Research Topics
| K Luan PhanSummaryAffiliation: University of Chicago Country: USA Publications
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Publications
Anterior cingulate neurochemistry in social anxiety disorder: 1H-MRS at 4 TeslaK Luan Phan
Department of Psychiatry, Pritzker School of Medicine, The University of Chicago, 5841 South Maryland Avenue MC3077 L 461, Chicago, IL, USA
Neuroreport 16:183-6. 2005..Anterior cingulate glutamate/creatine levels were also correlated with intensity of social anxiety symptoms. These findings provide new evidence of glutamate's involvement in the neural mechanism underlying social phobia...- Neural substrates for voluntary suppression of negative affect: a functional magnetic resonance imaging studyK Luan Phan
Department of Psychiatry, University of Chicago, Chicago, Illinois 60637 1470, USA
Biol Psychiatry 57:210-9. 2005..Although the capacity to regulate emotions is critical to mental well-being, its neural substrates remain unclear... - Neural correlates of telling lies: a functional magnetic resonance imaging study at 4 TeslaK Luan Phan
Department of Psychiatry, Pritzker School of Medicine, University of Chicago, Chicago, IL 60637, USA
Acad Radiol 12:164-72. 2005.... - Association between amygdala hyperactivity to harsh faces and severity of social anxiety in generalized social phobiaK Luan Phan
Department of Psychiatry, Biological Sciences Division, The University of Chicago, Chicago, Illinois 60637, USA
Biol Psychiatry 59:424-9. 2006.... - Corticolimbic blood flow during nontraumatic emotional processing in posttraumatic stress disorderK Luan Phan
Department of Psychiatry, Pritzker School of Medicine, The University of Chicago, Chicago, Ill, USA
Arch Gen Psychiatry 63:184-92. 2006..Activation of the amygdala and lack of ventral MPFC deactivation to negatively valenced images in combat controls may reflect compensatory changes after trauma exposure that are not associated with PTSD... - Paralimbic and medial prefrontal cortical involvement in neuroendocrine responses to traumatic stimuliIsrael Liberzon
Department of Psychiatry, University of Michigan Medical School, Ann Arbor, MI, USA
Am J Psychiatry 164:1250-8. 2007..The authors used [(15)O]H(2)O positron emission tomography (PET) on subjects with posttraumatic stress disorder (PTSD) to study these circuits... 
Trait anxiety modulates anterior cingulate activation to threat interferenceHeide Klumpp
Department of Psychiatry, University of Michigan Ann Arbor, 4250 Plymouth Road, Ann Arbor, MI 48109, USA
Depress Anxiety 28:194-201. 2011..anterior cingulate cortex, "ACC") might play a role. In this study, we explored the hypothesis that trait anxiety would be associated with ACC activity in an attentional control task with varying levels of threat interference...- Subjective rating of emotionally salient stimuli modulates neural activityStephan F Taylor
Department of Psychiatry, University of Michigan, Ann Arbor, MI 48109, USA
Neuroimage 18:650-9. 2003..For both RTNG and PSVW, subjects activated the left fusiform gyrus. The results support the proposition that task instructions about how subjects should process evocative stimuli can affect neural activity... - Beyond threat: amygdala reactivity across multiple expressions of facial affectDaniel A Fitzgerald
Department of Psychiatry, The University of Chicago, 5841 South Maryland Avenue MC3077 (L-466C, Chicago, IL 60637-1470, USA
Neuroimage 30:1441-8. 2006..These results challenge the notion that the amygdala has a specialized role in processing certain emotions and suggest that the amygdala may have a more general-purpose function in processing salient information from faces... 
