MARY LOUISE PHILLIPS

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi Limbic and prefrontal responses to facial emotion expressions in depersonalization
    Erwin Lemche
    Section of Neuroscience and Emotion, Brain Image Analysis Unit, Neuroimaging Research Group, Centre for Neuroimaging Sciences, Institute of Psychiatry, London, UK
    Neuroreport 18:473-7. 2007
  2. ncbi Identifying functional neuroimaging biomarkers of bipolar disorder: toward DSM-V
    Mary L Phillips
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh, PA, USA
    Schizophr Bull 33:893-904. 2007
  3. ncbi Bipolar disorder diagnosis: challenges and future directions
    Mary L Phillips
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Lancet 381:1663-71. 2013
  4. ncbi Medication effects in neuroimaging studies of bipolar disorder
    Mary L Phillips
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Am J Psychiatry 165:313-20. 2008
  5. ncbi A neural model of voluntary and automatic emotion regulation: implications for understanding the pathophysiology and neurodevelopment of bipolar disorder
    M L Phillips
    Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Mol Psychiatry 13:829, 833-57. 2008
  6. ncbi Elevated striatal and decreased dorsolateral prefrontal cortical activity in response to emotional stimuli in euthymic bipolar disorder: no associations with psychotropic medication load
    Stefanie Hassel
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Bipolar Disord 10:916-27. 2008
  7. ncbi Functional neuroimaging studies of bipolar disorder: examining the wide clinical spectrum in the search for disease endophenotypes
    Lisa Pan
    University of Pittsburgh Medical Center, Pittsburgh, Philadelphia, USA
    Int Rev Psychiatry 21:368-79. 2009
  8. ncbi Abnormal left and right amygdala-orbitofrontal cortical functional connectivity to emotional faces: state versus trait vulnerability markers of depression in bipolar disorder
    Amelia Versace
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Biol Psychiatry 67:422-31. 2010
  9. ncbi Abnormally increased effective connectivity between parahippocampal gyrus and ventromedial prefrontal regions during emotion labeling in bipolar disorder
    Jorge R C Almeida
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Psychiatry Res 174:195-201. 2009
  10. ncbi Abnormal amygdala-prefrontal effective connectivity to happy faces differentiates bipolar from major depression
    Jorge Renner Cardoso de Almeida
    Department of Psychiatry, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania, USA
    Biol Psychiatry 66:451-9. 2009

Research Grants

  1. Toward the identification of biomarkers of bipolar disorder
    MARY LOUISE PHILLIPS; Fiscal Year: 2010
  2. Toward the identification of biomarkers of bipolar disorder
    Mary Phillips; Fiscal Year: 2009

Detail Information

Publications71

  1. ncbi Limbic and prefrontal responses to facial emotion expressions in depersonalization
    Erwin Lemche
    Section of Neuroscience and Emotion, Brain Image Analysis Unit, Neuroimaging Research Group, Centre for Neuroimaging Sciences, Institute of Psychiatry, London, UK
    Neuroreport 18:473-7. 2007
    ....
  2. ncbi Identifying functional neuroimaging biomarkers of bipolar disorder: toward DSM-V
    Mary L Phillips
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh, PA, USA
    Schizophr Bull 33:893-904. 2007
    ..Current and future research in bipolar disorder should focus on identification of disorder biomarkers to improve diagnostic accuracy and the mental heath of those with the disorder...
  3. ncbi Bipolar disorder diagnosis: challenges and future directions
    Mary L Phillips
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Lancet 381:1663-71. 2013
    ....
  4. ncbi Medication effects in neuroimaging studies of bipolar disorder
    Mary L Phillips
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Am J Psychiatry 165:313-20. 2008
    ..Withdrawing all individuals from medication and examining only unmedicated individuals may be clinically unfeasible, and examining only unmedicated individuals may render findings less generalizable...
  5. ncbi A neural model of voluntary and automatic emotion regulation: implications for understanding the pathophysiology and neurodevelopment of bipolar disorder
    M L Phillips
    Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Mol Psychiatry 13:829, 833-57. 2008
    ....
