Affiliation: University of Hawaii
- Accuracy of clinical criteria for AD in the Honolulu-Asia Aging Study, a population-based studyH Petrovitch
Pacific Health Research Institute, Honolulu, HI 96813, USA
Neurology 57:226-34. 2001..AD is neuropathologically confirmed for more than 80% of cases at major referral centers (primarily Caucasians); however, information on diagnostic accuracy in population-based studies and studies of different ethnic groups is limited...
- Plantation work and risk of Parkinson disease in a population-based longitudinal studyHelen Petrovitch
Department of Medicine, University of Hawaii John A Burns School of Medicine, USA
Arch Neurol 59:1787-92. 2002..Retrospective studies in humans demonstrate a link between exposure to agricultural lifestyle factors and PD...
- Association of olfactory dysfunction with risk for future Parkinson's diseaseG Webster Ross
Veterans Affairs Pacific Islands Health Care System, University of Hawaii John A Burns School of Medicine, Honolulu, HI 96819, USA
Ann Neurol 63:167-73. 2008..This study examines the association of olfactory dysfunction with future development of PD in Honolulu-Asia Aging Study cohort members..
- Characterization of Japanese-American men with a single neocortical AD lesion typeHelen Petrovitch
Pacific Health Research Institute, 846 South Hotel Street, Honolulu, HI 96813, USA
Neurobiol Aging 29:1448-55. 2008..Only the NP+NFT group showed a "dose-response" relationship with greater probability of dementia with higher neocortical frequencies of either AD lesion. The single neocortical AD lesion groups do not appear to represent early AD...
- AD lesions and infarcts in demented and non-demented Japanese-American menHelen Petrovitch
Pacific Health Research Institute, Kuakini Medical Center, University of Hawaii, 846 South Hotel Street, Honolulu, HI 96813, USA
Ann Neurol 57:98-103. 2005..Prevention of cerebrovascular lesions may be critically important in preserving late-life cognitive function...
- Recent clinical-pathologic research on the causes of dementia in late life: update from the Honolulu-Asia Aging StudyLon White
Honolulu Asia Aging Study, Kuakini Medical Center, Honolulu, HI, USA
J Geriatr Psychiatry Neurol 18:224-7. 2005..The results suggest that clinical diagnosis of dementia made during life may fail to reflect the pathogenic complexity of this condition in very elderly persons...
- Bowel movement frequency in late-life and substantia nigra neuron density at deathHelen Petrovitch
Pacific Health Research Institute, Honolulu, Hawaii, USA
Mov Disord 24:371-6. 2009..Constipation is associated with low SN neuron density independent of the presence of LB...
- Apolipoprotein E epsilon4 allele genotype and the effect of depressive symptoms on the risk of dementia in men: the Honolulu-Asia Aging StudyFumiko Irie
Pacific Health Research Institute, Honolulu, Hawaii, USA
Arch Gen Psychiatry 65:906-12. 2008..Recently, depression has also become recognized as a risk factor for dementia. However, the possible effect of the APOE genotype on the association between depression and dementia is unexamined...
- White matter lesions on brain magnetic resonance imaging scan and 5-year cognitive decline: the Honolulu-Asia aging studyMichiko Inaba
Department of Geriatric Medicine, John A Hartford Center of Excellence in Geriatrics, John A Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, USA
J Am Geriatr Soc 59:1484-9. 2011..To study white matter lesions (WMLs) and 5-year cognitive decline in elderly Japanese-American men...
- Association of olfactory dysfunction with incidental Lewy bodiesG Webster Ross
Veterans Affairs Pacific Islands Health Care System, Honolulu, Hawaii, USA
Mov Disord 21:2062-7. 2006..0 (P = 0.02). Olfactory dysfunction is associated with ILB. If incidental Lewy bodies represent presymptomatic stage of PD, olfactory testing may be a useful screening tool to identify those at high risk for developing PD...
- Bowel movement frequency in late-life and incidental Lewy bodiesRobert D Abbott
Division of Biostatistics and Epidemiology, University of Virginia School of Medicine, Charlottesville, Virginia 22908 0717, and Veterans Affairs Pacific Islands Health Care System, Honolulu, HI, USA
Mov Disord 22:1581-6. 2007..Infrequent bowel movements are associated with ILB. Findings provide evidence that constipation can predate the extrapyramidal signs of PD. Constipation could be one of the earliest markers of the beginning of PD processes...
