Richard Phipps

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. pmc Neu-164 and Neu-107, two novel antioxidant and anti-myeloperoxidase compounds, inhibit acute cigarette smoke-induced lung inflammation
    Thomas H Thatcher
    Department of Medicine, University of Rochester, Rochester, NY 14642, USA
    Am J Physiol Lung Cell Mol Physiol 305:L165-74. 2013
  2. pmc Attenuation of inflammatory mediator production by the NF-κB member RelB is mediated by microRNA-146a in lung fibroblasts
    David H McMillan
    Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Am J Physiol Lung Cell Mol Physiol 304:L774-81. 2013
  3. ncbi request reprint The CD40-CD40 ligand system: a potential therapeutic target in atherosclerosis
    R P Phipps
    University of Rochester School of Medicine and Dentistry, Department of Microbiology and Immunology, Cancer Center, Rochester NY 14642, USA
    Curr Opin Investig Drugs 2:773-7. 2001
  4. ncbi request reprint Fibroblast subsets in the human orbit: Thy-1+ and Thy-1- subpopulations exhibit distinct phenotypes
    Laura Koumas
    Departments of Microbiology and Immunology, James P Wilmot Cancer Center, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Rochester, NY 14642, USA
    Eur J Immunol 32:477-85. 2002
  5. ncbi request reprint On-road exposure to highway aerosols. 2. Exposures of aged, compromised rats
    Alison Elder
    Department of Environmental Medicine, University of Rochester, New York 14642, USA
    Inhal Toxicol 16:41-53. 2004
  6. pmc A putative role for platelet-derived PPARγ in vascular homeostasis demonstrated by anti-PPARγ induction of bleeding, thrombocytopenia and compensatory megakaryocytopoiesis
    Patricia J Simpson-Haidaris
    Department of Medicine, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Rochester, NY 14642, USA pj
    J Biotechnol 150:417-27. 2010
  7. ncbi request reprint The TRAF6, but not the TRAF2/3, binding domain of CD40 is required for cytokine production in human lung fibroblasts
    Jeffrey M Purkerson
    Department of Pediatrics, University of Rochester Medical Center, Rochester, NY 14642, USA
    Eur J Immunol 35:2920-8. 2005
  8. ncbi request reprint Enhanced synthesis of proinflammatory cytokines by vulvar vestibular fibroblasts: implications for vulvar vestibulitis
    David C Foster
    Department of Obstetrics and Gynecology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    Am J Obstet Gynecol 196:346.e1-8. 2007
  9. ncbi request reprint An association of soluble CD40 ligand (CD154) with adverse reactions to platelet transfusions
    Neil Blumberg
    Transfusion Medicine Unit and Clinical Laboratories, Department of Pathology and Laboratory Medicine, Hematology Oncology Unit, The University of Rochester Medical Center, Rochester, New York 14642, USA
    Transfusion 46:1813-21. 2006
  10. pmc Differences in the TGF-{beta}1-induced profibrotic response of anterior and posterior corneal keratocytes in vitro
    Holly B Hindman
    Flaum Eye Institute, University of Rochester Medical Center, Rochester, New York, USA
    Invest Ophthalmol Vis Sci 51:1935-42. 2010

Collaborators

  • Neil Blumberg
  • Terry J Smith
  • Charles Francis
  • Jill M Cholette
  • Wei Liu
  • Holly B Hindman
  • Jeffrey M Purkerson
  • Thomas H Thatcher
  • Robert Rose
  • Constantine G Haidaris
  • Krystel Huxlin
  • DAVID CHARLES FOSTER
  • I Rahman
  • Andrew Gianoukakis
  • G A Scott
  • A Sorisky
  • Aruna Kode
  • Hans D Ochs
  • Zheng Gen Jin
  • Carolyn J Baglole
  • Denise M Ray
  • Patricia J Sime
  • Sherry L Spinelli
  • Stephen J Pollock
  • Steven E Feldon
