LARYSA HALYNA PEVNY

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. ncbi request reprint The stem-cell menagerie
    Larysa Pevny
    Department of Genetics, Neuroscience Center, University of North Carolina, Chapel Hill, NC 27599, USA
    Trends Neurosci 26:351-9. 2003
  2. doi request reprint Sox2 roles in neural stem cells
    Larysa H Pevny
    Department of Genetics, University of North Carolina Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Int J Biochem Cell Biol 42:421-4. 2010
  3. ncbi request reprint SOX genes and neural progenitor identity
    Larysa Pevny
    Department of Genetics, Neuroscience Center, University of North Carolina CB 7264, 103 Mason Farm Road, Chapel Hill, North Carolina, NC 27599, USA
    Curr Opin Neurobiol 15:7-13. 2005
  4. pmc Correction of factor IX deficiency in mice by embryonic stem cells differentiated in vitro
    Jeffrey H Fair
    Department of Surgery, University of North Carolina, Chapel Hill, NC 27599, USA
    Proc Natl Acad Sci U S A 102:2958-63. 2005
  5. ncbi request reprint SOX2, a persistent marker for multipotential neural stem cells derived from embryonic stem cells, the embryo or the adult
    Pam Ellis
    Neuroscience Center, Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA
    Dev Neurosci 26:148-65. 2004
  6. ncbi request reprint SOX2 functions to maintain neural progenitor identity
    Victoria Graham
    Neuroscience Center, Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA
    Neuron 39:749-65. 2003
  7. ncbi request reprint Induction of hepatic differentiation in embryonic stem cells by co-culture with embryonic cardiac mesoderm
    Jeffrey H Fair
    Department of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Surgery 134:189-96. 2003
  8. pmc Nap1-regulated neuronal cytoskeletal dynamics is essential for the final differentiation of neurons in cerebral cortex
    Yukako Yokota
    UNC Neuroscience Center, Department of Cell and Molecular Physiology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    Neuron 54:429-45. 2007
  9. pmc Proliferative and transcriptional identity of distinct classes of neural precursors in the mammalian olfactory epithelium
    Eric S Tucker
    Department of Cell and Molecular Physiology, University of North Carolina at Chapel Hill, NC 27599, USA
    Development 137:2471-81. 2010
  10. ncbi request reprint "Runx"ing towards sensory differentiation
    Jian Zhong
    UNC Neuroscience Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Neuron 49:325-7. 2006

