Patrick Phillips

Summary

Affiliation: University of Oregon
Country: USA

Publications

  1. pmc Spontaneous mutational correlations for life-history, morphological and behavioral characters in Caenorhabditis elegans
    Suzanne Estes
    Center for Ecology and Evolutionary Biology, University of Oregon, Eugene, 97403, USA
    Genetics 170:645-53. 2005
  2. pmc Selection against males in Caenorhabditis elegans under two mutational treatments
    Diogo Manoel
    Centro de Biologia do Desenvolvimento, Instituto Gulbenkian de Ciencia, Apartado 14, 2781 901 Oeiras, Portugal
    Proc Biol Sci 274:417-24. 2007
  3. doi request reprint Mutation load and rapid adaptation favour outcrossing over self-fertilization
    Levi T Morran
    Center for Ecology and Evolutionary Biology, 5289 University of Oregon, Eugene, Oregon 97403 5289, USA
    Nature 462:350-2. 2009
  4. pmc Daily temperature fluctuations unpredictably influence developmental rate and morphology at a critical early larval stage in a frog
    Juliana M Arrighi
    Department of Biology, Reed College, 3203 SE Woodstock Blvd, Portland, OR 97202, USA
    BMC Ecol 13:18. 2013
  5. doi request reprint Self-fertilization sweeps up variation in the worm genome
    Patrick C Phillips
    Institute of Ecology and Evolution, University of Oregon, Eugene, USA
    Nat Genet 44:237-8. 2012
  6. pmc Evolutionary rates and centrality in the yeast gene regulatory network
    Richard Jovelin
    Center for Ecology and Evolutionary Biology, 5289 University of Oregon, Eugene, OR 97403, USA
    Genome Biol 10:R35. 2009
  7. pmc Does thermoregulatory behavior maximize reproductive fitness of natural isolates of Caenorhabditis elegans?
    Jennifer L Anderson
    Center for Ecology and Evolutionary Biology, University of Oregon, Eugene, OR 97402, USA
    BMC Evol Biol 11:157. 2011
  8. ncbi request reprint One perfect worm
    Patrick C Phillips
    Center for Ecology and Evolutionary Biology, University of Oregon, Eugene, OR 97403 5289, USA
    Trends Genet 22:405-7. 2006
  9. pmc Experimental evolution reveals antagonistic pleiotropy in reproductive timing but not life span in Caenorhabditis elegans
    Jennifer L Anderson
    Institute for Ecology and Evolution, University of Oregon, Eugene, OR 97403, USA
    J Gerontol A Biol Sci Med Sci 66:1300-8. 2011
  10. pmc Epistasis--the essential role of gene interactions in the structure and evolution of genetic systems
    Patrick C Phillips
    Center for Ecology and Evolution, University of Oregon, Eugene, Oregon 97403 USA
    Nat Rev Genet 9:855-67. 2008

