatrics 115:1048-57. 2005
    ..Specific recommendations for the treatment of patients on the basis of their responses to previously prescribed agents are summarized...
  26. ncbi Comparison of performance by otolaryngologists, pediatricians, and general practioners on an otoendoscopic diagnostic video examination
    Michael E Pichichero
    Elmwood Pediatric Group, University of Rochester Medical Center, 601 Elmwood Avenue, Box 672, Rochester, NY 14642, USA
    Int J Pediatr Otorhinolaryngol 69:361-6. 2005
    ....
  27. ncbi Diagnostic accuracy of otitis media and tympanocentesis skills assessment among pediatricians
    M E Pichichero
    Elmwood Pediatric Group, University of Rochester Medical Center, 601 Elmwood Avenue, Box 672, NY 14642, Rochester, USA
    Eur J Clin Microbiol Infect Dis 22:519-24. 2003
    ..The results indicate that pediatricians may often misdiagnose OME as AOM, but they select appropriate antibiotics about 80% of the time and can be trained to accurately perform tympanocentesis...
  28. ncbi Impact of a birth dose of hepatitis B vaccine on the reactogenicity and immunogenicity of diphtheria-tetanus-acellular pertussis-hepatitis B-inactivated poliovirus-Haemophilus influenzae type b combination vaccination
    Michael E Pichichero
    University of Rochester Medical Center, Rochester, NY 14642, USA
    Pediatr Infect Dis J 21:854-9. 2002
    ....
  29. ncbi Mercury concentrations and metabolism in infants receiving vaccines containing thiomersal: a descriptive study
    Michael E Pichichero
    Department of Microbiology Immunology, University of Rochester, Rochester, New York, NY, USA
    Lancet 360:1737-41. 2002
    ..We aimed to measure concentrations of mercury in blood, urine, and stools of infants who received such vaccines...
  30. ncbi Diagnostic accuracy, tympanocentesis training performance, and antibiotic selection by pediatric residents in management of otitis media
    Michael E Pichichero
    Elmwood Pediatric Group, University of Rochester Medical Center, Rochester, New York 14642, USA
    Pediatrics 110:1064-70. 2002
    ....
  31. ncbi Otitis media
    Michael E Pichichero
    Elmwood Pediatric Group, University of Rochester Medical Center, Rochester, NY 14642, USA
    Expert Opin Pharmacother 3:1073-90. 2002
    ..Best-practice for management of acute OM continues to advocate antibiotic therapy with careful, accurate diagnosis and consideration of the major pathogens and their mechanisms of resistance...
  32. ncbi Assessing diagnostic accuracy and tympanocentesis skills in the management of otitis media
    M E Pichichero
    Department of Microbiology, University of Rochester School of Medicine and Dentistry, NY 14642, USA
    Arch Pediatr Adolesc Med 155:1137-42. 2001
    ..The distinction between acute suppurative otitis media (AOM) and otitis media with effusion (OME) is important for antibiotic treatment decisions. Tympanocentesis may be useful in the diagnosis of AOM in selected patients...
  33. ncbi Acute otitis media disease management
    M E Pichichero
    Elmwood Pediatric Group, University of Rochester Medical Center, Rochester, NY 14642, USA
    Minerva Pediatr 55:415-38. 2003
    ..Three injections of ceftriaxone or gatifloxacin (when approved) or diagnostic/therapeutic tympanocentisis (when approved) become a third-line treatment option. No single antibiotic or management strategy is ideal for all patients...
  34. ncbi Frequency of symptomatic relapses of group A beta-hemolytic streptococcal tonsillopharyngitis in children from 4 pediatric practices following penicillin, amoxicillin, and cephalosporin antibiotic treatment
    Janet R Casey
    Legacy Pediatrics, University of Rochester, Rochester, New York, USA
    Clin Pediatr (Phila) 47:549-54. 2008
    ....
  35. ncbi Symptomatic relapse of group A beta-hemolytic streptococcal tonsillopharyngitis in children
    Janet R Casey
    University of Rochester School of Medicine, Elmwood Pediatric Group, Rochester, New York, USA
    Clin Pediatr (Phila) 46:307-10. 2007
    ..02). Clinicians should be aware that the rate of symptomatic failures after antibiotic therapy for group A beta-hemolytic streptococcal tonsillopharyngitis differs by drug and is not an uncommon event...
