H M Pettinati

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi request reprint Double-blind clinical trial of sertraline treatment for alcohol dependence
    H M Pettinati
    Center for the Study of Addictions, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, USA
    J Clin Psychopharmacol 21:143-53. 2001
  2. ncbi request reprint The status of naltrexone in the treatment of alcohol dependence: specific effects on heavy drinking
    Helen M Pettinati
    Center for the Study of Addictions, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6178, USA
    J Clin Psychopharmacol 26:610-25. 2006
  3. ncbi request reprint Choosing the right medication for the treatment of alcoholism
    Helen M Pettinati
    Department of Psychiatry, University of Pennsylvania, Treatment Research Center, 3900 Chestnut Street, Philadelphia, PA 19104 6178, USA
    Curr Psychiatry Rep 8:383-8. 2006
  4. pmc A double blind, placebo-controlled trial that combines disulfiram and naltrexone for treating co-occurring cocaine and alcohol dependence
    Helen M Pettinati
    Center for the Study of Addictions, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Addict Behav 33:651-67. 2008
  5. pmc Gender differences with high-dose naltrexone in patients with co-occurring cocaine and alcohol dependence
    Helen M Pettinati
    Department of Psychiatry, Center for the Study of Addictions, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Subst Abuse Treat 34:378-90. 2008
  6. ncbi request reprint Antidepressant treatment of co-occurring depression and alcohol dependence
    Helen M Pettinati
    Pennsylvania Veterans Affairs Center for the Studies of Addiction, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6178, USA
    Biol Psychiatry 56:785-92. 2004
  7. ncbi request reprint Gender differences in response to sertraline pharmacotherapy in Type A alcohol dependence
    Helen M Pettinati
    Center for the Study of Addictions, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Am J Addict 13:236-47. 2004
  8. pmc Effect of extended-release naltrexone (XR-NTX) on quality of life in alcohol-dependent patients
    Helen M Pettinati
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Alcohol Clin Exp Res 33:350-6. 2009
  9. pmc A double-blind, placebo-controlled trial combining sertraline and naltrexone for treating co-occurring depression and alcohol dependence
    Helen M Pettinati
    Center for the Studies of Addiction, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, USA
    Am J Psychiatry 167:668-75. 2010
  10. doi request reprint Efficacy of extended-release naltrexone in patients with relatively higher severity of alcohol dependence
    Helen M Pettinati
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Alcohol Clin Exp Res 35:1804-11. 2011

Research Grants

  1. BEHAVIORAL SUPPORT WITH PHARMACOTHERAPY FOR ALCOHOLICS
    Helen Pettinati; Fiscal Year: 2004
  2. SERTRALINE FOR ALCOHOL DEPENDENCE AND DEPRESSION
    Helen Pettinati; Fiscal Year: 2003
  3. INNOVATIVE APPROACHES FOR COCAINE PHARMACOTHERAPY
    Helen Pettinati; Fiscal Year: 2007

Detail Information

Publications54

  1. ncbi request reprint Double-blind clinical trial of sertraline treatment for alcohol dependence
    H M Pettinati
    Center for the Study of Addictions, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, USA
    J Clin Psychopharmacol 21:143-53. 2001
    ....
  2. ncbi request reprint The status of naltrexone in the treatment of alcohol dependence: specific effects on heavy drinking
    Helen M Pettinati
    Center for the Study of Addictions, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6178, USA
    J Clin Psychopharmacol 26:610-25. 2006
    ..Clinical trial results in this article are evaluated by the type of outcome measure used to determine naltrexone's treatment advantage, that is, measures related to reducing heavy drinking versus those related to increasing abstinence...
  3. ncbi request reprint Choosing the right medication for the treatment of alcoholism
    Helen M Pettinati
    Department of Psychiatry, University of Pennsylvania, Treatment Research Center, 3900 Chestnut Street, Philadelphia, PA 19104 6178, USA
    Curr Psychiatry Rep 8:383-8. 2006
    ..This report reviews the latest innovations in pharmacotherapy for the treatment of alcohol dependence, focusing on FDA-approved medications presently available to the treatment community...
