Michael Pezzone

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi A model of neural cross-talk and irritation in the pelvis: implications for the overlap of chronic pelvic pain disorders
    Michael A Pezzone
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA
    Gastroenterology 128:1953-64. 2005
  2. ncbi Cross-talk and sensitization of bladder afferent nerves
    Elena E Ustinova
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Neurourol Urodyn 29:77-81. 2010
  3. ncbi Sensitization of pelvic nerve afferents and mast cell infiltration in the urinary bladder following chronic colonic irritation is mediated by neuropeptides
    Elena E Ustinova
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Pittsburgh School of Medicine, Pennsylvania, USA
    Am J Physiol Renal Physiol 292:F123-30. 2007
  4. ncbi Colonic irritation in the rat sensitizes urinary bladder afferents to mechanical and chemical stimuli: an afferent origin of pelvic organ cross-sensitization
    Elena E Ustinova
    Division of Gastroenterology, Hepatology, and Nutrition, Univ. of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Am J Physiol Renal Physiol 290:F1478-87. 2006
  5. ncbi Convergence of bladder and colon sensory innervation occurs at the primary afferent level
    Julie A Christianson
    Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Pain 128:235-43. 2007
  6. ncbi Tyrphostin AG 126 inhibits development of postoperative ileus induced by surgical manipulation of murine colon
    Beverley A Moore
    Department of Medicine, Division of Gastroenterology, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
    Am J Physiol Gastrointest Liver Physiol 286:G214-24. 2004
  7. ncbi Mechanisms of polymicrobial sepsis-induced ileus
    Marcus Overhaus
    Department of Medicine, Division of Gastroenterology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15261, USA
    Am J Physiol Gastrointest Liver Physiol 287:G685-94. 2004
  8. ncbi Enhanced expression of mast cell growth factor and mast cell activation in the bladder following the resolution of trinitrobenzenesulfonic acid (TNBS) colitis in female rats
    Ruomei Liang
    Department of Medicine, Division of Gastroenterology, Hepatology, and Nutrition, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Neurourol Urodyn 26:887-93. 2007

Research Grants

  1. NEUROIMMUNE MECHANISMS OF VISCERAL HYPERALGESIA
    Michael Pezzone; Fiscal Year: 2003
  2. Neuroimmune Mechanisms of Visceral Pain
    Michael Pezzone; Fiscal Year: 2005
  3. Neurogenic Pathogenesis of Interstitial Cystitis
    Michael Pezzone; Fiscal Year: 2007

Collaborators

  • A J Bauer
  • M Overhaus
  • Elena E Ustinova
  • Matthew O Fraser
  • Ruomei Liang
  • Dmitriy W Gutkin
  • Julie A Christianson
  • Beverley A Moore
  • Brian M Davis
  • Radhika Patnam
  • Jennifer Grandis
  • Kevin Dyer

Detail Information

Publications9

  1. ncbi A model of neural cross-talk and irritation in the pelvis: implications for the overlap of chronic pelvic pain disorders
    Michael A Pezzone
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA
    Gastroenterology 128:1953-64. 2005
    ..We investigated the hypothesis that afferent irritation of one pelvic organ may adversely influence and sensitize another via neural interactions...
  2. ncbi Cross-talk and sensitization of bladder afferent nerves
    Elena E Ustinova
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Neurourol Urodyn 29:77-81. 2010
    ..Prolonged pelvic sensitization as mediated by these convergent and antidromic reflexive pathway may likewise lead to chronic pelvic pain and thus the overlap of chronic pelvic pain disorders...
  3. ncbi Sensitization of pelvic nerve afferents and mast cell infiltration in the urinary bladder following chronic colonic irritation is mediated by neuropeptides
    Elena E Ustinova
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Pittsburgh School of Medicine, Pennsylvania, USA
    Am J Physiol Renal Physiol 292:F123-30. 2007
    ..Depletion of neuropeptides from sensory afferents diminishes these effects, suggesting they play an important role...
  4. ncbi Colonic irritation in the rat sensitizes urinary bladder afferents to mechanical and chemical stimuli: an afferent origin of pelvic organ cross-sensitization
    Elena E Ustinova
    Division of Gastroenterology, Hepatology, and Nutrition, Univ. of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Am J Physiol Renal Physiol 290:F1478-87. 2006
    ..Interruption of the neural input to the bladder minimized this effect, suggesting a local afferent pathway from the colon. Thus, the overlap of CPP disorders may be a consequence of pelvic afferent cross-sensitization...
  5. ncbi Convergence of bladder and colon sensory innervation occurs at the primary afferent level
    Julie A Christianson
    Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Pain 128:235-43. 2007
    ....
  6. ncbi Tyrphostin AG 126 inhibits development of postoperative ileus induced by surgical manipulation of murine colon
    Beverley A Moore
    Department of Medicine, Division of Gastroenterology, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
    Am J Physiol Gastrointest Liver Physiol 286:G214-24. 2004
    ..These data demonstrate for the first time that inhibition of PTK activity may represent a novel approach for management of ileus in the clinical setting...
  7. ncbi Mechanisms of polymicrobial sepsis-induced ileus
    Marcus Overhaus
    Department of Medicine, Division of Gastroenterology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15261, USA
    Am J Physiol Gastrointest Liver Physiol 287:G685-94. 2004
    ....
  8. ncbi Enhanced expression of mast cell growth factor and mast cell activation in the bladder following the resolution of trinitrobenzenesulfonic acid (TNBS) colitis in female rats
    Ruomei Liang
    Department of Medicine, Division of Gastroenterology, Hepatology, and Nutrition, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Neurourol Urodyn 26:887-93. 2007
    ..We hypothesize that with time, colonic irritation can lead to neurogenic changes in the bladder and the development of chronic bladder sensitization...

Research Grants7

  1. NEUROIMMUNE MECHANISMS OF VISCERAL HYPERALGESIA
    Michael Pezzone; Fiscal Year: 2003
    ..abstract_text> ..
  2. Neuroimmune Mechanisms of Visceral Pain
    Michael Pezzone; Fiscal Year: 2005
    ..The aims of this project will be addressing several highly clinically relevant areas involving colonic sensory and motor function and will utilize physiological, electrophysiological, and molecular techniques. ..
  3. Neurogenic Pathogenesis of Interstitial Cystitis
    Michael Pezzone; Fiscal Year: 2007
    ..The studies proposed in this application will attempt to shed more light on the overlap and etiology of chronic pelvic pain syndromes and the role of cross-organ, afferent sensitization. ..