Research Topics
Genomes and Genes | Patrick PhillipsSummaryAffiliation: University of Oregon Country: USA Publications
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Detail Information
Publications
Spontaneous mutational correlations for life-history, morphological and behavioral characters in Caenorhabditis elegansSuzanne Estes
Center for Ecology and Evolutionary Biology, University of Oregon, Eugene, 97403, USA
Genetics 170:645-53. 2005..Observed mutational correlations are shown to be higher than those produced by the chance accumulation of nonpleiotropic mutations in the same lines...- Selection against males in Caenorhabditis elegans under two mutational treatmentsDiogo Manoel
Centro de Biologia do Desenvolvimento, Instituto Gulbenkian de Ciencia, Apartado 14, 2781 901 Oeiras, Portugal
Proc Biol Sci 274:417-24. 2007..We briefly interpret our results in light of current evolutionary theory of outcrossing rates... 
Mutation load and rapid adaptation favour outcrossing over self-fertilizationLevi T Morran
Center for Ecology and Evolutionary Biology, 5289 University of Oregon, Eugene, Oregon 97403 5289, USA
Nature 462:350-2. 2009....- Self-fertilization sweeps up variation in the worm genomePatrick C Phillips
Institute of Ecology and Evolution, University of Oregon, Eugene, USA
Nat Genet 44:237-8. 2012..Their analyses suggest that recent chromosome-scale selective sweeps have reduced C. elegans genetic diversity worldwide and strongly structured genetic variation across its genome... - Evolutionary rates and centrality in the yeast gene regulatory networkRichard Jovelin
Center for Ecology and Evolutionary Biology, 5289 University of Oregon, Eugene, OR 97403, USA
Genome Biol 10:R35. 2009..Here we examine the evolution of the yeast transcription factors in the context of the structure of the gene regulatory network... - Does thermoregulatory behavior maximize reproductive fitness of natural isolates of Caenorhabditis elegans?Jennifer L Anderson
Center for Ecology and Evolutionary Biology, University of Oregon, Eugene, OR 97402, USA
BMC Evol Biol 11:157. 2011..Here we test the co-adaptation hypothesis by studying an organism (Caenorhabditis elegans) in which both fitness and thermal preference can be reliably measured... - Experimental evolution reveals antagonistic pleiotropy in reproductive timing but not life span in Caenorhabditis elegansJennifer L Anderson
Institute for Ecology and Evolution, University of Oregon, Eugene, OR 97403, USA
J Gerontol A Biol Sci Med Sci 66:1300-8. 2011.... - Epistasis--the essential role of gene interactions in the structure and evolution of genetic systemsPatrick C Phillips
Center for Ecology and Evolution, University of Oregon, Eugene, Oregon 97403 USA
Nat Rev Genet 9:855-67. 2008.... 
One perfect wormPatrick C Phillips
Center for Ecology and Evolutionary Biology, University of Oregon, Eugene, OR 97403 5289, USA
Trends Genet 22:405-7. 2006..This suggests either wide-ranging migration and intense natural selection or recent dispersal, perhaps by human association. Either way, the effective population size of this ubiquitous model organism is unexpectedly small...- Testing hypotheses regarding the genetics of adaptationPatrick C Phillips
Center for Ecology and Evolutionary Biology, University of Oregon, Eugene, OR 97403 5289, USA
Genetica 123:15-24. 2005..Continuing advances in molecular technology may lead the way here, but some form of genetic testing is likely to be forever required... - Functional constraint and divergence in the G protein family in Caenorhabditis elegans and Caenorhabditis briggsaeRichard Jovelin
Center for Ecology and Evolutionary Biology, University of Oregon, Eugene, OR, 97403-5289, USA
Mol Genet Genomics 273:299-310. 2005..The presence of this motif in the same intron in the gpa-1 genes of C. elegans, C. briggsae and Caenorhabditis remanei suggests that it plays a role in the regulation of gpa-1, as well as other loci... - Studies of threespine stickleback developmental evolution: progress and promiseWilliam A Cresko
Center for Ecology and Evolutionary Biology, University of Oregon, Eugene, OR 97403 5289, USA
Genetica 129:105-26. 2007.... - Power and potential bias in field studies of natural selectionErika I Hersch
Center for Ecology and Evolutionary Biology, University of Oregon, Eugene, Oregon 97405 5289, USA
Evolution 58:479-85. 2004.... - Evolution of sarcomeric myosin heavy chain genes: evidence from fishKatrina McGuigan
Institute of Neurosciences, University of Oregon, USA
Mol Biol Evol 21:1042-56. 2004..One outcome of this high level of concerted evolution is that different fish taxa have different suites of MYH genes, i.e., true orthologs do not exist... - Mutation accumulation in populations of varying size: the distribution of mutational effects for fitness correlates in Caenorhabditis elegansSuzanne Estes
Center for Ecology and Evolutionary Biology, University of Oregon, Eugene, Oregon 97403, USA
Genetics 166:1269-79. 2004.... - The opportunity for canalization and the evolution of genetic networksStephen R Proulx
Center for Ecology and Evolutionary Biology, University of Oregon, Eugene, Oregon 97403 5289, USA
Am Nat 165:147-62. 2005..Because load induced through migration, segregation, developmental noise, and environmental variance is not mutation limited, each can cause strong selection for canalization... - Outcrossing and the maintenance of males within C. elegans populationsJennifer L Anderson
Center for Ecology and Evolutionary Biology, University of Oregon, Eugene, OR 97403, USA
J Hered 101:S62-74. 2010..Laboratory and field results still await full reconciliation, which may be facilitated by identifying the loci underlying among-strain differences in mating system dynamics... - Evolution and development of facial bone morphology in threespine sticklebacksCharles B Kimmel
Institute of Neuroscience and Center for Ecology and Evolutionary Biology, University of Oregon, Eugene, OR 97403, USA