  6. ncbi Elevated striatal and decreased dorsolateral prefrontal cortical activity in response to emotional stimuli in euthymic bipolar disorder: no associations with psychotropic medication load
    Stefanie Hassel
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Bipolar Disord 10:916-27. 2008
    ..We examined potential confounding effects of total psychotropic medication load and illness variables upon neural abnormalities...
  7. ncbi Functional neuroimaging studies of bipolar disorder: examining the wide clinical spectrum in the search for disease endophenotypes
    Lisa Pan
    University of Pittsburgh Medical Center, Pittsburgh, Philadelphia, USA
    Int Rev Psychiatry 21:368-79. 2009
    ..These approaches will help to improve diagnosis and the mental well-being of all individuals with BP...
  8. ncbi Abnormal left and right amygdala-orbitofrontal cortical functional connectivity to emotional faces: state versus trait vulnerability markers of depression in bipolar disorder
    Amelia Versace
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Biol Psychiatry 67:422-31. 2010
    ..Amygdala-orbitofrontal cortical (OFC) functional connectivity (FC) to emotional stimuli and relationships with white matter remain little examined in bipolar disorder individuals (BD)...
  9. ncbi Abnormally increased effective connectivity between parahippocampal gyrus and ventromedial prefrontal regions during emotion labeling in bipolar disorder
    Jorge R C Almeida
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Psychiatry Res 174:195-201. 2009
    ....
  10. ncbi Abnormal amygdala-prefrontal effective connectivity to happy faces differentiates bipolar from major depression
    Jorge Renner Cardoso de Almeida
    Department of Psychiatry, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania, USA
    Biol Psychiatry 66:451-9. 2009
    ..Emotion dysregulation is a core feature of bipolar disorder. Measures of dysfunction in neural systems supporting emotion regulation might therefore help discriminate bipolar from major depressive disorder...
  11. ncbi Elevated left and reduced right orbitomedial prefrontal fractional anisotropy in adults with bipolar disorder revealed by tract-based spatial statistics
    Amelia Versace
    Department of Psychiatry, University of Pittsburgh School of Medicine, 121 Meyran Ave, Pittsburgh, PA 15213, USA
    Arch Gen Psychiatry 65:1041-52. 2008
    ....
  12. ncbi Subcortical gray matter volume abnormalities in healthy bipolar offspring: potential neuroanatomical risk marker for bipolar disorder?
    Cecile D Ladouceur
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Am Acad Child Adolesc Psychiatry 47:532-9. 2008
    ..The goal of this study was to examine whole-brain regional GM volume in healthy bipolar offspring (HBO) relative to age-matched controls to identify possible structural abnormalities that may be associated with risk for BD...
  13. ncbi Brain structure and symptom dimension relationships in obsessive-compulsive disorder: a voxel-based morphometry study
    Andrew R Gilbert
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States
    J Affect Disord 109:117-26. 2008
    ..Past inconsistent results from structural neuroimaging studies of OCD may have resulted from the effects of these specific symptom dimensions as well as other socio-demographic and clinical variables upon gray matter (GM) volume...
  14. ncbi Interacting outcome retrieval, anticipation, and feedback processes in the human brain
    Nicholas D Walsh
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
    Cereb Cortex 20:271-81. 2010
    ..These results further advance our knowledge of how fundamental cognitive processes interact physiologically to give rise to higher-level behavioral control...
  15. ncbi Neuroimaging in bipolar disorder: a critical review of current findings
    Matthew T Keener
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Curr Psychiatry Rep 9:512-20. 2007
    ....
  16. ncbi Prefrontal cortical and striatal activity to happy and fear faces in bipolar disorder is associated with comorbid substance abuse and eating disorder
    Stefanie Hassel
    University of Pittsburgh, School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA, USA
    J Affect Disord 118:19-27. 2009
    ....
  17. ncbi Neural correlates of symptom dimensions in pediatric obsessive-compulsive disorder: a functional magnetic resonance imaging study
    Andrew R Gilbert
    University of Pittsburgh School of Medicine, USA
    J Am Acad Child Adolesc Psychiatry 48:936-44. 2009
    ..Similar symptom dimensions are apparent in childhood and adolescence, but their functional neural correlates remain to be elucidated...