Effects of MDMA on sociability and neural response to social threat and social rewardGillinder Bedi
Human Behavioral Pharmacology Laboratory, Department of Psychiatry, University of Chicago, 5841 S Maryland Ave, MC 3077, Chicago, IL 60637, USA
Psychopharmacology (Berl) 207:73-83. 2009..Despite their apparent importance in recreational and potential psychotherapeutic use of MDMA, the defining characteristics and neurobiological mechanisms of these interpersonal effects are poorly understood...- Altered central micro-opioid receptor binding after psychological traumaIsrael Liberzon
Department of Psychiatry, University of Michigan Medical School, Ann Arbor, Michigan 48109 0118, USA
Biol Psychiatry 61:1030-8. 2007..The mu-opioid neurotransmitter system, implicated in responses to stress and suppression of pain, is distributed in and is thought to regulate the function of brain regions that are implicated in affective processing... - Cannabinoid facilitation of fear extinction memory recall in humansChristine A Rabinak
Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA
Neuropharmacology 64:396-402. 2013..This article is part of a Special Issue entitled 'Cognitive Enhancers'... - Cannabinoid modulation of subgenual anterior cingulate cortex activation during experience of negative affectChristine A Rabinak
Department of Psychiatry, University of Michigan, Rachel Upjohn Building, 4250 Plymouth Road, Box 5765, Ann Arbor, MI 48109 2700, USA
J Neural Transm 119:701-7. 2012..This observation extends prior findings implicating a cortico-limbic, emotion-related central mechanism underlying cannabinoid function... - Insula reactivity and connectivity to anterior cingulate cortex when processing threat in generalized social anxiety disorderHeide Klumpp
Department of Psychiatry, University of Michigan, Rachel Upjohn Building, 4250 Plymouth Road, Ann Arbor, MI 48109 2700, USA
Biol Psychol 89:273-6. 2012..Findings indicate that aINS hyper-reactivity for fear faces in gSAD, compared to controls, involves reduced connectivity with a prefrontal region implicated in cognitive control and emotion regulation... - Amygdala reactivity to emotional faces at high and low intensity in generalized social phobia: a 4-Tesla functional MRI studyK Lira Yoon
Brain Imaging and Emotions Laboratory, Department of Psychiatry, University of Chicago, Chicago, IL 60637 1470, USA
Psychiatry Res 154:93-8. 2007..low) intensity expressions in the phobic group, suggesting that more arousing social-emotional cues contribute to limbic hyperactivity in GSP... - Amygdala and orbitofrontal reactivity to social threat in individuals with impulsive aggressionEmil F Coccaro
Department of Psychiatry, Biological Sciences Division and the Pritzker School of Medicine, The University of Chicago, Chicago, Illinois 60637 1470, USA
Biol Psychiatry 62:168-78. 2007..In this study we employed a social-emotional probe of amygdala-OFC function in individuals with impulsive aggression... - Habituation of rostral anterior cingulate cortex to repeated emotionally salient picturesK Luan Phan
Department of Psychiatry, University of Michigan, Ann Arbor, Ann Arbor, MI, USA
Neuropsychopharmacology 28:1344-50. 2003..These findings highlight the phasic activity of the rACC in emotional processing consistent with habituation... - Neural correlates of internally-generated disgust via autobiographical recall: a functional magnetic resonance imaging investigationDaniel A Fitzgerald
Clinical Neuroscience and Psychopharmacology Research Unit, Department of Psychiatry, University of Chicago, Chicago, IL, USA
Neurosci Lett 370:91-6. 2004..These findings suggest that areas previously associated with the perception of disgust (e.g., insula, basal ganglia) are also involved interoceptive experience of disgust... - Activation of the medial prefrontal cortex and extended amygdala by individual ratings of emotional arousal: a fMRI studyK Luan Phan
Department of Psychiatry, University of Michigan, Ann Arbor, Michigan 48109-0118, USA
Biol Psychiatry 53:211-5. 2003..CONCLUSIONS: Our findings demonstrate that individual behavioral data are useful in improving detection of activation in block-design functional imaging studies... - Corticolimbic function in impulsive aggressive behaviorEmil F Coccaro