Proc Natl Acad Sci U S A 102:5791-6. 2005..A quantitative trait locus is present on linkage group 19 that contributes in a major way to this phenotype... - Behavioral degradation under mutation accumulation in Caenorhabditis elegansBeverly C Ajie
Center for Ecology and Evolutionary Biology, University of Oregon, Eugene, 97503-5289, USA
Genetics 170:655-60. 2005..These results have important implications for the maintenance of genetic variation for behavior in natural populations as well as for expectations for behavioral change within endangered species and captive populations... - Accuracy and power of the likelihood ratio test for comparing evolutionary rates among genesJan Erik Aagaard
Center for Ecology and Evolutionary Biology, University of Oregon, Eugene, OR, 97403, USA
J Mol Evol 60:426-33. 2005..05), although relative rate differences of 25% or less may be difficult to detect... - Allelic divergence precedes and promotes gene duplicationStephen R Proulx
Center for Ecology and Evolutionary Biology, 5289 University of Oregon, Eugene, Oregon 97403, USA
Evolution 60:881-92. 2006..Thus, a solution to the paradox of the origin of organismal complexity via the expansion of gene families exists in the form of the deterministic spread of novel duplicates via natural selection... - Sexual partners for the stressed: facultative outcrossing in the self-fertilizing nematode Caenorhabditis elegansLevi T Morran
Center for Ecology and Evolutionary Biology, 335 Pacific Hall, 5289 University of Oregon, Eugene, Oregon 97403, USA
Evolution 63:1473-82. 2009..Such a shift in reproductive strategy should have a major impact on evolutionary change within these populations and may be a previously unrecognized feature of other highly selfing organisms... - High nucleotide divergence in developmental regulatory genes contrasts with the structural elements of olfactory pathways in caenorhabditisRichard Jovelin
Center for Ecology and Evolutionary Biology, University of Oregon, Eugene, Oregon 97403 5289, USA
Genetics 181:1387-97. 2009..These results show that, contrary to the emerging paradigm in the evolution of development, important structural changes can accumulate in transcription factors... - Natural transformation increases the rate of adaptation in the human pathogen Helicobacter pyloriDavid A Baltrus
Center for Ecology and Evolution, University of Oregon, Eugene, OR 97403, USA
Evolution 62:39-49. 2008..This finding demonstrates that there are generalized benefits to adaptation in both eukaryotes and prokaryotes even though the underlying processes are mechanistically different... - Thermal preference of Caenorhabditis elegans: a null model and empirical testsJennifer L Anderson
Center for Ecology and Evolutionary Biology, University of Oregon, Eugene, OR 97402, USA
J Exp Biol 210:3107-16. 2007..These results demonstrate the value of an explicit null model of thermal effects and highlight problems in the standard model of C. elegans thermotaxis, showing the value of using natural isolates for tests of complex natural behaviours... - Relaxed selection among duplicate floral regulatory genes in LamialesJan E Aagaard
Center for Ecology and Evolutionary Biology, University of Oregon, Eugene, OR 97403, USA
J Mol Evol 63:493-503. 2006..Several mechanisms are discussed that might be responsible for preservation of co-orthologs of FLO and DEF in Lamiales, including interactions among the genes of this regulatory pathway... - Selection and maintenance of androdioecy in Caenorhabditis elegansAndrew D Stewart
Department of Biology, University of Texas, Arlington, Texas 76019 0498, USA
Genetics 160:975-82. 2002..Factors such as variation in male mating ability and inbreeding depression could potentially lead to the long-term maintenance of males... - Persistence of changes in the genetic covariance matrix after a bottleneckMichael C Whitlock
Department of Zoology, University of British Columbia, Vancouver, Canada
Evolution 56:1968-75. 2002..This change did not return the populations toward their original state before the population bottlenecks. We conclude that the genetic covariance matrix can change as a result of mild genetic drift over a short span of time... - Beyond induced mutants: using worms to study natural variation in genetic pathwaysJan E Kammenga
Laboratory of Nematology, Wageningen University, Wageningen, The Netherlands
Trends Genet 24:178-85. 2008..for studying genetic variation, with a focus on pathways associated with human disease... - Variation in pleiotropy and the mutational underpinnings of the G-matrixSuzanne Estes
Department of Biology, Portland State University, Portland, Oregon 97201, USA
Evolution 60:2655-60. 2006..e., small-effect mutations reduce the magnitude of covariation between characters), but do not change the direction of this covariation... - Genetic variation for outcrossing among Caenorhabditis elegans isolatesHenrique Teotónio
Centro de Biologia do Desenvolvimento, Instituto Gulbenkian de Ciencia, Apartado 14 P 2781 901 Oeiras, Portugal
Evolution 60:1300-5. 2006..However, these measures are uncorrelated with outcrossing characters. The data presented here contribute to an understanding of male maintenance in natural populations through their role in outcrossing... - Ecological and developmental context of natural selection: maternal effects and thermally induced plasticity in the frog Bombina orientalisRobert H Kaplan
Department of Biology, Reed College, Portland, Oregon 97202, USA
Evolution 60:142-56. 2006.... - Evolutionary genetics: who shouldn't be your daddyPatrick C Phillips
Nature 451:640-1. 2008
Research Grants
- QUANITITATIVE TRAIT LOCI FOR CHEMOSENSATIONPatrick Phillips; Fiscal Year: 2002..e., difference in mean chemotactic behavior between the two F1 hybrid classes) will be tested to determine whether naturally occurring alleles interact with the candidate locus mutations. ..