Joanna J Phillips

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc PDGFRA amplification is common in pediatric and adult high-grade astrocytomas and identifies a poor prognostic group in IDH1 mutant glioblastoma
    Joanna J Phillips
    Department of Pathology, University of California San Francisco, San Francisco, CA, USA
    Brain Pathol 23:565-73. 2013
  2. pmc Novel therapeutic targets in the brain tumor microenvironment
    Joanna J Phillips
    Department of Neurological Surgery, University of California San Francisco, USA
    Oncotarget 3:568-75. 2012
  3. pmc Heparan sulfate sulfatase SULF2 regulates PDGFRα signaling and growth in human and mouse malignant glioma
    Joanna J Phillips
    Department of Neurological Surgery, UCSF, San Francisco, California 94158, USA
    J Clin Invest 122:911-22. 2012
  4. pmc Pituicytoma: characterization of a unique neoplasm by histology, immunohistochemistry, ultrastructure, and array-based comparative genomic hybridization
    Joanna J Phillips
    Neuropathology Unit, University of California San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143 0102, USA
    Arch Pathol Lab Med 134:1063-9. 2010
  5. pmc Non-invasive in vivo assessment of IDH1 mutational status in glioma
    Myriam M Chaumeil
    Department of Radiology and Biomedical Imaging, University of California San Francisco, 1700 4th Street, San Francisco, California 94158, USA
    Nat Commun 4:2429. 2013
  6. pmc Evaluation of heterogeneous metabolic profile in an orthotopic human glioblastoma xenograft model using compressed sensing hyperpolarized 3D 13C magnetic resonance spectroscopic imaging
    Ilwoo Park
    Department of Radiology and Biomedical Imaging, Surbeck Laboratory of Advanced Imaging, University of California, San Francisco, California, USA
    Magn Reson Med 70:33-9. 2013
  7. pmc Magnetic resonance of 2-hydroxyglutarate in IDH1-mutated low-grade gliomas
    Adam Elkhaled
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA 94158, USA
    Sci Transl Med 4:116ra5. 2012
  8. pmc Na⁺/K⁺-ATPase β2-subunit (AMOG) expression abrogates invasion of glioblastoma-derived brain tumor-initiating cells
    Matthew Z Sun
    Corresponding Author Andrew T Parsa, MD, PhD, Department of Neurological Surgery, University of California, San Francisco, 505 Parnassus Ave, San Francisco, CA 94117
    Neuro Oncol 15:1518-31. 2013
  9. pmc Increased microglia/macrophage gene expression in a subset of adult and pediatric astrocytomas
    Jane R Engler
    Department of Neurological Surgery, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 7:e43339. 2012
  10. pmc Choline metabolism, proliferation, and angiogenesis in nonenhancing grades 2 and 3 astrocytoma
    Tracy R McKnight
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA
    J Magn Reson Imaging 33:808-16. 2011

Detail Information

Publications30

  1. pmc PDGFRA amplification is common in pediatric and adult high-grade astrocytomas and identifies a poor prognostic group in IDH1 mutant glioblastoma
    Joanna J Phillips
    Department of Pathology, University of California San Francisco, San Francisco, CA, USA
    Brain Pathol 23:565-73. 2013
    ..To our knowledge, this is the largest survey of PDGFRA status in adult and pediatric HGAs and suggests PDGFRA amplification increases with grade and is associated with a less favorable prognosis in IDH1 mutant de novo GBMs. ..
  2. pmc Novel therapeutic targets in the brain tumor microenvironment
    Joanna J Phillips
    Department of Neurological Surgery, University of California San Francisco, USA
    Oncotarget 3:568-75. 2012
    ..Here we examine HSPGs and the enzymes that modify them in GBM. We compare their expression across tumor subtypes, their potential roles in oncogenesis, and their potential as novel therapeutic targets in GBM...