Collaborators

Detail Information

Publications11

  1. ncbi request reprint The stem-cell menagerie
    Larysa Pevny
    Department of Genetics, Neuroscience Center, University of North Carolina, Chapel Hill, NC 27599, USA
    Trends Neurosci 26:351-9. 2003
    ....
  2. doi request reprint Sox2 roles in neural stem cells
    Larysa H Pevny
    Department of Genetics, University of North Carolina Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Int J Biochem Cell Biol 42:421-4. 2010
    ..In both systems, Sox2 action is markedly dose-dependent, and downstream-target gene studies are beginning to reveal the mechanisms of Sox2 function...
  3. ncbi request reprint SOX genes and neural progenitor identity
    Larysa Pevny
    Department of Genetics, Neuroscience Center, University of North Carolina CB 7264, 103 Mason Farm Road, Chapel Hill, North Carolina, NC 27599, USA
    Curr Opin Neurobiol 15:7-13. 2005
    ....
  4. pmc Correction of factor IX deficiency in mice by embryonic stem cells differentiated in vitro
    Jeffrey H Fair
    Department of Surgery, University of North Carolina, Chapel Hill, NC 27599, USA
    Proc Natl Acad Sci U S A 102:2958-63. 2005
    ..The PEP engraftment was not associated with detectable cell fusion, and the transplantation was accompanied with only a low incidence of teratoma formation...
  5. ncbi request reprint SOX2, a persistent marker for multipotential neural stem cells derived from embryonic stem cells, the embryo or the adult
    Pam Ellis
    Neuroscience Center, Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA
    Dev Neurosci 26:148-65. 2004
    ..These studies demonstrate that SOX2 may meet the requirements of a universal neural stem cell marker and provides a means to identify cells which fulfill the basic criteria of a stem cell: self-renewal and multipotent differentiation...
  6. ncbi request reprint SOX2 functions to maintain neural progenitor identity
    Victoria Graham
    Neuroscience Center, Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA
    Neuron 39:749-65. 2003
    ..Taken together, these data indicate that SOXB1 signaling is both necessary and sufficient to maintain panneural properties of neural progenitor cells...
  7. ncbi request reprint Induction of hepatic differentiation in embryonic stem cells by co-culture with embryonic cardiac mesoderm
    Jeffrey H Fair
    Department of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Surgery 134:189-96. 2003
    ....
  8. pmc Nap1-regulated neuronal cytoskeletal dynamics is essential for the final differentiation of neurons in cerebral cortex
    Yukako Yokota
    UNC Neuroscience Center, Department of Cell and Molecular Physiology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    Neuron 54:429-45. 2007
    ..Thus, Nap1 plays an essential role in facilitating neuronal cytoskeletal changes underlying the postmigratory differentiation of cortical neurons, a critical step in functional wiring of the cortex...
  9. pmc Proliferative and transcriptional identity of distinct classes of neural precursors in the mammalian olfactory epithelium
    Eric S Tucker
    Department of Cell and Molecular Physiology, University of North Carolina at Chapel Hill, NC 27599, USA
    Development 137:2471-81. 2010
    ....
  10. ncbi request reprint "Runx"ing towards sensory differentiation
    Jian Zhong
    UNC Neuroscience Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Neuron 49:325-7. 2006
    ..These findings emphasize the importance of intrinsic genetic programs in generating the diversity of DRG neurons and specifying the circuits into which they incorporate...
  11. pmc The role of neuregulin-ErbB4 interactions on the proliferation and organization of cells in the subventricular zone
    H T Ghashghaei
    University of North Carolina Neuroscience Center and the Department of Cell and Molecular Physiology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    Proc Natl Acad Sci U S A 103:1930-5. 2006
    ..Furthermore, these studies identify NRG2 as a factor capable of promoting SVZ proliferation, leading to the formation of new neurons in vivo...

Research Grants14

  1. SOX2 is a dose-dependent regulator of retinal neural progenitor competence
    Larysa Pevny; Fiscal Year: 2009
    ..PUBLIC HEALTH REVELANCE: We will utilize mouse genetic tools and cellular assays to dissect the molecular mechanisms affected by the expression levels of SOX2 in retinal progenitors. ..
  2. SOX2 is a dose-dependent regulator of retinal neural progenitor competence
    LARYSA HALYNA PEVNY; Fiscal Year: 2010
    ..PUBLIC HEALTH REVELANCE: We will utilize mouse genetic tools and cellular assays to dissect the molecular mechanisms affected by the expression levels of SOX2 in retinal progenitors. ..
  3. Selective Ablation of SOX-2 Expressing Neural Stem Cells
    Larysa Pevny; Fiscal Year: 2009
    ..Understanding the origin, fate and function of NSCs will advance efforts to manipulate NSCs for therapeutic purposes. ..
  4. Selective Ablation of SOX-2 Expressing Neural Stem Cells
    Larysa Pevny; Fiscal Year: 2007
    ..Understanding the origin, fate and function of NSCs will advance efforts to manipulate NSCs for therapeutic purposes. ..
  5. Role of SOX-B1 Factors in Neural Development
    Larysa Pevny; Fiscal Year: 2006
    ..Only through a thorough understanding of the cellular and molecular mechanisms will researchers be able to efficiently direct stem cell differentiation into specific cell types needed for transplantation. ..
  6. Selective Ablation of SOX-2 Expressing Neural Stem Cells
    LARYSA HALYNA PEVNY; Fiscal Year: 2010
    ..Understanding the origin, fate and function of NSCs will advance efforts to manipulate NSCs for therapeutic purposes. ..