Research Grants

  1. QUANITITATIVE TRAIT LOCI FOR CHEMOSENSATION
    Patrick Phillips; Fiscal Year: 2002

Collaborators

Detail Information

Publications34

  1. pmc Spontaneous mutational correlations for life-history, morphological and behavioral characters in Caenorhabditis elegans
    Suzanne Estes
    Center for Ecology and Evolutionary Biology, University of Oregon, Eugene, 97403, USA
    Genetics 170:645-53. 2005
    ..Observed mutational correlations are shown to be higher than those produced by the chance accumulation of nonpleiotropic mutations in the same lines...
  2. pmc Selection against males in Caenorhabditis elegans under two mutational treatments
    Diogo Manoel
    Centro de Biologia do Desenvolvimento, Instituto Gulbenkian de Ciencia, Apartado 14, 2781 901 Oeiras, Portugal
    Proc Biol Sci 274:417-24. 2007
    ..We briefly interpret our results in light of current evolutionary theory of outcrossing rates...
  3. doi request reprint Mutation load and rapid adaptation favour outcrossing over self-fertilization
    Levi T Morran
    Center for Ecology and Evolutionary Biology, 5289 University of Oregon, Eugene, Oregon 97403 5289, USA
    Nature 462:350-2. 2009
    ....
  4. pmc Daily temperature fluctuations unpredictably influence developmental rate and morphology at a critical early larval stage in a frog
    Juliana M Arrighi
    Department of Biology, Reed College, 3203 SE Woodstock Blvd, Portland, OR 97202, USA
    BMC Ecol 13:18. 2013
    ....
  5. doi request reprint Self-fertilization sweeps up variation in the worm genome
    Patrick C Phillips
    Institute of Ecology and Evolution, University of Oregon, Eugene, USA
    Nat Genet 44:237-8. 2012
    ..Their analyses suggest that recent chromosome-scale selective sweeps have reduced C. elegans genetic diversity worldwide and strongly structured genetic variation across its genome...
  6. pmc Evolutionary rates and centrality in the yeast gene regulatory network
    Richard Jovelin
    Center for Ecology and Evolutionary Biology, 5289 University of Oregon, Eugene, OR 97403, USA
    Genome Biol 10:R35. 2009
    ..Here we examine the evolution of the yeast transcription factors in the context of the structure of the gene regulatory network...
  7. pmc Does thermoregulatory behavior maximize reproductive fitness of natural isolates of Caenorhabditis elegans?
    Jennifer L Anderson
    Center for Ecology and Evolutionary Biology, University of Oregon, Eugene, OR 97402, USA
    BMC Evol Biol 11:157. 2011
    ..Here we test the co-adaptation hypothesis by studying an organism (Caenorhabditis elegans) in which both fitness and thermal preference can be reliably measured...
  8. ncbi request reprint One perfect worm
    Patrick C Phillips
    Center for Ecology and Evolutionary Biology, University of Oregon, Eugene, OR 97403 5289, USA
    Trends Genet 22:405-7. 2006
    ..This suggests either wide-ranging migration and intense natural selection or recent dispersal, perhaps by human association. Either way, the effective population size of this ubiquitous model organism is unexpectedly small...
  9. pmc Experimental evolution reveals antagonistic pleiotropy in reproductive timing but not life span in Caenorhabditis elegans
    Jennifer L Anderson
    Institute for Ecology and Evolution, University of Oregon, Eugene, OR 97403, USA
    J Gerontol A Biol Sci Med Sci 66:1300-8. 2011
    ....
  10. pmc Epistasis--the essential role of gene interactions in the structure and evolution of genetic systems
    Patrick C Phillips
    Center for Ecology and Evolution, University of Oregon, Eugene, Oregon 97403 USA
    Nat Rev Genet 9:855-67. 2008
    ....
  11. ncbi request reprint Testing hypotheses regarding the genetics of adaptation
    Patrick C Phillips
    Center for Ecology and Evolutionary Biology, University of Oregon, Eugene, OR 97403 5289, USA
    Genetica 123:15-24. 2005
    ..Continuing advances in molecular technology may lead the way here, but some form of genetic testing is likely to be forever required...
  12. ncbi request reprint Functional constraint and divergence in the G protein family in Caenorhabditis elegans and Caenorhabditis briggsae
    Richard Jovelin
    Center for Ecology and Evolutionary Biology, University of Oregon, Eugene, OR, 97403 5289, USA
    Mol Genet Genomics 273:299-310. 2005
