Irina Petrushina

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc The immunological potency and therapeutic potential of a prototype dual vaccine against influenza and Alzheimer's disease
    Hayk Davtyan
    Department of Molecular Immunology, Institute for Molecular Medicine, Huntington Beach, CA 92647, USA
    J Transl Med 9:127. 2011
  2. pmc Mannan-Abeta28 conjugate prevents Abeta-plaque deposition, but increases microhemorrhages in the brains of vaccinated Tg2576 (APPsw) mice
    Irina Petrushina
    The Institute for Brain Aging and Dementia, University of California Irvine, Irvine, CA 92697 4540, USA
    J Neuroinflammation 5:42. 2008
  3. pmc Adjuvant-dependent modulation of Th1 and Th2 responses to immunization with beta-amyloid
    David H Cribbs
    Institute for Brain Aging and Dementia, University of California Irvine, Irvine, CA 92697 4540, USA
    Int Immunol 15:505-14. 2003
  4. pmc Alzheimer's disease peptide epitope vaccine reduces insoluble but not soluble/oligomeric Abeta species in amyloid precursor protein transgenic mice
    Irina Petrushina
    The Institute for Brain Aging and Dementia, University of California, Irvine, Irvine, California 92697 4540, USA
    J Neurosci 27:12721-31. 2007
  5. pmc The MultiTEP platform-based Alzheimer's disease epitope vaccine activates a broad repertoire of T helper cells in nonhuman primates
    Hayk Davtyan
    Department of Molecular Immunology, Institute for Molecular Medicine, Huntington Beach, CA, USA Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA, USA
    Alzheimers Dement 10:271-83. 2014
  6. ncbi request reprint Importance of IgG2c isotype in the immune response to beta-amyloid in amyloid precursor protein/transgenic mice
    Irina Petrushina
    The Institute for Brain Aging and Dementia, University of California Irvine, Irvine, CA 92697 4540, Irvine USA
    Neurosci Lett 338:5-8. 2003

Collaborators

  • Anahit Ghochikyan
  • Vitaly Vasilevko
  • Elizabeth Head
  • Hayk Davtyan
  • Michael G Agadjanyan
  • David H Cribbs
  • Arpine Davtyan
  • Armine Hovakimyan
  • Adolfo Garcia-Sastre
  • Dmitriy Zamarin
  • Luis Martinez-Sobrido
  • Richard Cadagan
  • Nina Movsesyan
  • Randy A Albrecht
  • Thomas Kieber-Emmons
  • Mike Tran
  • Patrick Kesslak
  • Nadya Sadzikava
  • Carl W Cotman
  • Davit Babikyan

Detail Information

Publications6

  1. pmc The immunological potency and therapeutic potential of a prototype dual vaccine against influenza and Alzheimer's disease
    Hayk Davtyan
    Department of Molecular Immunology, Institute for Molecular Medicine, Huntington Beach, CA 92647, USA
    J Transl Med 9:127. 2011
    ..We hypothesized that in elderly people with pre-existing memory Th cells specific to influenza this dual vaccine will simultaneously boost anti-influenza immunity and induce production of therapeutically active anti-Aβ antibodies...
  2. pmc Mannan-Abeta28 conjugate prevents Abeta-plaque deposition, but increases microhemorrhages in the brains of vaccinated Tg2576 (APPsw) mice
    Irina Petrushina
    The Institute for Brain Aging and Dementia, University of California Irvine, Irvine, CA 92697 4540, USA
    J Neuroinflammation 5:42. 2008
    ..In the current study, we tested the efficacy of this vaccine configuration in amyloid precursor protein (APP) transgenic mice (Tg2576)...
  3. pmc Adjuvant-dependent modulation of Th1 and Th2 responses to immunization with beta-amyloid
    David H Cribbs
    Institute for Brain Aging and Dementia, University of California Irvine, Irvine, CA 92697 4540, USA
    Int Immunol 15:505-14. 2003
    ....
  4. pmc Alzheimer's disease peptide epitope vaccine reduces insoluble but not soluble/oligomeric Abeta species in amyloid precursor protein transgenic mice
    Irina Petrushina
    The Institute for Brain Aging and Dementia, University of California, Irvine, Irvine, California 92697 4540, USA
    J Neurosci 27:12721-31. 2007
    ....
  5. pmc The MultiTEP platform-based Alzheimer's disease epitope vaccine activates a broad repertoire of T helper cells in nonhuman primates
    Hayk Davtyan
    Department of Molecular Immunology, Institute for Molecular Medicine, Huntington Beach, CA, USA Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA, USA
    Alzheimers Dement 10:271-83. 2014
    ..As a prelude to clinical trials we have characterized B- and T-cell immune responses in macaques to AD vaccine candidates: AV-1955 and its slightly modified version, AV-1959 (with 3 additional promiscuous Th epitopes)...
  6. ncbi request reprint Importance of IgG2c isotype in the immune response to beta-amyloid in amyloid precursor protein/transgenic mice
    Irina Petrushina
    The Institute for Brain Aging and Dementia, University of California Irvine, Irvine, CA 92697 4540, Irvine USA
    Neurosci Lett 338:5-8. 2003
    ..Our results suggest that APP/Tg2576 and major histocompatibilty complex-matched parental strains are not expressing IgG2a, producing instead IgG2c anti-Abeta antibodies...