Clinical Neuroscience and Psychopharmacology Research Unit, Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, Illinois
Biol Psychiatry 69:1153-9. 2011..We review psychiatric disorders, including borderline personality disorder and antisocial personality disorder, characterized by elevated reactive aggression, focusing on abnormalities in these three neural systems... - The neural correlates of intertemporal decision-making: contributions of subjective value, stimulus type, and trait impulsivityChandra Sekhar Sripada
Department of Psychiatry, University of Michigan, Ann Arbor, Michigan 48109 2700, USA
Hum Brain Mapp 32:1637-48. 2011..These findings significantly advance our understanding of the specificity and overlap of functions subserved by different regions involved in intertemporal decision-making, and help to reconcile conflicting accounts in the literature... - Preliminary evidence of white matter abnormality in the uncinate fasciculus in generalized social anxiety disorderK Luan Phan
Department of Psychiatry, University of Michigan, Ann Arbor, Michigan 48105, USA
Biol Psychiatry 66:691-4. 2009..The goal of this study was to investigate brain frontal WM abnormalities using diffusion tensor imaging (DTI) in patients with social anxiety disorder... - Shifting the focus of attention modulates amygdala and anterior cingulate cortex reactivity to emotional facesHeide Klumpp
Department of Psychiatry, University of Michigan, Ann Arbor, MI 48109 2700, USA
Neurosci Lett 514:210-3. 2012..Results indicate that simply and volitionally directing attention toward or away from emotional content correspondingly modulates amygdala and ACC activity... - Functional neuroimaging of mentalizing during the trust game in social anxiety disorderChandra Sehkar Sripada
Psychiatry Affective Neuroimaging Laboratory, Department of Psychiatry, University of Michigan, MI 48109 2700, USA
Neuroreport 20:984-9. 2009..Diminished medial prefrontal cortex function may play a role in the social-cognitive pathophysiology of social anxiety... - Amygdala and insula response to emotional images in patients with generalized social anxiety disorderSabin G Shah
Department of Psychiatry, University of Michigan, Ann Arbor, Mich 48109 2700, USA
J Psychiatry Neurosci 34:296-302. 2009..However, few studies have examined brain responses in socially anxious participants during general emotional processing. We examined brain response to emotionally evocative images in patients with gSAD and matched healthy controls... - Extended amygdala and emotional salience: a PET activation study of positive and negative affectIsrael Liberzon
Department of Psychiatry, University of Michigan, Ann Arbor, USA
Neuropsychopharmacology 28:726-33. 2003.... - Effects of alcohol on brain responses to social signals of threat in humansChandra Sekhar Sripada
Department of Psychiatry, University of Michigan, Ann Arbor, MI 48109, USA
Neuroimage 55:371-80. 2011..The current findings fit well with the notion that alcohol may attenuate threat-based responding and provide a potential brain-based mechanism for the link between alcohol and anxiety and/or social threat perception... - Neural response to emotional salience in schizophreniaStephan F Taylor
Department of Psychiatry, University of Michigan, Ann Arbor, MI 48109, USA
Neuropsychopharmacology 30:984-95. 2005..Reduced modulation of visual cortex by emotionally salient stimuli also suggests a failure to organize cerebral activity at a global level... - Emotional experience modulates brain activity during fixation periods between tasksSean Pitroda
Pritzker School of Medicine, University of Chicago, Chicago, IL, USA
Neurosci Lett 443:72-6. 2008.... - Cannabinoid modulation of amygdala reactivity to social signals of threat in humansK Luan Phan
Department of Psychiatry, University of Michigan and Veterans Affairs Ann Arbor Healthcare System, Ann Arbor, Michigan 48109, USA
J Neurosci 28:2313-9. 2008.... - The role of glutamate in anxiety and related disordersBernadette M Cortese
Department of Psychiatry, Pennsylvania State University College of Medicine, Hershey, PA, USA