  3. pmc Heparan sulfate sulfatase SULF2 regulates PDGFRα signaling and growth in human and mouse malignant glioma
    Joanna J Phillips
    Department of Neurological Surgery, UCSF, San Francisco, California 94158, USA
    J Clin Invest 122:911-22. 2012
    ..Our results suggest the bioavailability of growth factors from the microenvironment is a significant contributor to tumor growth in a major subset of human GBM...
  4. pmc Pituicytoma: characterization of a unique neoplasm by histology, immunohistochemistry, ultrastructure, and array-based comparative genomic hybridization
    Joanna J Phillips
    Neuropathology Unit, University of California San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143 0102, USA
    Arch Pathol Lab Med 134:1063-9. 2010
    ..This pattern of genetic changes only partially overlaps with the genomic alterations reported in pituitary adenomas. In summary, our data suggest that pituicytomas are a unique subset of tumors of the sellar region...
  5. pmc Non-invasive in vivo assessment of IDH1 mutational status in glioma
    Myriam M Chaumeil
    Department of Radiology and Biomedical Imaging, University of California San Francisco, 1700 4th Street, San Francisco, California 94158, USA
    Nat Commun 4:2429. 2013
    ..In contrast, in cells that express mutant IDH1, hyperpolarized [1-(13)C] 2-hydroxyglutarate is also observed, both in cell lysates and in vivo in orthotopic tumours. ..
  6. pmc Evaluation of heterogeneous metabolic profile in an orthotopic human glioblastoma xenograft model using compressed sensing hyperpolarized 3D 13C magnetic resonance spectroscopic imaging
    Ilwoo Park
    Department of Radiology and Biomedical Imaging, Surbeck Laboratory of Advanced Imaging, University of California, San Francisco, California, USA
    Magn Reson Med 70:33-9. 2013
    ..The results from pathology confirmed the different characteristics of (13)C metabolic profiles between viable, non-necrotic, nonhypoxic tumor, and necrotic, hypoxic tissue...
  7. pmc Magnetic resonance of 2-hydroxyglutarate in IDH1-mutated low-grade gliomas
    Adam Elkhaled
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA 94158, USA
    Sci Transl Med 4:116ra5. 2012
    ..Such information may augment the ability of clinicians to monitor therapeutic response and provide criteria for stratifying patients to specific treatment regimens...
  8. pmc Na⁺/K⁺-ATPase β2-subunit (AMOG) expression abrogates invasion of glioblastoma-derived brain tumor-initiating cells
    Matthew Z Sun
    Corresponding Author Andrew T Parsa, MD, PhD, Department of Neurological Surgery, University of California, San Francisco, 505 Parnassus Ave, San Francisco, CA 94117
    Neuro Oncol 15:1518-31. 2013
    ....
  9. pmc Increased microglia/macrophage gene expression in a subset of adult and pediatric astrocytomas
    Jane R Engler
    Department of Neurological Surgery, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 7:e43339. 2012
    ..These studies support a role for the immune response, particularly the microglia/macrophage response, in the biology of an important subset of GBM. Identification of this subset may be important for future therapeutic stratification...
  10. pmc Choline metabolism, proliferation, and angiogenesis in nonenhancing grades 2 and 3 astrocytoma
    Tracy R McKnight
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA
    J Magn Reson Imaging 33:808-16. 2011
    ..PC and glycerophosphocholine (GPC) are involved in phospholipid metabolism that accompanies mitosis. PC is the predominant peak in Grade 4 astrocytoma (GBM) while GPC dominates in AS2...
  11. doi Current management of choroid plexus carcinomas
    Matthew Z Sun
    Department of Neurological Surgery, University of California San Francisco, 505 Parnassus Ave, San Francisco, CA, 94117, USA
    Neurosurg Rev 37:179-92; discussion 192. 2014
    ..In this paper we summarize the current management of CPC in the literature. Further studies are needed to standardize the treatment paradigm for this malignant brain tumor...
  12. pmc Regional variation in histopathologic features of tumor specimens from treatment-naive glioblastoma correlates with anatomic and physiologic MR Imaging
    Ramon F Barajas
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94158 2330, USA
    Neuro Oncol 14:942-54. 2012
    ..Image-guided tissue acquisition and assessment of residual tumor from treatment-naive GBM should be guided by DSC in CE regions and by DWI in NE regions...