  36. ncbi Preferred antibiotics for treatment of acute otitis media: comparison of practicing pediatricians, general practitioners, and otolaryngologists
    Michael E Pichichero
    Elmwood Pediatric Group, University of Rochester Medical Center, 601 Elmwood Avenue, Box 672, Rochester, NY 14642, USA
    Clin Pediatr (Phila) 44:575-8. 2005
    ..After instruction that provides the rationale for guideline-recommended agents based on pharmacokinetics/pharmacodynamics and double tympanocentesis trials, endorsement of recommended antibiotics significantly improved to >90%...
  37. ncbi Changes in frequency and pathogens causing acute otitis media in 1995-2003
    Janet R Casey
    Elmwood Pediatric Group, Department of Pediatrics, University of Rochester, Rochester, NY, USA
    Pediatr Infect Dis J 23:824-8. 2004
    ..Fewer S. pneumoniae AOM isolates are penicillin-resistant and more H. influenzae are beta-lactamase-producing...
  38. ncbi New patterns in the otopathogens causing acute otitis media six to eight years after introduction of pneumococcal conjugate vaccine
    Janet R Casey
    Department of Pediatrics, University of Rochester, Rochester, NY, USA
    Pediatr Infect Dis J 29:304-9. 2010
    ....
  39. ncbi Efficacy of cephalexin two vs. three times daily vs. cefadroxil once daily for streptococcal tonsillopharyngitis
    Correne D Curtin
    Elmwood Pediatric Group, Rochester, New York 14642, USA
    Clin Pediatr (Phila) 42:519-26. 2003
    ..Cephalexin dosed twice daily or three times daily and cefadroxil dosed once daily appear equivalent in bacteriologic and clinical cure of GABHS tonsillopharyngitis...
  40. ncbi Pathogen shifts and changing cure rates for otitis media and tonsillopharyngitis
    Michael E Pichichero
    Department of Microbiology and Immunology, Pediatrics and Medicine, University of Rochester Medical Center, Elmwood Pediatric Group, Rochester, New York 14642, USA
    Clin Pediatr (Phila) 45:493-502. 2006
    ..Recent results with amoxicillin suggest its efficacy is also waning. Cephalosporins have the highest bacteriologic and clinical efficacy. This has implications for optimal antibiotic therapy...
  41. ncbi Breast-feeding is associated with a reduced frequency of acute otitis media and high serum antibody levels against NTHi and outer membrane protein vaccine antigen candidate P6
    Albert Sabirov
    Department of Microbiology Immunology, University of Rochester, Rochester, New York 14627, USA
    Pediatr Res 66:565-70. 2009
    ..Higher serum IgG might facilitate protection against AOM and NP colonization in breast-fed children...
  42. ncbi Evolving microbiology and molecular epidemiology of acute otitis media in the pneumococcal conjugate vaccine era
    Michael E Pichichero
    Department of Microbiology and Immunology, University of Rochester, Rochester, New York 14642, USA urmc rochester edu
    Pediatr Infect Dis J 26:S12-6. 2007
    ..Expansion of the number of serotypes included in pneumococcal conjugate vaccines is needed to sustain a long-term benefit from immunization against these bacteria...
  43. ncbi Novel type of Streptococcus pneumoniae causing multidrug-resistant acute otitis media in children
    Qingfu Xu
    University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    Emerg Infect Dis 15:547-51. 2009
    ..pneumoniae in which all strains had 6 of the same alleles as ST-156. The multidrug-resistant strains related to ST-156 expressed different capsular serotypes: 9V, 14, 11A, 15C, and 19F...
  44. ncbi The evidence base for cephalosporin superiority over penicillin in streptococcal pharyngitis
    Janet R Casey
    Elmwood Pediatric Group, University of Rochester, Rochester, NY 14642, USA
    Diagn Microbiol Infect Dis 57:39S-45S. 2007
    ..This review examines the evidence supporting the use of cephalosporins as a first choice of treatment for many patients with GABHS pharyngitis...
