Robert Philibert

Summary

Affiliation: University of Iowa
Country: USA

Publications

  1. ncbi request reprint The genomic structure and developmental expression patterns of the human OPA-containing gene (HOPA)
    R A Philibert
    Department of Psychiatry, University of Iowa, Iowa City 52242 1000, USA
    Hum Genet 105:174-8. 1999
  2. ncbi request reprint A meta-analysis of the association of the HOPA12bp polymorphism and schizophrenia
    Robert A Philibert
    Department of Psychiatry, Neuroscience Program, The University of Iowa, Iowa City, IA 52242 1000, USA
    Psychiatr Genet 16:73-6. 2006
  3. ncbi request reprint Role of MED12 in transcription and human behavior
    Robert A Philibert
    The University of Iowa, Department of Psychiatry, Neuroscience Program, Room 2 126 MEB, Iowa City, IA 52242 1000, USA
    Pharmacogenomics 8:909-16. 2007
  4. pmc Effects of genotype and child abuse on DNA methylation and gene expression at the serotonin transporter
    Meeshanthini Vijayendran
    Chemical and Biochemical Engineering, The University of Iowa Iowa City, IA, USA
    Front Psychiatry 3:55. 2012
  5. pmc A cross-platform genome-wide comparison of the relationship of promoter DNA methylation to gene expression
    Jeffrey M Plume
    Department of Psychiatry, The University of Iowa Iowa City, IA, USA
    Front Genet 3:12. 2012
  6. pmc The impact of recent alcohol use on genome wide DNA methylation signatures
    Robert A Philibert
    Department of Psychiatry, The University of Iowa, Iowa City IA, USA
    Front Genet 3:54. 2012
  7. pmc The effect of smoking on DNA methylation of peripheral blood mononuclear cells from African American women
    Meeshanthini V Dogan
    Department of Psychiatry, University of Iowa, Rm 2 126 MEB, 500 Newton Road, Iowa City, IA 52242, USA
    BMC Genomics 15:151. 2014
  8. pmc Demethylation of the aryl hydrocarbon receptor repressor as a biomarker for nascent smokers
    Robert A Philibert
    Department of Psychiatry, The University of Georgia, Athens, GA, USA
    Epigenetics 7:1331-8. 2012
  9. pmc Role of GABRA2 on risk for alcohol, nicotine, and cannabis dependence in the Iowa Adoption Studies
    Robert A Philibert
    Department of Psychiatry, The University of Iowa, Iowa City, IA 52242 1000, USA
    Psychiatr Genet 19:91-8. 2009
  10. ncbi request reprint Serotonin transporter mRNA levels are associated with the methylation of an upstream CpG island
    Robert Philibert
    Department of Psychiatry, The University of Iowa, Psychiatry Research MEB, Iowa City, Iowa, USA
    Am J Med Genet B Neuropsychiatr Genet 144:101-5. 2007