  13. pmc Comparison of DSC-MRI post-processing techniques in predicting microvascular histopathology in patients newly diagnosed with GBM
    Emma Essock-Burns
    The UC Berkeley UCSF Graduate Program in Bioengineering, University of California, San Francisco, San Francisco, CA 94158, USA
    J Magn Reson Imaging 38:388-400. 2013
    ....
  14. pmc Proteoglycans and their roles in brain cancer
    Anna Wade
    Department of Neurological Surgery, UCSF, San Francisco, CA 94158, USA
    FEBS J 280:2399-417. 2013
    ....
  15. pmc Cooperative interactions of BRAFV600E kinase and CDKN2A locus deficiency in pediatric malignant astrocytoma as a basis for rational therapy
    Emmanuelle Huillard
    Department of Pediatrics, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 109:8710-5. 2012
    ..Our findings indicate a rational therapeutic strategy for treating a subset of pediatric astrocytomas with BRAF(V600E) mutation and CDKN2A deficiency...
  16. ncbi The alternative lengthening of telomere phenotype is significantly associated with loss of ATRX expression in high-grade pediatric and adult astrocytomas: a multi-institutional study of 214 astrocytomas
    Malak Abedalthagafi
    1 Division of Neuropathology, Department of Pathology, University of California, San Francisco, San Francisco, CA, USA 2 Division of Surgical Pathology, Department of Pathology, University of California, San Francisco, San Francisco, CA, USA
    Mod Pathol 26:1425-32. 2013
    ..03 for each). In summary, our data show that the ALT and ATRX protein alterations are common in both pediatric and adult high-grade astrocytomas, often with associated PDGFRA gene amplification. ..
  17. pmc Characterization of metabolites in infiltrating gliomas using ex vivo (1) H high-resolution magic angle spinning spectroscopy
    Adam Elkhaled
    University of California, Berkeley and University of California, San Francisco Graduate Program in Bioengineering, University of California, Berkeley San Francisco, CA, USA Department of Radiology and Biomedical Imaging, University of California, San Francisco UCSF, CA, USA
    NMR Biomed 27:578-93. 2014
    ..2014 The Authors. NMR in Biomedicine published by John Wiley & Sons, Ltd. ..
  18. doi Characterization of a diffuse intrinsic pontine glioma cell line: implications for future investigations and treatment
    Rintaro Hashizume
    Department of Neurological Surgery, Brain Tumor Research Center, University of California San Francisco, San Francisco, CA 94143 0520, USA
    J Neurooncol 110:305-13. 2012
    ..The hTERT modified cells are tumorigenic in athymic rodents, and produce brainstem tumors that recapitulate the infiltrative growth of brainstem gliomas in patients...
  19. pmc VEGF inhibits tumor cell invasion and mesenchymal transition through a MET/VEGFR2 complex
    Kan V Lu
    Department of Neurological Surgery, University of California, Helen Diller Family Cancer Research Center, San Francisco, CA 94143, USA
    Cancer Cell 22:21-35. 2012
    ..Inhibition of MET in GBM mouse models blocks mesenchymal transition and invasion provoked by VEGF ablation, resulting in substantial survival benefit...
  20. pmc Clinical stratification of glioblastoma based on alterations in retinoblastoma tumor suppressor protein (RB1) and association with the proneural subtype
    Patricia Goldhoff
    Division of Neuropathology, Department of Pathology, University of California, San Francisco, San Francisco, California 94143, USA
    J Neuropathol Exp Neurol 71:83-9. 2012
    ..01). These data support the use of IHC for determining RB1 status in clinical GBM specimens and suggest that RB1 alterations may be more common in certain GBM subgroups...
  21. ncbi Pilocytic astrocytomas of the optic nerve and their relation to pilocytic astrocytomas elsewhere in the central nervous system
    Gerald F Reis
    Neuropathology Unit, Department of Anatomic Pathology, UCSF School of Medicine, San Francisco, CA, USA
    Mod Pathol 26:1279-87. 2013
    ....