  18. ncbi Abnormally reduced dorsomedial prefrontal cortical activity and effective connectivity with amygdala in response to negative emotional faces in postpartum depression
    Eydie L Moses-Kolko
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Am J Psychiatry 167:1373-80. 2010
    ..The authors examined activity in response to negative emotional faces in the dorsomedial pre-frontal cortex and amygdala, key emotion regulatory neural regions of importance to both mothering and depression...
  19. ncbi Healthy adolescents' neural response to reward: associations with puberty, positive affect, and depressive symptoms
    Erika E Forbes
    University of Pittsburgh, USA
    J Am Acad Child Adolesc Psychiatry 49:162-72.e1-5. 2010
    ..The current study focused on puberty-specific changes in brain function and their association with mood...
  20. ncbi Impaired sustained attention and executive dysfunction: bipolar disorder versus depression-specific markers of affective disorders
    Fadi T Maalouf
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, USA
    Neuropsychologia 48:1862-8. 2010
    ..To identify neurocognitive measures that could be used as objective markers of bipolar disorder...
  21. ncbi Fearful faces influence attentional control processes in anxious youth and adults
    Cecile D Ladouceur
    Department of Psychiatry, University of Pittsburgh Schoolof Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Emotion 9:855-64. 2009
    ..These findings suggest that anxious individuals, particularly younger ones, exhibit difficulty resisting interference from threat-related stimuli when greater attentional resources are being recruited...
  22. ncbi Elevated amygdala activity to sad facial expressions: a state marker of bipolar but not unipolar depression
    Jorge R C Almeida
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Biol Psychiatry 67:414-21. 2010
    ....
  23. ncbi Reduced gray matter volume in ventral prefrontal cortex but not amygdala in bipolar disorder: significant effects of gender and trait anxiety
    Jorge R C Almeida
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Psychiatry Res 171:54-68. 2009
    ..PMRG is part of medial prefrontal network implicated in visceromotor and emotion regulation...
  24. ncbi Distinguishing between unipolar depression and bipolar depression: current and future clinical and neuroimaging perspectives
    Jorge Renner Cardoso de Almeida
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Biol Psychiatry 73:111-8. 2013
    ..Ultimately, these approaches might provide biomarkers to identify individuals at future risk for BD versus UD and biological targets for more personalized treatment and new treatment developments for BD and UD depression...
  25. ncbi Abnormal Left-Sided Orbitomedial Prefrontal Cortical-Amygdala Connectivity during Happy and Fear Face Processing: A Potential Neural Mechanism of Female MDD
    Jorge Renner Cardoso de Almeida
    Department of Psychiatry, University of Pittsburgh School of Medicine Pittsburgh, PA, USA
    Front Psychiatry 2:69. 2011
    ..003). Conclusion: Different patterns of abnormal prefrontal cortical-amygdala connectivity to happy and fearful stimuli might represent neural mechanisms for the excessive self-reproach and comorbid anxiety that characterize female MDD...
  26. ncbi Reward-related brain function and sleep in pre/early pubertal and mid/late pubertal adolescents
    Stephanie M Holm
    University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Adolesc Health 45:326-34. 2009
    ..As part of a larger study examining puberty-specific changes in adolescents' reward-related brain function, the current article focuses on the relationship between functional neuroimaging measures of reward and measures of sleep...
  27. ncbi Changes in male brain responses to emotional faces from adolescence to middle age
    Quinton Deeley
    Section of Brain Maturation, King s College London Institute of Psychiatry, De Crespigny Park, London, UK
    Neuroimage 40:389-97. 2008
    ....
  28. ncbi An event related functional magnetic resonance imaging study of facial emotion processing in Asperger syndrome
    Quinton Deeley
    Section of Brain Maturation, De Crespigny Park, London, UK
    Biol Psychiatry 62:207-17. 2007
    ..However nobody has examined brain function in people with AS when implicitly (unconsciously) processing four primary emotions at varying emotional intensities...