Collaborators

Detail Information

Publications42

  1. ncbi request reprint The genomic structure and developmental expression patterns of the human OPA-containing gene (HOPA)
    R A Philibert
    Department of Psychiatry, University of Iowa, Iowa City 52242 1000, USA
    Hum Genet 105:174-8. 1999
    ..We conclude that the delineation of the function of the HOPA gene locus merits further study...
  2. ncbi request reprint A meta-analysis of the association of the HOPA12bp polymorphism and schizophrenia
    Robert A Philibert
    Department of Psychiatry, Neuroscience Program, The University of Iowa, Iowa City, IA 52242 1000, USA
    Psychiatr Genet 16:73-6. 2006
    ..We found that the presence of the HOPA12bp is a significant risk factor for psychosis for both men and women and suggest that differences in the case definition of schizophrenia may affect the strength of the association...
  3. ncbi request reprint Role of MED12 in transcription and human behavior
    Robert A Philibert
    The University of Iowa, Department of Psychiatry, Neuroscience Program, Room 2 126 MEB, Iowa City, IA 52242 1000, USA
    Pharmacogenomics 8:909-16. 2007
    ....
  4. pmc Effects of genotype and child abuse on DNA methylation and gene expression at the serotonin transporter
    Meeshanthini Vijayendran
    Chemical and Biochemical Engineering, The University of Iowa Iowa City, IA, USA
    Front Psychiatry 3:55. 2012
    ....
  5. pmc A cross-platform genome-wide comparison of the relationship of promoter DNA methylation to gene expression
    Jeffrey M Plume
    Department of Psychiatry, The University of Iowa Iowa City, IA, USA
    Front Genet 3:12. 2012
    ....
  6. pmc The impact of recent alcohol use on genome wide DNA methylation signatures
    Robert A Philibert
    Department of Psychiatry, The University of Iowa, Iowa City IA, USA
    Front Genet 3:54. 2012
    ..We conclude that recent alcohol use is associated with widespread changes in DNA methylation in women and that further study to confirm these findings and determine their relationship to somatic function are in order...
  7. pmc The effect of smoking on DNA methylation of peripheral blood mononuclear cells from African American women
    Meeshanthini V Dogan
    Department of Psychiatry, University of Iowa, Rm 2 126 MEB, 500 Newton Road, Iowa City, IA 52242, USA
    BMC Genomics 15:151. 2014
    ..In addition, complementary bioinformatic analyses were conducted to delineate possible pathways affected by long-term smoking...
  8. pmc Demethylation of the aryl hydrocarbon receptor repressor as a biomarker for nascent smokers
    Robert A Philibert
    Department of Psychiatry, The University of Georgia, Athens, GA, USA
    Epigenetics 7:1331-8. 2012
    ..We also suggest that the AHRR/AHR pathway may be functional in the response of peripheral white blood cells to tobacco smoke exposure...
  9. pmc Role of GABRA2 on risk for alcohol, nicotine, and cannabis dependence in the Iowa Adoption Studies
    Robert A Philibert
    Department of Psychiatry, The University of Iowa, Iowa City, IA 52242 1000, USA
    Psychiatr Genet 19:91-8. 2009
    ..The exact identity of the causal variant(s), and the relationship of these variants to other forms of substance use and behavioral illness is, however, uncertain...
  10. ncbi request reprint Serotonin transporter mRNA levels are associated with the methylation of an upstream CpG island
    Robert Philibert
    Department of Psychiatry, The University of Iowa, Psychiatry Research MEB, Iowa City, Iowa, USA
    Am J Med Genet B Neuropsychiatr Genet 144:101-5. 2007
    ..We suggest that these findings have significant implications for the understanding of the role of this locus in behavioral illness...
  11. ncbi request reprint No association of the C677T methylenetetrahydrofolate reductase polymorphism with schizophrenia
    Robert Philibert
    Department of Psychiatry, The University of Iowa, Psychiatry Research MEB, Iowa City, IA 52242 1000, USA
    Psychiatr Genet 16:221-3. 2006
    ..Neither the T allele nor the TT genotype was associated with increased risk for schizophrenia. These results do not support a role for the C677T MTHFR variant in schizophrenia...