  45. ncbi Meta-analysis of cephalosporin versus penicillin treatment of group A streptococcal tonsillopharyngitis in children
    Janet R Casey
    Department of Pediatrics, Elmwood Pediatric Group, University of Rochester, Rochester, New York 14620, USA
    Pediatrics 113:866-82. 2004
    ..To conduct a meta-analysis of randomized, controlled trials of cephalosporin versus penicillin treatment of group A beta-hemolytic streptococcal (GABHS) tonsillopharyngitis in children...
  46. ncbi Metaanalysis of short course antibiotic treatment for group a streptococcal tonsillopharyngitis
    Janet R Casey
    Department of Pediatrics, Elmwood Pediatric Group, University of Rochester Medical Center, NY, USA
    Pediatr Infect Dis J 24:909-17. 2005
    ..To compare bacterial and clinical cure rates in patients with group A streptococcal (GAS) tonsillopharyngitis treated with oral beta-lactam or macrolide antibiotics for 4-5 days versus 10-day comparators...
  47. ncbi Mucosal vaccination with a multicomponent adenovirus-vectored vaccine protects against Streptococcus pneumoniae infection in the lung
    Maria T Arévalo
    Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    FEMS Immunol Med Microbiol 55:346-51. 2009
    ..pneumoniae strain D39 colonization in mouse lungs. Taken together, these data demonstrate the feasibility of developing a mucosal vaccine against S. pneumoniae using recombinant adenoviruses for antigen delivery...
  48. ncbi Prospective identification and treatment of children with pediatric autoimmune neuropsychiatric disorder associated with group A streptococcal infection (PANDAS)
    Marie Lynd Murphy
    Elmwood Pediatric Group, University of Rochester Medical Center, 601 Elmwood Ave, Box 672, Rochester, NY 14642, USA
    Arch Pediatr Adolesc Med 156:356-61. 2002
    ..CONCLUSION: To our knowledge, this is the first prospective study to confirm that PANDAS is associated with acute GABHS tonsillopharyngitis and responds to appropriate antibiotic therapy at the sentinel episode...
  49. ncbi Meta-analysis of cephalosporins versus penicillin for treatment of group A streptococcal tonsillopharyngitis in adults
    Janet R Casey
    University of Rochester, Elmwood Pediatric Group, Rochester, New York 14620, USA
    Clin Infect Dis 38:1526-34. 2004
    ..This meta-analysis indicates that the likelihood of bacteriologic and clinical failure in the treatment of GABHS tonsillopharyngitis is 2 times higher for oral penicillin than for oral cephalosporins...
  50. ncbi Efficacy of penicillin vs. amoxicillin in children with group A beta hemolytic streptococcal tonsillopharyngitis
    Correne Curtin-Wirt
    Elmwood Pediatric Group, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Clin Pediatr (Phila) 42:219-25. 2003
    ..84, 95% confidence interval 1.02-3.29); the same was true for dinical cure (OR = 1.99, 95% CI = 1.02-3.87). Amoxicillin may be superior to penicillin for bacteriologic and clinical cure of GABHS tonsillopharyngitis...
  51. ncbi Higher dosages of azithromycin are more effective in treatment of group A streptococcal tonsillopharyngitis
    Janet R Casey
    Department of Pediatrics, Elmwood Pediatric Group, University of Rochester Medical Center, New York, USA
    Clin Infect Dis 40:1748-55. 2005
    ..In this study, our objective was to determine the optimal dose of azithromycin for treatment of GAS tonsillopharyngitis in children and adults by analyzing trials that used different dose regimens...
  52. ncbi Mercury levels in premature and low birth weight newborn infants after receipt of thimerosal-containing vaccines
    Michael E Pichichero
    University of Rochester, Rochester, NY, USA
    J Pediatr 155:495-9. 2009
    ..We conducted a population-based pharmacokinetic study to assess blood levels and elimination of mercury after vaccination of premature infants born at > or =32 and <37 weeks of gestation and with birth weight > or =2000 but <3000 g...
  53. ncbi White blood cell count can aid judicious antibiotic prescribing in acute upper respiratory infections in children
    Janet R Casey
    Elmwood Pediatric Group, Rochester, NY 14642, USA
    Clin Pediatr (Phila) 42:113-9. 2003
    ..With this approach, return office visits in the following 2 weeks were infrequent (13% of 737 patients), and no child had significant bacterial illness that was missed. With selective use of WBC count testing..