  29. ncbi Sex differences in neural responses to disgusting visual stimuli: implications for disgust-related psychiatric disorders
    Xavier Caseras
    Department of Psychological Medicine, King s College London, Institute of Psychiatry, United Kingdom
    Biol Psychiatry 62:464-71. 2007
    ..The aim of this functional magnetic resonance imaging (fMRI) study was to examine possible sex differences in neural responses to disgust-inducing stimuli that might help explain this female predominance...
  30. ncbi Neural responses to facial expressions of disgust but not fear are modulated by washing symptoms in OCD
    Natalia S Lawrence
    Division of Psychological Medicine, Section of Neuroscience and Emotion, King s College London, London, United Kingdom
    Biol Psychiatry 61:1072-80. 2007
    ..This study explored neural systems underlying sensitivity to symptom-unrelated disgust and fear in OCD using functional neuroimaging...
  31. ncbi Emotional memory in depersonalization disorder: a functional MRI study
    Nicholas Medford
    Division of Psychological Medicine, P O Box 68, Institute of Psychiatry, DeCrespigny Park, London SE5 8AF, UK
    Psychiatry Res 148:93-102. 2006
    ..This study provides further evidence that patients with DPD do not process emotionally salient material in the same way as healthy controls, in accordance with their subjective descriptions of reduced or absent emotional responses...
  32. ncbi Differential neural responses to overt and covert presentations of facial expressions of fear and disgust
    Mary L Phillips
    Section of Neuroscience and Emotion, Department of Psychological Medicine, Institute of Psychiatry, KCL, London, UK
    Neuroimage 21:1484-96. 2004
    ..These results therefore suggest distinct neural correlates of conscious and unconscious emotion perception...
  33. ncbi A double dissociation of ventromedial prefrontal cortical responses to sad and happy stimuli in depressed and healthy individuals
    Paul A Keedwell
    Department of Psychological Medicine, Institute of Psychiatry, London, England
    Biol Psychiatry 58:495-503. 2005
    ..We wished to corroborate these results by examining neural responses to personally relevant happy and sad stimuli in MDD and healthy individuals within the same paradigm...
  34. ncbi A differential pattern of neural response toward sad versus happy facial expressions in major depressive disorder
    Simon Surguladze
    Institute of Psychiatry, King s College London, London
    Biol Psychiatry 57:201-9. 2005
    ..In depressed individuals, implicit and explicit attentional biases away from happy and toward sad stimuli have been demonstrated. These may be associated with the negative cognitions in these individuals...
  35. ncbi Dysregulation of arousal and amygdala-prefrontal systems in paranoid schizophrenia
    Leanne M Williams
    The Brain Dynamics Centre, Westmead Hospital and University of Sydney, NSW, Australia
    Am J Psychiatry 161:480-9. 2004
    ..It was predicted that paranoid patients would be distinguished by a disjunction of hyperarousal but reduced amygdala and medial prefrontal activity relative to both healthy comparison subjects and patients with nonparanoid schizophrenia...
  36. ncbi Functional neuroanatomy of body shape perception in healthy and eating-disordered women
    Rudolf Uher
    Institute of Psychiatry, King s College London, London
    Biol Psychiatry 58:990-7. 2005
    ..Abnormalities in perception and evaluation of body shape are a hallmark of eating disorders...
  37. ncbi Subcortical and ventral prefrontal cortical neural responses to facial expressions distinguish patients with bipolar disorder and major depression
    Natalia S Lawrence
    Section of Neuroscience and Emotion, Institute of Psychiatry, London, United Kingdom
    Biol Psychiatry 55:578-87. 2004
    ..CONCLUSIONS: Compared with healthy controls and MDD patients, BD patients demonstrated increased subcortical and ventral prefrontal cortical responses to both positive and negative emotional expressions...
  38. ncbi Neural correlates of anxiety associated with obsessive-compulsive symptom dimensions in normal volunteers
    David Mataix-Cols
    Division of Psychological Medicine, GKT School of Medicine and Institute of Psychiatry, London, United Kingdom
    Biol Psychiatry 53:482-93. 2003
    ..Further investigation of the neural basis of OCD symptom dimensions is required...