    ..The presence of this motif in the same intron in the gpa-1 genes of C. elegans, C. briggsae and Caenorhabditis remanei suggests that it plays a role in the regulation of gpa-1, as well as other loci...
  13. ncbi request reprint Evolution of sarcomeric myosin heavy chain genes: evidence from fish
    Katrina McGuigan
    Institute of Neurosciences, University of Oregon, USA
    Mol Biol Evol 21:1042-56. 2004
    ..One outcome of this high level of concerted evolution is that different fish taxa have different suites of MYH genes, i.e., true orthologs do not exist...
  14. ncbi request reprint Power and potential bias in field studies of natural selection
    Erika I Hersch
    Center for Ecology and Evolutionary Biology, University of Oregon, Eugene, Oregon 97405 5289, USA
    Evolution 58:479-85. 2004
    ....
  15. ncbi request reprint Studies of threespine stickleback developmental evolution: progress and promise
    William A Cresko
    Center for Ecology and Evolutionary Biology, University of Oregon, Eugene, OR 97403 5289, USA
    Genetica 129:105-26. 2007
    ....
  16. pmc Mutation accumulation in populations of varying size: the distribution of mutational effects for fitness correlates in Caenorhabditis elegans
    Suzanne Estes
    Center for Ecology and Evolutionary Biology, University of Oregon, Eugene, Oregon 97403, USA
    Genetics 166:1269-79. 2004
    ....
  17. ncbi request reprint The opportunity for canalization and the evolution of genetic networks
    Stephen R Proulx
    Center for Ecology and Evolutionary Biology, University of Oregon, Eugene, Oregon 97403 5289, USA
    Am Nat 165:147-62. 2005
    ..Because load induced through migration, segregation, developmental noise, and environmental variance is not mutation limited, each can cause strong selection for canalization...
  18. pmc Outcrossing and the maintenance of males within C. elegans populations
    Jennifer L Anderson
    Center for Ecology and Evolutionary Biology, University of Oregon, Eugene, OR 97403, USA
    J Hered 101:S62-74. 2010
    ..Laboratory and field results still await full reconciliation, which may be facilitated by identifying the loci underlying among-strain differences in mating system dynamics...
  19. pmc Behavioral degradation under mutation accumulation in Caenorhabditis elegans
    Beverly C Ajie
    Center for Ecology and Evolutionary Biology, University of Oregon, Eugene, 97503 5289, USA
    Genetics 170:655-60. 2005
    ..These results have important implications for the maintenance of genetic variation for behavior in natural populations as well as for expectations for behavioral change within endangered species and captive populations...
  20. pmc Evolution and development of facial bone morphology in threespine sticklebacks
    Charles B Kimmel
    Institute of Neuroscience and Center for Ecology and Evolutionary Biology, University of Oregon, Eugene, OR 97403, USA
    Proc Natl Acad Sci U S A 102:5791-6. 2005
    ..A quantitative trait locus is present on linkage group 19 that contributes in a major way to this phenotype...
  21. ncbi request reprint Accuracy and power of the likelihood ratio test for comparing evolutionary rates among genes
    Jan Erik Aagaard
    Center for Ecology and Evolutionary Biology, University of Oregon, Eugene, OR, 97403, USA
    J Mol Evol 60:426-33. 2005
    ..05), although relative rate differences of 25% or less may be difficult to detect...
  22. ncbi request reprint Allelic divergence precedes and promotes gene duplication
    Stephen R Proulx
    Center for Ecology and Evolutionary Biology, 5289 University of Oregon, Eugene, Oregon 97403, USA
    Evolution 60:881-92. 2006
    ..Thus, a solution to the paradox of the origin of organismal complexity via the expansion of gene families exists in the form of the deterministic spread of novel duplicates via natural selection...
  23. doi request reprint Sexual partners for the stressed: facultative outcrossing in the self-fertilizing nematode Caenorhabditis elegans
    Levi T Morran
    Center for Ecology and Evolutionary Biology, 335 Pacific Hall, 5289 University of Oregon, Eugene, Oregon 97403, USA
    Evolution 63:1473-82. 2009
    ..Such a shift in reproductive strategy should have a major impact on evolutionary change within these populations and may be a previously unrecognized feature of other highly selfing organisms...
  24. pmc High nucleotide divergence in developmental regulatory genes contrasts with the structural elements of olfactory pathways in caenorhabditis