  22. pmc Pyruvate kinase M2 expression, but not pyruvate kinase activity, is up-regulated in a grade-specific manner in human glioma
    Joydeep Mukherjee
    Department of Neurological Surgery, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 8:e57610. 2013
    ..These results show that pyruvate kinase M expression, but not pyruvate kinase activity, is regulated in a grade-specific manner in glioma, but that changes in both PK activity and PKM2 expression contribute to growth of GBM...
  23. ncbi Neurolisteriosis presenting as cervical myelitis in an immunocompetent patient
    S Andrew Josephson
    Department of Neurology, University of California, San Francisco, CA 94143 0114, USA
    Neurology 66:1122-3. 2006
  24. doi Detection of early response to temozolomide treatment in brain tumors using hyperpolarized 13C MR metabolic imaging
    Ilwoo Park
    Surbeck Laboratory of Advanced Imaging, Department of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA
    J Magn Reson Imaging 33:1284-90. 2011
    ..To demonstrate the feasibility of using DNP hyperpolarized [1-(13)C]-pyruvate to measure early response to temozolomide (TMZ) therapy using an orthotopic human glioblastoma xenograft model...
  25. pmc Epigenetic biomarkers of T-cells in human glioma
    John K Wiencke
    Department of Neurological Surgery, University of California San Francisco, San Francisco, CA USA
    Epigenetics 7:1391-402. 2012
    ....
  26. pmc EMR-3: a potential mediator of invasive phenotypic variation in glioblastoma and novel therapeutic target
    Ari J Kane
    Department of Neurological Surgery, Division of Neuropathology, University of California at San Francisco, San Francisco, California 94143, USA
    Neuroreport 21:1018-22. 2010
    ..EMR-3 is a potential mediator of cellular invasion in GBM. Given the poor survival associated with high levels of EMR-3 expression in glioma patients, our results provide impetus to explore EMR-3 as a potential therapeutic target...
  27. pmc Distinct neural stem cell populations give rise to disparate brain tumors in response to N-MYC
    Fredrik J Swartling
    University of California, Department of Neurology, Brain Tumor Research Center and Helen Diller Family Comprehensive Cancer Center, San Francisco, CA 94158, USA
    Cancer Cell 21:601-13. 2012
    ..These differences were regulated in part by the transcription factor SOX9, activated in the SHH subclass of human medulloblastoma. Our results demonstrate context-dependent transformation of NSCs in response to a common oncogenic signal...
  28. pmc Frequent truncating mutations of STAG2 in bladder cancer
    David A Solomon
    1 Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University School of Medicine, Washington, DC, USA 2 Department of Pathology, University of California, San Francisco, San Francisco, California, USA
    Nat Genet 45:1428-30. 2013
    ..Our studies suggest that STAG2 has a role in controlling chromosome number but not the proliferation of bladder cancer cells. These findings identify STAG2 as one of the most commonly mutated genes in bladder cancer. ..
  29. ncbi Tuberculoma of the central nervous system
    Arthur R Delance
    Department of Neurological Surgery, University of California, San Francisco, 505 Parnassus Ave, Room 779M, San Francisco, CA 94143 0112, USA
    J Clin Neurosci 20:1333-41. 2013
    ..This review synthesizes pertinent findings in the literature surrounding central nervous system tuberculoma in an effort to highlight recent advances in pathophysiology, diagnosis, and treatment...
  30. pmc Ex vivo MR spectroscopic measure differentiates tumor from treatment effects in GBM
    Radhika Srinivasan
    Department of Radiology and Biomedical Imaging, 1700 4th Street, Byers Hall, Suite 301, San Francisco, CA 94143 2532, USA
    Neuro Oncol 12:1152-61. 2010
    ..Low levels of MCI for tumor were associated with a reduced apparent diffusion coefficient and elevated choline-N-acetyl-aspartate index derived from in vivo MR images...