Shane A Phillips

Summary

Affiliation: University of Illinois at Chicago
Country: USA

Publications

  1. pmc Thrombin increases inflammatory cytokine and angiogenic growth factor secretion in human adipose cells in vitro
    Jennifer L Strande
    Division of Cardiovascular Medicine, Medical College of Wisconsin, Milwaukee, WI, USA
    J Inflamm (Lond) 6:4. 2009
  2. pmc Benefit of low-fat over low-carbohydrate diet on endothelial health in obesity
    Shane A Phillips
    Department of Medicine, Cardiovascular Center, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Hypertension 51:376-82. 2008
  3. pmc Resistance and aerobic exercise protects against acute endothelial impairment induced by a single exposure to hypertension during exertion
    Shane A Phillips
    Department of Physical Therapy, University of Illinois at Chicago, Chicago, Illinois, USA
    J Appl Physiol 110:1013-20. 2011
  4. pmc Measuring FMD in the brachial artery: how important is QRS gating?
    Tinoy J Kizhakekuttu
    Cardiovascular Medicine Division, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    J Appl Physiol 109:959-65. 2010
  5. ncbi request reprint Chronic intermittent hypoxia alters NE reactivity and mechanics of skeletal muscle resistance arteries
    Shane A Phillips
    Department of Physiology, Medical College of Wisconsin, Milwaukee, USA
    J Appl Physiol 100:1117-23. 2006
  6. ncbi request reprint Chronic AT(1) receptor blockade alters mechanisms mediating responses to hypoxia in rat skeletal muscle resistance arteries
    Shane A Phillips
    Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Am J Physiol Heart Circ Physiol 287:H545-52. 2004
  7. ncbi request reprint Restoration of normal vascular relaxation mechanisms in cerebral arteries by chromosomal substitution in consomic SS.13BN rats
    Ines Drenjancevic-Peric
    Dept of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Am J Physiol Heart Circ Physiol 289:H188-95. 2005
  8. pmc Increased ANG II sensitivity following recovery from acute kidney injury: role of oxidant stress in skeletal muscle resistance arteries
    Shane A Phillips
    Department of Physical Therapy, University of Illinois Chicago, Chicago, Illinois, USA
    Am J Physiol Regul Integr Comp Physiol 298:R1682-91. 2010
  9. ncbi request reprint Chronic At1 receptor blockade alters the mechanisms mediating hypoxic dilation in middle cerebral arteries
    Shane A Phillips
    Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    J Cardiovasc Pharmacol 46:706-12. 2005
  10. pmc Improvements in vascular health by a low-fat diet, but not a high-fat diet, are mediated by changes in adipocyte biology
    Krista A Varady
    Department of Kinesiology and Nutrition, University of Illinois, Chicago, Chicago, IL, USA
    Nutr J 10:8. 2011