  • Tatiana M Garcia-Bates
  • Laura Koumas
  • Steven H Bernstein
  • Sanjay B Maggirwar
  • David H McMillan
  • Elizabeth P Ryan
  • Sarah G Harris
  • Roger S Smith
  • Patricia J Simpson-Haidaris
  • Thomas I Murant
  • Mark B Taubman
  • Indika Edirisinghe
  • Samuel Caito
  • Matthew P Bernard
  • Charles W O'Loughlin
  • Katherine M A O'Reilly
  • Filiz Akbiyik
  • Chantal K Turner
  • Simona Bancos
  • Naxin Guo
  • Kurt M Bertram
  • Saravanan Rajendrasozhan
  • Geniece M Lehmann
  • Se Ran Yang
  • Kathryn E Seweryniak
  • Jamie J O'Brien
  • Ziye Sui
  • Shira Landskroner-Eiger
  • Stephen E Feldon
  • Heather A Burgess
  • Julia Kaufman
  • Alison Elder
  • David S Nieves
  • Christine A Martey
  • Rachel L Roper
  • Collynn F Woeller
  • Ann E Casey
  • Jacqueline M Gertz
  • Nipa A Mody
  • Srinivasa D Narasipura
  • Michael R King
  • Richard T Libby
  • Arshad Rahman
  • Chelsea Wong
  • David Adenuga
  • Hongwei Yao
  • Thomas A Gasiewicz
  • Stephen Dewhurst
  • Harris A Gelbard
  • Giovanni Schifitto
  • Lynn F Sniderhan
  • Steven D Wittlin
  • Nicholas Chiorazzi
  • Tatiana M Garcia
  • Matthew Bernard
  • Raymond E Felgar
  • Seth M Bushinsky
  • Kuljeet Kaur
  • Christine M Malboeuf
  • Sireesha Y Reddy
  • Heather F Lakatos
  • D J John Park
  • Michelle Redonnet
  • John Van Kirk
  • Donald Chang

Detail Information

Publications58

  1. pmc Neu-164 and Neu-107, two novel antioxidant and anti-myeloperoxidase compounds, inhibit acute cigarette smoke-induced lung inflammation
    Thomas H Thatcher
    Department of Medicine, University of Rochester, Rochester, NY 14642, USA
    Am J Physiol Lung Cell Mol Physiol 305:L165-74. 2013
    ..These compounds may have promise in preventing or treating lung disease associated with chronic smoke exposure, including COPD. ..
  2. pmc Attenuation of inflammatory mediator production by the NF-κB member RelB is mediated by microRNA-146a in lung fibroblasts
    David H McMillan
    Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Am J Physiol Lung Cell Mol Physiol 304:L774-81. 2013
    ..RelB and miRNA-146a may therefore be new therapeutic targets in the treatment of lung inflammation caused by various agents and conditions...
  3. ncbi request reprint The CD40-CD40 ligand system: a potential therapeutic target in atherosclerosis
    R P Phipps
    University of Rochester School of Medicine and Dentistry, Department of Microbiology and Immunology, Cancer Center, Rochester NY 14642, USA
    Curr Opin Investig Drugs 2:773-7. 2001
    ..Blockade of the CD40-CD154 pathway by biologicals or small molecules may prove valuable in the treatment of atherosclerosis...
  4. ncbi request reprint Fibroblast subsets in the human orbit: Thy-1+ and Thy-1- subpopulations exhibit distinct phenotypes
    Laura Koumas
    Departments of Microbiology and Immunology, James P Wilmot Cancer Center, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Rochester, NY 14642, USA
    Eur J Immunol 32:477-85. 2002
    ..These observations suggest that fibroblast subsets in the human orbit play distinct roles in the regulation of immune and inflammatory responses crucial in the initiation and development of thyroid-associated ophthalmopathy...
  5. ncbi request reprint On-road exposure to highway aerosols. 2. Exposures of aged, compromised rats
    Alison Elder
    Department of Environmental Medicine, University of Rochester, New York 14642, USA
    Inhal Toxicol 16:41-53. 2004
    ..Furthermore, they demonstrate that on-road exposures are feasible and could be performed in future studies with more continuous particle exposures...