- Prospective association between low and high total and low-density lipoprotein cholesterol and coronary heart disease in elderly menJ David Curb
Honolulu Heart Program, Kuakini Medical Center, Honolulu, Hawaii, USA
J Am Geriatr Soc 52:1975-80. 2004..To examine the relationship between total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) and the incidence of coronary heart disease (CHD) in elderly men...
- Parkinsonian signs and substantia nigra neuron density in decendents elders without PDG Webster Ross
Honolulu Department of Veteran s Affairs, Honolulu, HI, USA
Ann Neurol 56:532-9. 2004..There was a significant association of increasing number of signs present with decreasing neuron density in both quadrants (p = 0.001 for trend). Low SN neuron density may be the basis for parkinsonian signs in the elderly without PD...
- High density lipoprotein cholesterol and the risk of stroke in elderly men: the Honolulu heart programJ David Curb
Pacific Health Research Institute, Honolulu, HI 96817, USA
Am J Epidemiol 160:150-7. 2004..These findings suggest that HDL cholesterol level is inversely related to the risk of thromboembolic stroke in elderly men. Whether HDL cholesterol alters the effect of other factors on stroke risk in elderly men warrants further study...
- Coffee intake in midlife and risk of dementia and its neuropathologic correlatesRebecca P Gelber
Honolulu Asia Aging Study at Kuakini Medical Center, VA Pacific Islands Healthcare System, Honolulu, HI, USA
J Alzheimers Dis 23:607-15. 2011....
- Brain organochlorines and Lewy pathology: the Honolulu-Asia Aging StudyG Webster Ross
Veterans Affairs Pacific Islands Health Care System, Honolulu, Hawaii 96819, USA
Mov Disord 27:1418-24. 2012..013), the results were insignificant when correcting for multiple testing. Although consistent with earlier accounts of an association between organochlorines and clinical PD, associations with Lewy pathology warrant further study...
- Does cultural assimilation influence prevalence and presentation of depressive symptoms in older Japanese American men? The Honolulu-Asia aging studyNobuharu Harada
John A Hartford Center of Excellence in Geriatrics, Department of Geriatric Medicine, John A Burns School of Medicine, University of Hawaii, Honolulu, HI 96817, USA
Am J Geriatr Psychiatry 20:337-45. 2012..We studied the influence of cultural assimilation on the prevalence and presentation of depressive symptoms in elderly Japanese American men...
- Pre-motor features of Parkinson's disease: the Honolulu-Asia Aging Study experienceG Webster Ross
Veterans Affairs Pacific Islands Health Care System, Honolulu, Hawaii 96819, USA
Parkinsonism Relat Disord 18:S199-202. 2012....
- Association of TTR polymorphisms with hippocampal atrophy in Alzheimer disease familiesKaren T Cuenco
Department of Medicine, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
Neurobiol Aging 32:249-56. 2011..Results for the other MRI traits were unremarkable. This study highlights the potential value of neuroimaging endophenotypes as a tool for finding genes influencing AD pathogenesis...
- Effect of walking distance on 8-year incident depressive symptoms in elderly men with and without chronic disease: the Honolulu-Asia Aging StudyToby L Smith
John A Hartford Center of Excellence in Geriatrics, Department of Geriatric Medicine, John A Burns School of Medicine, University of Hawaii, Honolulu, Hawaii 96817, USA
J Am Geriatr Soc 58:1447-52. 2010..To determine the effect of walking on incident depressive symptoms in elderly Japanese-American men with and without chronic disease...
- Cerebrovascular pathology and dementia in autopsied Honolulu-Asia Aging Study participantsLon White
Kuakini Medical Center, 846 S Hotel Street, Honolulu, HI 96813, USA
Ann N Y Acad Sci 977:9-23. 2002..The cerebrovascular lesion type most essentially and inclusively related to dementia was multiple microinfarction...
- The American Diabetes Association and World Health Organization classifications for diabetes: their impact on diabetes prevalence and total and cardiovascular disease mortality in elderly Japanese-American menBeatriz L Rodriguez
Division of Clinical Epidemiology and the Department of Geriatric Medicine, John A Burns School of Medicine, University of Hawaii at Manoa, Hawaii
Diabetes Care 25:951-5. 2002....
- Association of distinct variants in SORL1 with cerebrovascular and neurodegenerative changes related to Alzheimer diseaseKaren T Cuenco
Genetics Program, Department of Medicine, Room L320, Boston University School of Medicine, 715 Albany St, Boston, MA 02118, USA
Arch Neurol 65:1640-8. 2008....