  12. ncbi request reprint The association of the HOPA(12bp) polymorphism with schizophrenia in the NIMH Genetics Initiative for Schizophrenia sample
    Robert A Philibert
    Department of Psychiatry, The University of Iowa, Iowa City, Iowa 52242 1000, USA
    Am J Med Genet B Neuropsychiatr Genet 144:743-7. 2007
    ....
  13. ncbi request reprint Transcriptional profiling of lymphoblast lines from subjects with panic disorder
    Robert A Philibert
    Department of Psychiatry, The University of Iowa, Iowa City, Iowa 52242, USA
    Am J Med Genet B Neuropsychiatr Genet 144:674-82. 2007
    ..Further studies are necessary to correlate these changes in these hemopoetically derived cells with those changes postulated to occur in the CNS in association with PD...
  14. ncbi request reprint Transcriptional profiling of subjects from the Iowa adoption studies
    Robert A Philibert
    Department of Psychiatry, The University of Iowa, Iowa City, Iowa 52242, USA
    Am J Med Genet B Neuropsychiatr Genet 144:683-90. 2007
    ..We conclude that the use of expression profiling may contribute significant insights into the biology of complex behavioral disorders...
  15. pmc Comparison of the genotyping results using DNA obtained from blood and saliva
    Robert A Philibert
    Department of Psychiatry, The University of Iowa, Iowa City, IA, 52242 1000, USA
    Psychiatr Genet 18:275-81. 2008
    ..However, the comparability of DNA from these two sources has not been rigorously analyzed by unbiased sources...
  16. pmc MAOA methylation is associated with nicotine and alcohol dependence in women
    Robert A Philibert
    Department of Psychiatry, The University of Iowa, Iowa City, Iowa, USA
    Am J Med Genet B Neuropsychiatr Genet 147:565-70. 2008
    ..10). We conclude that methylation of MAOA may play a significant role in common psychiatric illness and that further examination of epigenetic processes at this locus is in order...
  17. pmc The relationship of 5HTT (SLC6A4) methylation and genotype on mRNA expression and liability to major depression and alcohol dependence in subjects from the Iowa Adoption Studies
    Robert A Philibert
    Department of Psychiatry, The University of Iowa, Iowa City, Iowa, USA
    Am J Med Genet B Neuropsychiatr Genet 147:543-9. 2008
    ....
  18. pmc Examination of the nicotine dependence (NICSNP) consortium findings in the Iowa adoption studies population
    Robert A Philibert
    Department of Psychiatry and Neuroscience and Genetics Programs, University of Iowa, Rm 2 126 MEB, Iowa City, IA 52242, USA
    Nicotine Tob Res 11:286-92. 2009
    ..Two of the most prominent studies were conducted by the Collaborative Study of the Genetics of Nicotine Dependence (NICSNP) Consortium using both candidate gene and high-density association approaches...
  19. ncbi request reprint Population-based association analyses of the HOPA12bp polymorphism for schizophrenia and hypothyroidism
    R A Philibert
    Department of Psychiatry, The University of Iowa, Iowa City 52242 1000, USA
    Am J Med Genet 105:130-4. 2001
    ....
  20. ncbi request reprint Role of elastin polymorphisms in panic disorder
    Robert A Philibert
    Department of Psychiatry, The University of Iowa, Rm 2 205 Psychiatry Research MEB, Iowa City, Iowa, USA
    Am J Med Genet B Neuropsychiatr Genet 117:7-10. 2003
    ..In our pedigrees, exonic polymorphisms in ELN do not play a major role in the genetic vulnerability to PD...
  21. ncbi request reprint Association of an exonic LDHA polymorphism with altered respiratory response in probands at high risk for panic disorder
    Robert A Philibert
    Department of Psychiatry, The University of Iowa, Iowa City, Iowa 52242 1000, USA
    Am J Med Genet B Neuropsychiatr Genet 117:11-7. 2003
    ....
  22. ncbi request reprint The association of the D2S2944 124 bp allele with recurrent early onset major depressive disorder in women
    Robert Philibert
    Department of Psychiatry, The University of Iowa, Iowa City, Iowa 52242 1000, USA
    Am J Med Genet B Neuropsychiatr Genet 121:39-43. 2003
    ....
  23. pmc The relationship of deiodinase 1 genotype and thyroid function to lifetime history of major depression in three independent populations