  6. pmc A putative role for platelet-derived PPARγ in vascular homeostasis demonstrated by anti-PPARγ induction of bleeding, thrombocytopenia and compensatory megakaryocytopoiesis
    Patricia J Simpson-Haidaris
    Department of Medicine, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Rochester, NY 14642, USA pj
    J Biotechnol 150:417-27. 2010
    ..Furthermore, a major pitfall associated with MoAb production against closely related molecules is that monoclonicity does not guarantee monospecificity, an issue worth further scientific scrutiny...
  7. ncbi request reprint The TRAF6, but not the TRAF2/3, binding domain of CD40 is required for cytokine production in human lung fibroblasts
    Jeffrey M Purkerson
    Department of Pediatrics, University of Rochester Medical Center, Rochester, NY 14642, USA
    Eur J Immunol 35:2920-8. 2005
    ..Thus, targeting TRAF6 function through pharmacological intervention may represent a viable strategy for modulating localized inflammation...
  8. ncbi request reprint Enhanced synthesis of proinflammatory cytokines by vulvar vestibular fibroblasts: implications for vulvar vestibulitis
    David C Foster
    Department of Obstetrics and Gynecology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    Am J Obstet Gynecol 196:346.e1-8. 2007
    ....
  9. ncbi request reprint An association of soluble CD40 ligand (CD154) with adverse reactions to platelet transfusions
    Neil Blumberg
    Transfusion Medicine Unit and Clinical Laboratories, Department of Pathology and Laboratory Medicine, Hematology Oncology Unit, The University of Rochester Medical Center, Rochester, New York 14642, USA
    Transfusion 46:1813-21. 2006
    ..PLTs are the primary source of soluble CD40 ligand (sCD40L). Engagement of the receptor for CD40L induces synthesis of proinflammatory mediators including interleukin (IL)-6, IL-8, and monocyte chemotactic protein-1 (MCP-1)...
  10. pmc Differences in the TGF-{beta}1-induced profibrotic response of anterior and posterior corneal keratocytes in vitro
    Holly B Hindman
    Flaum Eye Institute, University of Rochester Medical Center, Rochester, New York, USA
    Invest Ophthalmol Vis Sci 51:1935-42. 2010
    ..This heterogeneity of keratocyte response may impact wound closure after mechanical wounding...
  11. pmc An association between decreased cardiopulmonary complications (transfusion-related acute lung injury and transfusion-associated circulatory overload) and implementation of universal leukoreduction of blood transfusions
    Neil Blumberg
    Transfusion Medicine Unit, and the Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
    Transfusion 50:2738-44. 2010
    ..Cardiopulmonary adverse events after transfusion include transfusion-related acute lung injury (TRALI) and transfusion-associated circulatory overload (TACO), which are potentially lethal and incompletely understood...
  12. pmc Peroxisome proliferator-activated receptor gamma overexpression suppresses growth and induces apoptosis in human multiple myeloma cells
    Tatiana M Garcia-Bates
    Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Clin Cancer Res 14:6414-25. 2008
    ..To further understand the role of PPARgamma, we examined the functional consequences of its overexpression in human multiple myeloma...
  13. ncbi request reprint Human multiple myeloma cells express peroxisome proliferator-activated receptor gamma and undergo apoptosis upon exposure to PPARgamma ligands
    Denise M Ray
    The Lung Biology and Disease Program, Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, NY 14642, USA
    Clin Immunol 113:203-13. 2004
    ..These new findings support that PPARgamma ligands may represent a novel therapy for multiple myeloma...
  14. ncbi request reprint More than structural cells, fibroblasts create and orchestrate the tumor microenvironment
    Carolyn J Baglole
    Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, and Lymphoma Biology Program, James P Wilmot Cancer Center, Rochester, New York 14642, USA
    Immunol Invest 35:297-325. 2006
    ..This review will highlight the emerging role of the complex fibroblastic stroma in establishing a microenvironment supporting malignant transformation, tumor growth and attenuation of host anti-tumor immune responses...
  15. ncbi request reprint Differential COX localization and PG release in Thy-1(+) and Thy-1(-) human female reproductive tract fibroblasts
    Laura Koumas
    Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Lung Biology and Disease Program, Rochester, New York 14642, USA
    Am J Physiol Cell Physiol 283:C599-608. 2002
    ....