  4. pmc A double blind, placebo-controlled trial that combines disulfiram and naltrexone for treating co-occurring cocaine and alcohol dependence
    Helen M Pettinati
    Center for the Study of Addictions, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Addict Behav 33:651-67. 2008
    ..This is a double blind, placebo-controlled trial that evaluated the efficacy of disulfiram, naltrexone and their combination in patients with co-occurring cocaine and alcohol dependence...
  5. pmc Gender differences with high-dose naltrexone in patients with co-occurring cocaine and alcohol dependence
    Helen M Pettinati
    Department of Psychiatry, Center for the Study of Addictions, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Subst Abuse Treat 34:378-90. 2008
    ..Thus, 150 mg/day naltrexone added to a psychosocial treatment resulted in reductions in cocaine and alcohol use and drug severity in men, compared to higher rates of cocaine and alcohol use and drug severity in women...
  6. ncbi request reprint Antidepressant treatment of co-occurring depression and alcohol dependence
    Helen M Pettinati
    Pennsylvania Veterans Affairs Center for the Studies of Addiction, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6178, USA
    Biol Psychiatry 56:785-92. 2004
    ....
  7. ncbi request reprint Gender differences in response to sertraline pharmacotherapy in Type A alcohol dependence
    Helen M Pettinati
    Center for the Study of Addictions, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Am J Addict 13:236-47. 2004
    ..There were no significant differences in drinking with sertraline compared to placebo in Type B alcoholic men or women...
  8. pmc Effect of extended-release naltrexone (XR-NTX) on quality of life in alcohol-dependent patients
    Helen M Pettinati
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Alcohol Clin Exp Res 33:350-6. 2009
    ..2005). A 24-week, randomized, double-blind, placebo-controlled study established the efficacy and safety of XR-NTX in this patient population. In this report, the effect of XR-NTX on quality of life (QOL) was examined...
  9. pmc A double-blind, placebo-controlled trial combining sertraline and naltrexone for treating co-occurring depression and alcohol dependence
    Helen M Pettinati
    Center for the Studies of Addiction, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, USA
    Am J Psychiatry 167:668-75. 2010
    ....
  10. doi request reprint Efficacy of extended-release naltrexone in patients with relatively higher severity of alcohol dependence
    Helen M Pettinati
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Alcohol Clin Exp Res 35:1804-11. 2011
    ....
  11. ncbi request reprint The effects of naltrexone on alcohol and cocaine use in dually addicted patients
    D W Oslin
    Department of Psychiatry, University of Pennsylvania, Philadelphia, USA
    J Subst Abuse Treat 16:163-7. 1999
    ..The results of this study provide a rationale for a double-blind placebo-controlled study of the efficacy of naltrexone in this difficult to treat but prevalent population...
  12. ncbi request reprint Sertraline treatment for alcohol dependence: interactive effects of medication and alcoholic subtype
    H M Pettinati
    Center for the Study of Addictions, Department of Psychiatry, University of Pennsylvania School of Medicine, and the Philadelphia Veterans Affairs Medical Center, 19104 6178, USA
    Alcohol Clin Exp Res 24:1041-9. 2000
    ..e., those with lower risk/severity of alcoholism and psychopathology. The aim of the present study was to explore the validity of differential responding by alcohol-dependent subtypes using the serotonin reuptake inhibitor, sertraline...
  13. ncbi request reprint Psychometric properties of the Penn Alcohol Craving Scale
    B A Flannery
    Department of Psychiatry, University of Pennsylvania, Philadelphia 19104, USA
    Alcohol Clin Exp Res 23:1289-95. 1999
    ..Each question is scaled from 0 to 6...
  14. pmc Predictors of treatment outcome in outpatient cocaine and alcohol dependence treatment
    Jamshid Ahmadi
    Treatment Research Center, Department of Psychiatry, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA jamshid
    Am J Addict 18:81-6. 2009
    ..Initial UDS results and CSSA scores are very useful predictors of treatment outcome and could be used as stratifying variables in outpatient cocaine and alcohol medication trials...