  39. ncbi Functional and biochemical alterations of the medial frontal cortex in obsessive-compulsive disorder
    Murat Yucel
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Victoria 3053, Australia
    Arch Gen Psychiatry 64:946-55. 2007
    ..However, the precise regions and the neural alterations associated with this abnormality remain unclear...
  40. ncbi Ketamine alters neural processing of facial emotion recognition in healthy men: an fMRI study
    Kathryn M Abel
    Department of Psychiatry and Behavioural Sciences, Manchester University, 7th Floor, Williamson Building, Oxford Road, Manchester M13 9PL Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
    Neuroreport 14:387-91. 2003
    ..Emotional blunting may be associated with reduced limbic responses to emotional stimuli and a relative increase in the visual cortical response to neutral stimuli...
  41. ncbi Stroop performance in bipolar disorder: further evidence for abnormalities in the ventral prefrontal cortex
    Dina M Kronhaus
    Institute for Adaptive and Neural Computation, School of Informatics, The University of Edinburgh, Edinburgh, UK
    Bipolar Disord 8:28-39. 2006
    ..We aimed to examine the relationship between functional abnormalities, impaired task performance and the severity of depressive symptoms in bipolar patients...
  42. ncbi A reversal of the normal pattern of parahippocampal response to neutral and fearful faces is associated with reality distortion in schizophrenia
    Simon Surguladze
    Division of Psychological Medicine, Kings College London Institute and Brain Image Analysis Unit of Psychiatry, London, UK
    Biol Psychiatry 60:423-31. 2006
    ..The neural mechanisms underlying this deficit and the relationship with different symptoms remain poorly understood...
  43. ncbi Redefining bipolar disorder: toward DSM-V
    Mary L Phillips
    Am J Psychiatry 163:1135-6. 2006
  44. ncbi Task instructions modulate neural responses to fearful facial expressions
    Kezia Lange
    Institute of Psychiatry, London, United Kingdom
    Biol Psychiatry 53:226-32. 2003
    ..CONCLUSIONS: Neural responses to fearful facial expressions are modulated by task instructions...
  45. ncbi Distinct neural correlates of washing, checking, and hoarding symptom dimensions in obsessive-compulsive disorder
    David Mataix-Cols
    Department of Psychological Medicine, Institute of Psychiatry, London, England
    Arch Gen Psychiatry 61:564-76. 2004
    ....
  46. ncbi A preferential increase in the extrastriate response to signals of danger
    Simon A Surguladze
    Section of Neuroscience and Emotion, Division of Psychological Medicine, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
    Neuroimage 19:1317-28. 2003
    ..We suggest that this differential pattern of response to different categories of emotional signals allows the preferential direction of visual attention to signals of imminent danger than to other, less-salient emotional stimuli...
  47. ncbi Patterns of neural response to emotive stimuli distinguish the different symptom dimensions of obsessive-compulsive disorder
    Mary L Phillips
    Division of Psychological Medicine, Guy's King's and St. Thomas' School of Medicine and Institute of Psychiatry, London, UK
    CNS Spectr 9:275-83. 2004
    ....
  48. ncbi Chronic depersonalization following illicit drug use: a controlled analysis of 40 cases
    Nicholas Medford
    Depersonalization Research Unit and Division of Psychological Medicine, Institute of Psychiatry, London, UK
    Addiction 98:1731-6. 2003
    ....
  49. ncbi Neurobiology of emotion perception II: Implications for major psychiatric disorders
    Mary L Phillips
    Division of Psychological Medicine, Institute of Psychiatry, London, United Kingdom
    Biol Psychiatry 54:515-28. 2003
    ..We suggest that distinct patterns of structural and functional abnormalities in neural systems important for emotion processing are associated with specific symptoms of schizophrenia and bipolar and major depressive disorder...
  50. ncbi Neurobiology of emotion perception I: The neural basis of normal emotion perception
    Mary L Phillips
    Division of Psychological Medicine, Institute of Psychiatry, London, United Kingdom
    Biol Psychiatry 54:504-14. 2003
    ..We suggest that the extent to which a stimulus is identified as emotive and is associated with the production of an affective state may be dependent upon levels of activity within these two neural systems...
