BETH PFLUG

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi request reprint Endothelin-1 promotes cell survival in renal cell carcinoma through the ET(A) receptor
    Beth R Pflug
    Department of Urology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Cancer Lett 246:139-48. 2007
  2. pmc Endothelin-1 inhibits apoptosis in prostate cancer
    Joel B Nelson
    Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15232, USA
    Neoplasia 7:631-7. 2005
  3. doi request reprint Longitudinal analysis of androgen deprivation of prostate cancer cells identifies pathways to androgen independence
    Jason M D'Antonio
    Program in Cellular and Molecular Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15232, USA
    Prostate 68:698-714. 2008
  4. ncbi request reprint Role of endothelin axis in progression to aggressive phenotype of prostate adenocarcinoma
    Geeta Godara
    Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Prostate 65:27-34. 2005
  5. ncbi request reprint Function and survival of dendritic cells depend on endothelin-1 and endothelin receptor autocrine loops
    Georgi Guruli
    Department of Urology, University of Pittsburgh School of Medicine, PA, USA
    Blood 104:2107-15. 2004
  6. ncbi request reprint Increased fatty acid synthase expression and activity during progression of prostate cancer in the TRAMP model
    Beth R Pflug
    University of Pittsburgh, Department of Urology, Pittsburgh, Pennsylvania 15232, USA
    Prostate 57:245-54. 2003
  7. ncbi request reprint Fatty acid synthase gene overexpression and copy number gain in prostate adenocarcinoma
    Uzma S Shah
    Department of Urology, University of Pittsburgh, PA 15232, USA
    Hum Pathol 37:401-9. 2006
  8. ncbi request reprint Distinct patterns of endothelin axis expression in primary prostate cancer
    Geeta Godara
    Department of Urology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15232, USA
    Urology 70:209-15. 2007
  9. ncbi request reprint Differential roles of peripheral and spinal endothelin receptors in the micturition reflex in rats
    Teruyuki Ogawa
    Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Urol 172:1533-7. 2004
  10. ncbi request reprint Endothelin A receptor blockade does not alter PSA secretion in prostate cancer cell lines
    Stefana Pecher
    Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15232, USA
    Prostate 60:175-7. 2004