  16. pmc Cigarette smoke-induced expression of heme oxygenase-1 in human lung fibroblasts is regulated by intracellular glutathione
    Carolyn J Baglole
    University of Rochester School of Medicine and Dentistry, Dept of Environmental Medicine, Rochester, NY 14642, USA
    Am J Physiol Lung Cell Mol Physiol 295:L624-36. 2008
    ..These data support the concept that changes in the cellular redox status brought on by cigarette smoke induce HO-1 in fibroblasts. This increase in HO-1 may help protect against cigarette smoke-induced inflammation and/or cell death...
  17. ncbi request reprint The Pseudomonas autoinducer N-(3-oxododecanoyl) homoserine lactone induces cyclooxygenase-2 and prostaglandin E2 production in human lung fibroblasts: implications for inflammation
    Roger S Smith
    Department of Microbiology and Immunology, University of Rochester, NY 14642, USA
    J Immunol 169:2636-42. 2002
    ..These studies further reinforce the concept that bacterial AHLs not only regulate bacterial virulence but also stimulate the activities of eukaryotic cells important for inflammation and immune defenses...
  18. ncbi request reprint Expression of CD154 (CD40 ligand) by human lung fibroblasts: differential regulation by IFN-gamma and IL-13, and implications for fibrosis
    Julia Kaufman
    Department of Microbiology and Immunology, Lung Biology and Disease Program, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    J Immunol 172:1862-71. 2004
    ..We speculate that fibroblast-derived CD40L plays a role in promoting fibroblast activation and possibly in interaction with CD40 bearing cells...
  19. doi request reprint Washing red blood cells and platelets transfused in cardiac surgery reduces postoperative inflammation and number of transfusions: results of a prospective, randomized, controlled clinical trial
    Jill M Cholette
    Department of Pediatrics, University of Rochester, Rochester, NY, USA
    Pediatr Crit Care Med 13:290-9. 2012
    ..We hypothesize that washing red blood cells and platelets transfused to these patients will reduce postoperative transfusion-related immune modulation and inflammation...
  20. pmc The aryl hydrocarbon receptor attenuates tobacco smoke-induced cyclooxygenase-2 and prostaglandin production in lung fibroblasts through regulation of the NF-kappaB family member RelB
    Carolyn J Baglole
    Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Biol Chem 283:28944-57. 2008
    ..The association between RelB and AhR may represent a new therapeutic and more selective target with which to combat inflammation-associated diseases...
  21. ncbi request reprint Human bone marrow megakaryocytes and platelets express PPARgamma, and PPARgamma agonists blunt platelet release of CD40 ligand and thromboxanes
    Filiz Akbiyik
    Box 850, Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Rochester, NY 14642, USA
    Blood 104:1361-8. 2004
    ..This may represent a novel mechanism for treatment of inflammation, thrombosis, and vascular disease in high-risk patients...
  22. pmc The Pseudomonas aeruginosa quorum-sensing molecule N-(3-oxododecanoyl)homoserine lactone contributes to virulence and induces inflammation in vivo
    Roger S Smith
    Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Bacteriol 184:1132-9. 2002
    ..Therefore, the quorum-sensing systems of P. aeruginosa contribute to its pathogenesis both by regulating expression of virulence factors (exoenzymes and toxins) and by inducing inflammation...
  23. pmc Platelets and megakaryocytes contain functional nuclear factor-kappaB
    Sherry L Spinelli
    Department of Environmental Medicine, Box 850, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, New York 14642, USA
    Arterioscler Thromb Vasc Biol 30:591-8. 2010
    ..We discovered that human megakaryocytes and platelets express the majority of NF-kappaB family members, including the regulatory inhibitor-kappaB (I-kappaB) and I-kappa kinase (IKK) molecules...
  24. pmc Molecular regulation of cigarette smoke induced-oxidative stress in human retinal pigment epithelial cells: implications for age-related macular degeneration
    Kurt M Bertram
    Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Am J Physiol Cell Physiol 297:C1200-10. 2009
    ..These data support the hypothesis that cigarette smoke contributes to AMD pathogenesis by causing oxidative damage and cell death to RPE cells...
