Sem Phan

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. ncbi request reprint The myofibroblast in pulmonary fibrosis
    Sem H Phan
    Department of Pathology, University of Michigan, Ann Arbor, MI 48109 0602, USA
    Chest 122:286S-289S. 2002
  2. ncbi request reprint Eosinophils and T lymphocytes possess distinct roles in bleomycin-induced lung injury and fibrosis
    Francois Huaux
    Department of Pathology, University of Michigan, Ann Arbor, MI 48109 0602, USA
    J Immunol 171:5470-81. 2003
  3. pmc Characterization of vascular strain during in-vitro angioplasty with high-resolution ultrasound speckle tracking
    Prashant Patel
    Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA
    Theor Biol Med Model 7:36. 2010
  4. doi request reprint Genesis of the myofibroblast in lung injury and fibrosis
    Sem H Phan
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109 2200, USA
    Proc Am Thorac Soc 9:148-52. 2012
  5. pmc Biology of fibroblasts and myofibroblasts
    Sem H Phan
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109 2200, USA
    Proc Am Thorac Soc 5:334-7. 2008
  6. pmc Bone marrow-derived progenitor cells in pulmonary fibrosis
    Naozumi Hashimoto
    Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Clin Invest 113:243-52. 2004
  7. pmc Notch1 signaling in FIZZ1 induction of myofibroblast differentiation
    Tianju Liu
    Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109 2200, USA
    Am J Pathol 174:1745-55. 2009
  8. ncbi request reprint Dual roles of IL-4 in lung injury and fibrosis
    Francois Huaux
    Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA
    J Immunol 170:2083-92. 2003
  9. ncbi request reprint PPAR-gamma agonists inhibit profibrotic phenotypes in human lung fibroblasts and bleomycin-induced pulmonary fibrosis
    Jami E Milam
    Univ of Michigan, Division of Pulmonary and Critical Care Medicine, 109 Zina Pitcher Pl, 4062 BSRB, Ann Arbor, MI 48109 2200, USA
    Am J Physiol Lung Cell Mol Physiol 294:L891-901. 2008
  10. pmc Telomerase activity is required for bleomycin-induced pulmonary fibrosis in mice
    Tianju Liu
    Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109 2200, USA
    J Clin Invest 117:3800-9. 2007

Research Grants

Collaborators

Detail Information

Publications43

  1. ncbi request reprint The myofibroblast in pulmonary fibrosis
    Sem H Phan
    Department of Pathology, University of Michigan, Ann Arbor, MI 48109 0602, USA
    Chest 122:286S-289S. 2002
    ..In view of these properties, the persistence or prolonged survival of the myofibroblast may be key to understanding why certain forms of lung injury may result in progressive disease, terminating in end-stage disease...
  2. ncbi request reprint Eosinophils and T lymphocytes possess distinct roles in bleomycin-induced lung injury and fibrosis
    Francois Huaux
    Department of Pathology, University of Michigan, Ann Arbor, MI 48109 0602, USA
    J Immunol 171:5470-81. 2003
    ....
  3. pmc Characterization of vascular strain during in-vitro angioplasty with high-resolution ultrasound speckle tracking
    Prashant Patel
    Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA
    Theor Biol Med Model 7:36. 2010
    ....
  4. doi request reprint Genesis of the myofibroblast in lung injury and fibrosis
    Sem H Phan
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109 2200, USA
    Proc Am Thorac Soc 9:148-52. 2012
    ..Future studies with the help of newly developed technical advancements should expedite discovery in this direction...
  5. pmc Biology of fibroblasts and myofibroblasts
    Sem H Phan
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109 2200, USA
    Proc Am Thorac Soc 5:334-7. 2008
    ..Future studies into these various unsettled areas are essential to provide further insights that may help provide the pathway for novel translational approaches...
  6. pmc Bone marrow-derived progenitor cells in pulmonary fibrosis
    Naozumi Hashimoto
    Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Clin Invest 113:243-52. 2004
    ..Thus the collagen-producing lung fibroblasts in pulmonary fibrosis can also be derived from BM progenitor cells...