  51. ncbi Depersonalisation disorder: clinical features of 204 cases
    Dawn Baker
    Hartside Unit, St Nicholas Hospital, Gosforth, Newcastle NE3 3XT, London
    Br J Psychiatry 182:428-33. 2003
    ..CONCLUSIONS: Depersonalisation disorder is a recognisable clinical entity but appears to have significant comorbidity with anxiety and depression. Research into its aetiology and treatment is warranted...
  52. ncbi Perception of emotions from faces and voices following unilateral brain damage
    Katarzyna Kucharska-Pietura
    Section of Cognitive Neuropsychiatry, Division of Psychological Medicine, Institute of Psychiatry-P068, De Crespigny Park, London SE5 8AF, UK
    Neuropsychologia 41:1082-90. 2003
    ..It is possible that the left hemisphere has a particular role in the perception of emotion conveyed through meaningful speech...
  53. ncbi The effect of negative emotional context on neural and behavioural responses to oesophageal stimulation
    Mary L Phillips
    Division of Psychological Medicine, Guy's, St Thomas' and King's College School of Clinical Medicine and Institute of Psychiatry, London, UK
    Brain 126:669-84. 2003
    ....
  54. ncbi Ketamine and fMRI BOLD signal: distinguishing between effects mediated by change in blood flow versus change in cognitive state
    Kathryn M Abel
    Institute of Psychiatry, London, United Kingdom
    Hum Brain Mapp 18:135-45. 2003
    ....
  55. ncbi Decision making and set shifting impairments are associated with distinct symptom dimensions in obsessive-compulsive disorder
    Natalia S Lawrence
    Section of Neuroscience and Emotion, Division of Psychological Medicine and Psychiatry, Institute of Psychiatry, King s College London, London, England
    Neuropsychology 20:409-19. 2006
    ..These results help explain previous inconsistent findings in neuropsychological research in OCD and support recent neuroimaging data showing dissociable neural mechanisms involved in mediating the different OCD symptom dimensions...
  56. ncbi Recognition accuracy and response bias to happy and sad facial expressions in patients with major depression
    Simon A Surguladze
    Section of Neuroscience and Emotion, Division of Psychological Medicine, Institute of Psychiatry, King s College London, London, United Kingdom
    Neuropsychology 18:212-8. 2004
    ..The authors suggest that, in depressed patients, the inability to accurately identify subtle changes in facial expression displayed by others in social situations may underlie the impaired interpersonal functioning...
  57. ncbi Autonomic response in the perception of disgust and happiness in depersonalization disorder
    Mauricio Sierra
    Institute of Psychiatry, Denmark Hill, London, UK
    Psychiatry Res 145:225-31. 2006
    ..The findings of this study provide further support to the idea that patients with depersonalization have a selective impairment in the processing of threatening or unpleasant emotional stimuli...
  58. ncbi The development of emotion-processing in children: effects of age, emotion, and intensity
    Catherine M Herba
    Department of Psychological Medicine, Institute of Psychiatry, KCL, UK
    J Child Psychol Psychiatry 47:1098-106. 2006
    ..This study examined the effects of age and two novel factors (intensity and emotion category) on healthy children's developing emotion-processing from 4 to 15 years using two matching paradigms...
  59. ncbi Facial emotion processing in criminal psychopathy. Preliminary functional magnetic resonance imaging study
    Quinton Deeley
    Section of Brain Maturation, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
    Br J Psychiatry 189:533-9. 2006
    ..CONCLUSIONS: People with psychopathy have biological differences from controls when processing facial emotion, and the pattern of response differs according to emotion type...
  60. ncbi The neural basis of mood dysregulation in bipolar disorder
    Mary L Phillips
    Institute of Psychiatry, London, UK
    Cogn Neuropsychiatry 11:233-49. 2006
    ....
  61. ncbi Human attachment security is mediated by the amygdala: evidence from combined fMRI and psychophysiological measures
    Erwin Lemche
    Division of Psychological Medicine, Section of Neuroscience and Emotion, Institute of Psychiatry, London, United Kingdom
    Hum Brain Mapp 27:623-35. 2006
    ..We thereby demonstrate a key role of the amygdala in mediating autonomic activity associated with human attachment insecurity...