  25. pmc Peroxisome proliferator-activated receptor gamma ligands enhance human B cell antibody production and differentiation
    Tatiana M Garcia-Bates
    Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    J Immunol 183:6903-12. 2009
    ..These new findings indicate that low doses of PPARgamma/RXRalpha ligands could be used as a new type of adjuvant to stimulate Ab production...
  26. pmc CpG oligodeoxynucleotides induce cyclooxygenase-2 in human B lymphocytes: implications for adjuvant activity and antibody production
    Matthew P Bernard
    Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Clin Immunol 125:138-48. 2007
    ....
  27. ncbi request reprint Cyclooxygenase-2 inhibition attenuates antibody responses against human papillomavirus-like particles
    Elizabeth P Ryan
    Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, USA
    J Immunol 177:7811-9. 2006
    ....
  28. pmc Mast cell-derived prostaglandin D2 controls hyaluronan synthesis in human orbital fibroblasts via DP1 activation: implications for thyroid eye disease
    Naxin Guo
    Department of Ophthalmology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Biol Chem 285:15794-804. 2010
    ..Mast cell-derived PGD(2) increased HA production via activation of DP1. Selectively targeting the production of PGD(2) and/or activation of DP1 may prevent pathological changes associated with TED...
  29. ncbi request reprint Prostaglandins as modulators of immunity
    Sarah G Harris
    Dept of Microbiology and the James P Wilmot Cancer Center, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Trends Immunol 23:144-50. 2002
    ..Understanding the diverse activities of these prostaglandins is crucial for the development of new therapies aimed at immune modulation...
  30. ncbi request reprint Constitutive and activation-inducible cyclooxygenase-2 expression enhances survival of chronic lymphocytic leukemia B cells
    Elizabeth P Ryan
    Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Clin Immunol 120:76-90. 2006
    ..It will therefore be important to evaluate drugs that inhibit Cox-2 as potential therapeutic agents in B-CLL in vivo...
  31. pmc Memory B cells from older people express normal levels of cyclooxygenase-2 and produce higher levels of IL-6 and IL-10 upon in vitro activation
    Simona Bancos
    Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, NY 14642, USA
    Cell Immunol 266:90-7. 2010
    ..However, we found that activated memory B cells from older people produce higher levels of IL-6 and IL-10 compared to young adults. Therefore, the dysregulated cytokine production could contribute to immune senescence in the elderly...
  32. ncbi request reprint 15-deoxy-Delta 12,14-PGJ2 induces IL-8 production in human T cells by a mitogen-activated protein kinase pathway
    Sarah G Harris
    Cancer Center, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA
    J Immunol 168:1372-9. 2002
    ..The implications of this research also include that caution is warranted in assigning a solely anti-inflammatory role for 15-d-PGJ(2)...
  33. pmc Developmental changes in soluble CD40 ligand
    Jill M Cholette
    Department of Pediatrics, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Pediatr 152:50-4, 54.e1. 2008
    ..To determine if soluble CD40 ligand (sCD40L; formally CD154) levels vary with age and to identify age-dependent ranges in healthy pediatric and adult populations...
  34. ncbi request reprint Rosiglitazone and 15-deoxy-Delta12,14-prostaglandin J2, PPARgamma agonists, differentially regulate cigarette smoke-mediated pro-inflammatory cytokine release in monocytes/macrophages
    Samuel Caito
    Department of Environmental Medicine, Lung Biology and Disease Program, University of Rochester Medical Center, Rochester, New York 14642 USA
    Antioxid Redox Signal 10:253-60. 2008
    ..These data have implications in designing therapies for treatment of COPD and pulmonary fibrosis...
  35. pmc Aryl hydrocarbon receptor-deficient mice develop heightened inflammatory responses to cigarette smoke and endotoxin associated with rapid loss of the nuclear factor-kappaB component RelB
    Thomas H Thatcher
    Department of Medicine, University of Rochester, Rochester, New York 14642, USA
    Am J Pathol 170:855-64. 2007
    ....