CNS Spectr 10:820-30. 2005..Collectively, the data suggest that future studies on the mechanism of and clinical efficacy of glutamatergic agents in anxiety disorders are appropriately warranted... - Functional neuroanatomy of emotion: a meta-analysis of emotion activation studies in PET and fMRIK Luan Phan
Department of Psychiatry, University of Michigan, Ann Arbor, Michigan 48109, USA
Neuroimage 16:331-48. 2002..This review provides a critical comparison of findings across individual studies and suggests that separate brain regions are involved in different aspects of emotion... - A functional neuroimaging study of motivation and executive functionStephan F Taylor
Department of Psychiatry, University of Michigan, Ann Arbor, MI 48109 0118, USA
Neuroimage 21:1045-54. 2004..Areas of overlap and interaction may integrate information about value, or they may represent a general effect of motivation increasing neural effort... - Neural substrates of alcohol-induced smoking urge in heavy drinking nondaily smokersAndrea King
Department of Psychiatry and Behavioral Neuroscience, The University of Chicago, Chicago, IL 60637, USA
Neuropsychopharmacology 35:692-701. 2010.... - Corticolimbic brain reactivity to social signals of threat before and after sertraline treatment in generalized social phobiaK Luan Phan
Department of Psychiatry, University of Illinois at Chicago, and Mental Health Service Line, Jesse Brown VA Medical Center, Chicago, Illinois Department of Psychiatry, University of Michigan, Ann Arbor, Michigan Electronic address
Biol Psychiatry 73:329-36. 2013..Although selective serotonin reuptake inhibitor (SSRI) treatment is known to be an effective treatment, little is known about the mechanism through which these agents exert their anxiolytic effects at a brain level in gSP... - Personality predictors of antiaggressive response to fluoxetine: inverse association with neuroticism and harm avoidanceK Luan Phan
Department of Psychiatry, University of Michigan, Ann Arbor, Michigan, USA
Int Clin Psychopharmacol 26:278-83. 2011.... - Brain-imaging studies of posttraumatic stress disorderIsrael Liberzon
Department of Psychiatry, University of Michigan, Ann Arbor, Michigan, USA
CNS Spectr 8:641-50. 2003..This article reviews the literature on structural, functional, and neurochemical brain-imaging studies of PTSD... - Oxytocin enhances resting-state connectivity between amygdala and medial frontal cortexChandra Sekhar Sripada
Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA
Int J Neuropsychopharmacol 16:255-60. 2013.... - mu-Opioid receptors and limbic responses to aversive emotional stimuliIsrael Liberzon
Department of Psychiatry, Veterans Administration Medical Center, University of Michigan, Ann Arbor, MI 48105, USA
Proc Natl Acad Sci U S A 99:7084-9. 2002..This is consistent with an inhibitory/anxiolytic role of the endogenous opioid system in limbic regions of the temporal lobe and basal forebrain... - Neuroimaging and personality disordersMichael S McCloskey
Department of Psychiatry, MC 3077, University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA
Curr Psychiatry Rep 7:65-72. 2005.... - Amygdala-frontal connectivity during emotion regulationSarah J Banks
Brain Imaging and Emotions Laboratory, Department of Psychiatry, University of Chicago, Chicago, IL 60637, USA
Soc Cogn Affect Neurosci 2:303-12. 2007..These findings highlight the importance of functional connectivity within limbic-frontal circuitry during emotion regulation... - Corticolimbic blood flow in posttraumatic stress disorder during script-driven imageryJennifer C Britton
Neuroscience Program, University of Michigan, Michigan, USA
Biol Psychiatry 57:832-40. 2005..CONCLUSIONS: Trauma-specific patterns may represent potential compensatory changes to traumatic reminders, while patterns observed only in the PTSD group may reflect neural substrates specific to PTSD pathophysiology... - Neural correlates of individual ratings of emotional salience: a trial-related fMRI studyK Luan Phan
Department of Psychiatry and Behvioral Neuroscience, Wayne State University School of Medicine, Detroit, MI 48201, USA