  7. pmc Notch1 signaling in FIZZ1 induction of myofibroblast differentiation
    Tianju Liu
    Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109 2200, USA
    Am J Pathol 174:1745-55. 2009
    ..These knockout mice also showed impaired lung fibrosis. These findings suggest that Notch1 signaling in response to FIZZ1 may play a significant role in myofibroblast differentiation during lung fibrosis...
  8. ncbi request reprint Dual roles of IL-4 in lung injury and fibrosis
    Francois Huaux
    Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA
    J Immunol 170:2083-92. 2003
    ..Taken together, these data suggest dual effects of IL-4 in this model of lung fibrosis: 1) limiting early recruitment of T lymphocytes, and 2) stimulation of fibrosis chronically...
  9. ncbi request reprint PPAR-gamma agonists inhibit profibrotic phenotypes in human lung fibroblasts and bleomycin-induced pulmonary fibrosis
    Jami E Milam
    Univ of Michigan, Division of Pulmonary and Critical Care Medicine, 109 Zina Pitcher Pl, 4062 BSRB, Ann Arbor, MI 48109 2200, USA
    Am J Physiol Lung Cell Mol Physiol 294:L891-901. 2008
    ..These observations indicate that PPAR-gamma is an important regulator of fibroblast/myofibroblast activation and suggest a role for PPAR-gamma ligands as novel therapeutic agents for fibrotic lung diseases...
  10. pmc Telomerase activity is required for bleomycin-induced pulmonary fibrosis in mice
    Tianju Liu
    Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109 2200, USA
    J Clin Invest 117:3800-9. 2007
    ..Moreover, TERT induction is associated with increased survival of lung fibroblasts, which favors the development of fibrosis instead of injury resolution...
  11. pmc Nkx2.5/Csx represses myofibroblast differentiation
    Biao Hu
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109 2200, USA
    Am J Respir Cell Mol Biol 42:218-26. 2010
    ..5 as a repressor of alpha-SMA gene transcription, which may be of homeostatic significance as a means of suppressing myofibroblast differentiation in the absence of tissue injury...
  12. ncbi request reprint Regulation of telomerase activity in rat lung fibroblasts
    Tianju Liu
    Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109 0602, USA
    Am J Respir Cell Mol Biol 26:534-40. 2002
    ..The latter is consistent with the preferential expression of telomerase activity in fibroblasts relative to myofibroblasts...
  13. ncbi request reprint CCAAT/enhancer-binding protein beta isoforms and the regulation of alpha-smooth muscle actin gene expression by IL-1 beta
    Biao Hu
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Immunol 173:4661-8. 2004
    ..These data taken together suggest that C/EBPbeta isoforms regulate alpha-SMA gene expression, and that its inhibition by IL-1beta was due to preferential stimulation of LIP expression...
  14. ncbi request reprint Smad3 mediates transforming growth factor-beta-induced alpha-smooth muscle actin expression
    Biao Hu
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109 0602, USA
    Am J Respir Cell Mol Biol 29:397-404. 2003
    ..Taken together, these findings suggest a role for Smad3 in TGF-beta regulation of ASMA gene expression in myofibroblast differentiation...
  15. pmc Telomerase regulation of myofibroblast differentiation
    Tianju Liu
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Am J Respir Cell Mol Biol 34:625-33. 2006
    ..Conversely, expression of telomerase suppresses myofibroblast differentiation...
  16. ncbi request reprint Animal models of pulmonary fibrosis
    Mehrnaz Gharaee-Kermani
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA
    Methods Mol Med 117:251-9. 2005
    ..This chapter will describe two commonly used techniques, namely bleomycin and silica-induced, which have been developed for the study of pulmonary fibrosis in animal models...
  17. ncbi request reprint CC-chemokine receptor 2 required for bleomycin-induced pulmonary fibrosis
    Mehrnaz Gharaee-Kermani
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109 0602, USA
    Cytokine 24:266-76. 2003
    ..These findings suggest that CCR2 signaling plays a key role in bleomycin-induced pulmonary fibrosis by regulating fibrogenic cytokine expression and fibroblast responsiveness to TGF-beta...