  36. ncbi request reprint A novel ELISpot method for adherent cells
    Chantal K Turner
    Department of Environmental Medicine, University of Rochester, 601 Elmwood Ave, Rochester, NY 14642, USA
    J Immunol Methods 291:63-70. 2004
    ..Moreover, the assay is suitable for normal human adherent cells that are often short-lived and difficult to cultivate...
  37. ncbi request reprint Autologous T-lymphocytes stimulate proliferation of orbital fibroblasts derived from patients with Graves' ophthalmopathy
    Stephen E Feldon
    Department of Ophthalmology, University of Rochester, NY 14642, USA
    Invest Ophthalmol Vis Sci 46:3913-21. 2005
    ..GO is also characterized by autoimmune inflammation of orbital connective tissue with mononuclear cell infiltration, including T cells...
  38. ncbi request reprint The causes and treatment of reactions to platelet transfusions
    Neil Blumberg
    Transfusion 43:291-2; author reply 292. 2003
  39. pmc Immune mechanisms in thyroid eye disease
    Geniece M Lehmann
    Department of Environmental Medicine, University of Rochester, Rochester, New York 14642, USA
    Thyroid 18:959-65. 2008
    ....
  40. pmc Unique attributes of orbital fibroblasts and global alterations in IGF-1 receptor signaling could explain thyroid-associated ophthalmopathy
    Terry J Smith
    Division of Molecular Medicine, Department of Medicine, Harbor UCLA Medical Center, Torrance, California 90502, USA
    Thyroid 18:983-8. 2008
    ..In this brief review we attempt to survey our findings. We believe that they might provide a "roadmap" for further discovery into the pathogenesis of TAO. Clearly, more questions remain than those thus far answered...
  41. ncbi request reprint Orbital fibroblast heterogeneity may determine the clinical presentation of thyroid-associated ophthalmopathy
    Terry J Smith
    Division of Molecular Medicine, Harbor UCLA Medical Center, Torrance, California 90502, USA
    J Clin Endocrinol Metab 87:385-92. 2002
    ..These observations enhance our understanding of orbital adipogenesis and define previously unrecognized differences between fibroblasts from the extraocular muscle and connective tissue...
  42. ncbi request reprint Prostaglandin E2 and cAMP promote B lymphocyte class switching to IgG1
    Rachel L Roper
    Department of Environmental Medicine, James P Wilmot Cancer Center, School of Medicine and Dentistry, University of Rochester, Rochester, NY 14642, USA
    Immunol Lett 84:191-8. 2002
    ..PGE(2) is an important regulator of the immune response, shifting the balance towards a T helper type 2 response, directing selection of the isotypes produced, and promoting memory cell formation...
  43. pmc Thy-1 expression in human fibroblast subsets defines myofibroblastic or lipofibroblastic phenotypes
    Laura Koumas
    Department of Environmental Medicine, University of Rochester, Rochester, New York 14642, USA
    Am J Pathol 163:1291-300. 2003
    ....
  44. ncbi request reprint Inhibition of cyclooxygenase-2: a new targeted therapy for B-cell lymphoma?
    Richard P Phipps
    Leuk Res 28:109-11. 2004
    ..Having placed the COX pathway in this context, the discussion will then return to the provocative findings of Wun et al. [Leuk. Res., 28, 2004]...
  45. ncbi request reprint CD40 engagement prevents peroxisome proliferator-activated receptor gamma agonist-induced apoptosis of B lymphocytes and B lymphoma cells by an NF-kappaB-dependent mechanism
    Denise M Ray
    Department of Environmental Medicine, The Lung Biology and Disease Program, University of Rochester Medical Center, School of Medicine and Dentistry, NY 14642, USA
    J Immunol 174:4060-9. 2005
    ..Moreover, the ability of PPARgamma agonists to kill malignant B lineage cells has implications for their use as anti-B lymphoma agents...