  54. ncbi Variations in amoxicillin pharmacokinetic/pharmacodynamic parameters may explain treatment failures in acute otitis media
    Michael E Pichichero
    Rochester General Research Institute, Legacy Pediatric Group, Rochester, New York, USA
    Paediatr Drugs 11:243-9. 2009
    ..These findings suggest that variability in PK/PD parameters may impact amoxicillin concentrations in serum and MEF, possibly explaining some AOM treatment failures...
  55. ncbi Protective immunity against botulism provided by a single dose vaccination with an adenovirus-vectored vaccine
    Mingtao Zeng
    Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Box 672, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Vaccine 25:7540-8. 2007
    ..The data suggest that an adenovirus-vectored genetic vaccine is a highly efficient prophylaxis candidate against botulism...
  56. ncbi Azithromycin for the treatment of pertussis
    Michael E Pichichero
    Department of Microbiology and Immunology, University of Rochester Medical Center, 601 Elmwood Avenue, Box 672, Rochester, NY 14642, USA
    Pediatr Infect Dis J 22:847-9. 2003
  57. ncbi Rethinking the total cost of care in AOM and ABS: The impact of improved diagnostic accuracy and antibiotic treatment where high efficacy and adherence are achievable
    Michael E Pichichero
    University of Rochester Medical Center, Elmwood Pediatric Group, 601 Elmwood Ave, Box 672, Rochester, NY 14642, USA
    Am J Manag Care 12:S283-91. 2006
  58. ncbi A review of recommended antibiotic therapies with impact on outcomes in acute otitis media and acute bacterial sinusitis
    Michael E Pichichero
    University of Rochester Medical Center, Elmwood Pediatric Group, 601 Elmwood Ave, Box 672, Rochester, NY 14642, USA
    Am J Manag Care 12:S292-302. 2006
  59. ncbi N-fragment of edema factor as a candidate antigen for immunization against anthrax
    Mingtao Zeng
    Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box 672, Rochester, NY 14642, USA
    Vaccine 24:662-70. 2006
    ..Our data suggest that EF plays a role in eliciting protective immunity against anthrax, and that it should be included in a new generation multi-component subunit vaccine...
  60. ncbi Protection against anthrax by needle-free mucosal immunization with human anthrax vaccine
    Mingtao Zeng
    Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box 672, Rochester, New York 14642, USA
    Vaccine 25:3588-94. 2007
    ..anthracis Sterne spores. The data suggests that intranasal administration may be an effective immunization modality for an improved immunization program against anthrax...
  61. ncbi Clinical evaluation of Pediarix: a new pediatric combination vaccine
    Michael E Pichichero
    University of Rochester Medical Center, Rochester, New York 14642, USA
    Clin Pediatr (Phila) 42:393-400. 2003
  62. ncbi Use of selected cephalosporins in penicillin-allergic patients: a paradigm shift
    Michael E Pichichero
    University of Rochester Medical Center, Elmwood Pediatric Group, Rochester, NY 14642, USA
    Diagn Microbiol Infect Dis 57:13S-18S. 2007
    ..Particular emphasis is placed on the role of chemical structure in determining the risk of cross-reactivity between specific agents...
  63. ncbi Seven-year follow-up of vaccine response in extremely premature infants
    Khaver I Kirmani
    Department of Pediatrics, Strong Children's Research Center, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Pediatrics 109:498-504. 2002
    ..CONCLUSIONS: At 7 years of age, PT children had lower antibody titers to many vaccine antigens than FT children. However, most PT children maintained antibody titers in the protective range...
  64. ncbi A comparison of 2 white blood cell count devices to aid judicious antibiotic prescribing
    Janet R Casey
    Legacy Pediatrics, Department of Pediatrics, University of Rochester, Rochester, New York, 14642, USA
    Clin Pediatr (Phila) 48:291-4. 2009
    ..A simple and quick point-of-care WBC count device produces similar results as achievable with a Cell-Dyn counter for total WBCs and may assist in judicious antibiotic prescribing...
  65. ncbi Efficacy and safety of besifloxacin ophthalmic suspension 0.6% in children and adolescents with bacterial conjunctivitis: a post hoc, subgroup analysis of three randomized, double-masked, parallel-group, multicenter clinical trials
    Timothy L Comstock
    Medical Affairs, Global Pharmaceutical, Bausch and Lomb, Inc, Rochester, New York 14609, USA
    Paediatr Drugs 12:105-12. 2010
    ..Besifloxacin is a new topical fluoroquinolone, the first chlorofluoroquinolone, for the treatment of bacterial conjunctivitis...