- Are depressive symptoms a risk factor for mortality in elderly Japanese American men?: the Honolulu-Asia Aging StudyJunji Takeshita
The Honolulu Asia Aging Study, Kuakini Medical Center, 4th Floor, 1356 Lusitana Street, Honolulu, HI 96813, USA
Am J Psychiatry 159:1127-32. 2002..This study determined the influence of depressive symptoms on subsequent mortality of all causes...
- Benefits of off-pump bypass on neurologic and clinical morbidity: a prospective randomized trialJeffrey D Lee
Department of Surgery, University of Hawaii School of Medicine, Honolulu, Hawaii 96813, USA
Ann Thorac Surg 76:18-25; discussion 25-6. 2003..Neurologic and clinical morbidity after coronary artery bypass grafting (CABG) can be significant. By avoiding cardiopulmonary bypass, off-pump CABG (OPCAB) may reduce morbidity...
- Midlife pulse pressure and incidence of dementia: the Honolulu-Asia Aging StudyMichael H Freitag
Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA
Stroke 37:33-7. 2006..This study explores whether this association is attributable to the pulsatile, ie, pulse pressure (PP), or the nonpulsatile component of blood pressure (BP)...
- Environmental, life-style, and physical precursors of clinical Parkinson's disease: recent findings from the Honolulu-Asia Aging StudyRobert D Abbott
University of Virginia Health System, Department of Health Evaluation Sciences, 800717, Charlottesville, Virginia 22908 0717, USA
J Neurol 250:III30-9. 2003..This report describes the relations between environmental, life-style, and physical attributes and the incidence of PD that have been observed in the Honolulu-Asia Aging Study...
- Physical activity, physical function, and incident dementia in elderly men: the Honolulu-Asia Aging StudyDennis R Taaffe
School of Human Movement Studies, Faculty of Health Sciences, The University of Queensland, Brisbane, QLD 4072, Australia
J Gerontol A Biol Sci Med Sci 63:529-35. 2008..We examined the association of late life physical activity and the modifying effect of physical function with future risk of dementia in a well-characterized cohort of elderly men participating in the Honolulu-Asia Aging Study (HAAS)...
- Mid-life smoking and late-life dementia: the Honolulu-Asia Aging StudySuzanne L Tyas
Sanders Brown Center on Aging, Kentucky School of Public Health, University of Kentucky, 203B Sanders Brown Building, Lexington, KY, USA
Neurobiol Aging 24:589-96. 2003..This study suggests that amount smoked is associated with an increasing risk of AD and Alzheimer-type neuropathology up to heavy smoking levels. The lack of association in very heavy smokers may be due to a hardy survivor effect...
- AD brain pathology: vascular origins? Results from the HAAS autopsy studyLenore J Launer
Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, 7201 Wisconsin Ave, 3C 309 Bethesda, MD 20892, USA
Neurobiol Aging 29:1587-90. 2008..Our study suggests the burden of vascular and AD type lesions are independent of each other, and are consistent with an additive effect of the two types of lesions on cognitive impairment...
- A TGF-beta1 polymorphism association with dementia and neuropathologies: the HAASRita Peila
Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, National Institutes of Health, 7201 Wisconsin Avenue, Suite 3C 309, Bethesda, MD 20892 9205, USA
Neurobiol Aging 28:1367-73. 2007..2-0.9). The CC genotype was associated with an increase risk of neocortical plaques (OR(CC)=4.34, CI: 1.6-11.8). These preliminary data suggest that the TGF genetic variability may be important in the risk of vascular related dementia...
- Endogenous sex hormones, cognitive decline, and future dementia in old menMirjam I Geerlings
University Medical Center Utrecht, Julius Center for Health Sciences and Primary Care, Utrecht, The Netherlands
Ann Neurol 60:346-55. 2006..To estimate the association of endogenous levels of bioavailable testosterone and estradiol with risk for cognitive decline and dementia in old men...
- Occupational exposures and movement abnormalities among Japanese-American men: the Honolulu-Asia Aging StudyLuenda E Charles
Biostatistics and Epidemiology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505 2888, USA
Neuroepidemiology 26:130-9. 2006....
- Dietary magnesium intake and the future risk of coronary heart disease (the Honolulu Heart Program)Robert D Abbott
Division of Biostatistics and Epidemiology, Department of Health Evaluation Sciences, University of Virginia School of Medicine, PO Box 800717, Charlottesville, VA 22908 0717, USA
Am J Cardiol 92:665-9. 2003..We conclude that the intake of dietary Mg is associated with a reduced risk of CHD. Whether increases in dietary Mg intake can alter the future risk of disease warrants further study...