    Robert A Philibert
    Department of Psychiatry, The University of Iowa, Iowa City, USA
    Am J Med Genet B Neuropsychiatr Genet 156:593-9. 2011
    ..We conclude that genetic variation influencing thyroid function is a risk factor for MD. Given the evidence from prior studies, further investigations of role of HPT variation in etiology and treatment of MD are indicated...
  24. pmc Gene environment interactions with a novel variable Monoamine Oxidase A transcriptional enhancer are associated with antisocial personality disorder
    Robert A Philibert
    Department of Psychiatry, The University of Iowa, Iowa City, IA, USA
    Biol Psychol 87:366-71. 2011
    ....
  25. ncbi request reprint An association of Ephedra use with psychosis and autonomic hyperactivity
    Robert Philibert
    Department of Psychiatry and Neuroscience Program, The University of Iowa, Iowa City, Iowa 52242 1000, USA
    Ann Clin Psychiatry 16:167-9. 2004
    ..We conclude that the behavioral effects of Ephedra are a public health concern...
  26. pmc The effect of smoking on MAOA promoter methylation in DNA prepared from lymphoblasts and whole blood
    Robert A Philibert
    Department of Psychiatry, The University of Iowa, Iowa City, IA 52242 1000, USA
    Am J Med Genet B Neuropsychiatr Genet 153:619-28. 2010
    ....
  27. ncbi request reprint Association of a D2S2944 allele with depression specifically among those with substance abuse or antisocial personality
    Douglas R Langbehn
    Department of Psychiatry, Psychiatry Research, Room 1 326, Medical Education Building, University of Iowa, Iowa City, IA 52242, USA
    Drug Alcohol Depend 83:33-41. 2006
    ..We note that, in combination with additional liabilities towards depression in women and alcoholism/sociopathy in men, the 124-bp allele may provide a basis for the phenomenon of depressive spectrum illness proposed by Winokur...
  28. ncbi request reprint The association of a HOPA polymorphism with major depression and phobia
    Robert Philibert
    Department of Psychiatry, Neuroscience Program, The University of Iowa and Veterans Affairs Medical Center, Iowa City, IA 52242 1000, USA
    Compr Psychiatry 43:404-10. 2002
    ....
  29. ncbi request reprint Associations of the serotonin transporter promoter polymorphism with aggressivity, attention deficit, and conduct disorder in an adoptee population
    Remi J Cadoret
    Departments of Psychiatry and Biostatistics, and the Neuroscience Program, University of Iowa, Iowa City, IA
    Compr Psychiatry 44:88-101. 2003
    ..The results support the hypothesis that gene-biological family history interactions are involved in the externalizing behaviors studied and constitute interesting findings for future replication...
  30. ncbi request reprint Merging genetic and environmental effects in the Iowa Adoption Studies: focus on depression
    Robert Philibert
    University of lowa, lowa City, IA 52242 1000, USA
    Ann Clin Psychiatry 18:219-22. 2006
    ..One of the major reasons for this lack of progress is the phenomenon of gene-environment (GxE) interactions...
  31. pmc Association between the serotonin transporter promoter polymorphism (5-HTTLPR) and adult unresolved attachment
    Kristin M Caspers
    Department of Psychiatry, Carver College of Medicine, University of Iowa, USA
    Dev Psychol 45:64-76. 2009
    ..The findings challenge current thinking by demonstrating significant genetic influences on a phenomenon previously thought to be largely environmentally driven...
  32. ncbi request reprint Investigation of a candidate gene for schizophrenia on Xq13 previously associated with mental retardation and hypothyroidism
    L E DeLisi
    Department of Psychiatry, SUNY Stony Brook, NY 11794, USA
    Am J Med Genet 96:398-403. 2000
    ..In addition, the increased frequency of HOPA variants in this population may also provide a genetic basis for the familial association of thyroid disease and schizophrenia...
  33. ncbi request reprint The structure and expression of the human neuroligin-3 gene
    R A Philibert
    Department of Psychiatry, University of Iowa, Rm 2 126b Psychiatry Research MEB, Iowa City, IA 52242 1000, USA