  15. ncbi request reprint The relationship of Axis II personality disorders to other known predictors of addiction treatment outcome
    H M Pettinati
    Department of Psychiatry, University of Pennsylvania, Philadelphia, USA
    Am J Addict 8:136-47. 1999
    ..These findings highlighted the importance of the interrelationship of the relative prognostic value of three known predictors of addiction treatment...
  16. ncbi request reprint The use of selective serotonin reuptake inhibitors in treating alcoholic subtypes
    H M Pettinati
    Center for the Study of Addictions, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia Veterans Affairs Medical Center, USA
    J Clin Psychiatry 62:26-31. 2001
    ..Information from these studies is promising, suggesting the need for further investigation...
  17. pmc The therapeutic alliance in medical-based interventions impacts outcome in treating alcohol dependence
    W D Dundon
    Center for the Studies of Addiction, Department of Psychiatry, University of Pennsylvania School of Medicine, 3900 Chestnut Street, Philadelphia, PA 19104 6178, USA
    Drug Alcohol Depend 95:230-6. 2008
    ..The absence of other effects underscores the need for further research...
  18. ncbi request reprint Gender and psychiatric comorbidity: impact on clinical presentation of alcohol dependence
    H M Pettinati
    Department of Psychiatry, University of Pennsylvania, Philadelphia 19104, USA
    Am J Addict 9:242-52. 2000
    ..All with current comorbidity, irrespective of gender, reported more days of heavy drinking than other groups. When evaluating drinking status, gender and comorbidity should be considered...
  19. ncbi request reprint Sertraline treatment of co-occurring alcohol dependence and major depression
    Henry R Kranzler
    Department of Psychiatry, University of Connecticut School of Medicine, Farmington, CT 06030 2103, USA
    J Clin Psychopharmacol 26:13-20. 2006
    ..This multicenter, double-blind, placebo-controlled trial of sertraline was designed to address many of the potential methodological shortcomings of studies of co-occurring disorders...
  20. doi request reprint Genetic association analyses of PDYN polymorphisms with heroin and cocaine addiction
    T K Clarke
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, 125 South 31st Street, Philadelphia, PA 19104, USA
    Genes Brain Behav 11:415-23. 2012
    ..These data show that polymorphisms in PDYN are associated with opioid addiction in EAs and provide further evidence that these risk variants may be more relevant in females...
  21. ncbi request reprint Predicting treatment response to naltrexone: the influence of craving and family history
    J R Monterosso
    Center for the Study of Addictions, Department of Psychiatry, University of Pennsylvania, Philadelphia, Philadelphia Veteran Affairs Medical Center, USA
    Am J Addict 10:258-68. 2001
    ..05). In both cases, the interaction was in the predicted direction. These data suggest that patients with high levels of alcohol craving or a strong family history of alcoholism are more likely to benefit from naltrexone treatment...
  22. ncbi request reprint The effectiveness of telephone-based continuing care in the clinical management of alcohol and cocaine use disorders: 12-month outcomes
    James R McKay
    Department of Psychiatry, University of Pennsylvania, Treatment Research Center, 3900 Chestnut Street, Philadelphia, PA 19104, USA
    J Consult Clin Psychol 72:967-79. 2004
    ..However, in participants with alcohol dependence only (n = 91), TEL produced better alcohol use outcomes than STND on all measures examined and better outcomes than RP on some of the measures...
  23. doi request reprint A placebo-controlled randomized clinical trial of naltrexone in the context of different levels of psychosocial intervention
    David W Oslin
    Center for the Study of Addictions, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Alcohol Clin Exp Res 32:1299-308. 2008
    ....
  24. pmc Genetic variants in the cocaine- and amphetamine-regulated transcript gene (CARTPT) and cocaine dependence
    Falk W Lohoff
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Neurosci Lett 440:280-3. 2008
    ....
  25. pmc Association between the catechol-O-methyltransferase Val158Met polymorphism and cocaine dependence
    Falk W Lohoff
    Department of Psychiatry, Translational Research Laboratories, Center for Neurobiology and Behavior, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 33:3078-84. 2008
    ..Additional studies are required to elucidate the role of COMT in the pathophysiology of substance use disorders...