Collaborators

Detail Information

Publications17

  1. pmc Thrombin increases inflammatory cytokine and angiogenic growth factor secretion in human adipose cells in vitro
    Jennifer L Strande
    Division of Cardiovascular Medicine, Medical College of Wisconsin, Milwaukee, WI, USA
    J Inflamm (Lond) 6:4. 2009
    ..Therefore, the purpose of this study was to examine the expression of thrombin receptors (PAR1 and PAR4) human adipose tissue and whether thrombin stimulates an inflammatory cytokine and growth factor profile in human adipose tissue...
  2. pmc Benefit of low-fat over low-carbohydrate diet on endothelial health in obesity
    Shane A Phillips
    Department of Medicine, Cardiovascular Center, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Hypertension 51:376-82. 2008
    ..Despite similar degrees of weight loss and changes blood pressure, LF diets improved brachial artery flow-mediated dilation over LC diets. LF diets may confer greater cardiovascular protection than LC diets...
  3. pmc Resistance and aerobic exercise protects against acute endothelial impairment induced by a single exposure to hypertension during exertion
    Shane A Phillips
    Department of Physical Therapy, University of Illinois at Chicago, Chicago, Illinois, USA
    J Appl Physiol 110:1013-20. 2011
    ..Resistance and aerobic exercise may confer similar protection against acute vascular insults such as exertional hypertension...
  4. pmc Measuring FMD in the brachial artery: how important is QRS gating?
    Tinoy J Kizhakekuttu
    Cardiovascular Medicine Division, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    J Appl Physiol 109:959-65. 2010
    ..This finding may allow for simplification of FMD measurement and aid in the development of FMD as a potentially useful clinical tool...
  5. ncbi request reprint Chronic intermittent hypoxia alters NE reactivity and mechanics of skeletal muscle resistance arteries
    Shane A Phillips
    Department of Physiology, Medical College of Wisconsin, Milwaukee, USA
    J Appl Physiol 100:1117-23. 2006
    ..CIH also leads to an increased stiffness and reduced vessel wall distensibility that were not correctable with oral tempol treatment...
  6. ncbi request reprint Chronic AT(1) receptor blockade alters mechanisms mediating responses to hypoxia in rat skeletal muscle resistance arteries
    Shane A Phillips
    Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Am J Physiol Heart Circ Physiol 287:H545-52. 2004
    ..These data suggest that AT(1) receptor activation has an important role in maintaining the vascular release of prostaglandins responsible for mediating hypoxic dilation in skeletal muscle microvessels...
  7. ncbi request reprint Restoration of normal vascular relaxation mechanisms in cerebral arteries by chromosomal substitution in consomic SS.13BN rats
    Ines Drenjancevic-Peric
    Dept of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Am J Physiol Heart Circ Physiol 289:H188-95. 2005
    ..13(BN) rats...
  8. pmc Increased ANG II sensitivity following recovery from acute kidney injury: role of oxidant stress in skeletal muscle resistance arteries
    Shane A Phillips
    Department of Physical Therapy, University of Illinois Chicago, Chicago, Illinois, USA
    Am J Physiol Regul Integr Comp Physiol 298:R1682-91. 2010
    ..Taken together, this study demonstrates that AKI alters peripheral vascular responses by increasing oxidant stress, likely in the endothelium, via an undefined mechanism...
  9. ncbi request reprint Chronic At1 receptor blockade alters the mechanisms mediating hypoxic dilation in middle cerebral arteries
    Shane A Phillips
    Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    J Cardiovasc Pharmacol 46:706-12. 2005
    ....
  10. pmc Improvements in vascular health by a low-fat diet, but not a high-fat diet, are mediated by changes in adipocyte biology
    Krista A Varady
    Department of Kinesiology and Nutrition, University of Illinois, Chicago, Chicago, IL, USA
    Nutr J 10:8. 2011
    ..Moreover, the role that adipose tissue plays in mediating these diet-related effects are unknown...
  11. ncbi request reprint Oxidant stress and constrictor reactivity impair cerebral artery dilation in obese Zucker rats
    Shane A Phillips
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Am J Physiol Regul Integr Comp Physiol 288:R522-30. 2005
    ..However, oxidative stress-independent increases in myogenic tone and constrictor reactivity may contribute to blunted dilator responses of cerebral microvessels...
  12. ncbi request reprint Chronic intermittent hypoxia impairs endothelium-dependent dilation in rat cerebral and skeletal muscle resistance arteries
    Shane A Phillips
    Dept of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Am J Physiol Heart Circ Physiol 286:H388-93. 2004
    ..These findings suggest that exposure to CIH reduces the bioavailability of nitric oxide in the cerebral and skeletal muscle circulations and severely blunts vasodilator responsiveness to acute hypoxia...
  13. pmc Binge drinking impairs vascular function in young adults
    Melissa Goslawski
    Department of Physical Therapy, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    J Am Coll Cardiol 62:201-7. 2013
    ..The aim of this study was to assess whether young binge drinkers (BD) have impaired macrovascular and microvascular function and cardiovascular disease risk factors compared with age-matched alcohol abstainers (A)...
  14. ncbi request reprint The mechanism of flow-induced dilation in human adipose arterioles involves hydrogen peroxide during CAD
    Shane A Phillips
    Cardiovascular Center, Dept of Medicine, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Am J Physiol Heart Circ Physiol 292:H93-100. 2007
    ..This study provides evidence that adverse microvascular changes during CAD are evident in human visceral adipose, a tissue associated with CAD...
  15. pmc Apolipoprotein E enhances endothelial-NO production by modulating caveolin 1 interaction with endothelial NO synthase
    Lili Yue
    Department of Medicine, University of Illinois at Chicago, Chicago, IL, USA
    Hypertension 60:1040-6. 2012
    ..We conclude that macrophage-derived apoE enhances endothelial NO production by disrupting the inhibitory interaction of eNOS with cav-1. These results establish a novel mechanism by which apoE modulates endothelial cell function...
  16. doi request reprint Adipokine responses to acute resistance exercise in trained and untrained men
    Krista A Varady
    Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL 60612, USA
    Med Sci Sports Exerc 42:456-62. 2010
    ..This study tested the hypothesis that a single weight training session would beneficially modulate adipokine profile in a way that would exert protection against endothelial dysfunction, in trained but not sedentary subjects...
  17. ncbi request reprint High-salt diet impairs vascular relaxation mechanisms in rat middle cerebral arteries
    Julian H Lombard
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Physiol Heart Circ Physiol 284:H1124-33. 2003
    ..These observations suggest that angiotensin II suppression with a HS diet leads to impaired relaxation of cerebral arteries in response to vasodilator stimuli acting at the cell membrane...

Research Grants3

  1. Mechanisms of exertional hypertension and vascular dysfunction
    Shane Phillips; Fiscal Year: 2007
    ..Dr. David Gutterman, an established translational researcher, will provide mentorship during the initial stages of the candidates' independent research career. (End of Abstract) ..
  2. Effects of Low Carbohydrate and Low Fat Diets on Endothelium Function in Human Ob
    Shane A Phillips; Fiscal Year: 2010
    ....