  66. ncbi Acellular pertussis vaccine safety and efficacy in children, adolescents and adults
    Janet R Casey
    Elmwood Pediatric Group, University of Rochester, Rochester, New York 14620, USA
    Drugs 65:1367-89. 2005
    ..The economic impact of pertussis and transmission from adults to vulnerable infants provides a cost-benefit justification for widespread use of DTaP vaccines in all age groups with routine boosting every 10 years...
  67. ncbi Booster vaccinations: can immunologic memory outpace disease pathogenesis?
    Michael E Pichichero
    Rochester General Research Institute, Rochester General Hospital, Rochester, New York 14621, USA
    Pediatrics 124:1633-41. 2009
    ..With infectious diseases for which the pace of pathogenesis is slow, immune memory should be sufficient to prevent disease...
  68. ncbi Assessing diagnostic accuracy and tympanocentesis skills of South African physicians in management of otitis media
    Michael E Pichichero
    S Afr Med J 92:137-8. 2002
  69. ncbi Optimizing antibacterial therapy for community-acquired respiratory tract infections in children in an era of bacterial resistance
    Donald E Low
    Mount Sinai Hospital, Toronto, Canada
    Clin Pediatr (Phila) 43:135-51. 2004
    ..New antibacterials will continue to have a role in the treatment of RTIs in children, especially where resistance compromises existing therapies...
  70. ncbi Quality of the Haemophilus influenzae type b (Hib) antibody response induced by diphtheria-tetanus-acellular pertussis/Hib combination vaccines
    Philippe A Denoel
    GlaxoSmithKline Biologicals, Rue de l Institut 89, 1330 Rixensart, Belgium
    Clin Vaccine Immunol 14:1362-9. 2007
    ..In conclusion, in vitro and in vivo data as well as postmarketing vaccine effectiveness data attest to the ability of DTPa-based/Hib combination vaccines to effectively prevent Hib-induced disease in children...
  71. ncbi Does group A beta-hemolytic streptococcal infection increase risk for behavioral and neuropsychiatric symptoms in children?
    Eliana Miller Perrin
    Division of General Pediatrics and Adolescent Medicine, Department of Pediatrics, University of North Carolina at Chapel Hill, 200 Mason Farm Road, Chapel Hill, NC 27599 7220, USA
    Arch Pediatr Adolesc Med 158:848-56. 2004
    ..To determine whether group A beta-hemolytic streptococcal infections increase the risk of developing symptoms characteristic of the diagnosis pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS)...
  72. ncbi Detection and characterization of pediatric serum antibody to the OMP P5-homologous adhesin of nontypeable Haemophilus influenzae during acute otitis media
    Laura A Novotny
    Department of Pediatrics, College of Medicine and Public Health, Children's Research Institute, The Ohio State University, Rm W302, 700 Children's Drive, Columbus, OH 43205-2696, USA
    Vaccine 20:3590-7. 2002
    ..The immune recognition we observed encourages us to further develop a P5-fimbrin based vaccine component...
  73. ncbi Penicillin failures?!
    Michael E Pichichero
    Pediatrics 109:1189-90; author reply 1190-2. 2002
  74. ncbi Verification of components of acellular pertussis vaccines that have been distributed solely, been in routine use for the last two decades and contributed greatly to control of pertussis in Japan
    Michael E Pichichero
    Biologicals 33:59. 2005
  75. ncbi Acute otitis media: influence of the PCV-7 vaccine on changes in the disease and its management
    Stephen Brunton
    Carbarrus Family Medicine Residency Program, Charlotte, North Carolina, USA
    J Fam Pract 54:961-8. 2005
    ..In these cases, watchful waiting may be appropriate. This publication addresses presumed bacterial causes of AOM for which antibiotic use may be efficacious...

Research Grants2

  1. NTHi Immunity in Young Children
    Michael Pichichero; Fiscal Year: 2007
    ..The results gained from these studies will provide insight to the immune mechanisms involved in the pathogenesis of otitis media aid in the development of a vaccine for otits media. ..