  26. pmc A double-blind, placebo-controlled pilot trial of acamprosate for the treatment of cocaine dependence
    Kyle M Kampman
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
    Addict Behav 36:217-21. 2011
    ..Therefore, we conducted a double-blind placebo-controlled pilot trial of acamprosate for the treatment of cocaine dependence...
  27. pmc Combined effects of alcohol and hepatitis C: a secondary analysis of alcohol use biomarkers and high-risk behaviors from two medication trials for alcohol dependence
    Jennifer G Plebani
    Center for the Study of Addictions, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, United States address
    Addict Behav 35:123-8. 2010
    ..In addition, the relationship between Hepatitis C virus (HCV) infection and behavioral risk factors for HCV infection in these clinical populations were examined...
  28. pmc Gender differences in predictors of treatment attrition with high dose naltrexone in cocaine and alcohol dependence
    Jesse J Suh
    Center for Studies of Addiction, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA Suh
    Am J Addict 17:463-8. 2008
    ..Further research on the impact of pre-treatment and in-treatment gender differences with naltrexone is warranted...
  29. pmc Initiating acamprosate within-detoxification versus post-detoxification in the treatment of alcohol dependence
    Kyle M Kampman
    Department of Psychiatry, University of Pennsylvania School of Medicine, 3900, Chestnut Street, Philadelphia, PA 19104, USA
    Addict Behav 34:581-6. 2009
    ..This trial compared the efficacy of acamprosate, started at the beginning of detoxification, to acamprosate started at the completion of detoxification, in the treatment of alcohol dependence...
  30. pmc Association analysis between polymorphisms in the conserved dopamine neurotrophic factor (CDNF) gene and cocaine dependence
    Falk W Lohoff
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Neurosci Lett 453:199-203. 2009
    ..However, additional studies using larger sample sizes, comprehensive SNP coverage, and clinically homogenous populations are necessary before confidently excluding CDNF as a significant genetic risk factor for cocaine dependence...
  31. doi request reprint Association analysis between polymorphisms in the dopamine D2 receptor (DRD2) and dopamine transporter (DAT1) genes with cocaine dependence
    Falk W Lohoff
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Neurosci Lett 473:87-91. 2010
    ..However, additional studies using larger sample sizes and clinically homogenous populations are necessary before confidently excluding these variants as contributing genetic risk factors for CD...
  32. pmc A double-blind, placebo-controlled pilot trial of quetiapine for the treatment of Type A and Type B alcoholism
    Kyle M Kampman
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Clin Psychopharmacol 27:344-51. 2007
    ..Quetiapine is an atypical antipsychotic with a favorable side effect profile, and may be a promising medication for the treatment of alcohol dependence, particularly Type B alcoholism...
  33. pmc Treatment outcomes in type A and B alcohol dependence 6 months after serotonergic pharmacotherapy
    William Dundon
    Center for the Studies of Addiction, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6178, USA
    Alcohol Clin Exp Res 28:1065-73. 2004
    ..The purpose of this study was to assess in this original study group whether treatment gains in the type A alcoholics were maintained or whether treatment outcomes changed for the type B alcoholics after discontinuing pharmacotherapy...
  34. ncbi request reprint Patient attitudes toward treatment predict attendance in clinical pharmacotherapy trials of alcohol and drug treatment
    Helen M Pettinati
    Center for the Study of Addictions, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Am J Addict 12:324-35. 2003
    ..e., were more favorable on four of five of attitudinal dimensions. Thus, patient attitudes toward treatment may be useful in identifying areas that limit or improve treatment attendance...
  35. ncbi request reprint Cocaine dependence severity predicts outcome in outpatient detoxification from cocaine and alcohol
    Kyle M Kampman
    Department of Psychiatry, University of Pennsylvania School of Medicine, Treatment Research Center, 3900 Chestnut Street, Philadelphia, PA 19104, USA
    Am J Addict 13:74-82. 2004
    ..Among cocaine- and alcohol-dependent subjects, cocaine dependence severity appears to be a more important predictor of detoxification success than alcohol dependence severity...