  46. ncbi request reprint Crystalline and amorphous silica differentially regulate the cyclooxygenase-prostaglandin pathway in pulmonary fibroblasts: implications for pulmonary fibrosis
    Katherine M A O'Reilly
    Department of Medicine, University of Rochester School of Medicine, Rochester, NY 14642, USA
    Am J Physiol Lung Cell Mol Physiol 288:L1010-6. 2005
    ..Moreover, they suggest a mechanism to explain the differing fibrogenic potential of CS and AS. The molecules COX-2, PGE synthase, and PGE2 are identified as effectors in silicosis...
  47. ncbi request reprint Differential induction of apoptosis by cigarette smoke extract in primary human lung fibroblast strains: implications for emphysema
    Carolyn J Baglole
    Univ of Rochester School of Medicine and Dentistry, Dept of Environmental Medicine, 601 Elmwood Ave, Rochester, NY 14642, USA
    Am J Physiol Lung Cell Mol Physiol 291:L19-29. 2006
    ..Variations in the sensitivity of fibroblasts to cigarette smoke may account for the fact that only some smokers develop emphysema...
  48. ncbi request reprint Platelets as a novel target for PPARgamma ligands : implications for inflammation, diabetes, and cardiovascular disease
    Denise M Ray
    Department of Environmental Medicine and the Lung Biology and Disease Program, University of Rochester, Rochester, New York 14642, USA
    BioDrugs 20:231-41. 2006
    ..Targeting platelet PPARgamma will, therefore, be an important treatment strategy for the attenuation of chronic inflammatory processes and prevention of thrombus formation...
  49. ncbi request reprint Cigarette smoke induces cyclooxygenase-2 and microsomal prostaglandin E2 synthase in human lung fibroblasts: implications for lung inflammation and cancer
    Christine A Martey
    Chemistry Department, Shippensburg University, Pennsylvania 17257, USA
    Am J Physiol Lung Cell Mol Physiol 287:L981-91. 2004
    ..This chronic inflammatory state may act as one of the first steps towards epithelial transformation...
  50. pmc Activated human T lymphocytes express cyclooxygenase-2 and produce proadipogenic prostaglandins that drive human orbital fibroblast differentiation to adipocytes
    Steven E Feldon
    Department of Ophthalmology, University of Rochester, Rochester, NY 14642, USA
    Am J Pathol 169:1183-93. 2006
    ..They also suggest the possibility that, in addition to the orbit, T lymphocytes influence the deposition of fat in other tissues...
  51. ncbi request reprint The platelet as a therapeutic target for treating vascular diseases and the role of eicosanoid and synthetic PPARgamma ligands
    Denise M Ray
    Department of Environmental Medicine and the Lung Biology and Disease Program, University of Rochester, School of Medicine and Dentistry, Box 850, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Prostaglandins Other Lipid Mediat 82:68-76. 2007
    ..PPARgamma ligand treatment may prove useful for dampening unwanted platelet activation and chronic inflammatory diseases such as cardiovascular disease...
  52. ncbi request reprint Functional synergy between CD40 ligand and HIV-1 Tat contributes to inflammation: implications in HIV type 1 dementia
    Ziye Sui
    Interdepartmental Program in Neuroscience, University of Rochester School of Medicine, 601 Elmwood Avenue, Rochester, NY 14642, USA
    J Immunol 178:3226-36. 2007
    ..Taken together, our results show that CD40 signaling in microglia and monocytes can synergize with the effects of Tat, further amplifying inflammatory processes within the CNS and influencing neuronal survival...
  53. ncbi request reprint Dermatologic and immunologic findings in the immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome
    David S Nieves
    Department of Dermatology, University of Rochester, Rochester, NY, USA
    Arch Dermatol 140:466-72. 2004
    ..If untreated, affected males die early in life from malabsorption and other complications. To our knowledge, this syndrome has never been described in the dermatology literature...
  54. ncbi request reprint Isolation and phenotypic characterization of lung fibroblasts
    Carolyn J Baglole
    Department of Environmental Medicine, University of Rochester, NY, USA
    Methods Mol Med 117:115-27. 2005
    ..These subsets can then be used for experimentation to determine functional differences between fibroblasts derived from normal and pathological tissue such as scarred lung...