    Richard Jovelin
    Center for Ecology and Evolutionary Biology, University of Oregon, Eugene, Oregon 97403 5289, USA
    Genetics 181:1387-97. 2009
    ..These results show that, contrary to the emerging paradigm in the evolution of development, important structural changes can accumulate in transcription factors...
  25. ncbi request reprint Natural transformation increases the rate of adaptation in the human pathogen Helicobacter pylori
    David A Baltrus
    Center for Ecology and Evolution, University of Oregon, Eugene, OR 97403, USA
    Evolution 62:39-49. 2008
    ..This finding demonstrates that there are generalized benefits to adaptation in both eukaryotes and prokaryotes even though the underlying processes are mechanistically different...
  26. ncbi request reprint Thermal preference of Caenorhabditis elegans: a null model and empirical tests
    Jennifer L Anderson
    Center for Ecology and Evolutionary Biology, University of Oregon, Eugene, OR 97402, USA
    J Exp Biol 210:3107-16. 2007
    ..These results demonstrate the value of an explicit null model of thermal effects and highlight problems in the standard model of C. elegans thermotaxis, showing the value of using natural isolates for tests of complex natural behaviours...
  27. ncbi request reprint Relaxed selection among duplicate floral regulatory genes in Lamiales
    Jan E Aagaard
    Center for Ecology and Evolutionary Biology, University of Oregon, Eugene, OR 97403, USA
    J Mol Evol 63:493-503. 2006
    ..Several mechanisms are discussed that might be responsible for preservation of co-orthologs of FLO and DEF in Lamiales, including interactions among the genes of this regulatory pathway...
  28. doi request reprint Beyond induced mutants: using worms to study natural variation in genetic pathways
    Jan E Kammenga
    Laboratory of Nematology, Wageningen University, Wageningen, The Netherlands
    Trends Genet 24:178-85. 2008
    ..for studying genetic variation, with a focus on pathways associated with human disease...
  29. ncbi request reprint Persistence of changes in the genetic covariance matrix after a bottleneck
    Michael C Whitlock
    Department of Zoology, University of British Columbia, Vancouver, Canada
    Evolution 56:1968-75. 2002
    ..This change did not return the populations toward their original state before the population bottlenecks. We conclude that the genetic covariance matrix can change as a result of mild genetic drift over a short span of time...
  30. pmc Selection and maintenance of androdioecy in Caenorhabditis elegans
    Andrew D Stewart
    Department of Biology, University of Texas, Arlington, Texas 76019 0498, USA
    Genetics 160:975-82. 2002
    ..Factors such as variation in male mating ability and inbreeding depression could potentially lead to the long-term maintenance of males...
  31. ncbi request reprint Variation in pleiotropy and the mutational underpinnings of the G-matrix
    Suzanne Estes
    Department of Biology, Portland State University, Portland, Oregon 97201, USA
    Evolution 60:2655-60. 2006
    ..e., small-effect mutations reduce the magnitude of covariation between characters), but do not change the direction of this covariation...
  32. ncbi request reprint Genetic variation for outcrossing among Caenorhabditis elegans isolates
    Henrique Teotónio
    Centro de Biologia do Desenvolvimento, Instituto Gulbenkian de Ciencia, Apartado 14 P 2781 901 Oeiras, Portugal
    Evolution 60:1300-5. 2006
    ..However, these measures are uncorrelated with outcrossing characters. The data presented here contribute to an understanding of male maintenance in natural populations through their role in outcrossing...
  33. ncbi request reprint Ecological and developmental context of natural selection: maternal effects and thermally induced plasticity in the frog Bombina orientalis
    Robert H Kaplan
    Department of Biology, Reed College, Portland, Oregon 97202, USA
    Evolution 60:142-56. 2006
    ....
  34. doi request reprint Evolutionary genetics: who shouldn't be your daddy
    Patrick C Phillips
    Nature 451:640-1. 2008

Research Grants3

  1. QUANITITATIVE TRAIT LOCI FOR CHEMOSENSATION
    Patrick Phillips; Fiscal Year: 2002
    ..e., difference in mean chemotactic behavior between the two F1 hybrid classes) will be tested to determine whether naturally occurring alleles interact with the candidate locus mutations. ..