  62. ncbi Deconstructing bipolar disorder: a critical review of its diagnostic validity and a proposal for DSM-V and ICD-11
    Eduard Vieta
    Bipolar Disorders Program, Institute of Neuroscience, University of Barcelona Hospital Clinic, Barcelona, Spain
    Schizophr Bull 33:886-92. 2007
    ....
  63. ncbi Perception of facial and vocal affect by people with schizophrenia in early and late stages of illness
    Katarzyna Kucharska-Pietura
    Department of Psychological Medicine, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE5 8AF, UK
    Br J Psychiatry 187:523-8. 2005
    ..CONCLUSIONS: Emotion recognition deficits in schizophrenia are trait features of the disorder and increase with illness duration...
  64. ncbi The neural correlates of anhedonia in major depressive disorder
    Paul A Keedwell
    Section of Neuroscience and Emotion, Department of Psychological Medicine, Institute of Psychiatry, DeCrespigny Park, London, United Kingdom
    Biol Psychiatry 58:843-53. 2005
    ....
  65. ncbi Cognitive-behaviour therapy for depersonalisation disorder: an open study
    Elaine C M Hunter
    Department of Psychology, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
    Behav Res Ther 43:1121-30. 2005
    ..These initial results suggest that a CBT approach to DPD may be effective, but further trials with larger sample sizes and more rigorous research methodology are needed to determine the specificity of this approach...
  66. ncbi Emotional memory: separating content and context
    Nicholas Medford
    Section of Cognitive Neuropsychiatry, Department of Psychological Medicine, Institute of Psychiatry and GKT School of Medicine, King s College, London SE5 8AF, UK
    Psychiatry Res 138:247-58. 2005
    ..These findings, if applicable to the wider population, may have application in a range of psychiatric disorders where interactions between emotion and cognition are relevant...
  67. ncbi Orbitofrontal cortex response to angry faces in men with histories of suicide attempts
    Fabrice Jollant
    Universite Montpellier I, Institut National de la Santé et de la Recherche Médicale U 888, Centre Hospitalier Universitaire, Montpellier, France
    Am J Psychiatry 165:740-8. 2008
    ..The authors sought to elucidate the functional neural basis of the neurobiological abnormalities underlying the vulnerability to suicidal behavior...
  68. ncbi Medial prefrontal cortex activity associated with symptom provocation in eating disorders
    Rudolf Uher
    Institute of Psychiatry PO59, Eating Disorders Unit, King s College London, De Crespigny Park, London SE5 8AF, UK
    Am J Psychiatry 161:1238-46. 2004
    ..The authors sought to identify neural correlates of eating disorders in order to contribute to the debate on the genesis and classification of eating disorders and provide endophenotypes for genetic research...
  69. ncbi Individual differences in disgust sensitivity modulate neural responses to aversive/disgusting stimuli
    David Mataix-Cols
    King s College London, Institute of Psychiatry, London, UK
    Eur J Neurosci 27:3050-8. 2008
    ..The results have implications for disgust-related psychiatric disorders...
  70. ncbi Social threat perception and the evolution of paranoia
    Melissa J Green
    Macquarie Centre for Cognitive Science, Division of Linguistics and Psychology, Macquarie University, Sydney, 2109, Australia
    Neurosci Biobehav Rev 28:333-42. 2004
    ..As such, clinical levels of paranoia may represent the inevitable cost of efficient threat perception--or 'justified' suspicion--that is necessary for survival of the human species...
  71. ncbi Autonomic response in depersonalization disorder
    Mauricio Sierra
    Institute of Psychiatry, 103 Denmark Hill, London SE5 8AZ, England
    Arch Gen Psychiatry 59:833-8. 2002
    ..In this study, we tested the prediction that autonomic response to emotional stimuli would be reduced in patients with depersonalization disorder...

Research Grants3

  1. Toward the identification of biomarkers of bipolar disorder
    MARY LOUISE PHILLIPS; Fiscal Year: 2010
    ....
  2. Toward the identification of biomarkers of bipolar disorder
    Mary Phillips; Fiscal Year: 2009
    ....