    Gene 246:303-10. 2000
    ..These findings suggest a possible role for the neuroligin gene in mental retardation and that the role of the gene in humans may differ from its role in rats...
  34. ncbi request reprint Absence of a significant linkage between Na(+),K(+)-ATPase subunit (ATP1A3 and ATP1B3) genotypes and bipolar affective disorder in the old-order Amish
    R A Philibert
    Department of Psychiatry, University of College of Medicine, Iowa City, Iowa, USA
    Am J Med Genet 105:291-4. 2001
    ..We cannot exclude other genetic variants of the Na(+),K(+)-ATPase hypothesis for BPAD, whereby other loci may modifying Na(+),K(+)-ATPase activity...
  35. ncbi request reprint Polymorphism analysis of HOPA: a candidate gene for schizophrenia
    Harinder K Sandhu
    Department of Psychiatry, University of Iowa, Iowa City, Iowa, USA
    Am J Med Genet B Neuropsychiatr Genet 123:33-8. 2003
    ..We suggest that this evidence supports previous associations of HOPA(12 bp) with a broad range of neuropsychiatric illness and conclude that further studies of this uncommon polymorphism are merited...
  36. ncbi request reprint Association of the HOPA12bp allele with a large X-chromosome haplotype and positive symptom schizophrenia
    Ruth Spinks
    Department of Psychiatry, The University of Iowa, Psychiatry Research MEB, Iowa City, USA
    Am J Med Genet B Neuropsychiatr Genet 127:20-7. 2004
    ....
  37. ncbi request reprint An association study of PCQAP polymorphisms and schizophrenia
    Harinder K Sandhu
    Department of Psychiatry, The University of Iowa, Iowa City, Iowa 52242 1000, USA
    Psychiatr Genet 14:169-72. 2004
    ..Recently, DeLuca and colleagues reported that polymorphisms in a trinucleotide repeat in exon 7 of PCQAP were associated with schizophrenia in a case-control study of Italian schizophrenics...
  38. ncbi request reprint Looking forward in geriatric anxiety and depression: implications of basic science for the future
    Howard K Gershenfeld
    Departments of Psychiatry and Integrative Biology, University of Texas Southwestern Medical Center NC6 530, 5323 Harry Hines Blvd, Dallas, TX 75390 9070, USA
    Am J Geriatr Psychiatry 13:1027-40. 2005
    ..The reciprocal and recursive interactions among basic science, drug discovery, and clinical science will continue to provide hopeful themes for improving the lives of patients with treatment-refractive psychiatric illness...
  39. ncbi request reprint Relationship of serotonin transporter gene polymorphisms and haplotypes to mRNA transcription
    Sarah L Bradley
    Department of Psychiatry, The University of Iowa, Rm 2 126 MEB Psychiatry Research MEB, Iowa City, 52242, USA
    Am J Med Genet B Neuropsychiatr Genet 136:58-61. 2005
    ..We conclude that further examination of the role of 5HTT sequence variation in regulating 5HTT mRNA production is warranted...
  40. ncbi request reprint Association of elevated free T4 levels with depressive symptoms in patients with psychotic disorders
    Robert A Philibert
    Schizophr Res 87:334-5. 2006
  41. ncbi request reprint Therapeutic potential of targeting gene variants in schizophrenia
    Robert A Philibert
    Expert Rev Neurother 7:757-60. 2007

Research Grants9

  1. Genetic Studies of Substance Abuse in Iowa Adoptees
    Robert Philibert; Fiscal Year: 2004
    ....
  2. A thyroid receptor co-activator hypothesis for psychosis
    Robert Philibert; Fiscal Year: 2005
    ..The net effect will be to produce an independent investigator capable of functional and translational research. ..
  3. Genetic Studies of Substance Abuse in Iowa Adoptees
    Robert Philibert; Fiscal Year: 2005
    ....
  4. Genetic Studies of Substance Abuse in Iowa Adoptees
    Robert Philibert; Fiscal Year: 2006
    ....
  5. Genetic Studies of Substance Abuse in Iowa Adoptees
    Robert Philibert; Fiscal Year: 2007
    ....
  6. Examination of Genetic and GxE Effects in the Family and Community Health Studies
    Robert Philibert; Fiscal Year: 2009
    ....
  7. Examination of Genetic and GxE Effects in the Family and Community Health Studies
    Robert A Philibert; Fiscal Year: 2010
    ....