  36. ncbi request reprint A double-blind, placebo-controlled trial of modafinil for cocaine dependence
    Charles A Dackis
    University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Neuropsychopharmacology 30:205-11. 2005
    ..This study provides preliminary evidence, which should be confirmed by a larger study, that modafinil improves clinical outcome when combined with psychosocial treatment for cocaine dependence...
  37. ncbi request reprint Priority actions to improve the care of persons with co-occurring substance abuse and other mental disorders: a call to action
    CHARLES P O'BRIEN
    Department of Psychiatry, University of Pennsylvania School of Medicine, 3900 Chestnut Street, Philadelphia, PA 19104 6178, USA
    Biol Psychiatry 56:703-13. 2004
  38. ncbi request reprint Do patient characteristics and initial progress in treatment moderate the effectiveness of telephone-based continuing care for substance use disorders?
    James R McKay
    University of Pennsylvania, Treatment Research Center, Philadelphia, PA 19104, USA
    Addiction 100:216-26. 2005
    ..To determine whether substance use severity, psychiatric severity, social support, self-help attendance or motivation moderated substance use outcomes in a telephone-based continuing care intervention...
  39. ncbi request reprint The effectiveness of telephone-based continuing care for alcohol and cocaine dependence: 24-month outcomes
    James R McKay
    Department of Psychiatry, University of Pennsylvania, Philadelphia 19104, USA
    Arch Gen Psychiatry 62:199-207. 2005
    ....
  40. ncbi request reprint Carbohydrate-deficient transferrin levels reflect heavy drinking in alcohol-dependent women seeking treatment
    Margaret R Rukstalis
    Center for the Study of Addictions, Department of Psychiatry, University of Pennsylvania, and Philadelphia Medical Center for Veteran Affairs, Philadelphia Pennsylvania 19104, USA
    Alcohol Clin Exp Res 26:1539-44. 2002
    ..The study also examined the extent that E2 levels mediated the relationship between CDT levels and heavy drinking in the alcohol-dependent women...
  41. ncbi request reprint The status of disulfiram: a half of a century later
    Jesse J Suh
    Treatment Research Center, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Clin Psychopharmacol 26:290-302. 2006
    ..Preliminary evidence also suggests that disulfiram treatment could be a viable treatment for cocaine dependence because it was shown to reduce cocaine use among nonalcoholic, cocaine-dependent patients...
  42. ncbi request reprint An examination of potential sex and race effects in a study of continuing care for alcohol- and cocaine-dependent patients
    James R McKay
    Treatment Research Center, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6178, USA
    Alcohol Clin Exp Res 27:1321-3. 2003
  43. pmc Case-control association analysis of polymorphisms in the delta-opioid receptor, OPRD1, with cocaine and opioid addicted populations
    R C Crist
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Drug Alcohol Depend 127:122-8. 2013
    ..The MOR, however, interacts with and is regulated by many known MOR interacting proteins (MORIPs), including the δ-opioid receptor (DOR)...
  44. ncbi request reprint The status of serotonin-selective pharmacotherapy in the treatment of alcohol dependence
    Helen M Pettinati
    Center for the Study of Addictions, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Recent Dev Alcohol 16:247-62. 2003
    ..This chapter will discuss the usefulness of 5-HT-selective pharmacotherapy in treating alcohol dependence and will provide both historical and current perspectives on its use...
  45. ncbi request reprint Efficacy and tolerability of long-acting injectable naltrexone for alcohol dependence: a randomized controlled trial
    James C Garbutt
    Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill 27599 7160, USA
    JAMA 293:1617-25. 2005
    ..However, adherence to daily oral pharmacotherapy can be problematic, and clinical acceptance and utility of oral naltrexone have been limited...
  46. ncbi request reprint Relation of depression diagnoses to 2-year outcomes in cocaine-dependent patients in a randomized continuing care study
    James R McKay
    Department of Psychiatry, University of Pennsylvania, and Veterans Affairs Medical Center, Philadelphia 19104, USA
    Psychol Addict Behav 16:225-35. 2002
    ..The best alcohol outcomes were obtained in nondepressed patients who received RP. The results suggest that extended continuing care treatment may be warranted for cocaine-dependent patients with co-occurring depressive disorders...