  18. pmc Toll-like receptor 9 activation is a key mechanism for the maintenance of chronic lung inflammation
    Toshihiro Ito
    Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Am J Respir Crit Care Med 180:1227-38. 2009
    ..Accumulating evidence supports the hypothesis that the continuous host response to a persistent challenge can polarize the cytokine environment toward a Th2 cytokine phenotype, but the mechanisms responsible for this skewing are not clear...
  19. ncbi request reprint Tetrathiomolybdate therapy protects against bleomycin-induced pulmonary fibrosis in mice
    George J Brewer
    Department of Human Genetics, University of Michigan Medical School, Ann Arbor 48109 0618, USA
    J Lab Clin Med 141:210-6. 2003
    ..The protection afforded by TM was also reflected in significantly reduced bleomycin-induced body-weight loss. In the next phase of this work, we will seek to determine the mechanisms by which TM brings about this therapeutic benefit...
  20. ncbi request reprint Current and emerging drugs for idiopathic pulmonary fibrosis
    Mehrnaz Gharaee-Kermani
    University of Michigan Medical School, Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, 2215 Fuller Road, 11R, Ann Arbor, MI 48105, USA
    Expert Opin Emerg Drugs 12:627-46. 2007
    ..This article examines the body of evidence supporting present therapies and reviews the newer agents being tested in patients with idiopathic pulmonary fibrosis...
  21. ncbi request reprint New insights into the pathogenesis and treatment of idiopathic pulmonary fibrosis: a potential role for stem cells in the lung parenchyma and implications for therapy
    Mehrnaz Gharaee-Kermani
    Division of Pulmonary Medicine and Critical Care, Department of Internal Medicine, University of Michigan Medical School, 2215 Fuller Rd VAMC 11R, Ann Arbor, Michigan 48105, USA
    Pharm Res 24:819-41. 2007
    ..This article reviews the new concepts in the pathogenesis, current and future treatment options of pulmonary fibrosis, and the recent advances regarding the roles of stem cells in lung tissue repair, regeneration, and remodeling...
  22. pmc Gut-enriched Krüppel-like factor interaction with Smad3 inhibits myofibroblast differentiation
    Biao Hu
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109 0602, USA
    Am J Respir Cell Mol Biol 36:78-84. 2007
    ..It represents the first evidence to directly link GKLF with Smad3, a key intracellular mediator of TGF-beta signaling, which should lead to a clearer understanding of the mechanism of how GKLF regulates TGF-beta-induced gene expression...
  23. pmc Role of stem cell factor and bone marrow-derived fibroblasts in airway remodeling
    Vladislav A Dolgachev
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109 2200, USA
    Am J Pathol 174:390-400. 2009
    ....
  24. ncbi request reprint The role of urokinase in idiopathic pulmonary fibrosis and implication for therapy
    Mehrnaz Gharaee-Kermani
    University of Michigan Medical School, Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, 2215 Fuller Road, 11R, Ann Arbor, MI 48105, USA
    Expert Opin Investig Drugs 17:905-16. 2008
    ..The balance between the activating enzyme uPA, and its inhibitor PAI-1, is a critical determinant of the amount of scar development that follows...
  25. ncbi request reprint Protection from pulmonary fibrosis in leukotriene-deficient mice
    Marc Peters-Golden
    Department of Internal Medicine, University of Michigan Health System, Ann Arbor, Michigan 48109 0642, USA
    Am J Respir Crit Care Med 165:229-35. 2002
    ....
  26. ncbi request reprint Nephrogenic fibrosing dermopathy: a novel cutaneous fibrosing disorder in patients with renal failure
    Richard D Swartz
    Division of Nephrology, University of Michigan Health Systems, Ann Arbor 48109 0364, USA
    Am J Med 114:563-72. 2003
    ..Presently, there is no effective treatment, and the condition persists in most patients...
  27. ncbi request reprint Involvement of serum response factor isoforms in myofibroblast differentiation during bleomycin-induced lung injury
    Yan Yang
    Department of Pathology, Wayne State University School of Medicine, 540 E Canfield St, Rm 9248, Detroit, MI 48201, USA
    Am J Respir Cell Mol Biol 29:583-90. 2003
    ..Our studies therefore suggested a new mechanism whereby SRF and SRFDelta5 contribute to the emergence of myofibroblasts in lung injury and fibrosis...
