Benjamin D Philpot
Affiliation: University of North Carolina
Kim H, Kunz P, Mooney R, Philpot B, Smith S. Maternal Loss of Ube3a Impairs Experience-Driven Dendritic Spine Maintenance in the Developing Visual Cortex. J Neurosci. 2016;36:4888-94 pubmed publisher
..Therefore, normalizing spine maintenance is a potential therapeutic strategy. ..
Banerjee A, Larsen R, Philpot B, Paulsen O. Roles of Presynaptic NMDA Receptors in Neurotransmission and Plasticity. Trends Neurosci. 2016;39:26-39 pubmed publisher
..In this review we summarize the latest understanding of compartment-specific expression and function of preNMDARs, and how they contribute to synapse-specific and circuit-level information processing. ..
Sidorov M, Judson M, Kim H, Rougie M, Ferrer A, Nikolova V, et al
. Enhanced Operant Extinction and Prefrontal Excitability in a Mouse Model of Angelman Syndrome. J Neurosci. 2018;38:2671-2682 pubmed publisher
..We hypothesize that robust and reliable prefrontally encoded behavior may be used to model cognitive impairments in Angelman syndrome. ..
Larsen R, Smith I, Miriyala J, Han J, CORLEW R, Smith S, et al
. Synapse-specific control of experience-dependent plasticity by presynaptic NMDA receptors. Neuron. 2014;83:879-93 pubmed publisher
..Further, by coupling the pathway-specific optogenetic induction of tLTD with cell-type-specific NMDAR deletion, we find that visual experience modifies preNMDAR-mediated plasticity specifically at L4-L2/3 synapses. ..
Judson M, Wallace M, Sidorov M, Burette A, Gu B, van Woerden G, et al
. GABAergic Neuron-Specific Loss of Ube3a Causes Angelman Syndrome-Like EEG Abnormalities and Enhances Seizure Susceptibility. Neuron. 2016;90:56-69 pubmed publisher
..These results substantiate GABAergic Ube3a loss as the principal cause of circuit hyperexcitability in AS mice, lending insight into ictogenic mechanisms in AS. ..
Wallace M, van Woerden G, Elgersma Y, Smith S, Philpot B. Ube3a loss increases excitability and blunts orientation tuning in the visual cortex of Angelman syndrome model mice. J Neurophysiol. 2017;118:634-646 pubmed publisher
..Aberrant cellular properties in AS model mice could be improved by reinstating Ube3a in inhibitory neurons. These findings suggest that inhibitory neurons play a substantial role in the pathogenesis of AS. ..
Judson M, Burette A, Thaxton C, Pribisko A, Shen M, Rumple A, et al
. Decreased Axon Caliber Underlies Loss of Fiber Tract Integrity, Disproportional Reductions in White Matter Volume, and Microcephaly in Angelman Syndrome Model Mice. J Neurosci. 2017;37:7347-7361 pubmed publisher
..This defect is associated with slowed nerve conduction, which could contribute to behavioral deficits in AS, including motor dysfunction. ..
Thaxton C, KLOTH A, Clark E, Moy S, Chitwood R, Philpot B. Common Pathophysiology in Multiple Mouse Models of Pitt-Hopkins Syndrome. J Neurosci. 2018;38:918-936 pubmed publisher
..These data reveal convergent neurobiological characteristics of PTHS mouse models and support the further investigation of NMDA receptor antagonists as a possible PTHS treatment. ..