  47. ncbi request reprint Inpatient alcohol treatment in a private healthcare setting: which patients benefit and at what cost?
    H M Pettinati
    Department of Psychiatry, University of Pennsylvania, Philadelphia 19104 6178, USA
    Am J Addict 8:220-33. 1999
    ..The gap between inpatient and outpatient costs was also reduced when computed as a cost-effectiveness ratio, although treatment costs continued to remain proportionally higher with inpatient than outpatient treatment...
  48. ncbi request reprint Reduction in heavy drinking as a treatment outcome in alcohol dependence
    David R Gastfriend
    Alkermes, Cambridge, MA, USA
    J Subst Abuse Treat 33:71-80. 2007
    ....
  49. doi request reprint Improvement of physical health and quality of life of alcohol-dependent individuals with topiramate treatment: US multisite randomized controlled trial
    Bankole A Johnson
    Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, VA 22908 0623, USA
    Arch Intern Med 168:1188-99. 2008
    ..We sought to determine whether topiramate's antidrinking effects are bolstered by improvements in physical and psychosocial well-being...
  50. ncbi request reprint Early treatment response in alcohol dependence with extended-release naltrexone
    Domenic A Ciraulo
    Division of Psychiatry, Boston University School of Medicine, Boston, MA 02118 2393, USA
    J Clin Psychiatry 69:190-5. 2008
    ..We sought to determine the time course for onset of effect of intramuscular injectable extended-release naltrexone (XR-NTX), which has demonstrated efficacy for alcohol dependence...
  51. ncbi request reprint Combined pharmacotherapies and behavioral interventions for alcohol dependence: the COMBINE study: a randomized controlled trial
    Raymond F Anton
    Center for Drug and Alcohol Programs, Medical University of South Carolina, Charleston 29425, USA
    JAMA 295:2003-17. 2006
    ..Alcohol dependence treatment may include medications, behavioral therapies, or both. It is unknown how combining these treatments may impact their effectiveness, especially in the context of primary care and other nonspecialty settings...
  52. pmc Cost and cost-effectiveness of the COMBINE study in alcohol-dependent patients
    Gary A Zarkin
    RTI International, 3040 Cornwallis Rd, Research Triangle Park, NC 27709, USA
    Arch Gen Psychiatry 65:1214-21. 2008
    ..The costs and cost-effectiveness of these combinations are unknown and of interest to clinicians and policy makers...
  53. ncbi request reprint Using acquired knowledge and new technologies in alcoholism treatment trials
    Barbara A Flannery
    Center for Interdisciplinary Substance Abuse Research, RTI International, PO Box 12194, 3040 Cornwallis Road, Research Triangle Park, NC 27709 2194, USA
    Alcohol Clin Exp Res 26:423-9. 2002
    ..Flannery; (4) What should be the primary outcome measures in a clinical trial, by Damaris J. Rohsenow; (5) Innovative strategies for assessing functional outcomes in alcoholism treatment clinical trials, by Ron A. Cisler...
  54. ncbi request reprint Letter to the editor in regard to Timko, DeBenedetti, Moos, and Moos (2006): "Predictors of 16-year mortality among individuals initiating help-seeking for an alcoholic use disorder"
    Helen M Pettinati
    Alcohol Clin Exp Res 31:512. 2007

Research Grants11

  1. BEHAVIORAL SUPPORT WITH PHARMACOTHERAPY FOR ALCOHOLICS
    Helen Pettinati; Fiscal Year: 2004
    ..However, each study site has provided site-specific information on the budget, budget justifications, listing of key personnel, consultant/consortium agreements, and human subjects sections of their respective proposals. ..
  2. SERTRALINE FOR ALCOHOL DEPENDENCE AND DEPRESSION
    Helen Pettinati; Fiscal Year: 2003
    ..Overall, this project will determine if combining pharmacotherapies results in a better response in comorbidly depressed alcoholics than either medication alone or placebo. ..
  3. INNOVATIVE APPROACHES FOR COCAINE PHARMACOTHERAPY
    Helen Pettinati; Fiscal Year: 2007
    ..Component 4 describes a model that identifies potential individual genetic predictors to medication response. ..