  28. pmc FIZZ1 stimulation of myofibroblast differentiation
    Tianju Liu
    Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Am J Pathol 164:1315-26. 2004
    ..These results suggest a novel role for FIZZ1 in myofibroblast differentiation in pulmonary fibrosis...
  29. ncbi request reprint Inhibition of key cytokines by tetrathiomolybdate in the bleomycin model of pulmonary fibrosis
    George J Brewer
    Department of Human Genetics, University of Michigan, 5022 Kresge Building II, Ann Arbor, MI 48109 0534, USA
    J Inorg Biochem 98:2160-7. 2004
    ..The inhibition of tumor necrosis factor alpha suggests that diseases of tumor necrosis factor alpha overexpression are also potential targets of tetrathiomolybdate therapy...
  30. pmc Gender-based differences in bleomycin-induced pulmonary fibrosis
    Mehrnaz Gharaee-Kermani
    Department of Internal Medicine, University of Michigan Medical School, 210 Washtenaw, Box 2216, Ann Arbor, MI 48109 2216, USA
    Am J Pathol 166:1593-606. 2005
    ..This may provide a mechanism for a hormonally mediated intensification of pulmonary fibrosis...
  31. pmc Negative regulation of myofibroblast differentiation by PTEN (Phosphatase and Tensin Homolog Deleted on chromosome 10)
    Eric S White
    Division of Pulmonary and Critical Care Medicine, University of Michigan Medical School, 6301 MSRB III 0642, 1150 West Medical Center Drive, Ann Arbor, MI 48109 0642, USA
    Am J Respir Crit Care Med 173:112-21. 2006
    ..Myofibroblasts are primary effector cells in idiopathic pulmonary fibrosis (IPF). Defining mechanisms of myofibroblast differentiation may be critical to the development of novel therapeutic agents...
  32. ncbi request reprint Fibroblast phenotypes in pulmonary fibrosis
    Sem H Phan
    Department of Pathology, University of Michigan, Ann Arbor, Michigan, USA
    Am J Respir Cell Mol Biol 29:S87-92. 2003
  33. ncbi request reprint Regulation of found in inflammatory zone 1 expression in bleomycin-induced lung fibrosis: role of IL-4/IL-13 and mediation via STAT-6
    Tianju Liu
    Department of Pathology, University of Michigan Medical School, Ann Arbor 48109, USA
    J Immunol 173:3425-31. 2004
    ..This represents a potential mechanism by which IL-4/IL-13 could play a role in the pathogenesis of lung fibrosis...
  34. pmc The extrapulmonary origin of fibroblasts: stem/progenitor cells and beyond
    Vibha N Lama
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109 0602, USA
    Proc Am Thorac Soc 3:373-6. 2006
    ....
  35. pmc Epigenetic regulation of myofibroblast differentiation by DNA methylation
    Biao Hu
    Department of Pathology, University of Michigan Medical School, 109 Zina Pitcher Place, Ann Arbor, MI 48109 2200, USA
    Am J Pathol 177:21-8. 2010
    ..These findings suggest that DNA methylation mediated by DNA methyltransferase is an important mechanism regulating the alpha-SMA gene expression during myofibroblast differentiation...
  36. ncbi request reprint Kielin/chordin-like protein, a novel enhancer of BMP signaling, attenuates renal fibrotic disease
    Jingmei Lin
    Department of Pathology, University of Michigan, 1301 Catherine Street, Ann Arbor, Michigan 48109, USA
    Nat Med 11:387-93. 2005
    ..The data indicate an important role for KCP in attenuating the pathology of renal fibrotic disease...
  37. ncbi request reprint A profibrotic function of IL-12p40 in experimental pulmonary fibrosis
    Francois Huaux
    Units of Industrial Toxicology and Occupational Medicine, Faculty of Medicine, Brussels, Belgium
    J Immunol 169:2653-61. 2002
    ..Together, our data suggest that IL-12p40 plays an important role in silica-induced pulmonary inflammation and fibrosis, possibly by exacerbating macrophage recruitment...
