Robert Philibert

Summary

Affiliation: University of Iowa
Country: USA

Publications

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    Philibert R, Winfield S, Damschroder Williams P, Tengstrom C, Martin B, Ginns E. The genomic structure and developmental expression patterns of the human OPA-containing gene (HOPA). Hum Genet. 1999;105:174-8 pubmed
    ..We conclude that the delineation of the function of the HOPA gene locus merits further study. ..
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    Philibert R. A meta-analysis of the association of the HOPA12bp polymorphism and schizophrenia. Psychiatr Genet. 2006;16:73-6 pubmed
    ..We found that the presence of the HOPA12bp is a significant risk factor for psychosis for both men and women and suggest that differences in the case definition of schizophrenia may affect the strength of the association. ..
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    Philibert R, Madan A. Role of MED12 in transcription and human behavior. Pharmacogenomics. 2007;8:909-16 pubmed
  4. Andersen A, Dogan M, Beach S, Philibert R. Current and Future Prospects for Epigenetic Biomarkers of Substance Use Disorders. Genes (Basel). 2015;6:991-1022 pubmed publisher
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    Philibert R, Mac J. An association of Ephedra use with psychosis and autonomic hyperactivity. Ann Clin Psychiatry. 2004;16:167-9 pubmed
    ..We conclude that the behavioral effects of Ephedra are a public health concern. ..
  6. Dogan M, Shields B, Cutrona C, Gao L, Gibbons F, SIMONS R, et al. The effect of smoking on DNA methylation of peripheral blood mononuclear cells from African American women. BMC Genomics. 2014;15:151 pubmed publisher
  7. Dogan M, Lei M, Beach S, Brody G, Philibert R. Alcohol and tobacco consumption alter hypothalamic pituitary adrenal axis DNA methylation. Psychoneuroendocrinology. 2016;66:176-84 pubmed publisher
    ..We conclude that epigenetic studies of complex disorders involving the HPA axis need to carefully control for the effects of substance use in order to minimize the possibility of type I and type II errors. ..
  8. Philibert R, Todorov A, Andersen A, Hollenbeck N, Gunter T, Heath A, et al. Examination of the nicotine dependence (NICSNP) consortium findings in the Iowa adoption studies population. Nicotine Tob Res. 2009;11:286-92 pubmed publisher
    ..Further examination of the NICSNP findings in other population samples is indicated. ..
  9. Philibert R, Gunter T, Beach S, Brody G, Hollenbeck N, Andersen A, et al. Role of GABRA2 on risk for alcohol, nicotine, and cannabis dependence in the Iowa Adoption Studies. Psychiatr Genet. 2009;19:91-8 pubmed publisher
    ..We conclude that genetic variation at or near the GABRA2 locus significantly affects vulnerability not only to AD, but to other forms of substance use including ND and CD, and that the effects may be sex dependent. ..

More Information

Publications13

  1. Philibert R, Beach S, Gunter T, Todorov A, Brody G, Vijayendran M, et al. The relationship of deiodinase 1 genotype and thyroid function to lifetime history of major depression in three independent populations. Am J Med Genet B Neuropsychiatr Genet. 2011;156B:593-9 pubmed publisher
    ..We conclude that genetic variation influencing thyroid function is a risk factor for MD. Given the evidence from prior studies, further investigations of role of HPT variation in etiology and treatment of MD are indicated. ..
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    Philibert R, Nelson J, Sandhu H, Crowe R, Coryell W. Association of an exonic LDHA polymorphism with altered respiratory response in probands at high risk for panic disorder. Am J Med Genet B Neuropsychiatr Genet. 2003;117B:11-7 pubmed
  3. Philibert R, Gunter T, Beach S, Brody G, Madan A. MAOA methylation is associated with nicotine and alcohol dependence in women. Am J Med Genet B Neuropsychiatr Genet. 2008;147B:565-70 pubmed publisher
    ..10). We conclude that methylation of MAOA may play a significant role in common psychiatric illness and that further examination of epigenetic processes at this locus is in order. ..
  4. Philibert R, Beach S, Brody G. Demethylation of the aryl hydrocarbon receptor repressor as a biomarker for nascent smokers. Epigenetics. 2012;7:1331-8 pubmed publisher
    ..We also suggest that the AHRR/AHR pathway may be functional in the response of peripheral white blood cells to tobacco smoke exposure. ..