- Sex hormones and neuropathology in elderly men: the HAASDorothea Strozyk
Laboratory of Epidemiology, Demography and Biometry, National Institutes on Aging, National Institutes of Health, Bethesda, MD 20892, USA
Neurobiol Aging 28:62-8. 2007..This community-based autopsy study suggests that peripheral levels of sex hormones are associated with neurofibrillary tangles and micro-infarcts, but not with other neuropathologic markers of brain disease in elderly men...
- Influence of estrogen plus progestin on breast cancer and mammography in healthy postmenopausal women: the Women's Health Initiative Randomized TrialRowan T Chlebowski
Harbor UCLA Research and Education Institute, Torrance 90502, USA
JAMA 289:3243-53. 2003..Outstanding issues not previously addressed include characteristics of breast cancers observed among women using hormones and whether diagnosis may be influenced by hormone effects on mammography...
- Age-related changes in risk factor effects on the incidence of coronary heart diseaseRobert D Abbott
Division of Biostatistics and Epidemiology, University of Virginia School of Medicine, Charlottesville, VA, USA
Ann Epidemiol 12:173-81. 2002..The purpose of this report is to examine the potential for risk factor effects on the incidence of CHD to change over a broad range of ages from middle adulthood to late-life...
- Low LDL cholesterol and increased risk of Parkinson's disease: prospective results from Honolulu-Asia Aging StudyXuemei Huang
Department of Neurology, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599 7025, USA
Mov Disord 23:1013-8. 2008..2, 0.9). This prospective study supports the hypothesis that low LDL-C is associated with an increased risk of PD. Although confirmation is required, the underlying mechanisms may be useful in understanding key aspects of PD...
- Walking and dementia in physically capable elderly menRobert D Abbott
Division of Biostatistics and Epidemiology, University of Virginia School of Medicine, Charlottesville, USA
JAMA 292:1447-53. 2004..Evidence suggests that physical activity may be related to the clinical expression of dementia. Whether the association includes low-intensity activity such as walking is not known...
- Human serum albumin levels and cardiovascular risk factors in elderly Japanese-American men: the Honolulu Heart ProgramChung Eun Ha
Department of Native Hawaiian Health, John A Burns School of Medicine, University of Hawai i, Honolulu 96813, USA
Hawaii Med J 66:148, 150-2. 2007..However, the model R-square for all variables was only 0.10. In conclusion, HSA levels are significantly associated with several traditional cardiovascular risk factors, particularly serum lipid levels...
- A 32-year prospective study of change in body weight and incident dementia: the Honolulu-Asia Aging StudyRobert Stewart
Institute of Psychiatry, London, United Kingdom
Arch Neurol 62:55-60. 2005..The course of weight loss associated with dementia is unclear, particularly prior to and around the onset of the clinical syndrome...
- Associations of cortical astrogliosis with cognitive performance and dementia statusMichael L Kashon
Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Morgantown, WV 26505, USA
J Alzheimers Dis 6:595-604; discussion 673-81. 2004..Our findings underscore the need to look beyond standard neuropathological measures putatively linked to specific neuropathological conditions in efforts to identify common cellular and molecular processes that contribute to dementia...
- Cognitive deficits 3 to 6 years before dementia onset in a population sample: the Honolulu-Asia aging studyAnthony F Jorm
Centre for Mental Health Research, Australian National University, Canberra, Australia
J Am Geriatr Soc 53:452-5. 2005..To determine the type of cognitive deficits occurring 3 to 6 years before onset of dementia in a population sample...
- Reducing the risk of dementia: efficacy of long-term treatment of hypertensionRita Peila
Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
Stroke 37:1165-70. 2006..We evaluated the risk of dementia and cognitive decline associated with duration of antihypertensive treatment...
- Exercise and cognitive functionHelen Petrovitch
Lancet Neurol 4:690-1. 2005
- Low-fat dietary pattern and risk of treated diabetes mellitus in postmenopausal women: the Women's Health Initiative randomized controlled dietary modification trialLesley F Tinker
Women s Health Initiative, Fred Hutchinson Cancer Research Center, PO Box 19024, Mail Stop M3 A410, Seattle, WA 98109, USA
Arch Intern Med 168:1500-11. 2008..This study was undertaken to assess the effects of a low-fat dietary pattern on incidence of treated diabetes among generally healthy postmenopausal women...