  38. ncbi request reprint Therapies for bleomycin induced lung fibrosis through regulation of TGF-beta1 induced collagen gene expression
    Kenneth R Cutroneo
    Department of Biochemistry, College of Medicine, 89 Beaumont Avenue, University of Vermont, Burlington, Vermont 05405, USA
    J Cell Physiol 211:585-9. 2007
    ..Lung fibroblasts exist as subpopulations with one subset predominantly responding to fibrogenic stimuli which could be a specific cell therapeutic target for the onset and development of pulmonary fibrosis...
  39. pmc Chronic inhaled ovalbumin exposure induces antigen-dependent but not antigen-specific inhalational tolerance in a murine model of allergic airway disease
    Craig M Schramm
    Department of Pediatrics, Pulmonary Research Consortium, University of Connecticut School of Medicine, Farmington, Connecticut, USA
    Am J Pathol 164:295-304. 2004
    ..The symptomatic and asymptomatic allergic responses in human asthmatics could be explained by similar variable or discontinuous exposures to aeroantigens...
  40. ncbi request reprint Characterization of the effect of interleukin-10 on silica-induced lung fibrosis in mice
    Virginie Barbarin
    Industrial Toxicology and Occupational Medicine Unit, Faculty of Medicine, University Hospital of Mont Godinne, Yvoir, Universite Catholique de Louvain, Brussels, Belgium
    Am J Respir Cell Mol Biol 31:78-85. 2004
    ..These effects appear to be independent of the enhanced lung CD4+ T-lymphocytosis observed in IL-10-deficient mice...
  41. pmc The myofibroblast: one function, multiple origins
    Boris Hinz
    Laboratory of Cell Biophysics, Ecole Polytechnique Federale de Lausanne EPFL, Bâtiment SG AA B143, Station 15, CH 1015 Lausanne, Switzerland
    Am J Pathol 170:1807-16. 2007
    ....
  42. pmc Role of Eotaxin-1 (CCL11) and CC chemokine receptor 3 (CCR3) in bleomycin-induced lung injury and fibrosis
    Francois Huaux
    Unit of Industrial Toxicology and Occupational Medicine, Universite Catholique de Louvain, Brussels, Belgium
    Am J Pathol 167:1485-96. 2005
    ..Together, these data suggest that CCL11 and CCR3 are important in the pulmonary recruitment of granulocytes and play significant pathogenic roles in blm-induced lung fibrosis...
  43. ncbi request reprint TGF-beta1-induced Smad 3 binding to the Smad 7 gene: knockout of Smad 7 gene transcription by sense phosphorothioate oligos, autoregulation, and effect on TGF-beta1 secretion: bleomycin acts through TGF-beta1
    Kenneth R Cutroneo
    Department of Biochemistry, College of Medicine, University of Vermont, Burlington, Vermont 05405 0068, USA
    J Cell Biochem 89:474-83. 2003
    ....

Research Grants24

  1. MYOFIBROBLASTS IN PULMONARY FIBROSIS
    Sem Phan; Fiscal Year: 2006
    ..abstract_text> ..
  2. A novel telomerase expressing lung fibroblast phenotype
    Sem Phan; Fiscal Year: 2007
    ..abstract_text> ..
  3. MECHANISMS OF PULMONARY FIBROSIS
    Sem Phan; Fiscal Year: 2007
    ..abstract_text> ..
  4. MYOFIBROBLASTS IN PULMONARY FIBROSIS
    Sem H Phan; Fiscal Year: 2010
    ..Improvement in understanding these processes will provide much needed insight into potentially novel treatments as well as approaches for management of patients with these diseases. ..
  5. MYOFIBROBLASTS IN PULMONARY FIBROSIS
    Sem Phan; Fiscal Year: 2002
    ....
  6. A novel telomerase expressing lung fibroblast phenotype
    Sem H Phan; Fiscal Year: 2010
    ..It is hoped that attainment of the study's objectives will provide new ideas for effective treatment and management of these diseases. ..