Research Grants

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Endothelin-1 promotes cell survival in renal cell carcinoma through the ET(A) receptor
    Beth R Pflug
    Department of Urology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Cancer Lett 246:139-48. 2007
    ..Collectively, these data support the therapeutic targeting of the ET(A) receptor as a novel treatment strategy for RCC...
  2. pmc Endothelin-1 inhibits apoptosis in prostate cancer
    Joel B Nelson
    Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15232, USA
    Neoplasia 7:631-7. 2005
    ..These data support the combination of ET(A) antagonists and apoptosis-inducing therapies for prostate cancer treatment...
  3. doi request reprint Longitudinal analysis of androgen deprivation of prostate cancer cells identifies pathways to androgen independence
    Jason M D'Antonio
    Program in Cellular and Molecular Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15232, USA
    Prostate 68:698-714. 2008
    ..Following androgen ablation therapy, the majority of prostate cancer patients develop treatment resistance with a median time of 18-24 months to disease progression...
  4. ncbi request reprint Role of endothelin axis in progression to aggressive phenotype of prostate adenocarcinoma
    Geeta Godara
    Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Prostate 65:27-34. 2005
    ..We investigated endothelin receptor expression in increasingly aggressive phenotype and in vivo effects of combination therapy using ET(A) antagonist with paclitaxel...
  5. ncbi request reprint Function and survival of dendritic cells depend on endothelin-1 and endothelin receptor autocrine loops
    Georgi Guruli
    Department of Urology, University of Pittsburgh School of Medicine, PA, USA
    Blood 104:2107-15. 2004
    ..Therefore, ET-1/ETA/ETB autocrine/paracrine loops on DCs appear to be essential for the normal maturation and function of human DCs, presenting a unique target for immunomodulatory therapies...
  6. ncbi request reprint Increased fatty acid synthase expression and activity during progression of prostate cancer in the TRAMP model
    Beth R Pflug
    University of Pittsburgh, Department of Urology, Pittsburgh, Pennsylvania 15232, USA
    Prostate 57:245-54. 2003
    ..Sensitivity to FAS anti-metabolites was also analyzed in TRAMP prostate tumor cells and tissue to determine therapeutic potential of FAS inhibition in the treatment of prostate cancer...
  7. ncbi request reprint Fatty acid synthase gene overexpression and copy number gain in prostate adenocarcinoma
    Uzma S Shah
    Department of Urology, University of Pittsburgh, PA 15232, USA
    Hum Pathol 37:401-9. 2006
    ..These findings suggest that FASN gene copy number increases may be involved in the resultant increase in FASN protein expression observed in prostatic disease...
  8. ncbi request reprint Distinct patterns of endothelin axis expression in primary prostate cancer
    Geeta Godara
    Department of Urology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15232, USA
    Urology 70:209-15. 2007
    ..We examined ET axis expression in prostate cancer, prostatic intraepithelial neoplasia, and normal adjacent tissue and then analyzed the relationship of the protein levels with disease progression...
  9. ncbi request reprint Differential roles of peripheral and spinal endothelin receptors in the micturition reflex in rats
    Teruyuki Ogawa
    Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Urol 172:1533-7. 2004
    ..We investigated the effects of endothelin (ET) receptor activation in the bladder and the spinal cord on the micturition reflex in urethane anesthetized rats...
  10. ncbi request reprint Endothelin A receptor blockade does not alter PSA secretion in prostate cancer cell lines
    Stefana Pecher
    Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15232, USA
    Prostate 60:175-7. 2004
    ..It is our hypothesis that this decrease is due to anti-tumoral activity and not a reduction in PSA secretion at the cellular level...
  11. doi request reprint (Z)-1,1-Dichloro-2-(4-methoxyphenyl)-3-phenylcyclopropane induces concentration-dependent growth inhibition, apoptosis, and coordinates regulation of apoptotic genes in TRAMP cells
    Catherine A Thomas
    Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Urol Oncol 26:378-85. 2008
    ..2-(4-methoxyphenyl)-A(II) inhibits proliferation and induces apoptosis in the in vivo-adaptable TRAMP cells, suggesting the compound should be further examined in preclinical models...
  12. pmc Endothelin receptor A blockade enhances taxane effects in prostate cancer
    Ardavan Akhavan
    Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Neoplasia 8:725-32. 2006
    ..This study demonstrates ABT-627 to have additive antitumor effects when used in combination with taxane drugs both in vitro and in vivo...
  13. pmc Translocator protein blockade reduces prostate tumor growth
    Arlee Fafalios
    Department of Urology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Clin Cancer Res 15:6177-84. 2009
    ..The goal of our study was to examine the expression and biological relevance of TSPO in prostate cancer and show that the commonly prescribed benzodiazepine lorazepam, a ligand for TSPO, exhibits anticancer properties...
  14. pmc Therapeutic effects of endothelin-A receptor antagonist on bladder overactivity in rats with chronic spinal cord injury
    Teruyuki Ogawa
    Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Urology 71:341-5. 2008
    ..We investigated the effects of suppression of endothelin-A (ET(A)) receptors on bladder function and ET-1 levels in the bladder in rats with chronic spinal cord injury (SCI)...
  15. ncbi request reprint Stat3 enhances the growth of LNCaP human prostate cancer cells in intact and castrated male nude mice
    Fernando DeMiguel
    Department of Urology and Cancer Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Prostate 52:123-9. 2002
    ..Stat3, a member of the family of signal transducers and activators of transcription, is activated in numerous cancers, including prostate. This study is to investigate the role of Stat3 activation in the growth of prostate cancer cells...

Research Grants4

  1. Fatty Acid Synthase in Prostate Tumorigenesis
    BETH PFLUG; Fiscal Year: 2007
    ....