Neuroimage 21:768-80. 2004..The findings highlight both overlapping and segregated neural representations of intrinsic value and personal relevance during the appraisal of emotional stimuli... - Functional neuroimaging studies of human emotionsK Luan Phan
Department of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, Michigan 48201, USA
CNS Spectr 9:258-66. 2004..This paper will review observations in several regions of interest in limbic (eg, amygdala, anterior cingulate cortex) and paralimbic (eg, medial prefrontal cortex, insula) brain regions in emotional responding... - Real-time fMRI of cortico-limbic brain activity during emotional processingK Luan Phan
Brain Imaging Research Division, Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, 9B University Health Center Rm 18, 4201 St Antoine Blvd, Detroit, MI 48201, USA
Neuroreport 15:527-32. 2004..Detecting cortico-limbic brain activation during perception and experience of emotionally salient visual stimuli with real-time fMRI technology is feasible... - Neural correlates of social and nonsocial emotions: An fMRI studyJennifer C Britton
Neuroscience Program, University of Michigan, Ann Arbor, MI 48109
Neuroimage 31:397-409. 2006..Overall, these findings highlight that sociality has a key role in processing emotional valence, which may have implications for patient populations with social and emotional deficits... - Valence, gender, and lateralization of functional brain anatomy in emotion: a meta-analysis of findings from neuroimagingTor D Wager
Department of Psychology, University of Michigan, Ann Arbor, MI 48109, USA
Neuroimage 19:513-31. 2003..The study provides evidence that lateralization of emotional activity is more complex and region-specific than predicted by previous theories of emotion and the brain... - Nonstationary cluster-size inference with random field and permutation methodsSatoru Hayasaka
Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109-2029, USA
Neuroimage 22:676-87. 2004..We include a detailed and consolidated description of Worsley nonstationary RFT cluster-size test... - An examination of acute changes in serotonergic neurotransmission using the loudness dependence measure of auditory cortex evoked activity: effects of citalopram, escitalopram and sertralineValérie Guille
Biological Psychiatry Research Unit, Brain Sciences Institute, Swinburne University of Technology, Melbourne, Vic, Australia
Hum Psychopharmacol 23:231-41. 2008..The aim of this study was to assess the sensitivity of the LDAEP to acute augmentation in central serotonergic neurotransmission in humans... - Dopamine receptor stimulation does not modulate the loudness dependence of the auditory evoked potential in humansRodney J Croft
Brain Sciences Institute, Swinburne University of Technology, Melbourne, Australia
Psychopharmacology (Berl) 188:92-9. 2006..Although the findings suggest that the LDAEP may not be modulated by acute changes in dopamine neurotransmission, further studies are needed to fully characterize its dopaminergic sensitivity... - Acute serotonin and dopamine depletion improves attentional control: findings from the stroop taskKirsty E Scholes
Behavioural Neuroscience Laboratory, Department of Physiology, Monash Centre for Brain and Behavior, Monash University, Melbourne, Vic, Australia
Neuropsychopharmacology 32:1600-10. 2007..These findings enhance our understanding of the neurochemical basis of attentional control and the possible cause of attentional control deficits in schizophrenia... - Differential effects of acute serotonin and dopamine depletion on prepulse inhibition and p50 suppression measures of sensorimotor and sensory gating in humansCollette Mann
Behavioural Neuroscience Laboratory, School of Psychology, Psychiatry and Psychological Medicine, Monash University, Melbourne, Vic, Australia
Neuropsychopharmacology 33:1653-66. 2008.... - Neural correlates of traumatic recall in posttraumatic stress disorderIsrael Liberzon
Psychiatry Service, Ann Arbor Veterans Affairs Medical Center, MI 48109, USA
Stress 6:151-6. 2003....
Research Grants
- Neuro-Genetic Markers of SSRI Treatment Response in Social Anxiety DisorderK Luan Phan; Fiscal Year: 2007....