  55. pmc Peroxisome proliferator-activated receptor gamma and retinoid X receptor transcription factors are released from activated human platelets and shed in microparticles
    Denise M Ray
    University of Rochester Medical Center, Environmental Medicine, Rochester, New York 14642, USA
    Thromb Haemost 99:86-95. 2008
    ....
  56. doi request reprint VEGFR-2 inhibition augments cigarette smoke-induced oxidative stress and inflammatory responses leading to endothelial dysfunction
    Indika Edirisinghe
    Department of Environmental Medicine, Lung Biology and Disease Program, University of Rochester Medical Center, 601 Elmwood Ave, Rochester, NY 14642, USA
    FASEB J 22:2297-310. 2008
    ..This explains the mechanism of endothelial dysfunction in smokers and has implications in understanding the pathogenesis of pulmonary and cardiovascular diseases...
  57. pmc High-dose but not low-dose mainstream cigarette smoke suppresses allergic airway inflammation by inhibiting T cell function
    Thomas H Thatcher
    Department of Medicine, Univ of Rochester, Rochester, NY 14642, USA
    Am J Physiol Lung Cell Mol Physiol 295:L412-21. 2008
    ....
  58. ncbi request reprint PPARgamma agonists inhibit TGF-beta induced pulmonary myofibroblast differentiation and collagen production: implications for therapy of lung fibrosis
    Heather A Burgess
    Department of Environmental Medicine, Univ of Rochester School of Medicine, 601 Elmwood Ave, Rochester, NY 14642, USA
    Am J Physiol Lung Cell Mol Physiol 288:L1146-53. 2005
    ..Thus PPARgamma agonists have novel and potent antifibrotic effects in human lung fibroblasts and may have potential for therapy of fibrotic diseases in the lung and other tissues...

Research Grants25

  1. Platelet Activation and Inflammatory Mediators
    Richard Phipps; Fiscal Year: 2007
    ..abstract_text> ..
  2. Normal and Type-2 Diabetic Platelet Proteomics and Storage for Transfusion
    Richard Phipps; Fiscal Year: 2007
    ..Overall, our findings will form the foundation for clinical studies to evaluate new biomarkers of platelet function and improve the platelet deterioration that occurs during the storage period prior to transfusion. (End of Abstract) ..
  3. Role of T cells and PPARgamma in Graves' orbital fibroblast adipogenesis
    Richard Phipps; Fiscal Year: 2007
    ..This new information will permit the development of new approaches to control inflammation and the pathologic differentiation of orbital fibroblasts important for TAO and other diseases that involve fat deposition. ..
  4. REGULATION OF IMMUNITY BY PROSTAGLANDINS
    Richard Phipps; Fiscal Year: 2009
    ..abstract_text> ..
  5. Role of T cells and PPARgamma in Graves' orbital fibroblast adipogenesis
    Richard Phipps; Fiscal Year: 2009
    ..This new information will permit the development of new approaches to control inflammation and the pathologic differentiation of orbital fibroblasts important for TAO and other diseases that involve fat deposition. ..
  6. Role of T cells and PPARgamma in Graves' orbital fibroblast adipogenesis
    Richard P Phipps; Fiscal Year: 2010
    ..This new information will permit the development of new approaches to control inflammation and the pathologic differentiation of orbital fibroblasts important for TAO and other diseases that involve fat deposition. ..
  7. Role of cyclooxygenase-2 in antibody responses to vaccination
    Richard Phipps; Fiscal Year: 2007
    ..Such a finding would improve our ability to respond to routine vaccination, as well as any bioterror threats. ..
  8. REGULATION OF IMMUNITY BY PROSTAGLANDINS
    Richard Phipps; Fiscal Year: 2002
    ..Immunodeficient patients such as the very young and elderly and those afflicted with cancer and AIDS might benefit from approaches to shape the immune response to vaccination at the outset. ..
  9. Role of T cells and PPARgamma in Graves' orbital fibroblast adipogenesis
    Richard Phipps; Fiscal Year: 2009
    ..This new information will permit the development of new approaches to control inflammation and the pathologic differentiation of orbital fibroblasts important for TAO and other diseases that involve fat deposition. ..