Helen Petrovitch

Summary

Affiliation: University of Hawaii
Country: USA

Publications

  1. ncbi Accuracy of clinical criteria for AD in the Honolulu-Asia Aging Study, a population-based study
    H Petrovitch
    Pacific Health Research Institute, Honolulu, HI 96813, USA
    Neurology 57:226-34. 2001
  2. ncbi Plantation work and risk of Parkinson disease in a population-based longitudinal study
    Helen Petrovitch
    Department of Medicine, University of Hawaii John A Burns School of Medicine, USA
    Arch Neurol 59:1787-92. 2002
  3. ncbi Association of olfactory dysfunction with risk for future Parkinson's disease
    G Webster Ross
    Veterans Affairs Pacific Islands Health Care System, University of Hawaii John A Burns School of Medicine, Honolulu, HI 96819, USA
    Ann Neurol 63:167-73. 2008
  4. ncbi Characterization of Japanese-American men with a single neocortical AD lesion type
    Helen Petrovitch
    Pacific Health Research Institute, 846 South Hotel Street, Honolulu, HI 96813, USA
    Neurobiol Aging 29:1448-55. 2008
  5. ncbi AD lesions and infarcts in demented and non-demented Japanese-American men
    Helen Petrovitch
    Pacific Health Research Institute, Kuakini Medical Center, University of Hawaii, 846 South Hotel Street, Honolulu, HI 96813, USA
    Ann Neurol 57:98-103. 2005
  6. ncbi Recent clinical-pathologic research on the causes of dementia in late life: update from the Honolulu-Asia Aging Study
    Lon White
    Honolulu Asia Aging Study, Kuakini Medical Center, Honolulu, HI, USA
    J Geriatr Psychiatry Neurol 18:224-7. 2005
  7. ncbi Bowel movement frequency in late-life and substantia nigra neuron density at death
    Helen Petrovitch
    Pacific Health Research Institute, Honolulu, Hawaii, USA
    Mov Disord 24:371-6. 2009
  8. ncbi Apolipoprotein E epsilon4 allele genotype and the effect of depressive symptoms on the risk of dementia in men: the Honolulu-Asia Aging Study
    Fumiko Irie
    Pacific Health Research Institute, Honolulu, Hawaii, USA
    Arch Gen Psychiatry 65:906-12. 2008
  9. ncbi White matter lesions on brain magnetic resonance imaging scan and 5-year cognitive decline: the Honolulu-Asia aging study
    Michiko Inaba
    Department of Geriatric Medicine, John A Hartford Center of Excellence in Geriatrics, John A Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, USA
    J Am Geriatr Soc 59:1484-9. 2011
  10. ncbi Association of olfactory dysfunction with incidental Lewy bodies
    G Webster Ross
    Veterans Affairs Pacific Islands Health Care System, Honolulu, Hawaii, USA
    Mov Disord 21:2062-7. 2006

Detail Information

Publications46

  1. ncbi Accuracy of clinical criteria for AD in the Honolulu-Asia Aging Study, a population-based study
    H Petrovitch
    Pacific Health Research Institute, Honolulu, HI 96813, USA
    Neurology 57:226-34. 2001
    ..AD is neuropathologically confirmed for more than 80% of cases at major referral centers (primarily Caucasians); however, information on diagnostic accuracy in population-based studies and studies of different ethnic groups is limited...
  2. ncbi Plantation work and risk of Parkinson disease in a population-based longitudinal study
    Helen Petrovitch
    Department of Medicine, University of Hawaii John A Burns School of Medicine, USA
    Arch Neurol 59:1787-92. 2002
    ..Retrospective studies in humans demonstrate a link between exposure to agricultural lifestyle factors and PD...
  3. ncbi Association of olfactory dysfunction with risk for future Parkinson's disease
    G Webster Ross
    Veterans Affairs Pacific Islands Health Care System, University of Hawaii John A Burns School of Medicine, Honolulu, HI 96819, USA
    Ann Neurol 63:167-73. 2008
    ..This study examines the association of olfactory dysfunction with future development of PD in Honolulu-Asia Aging Study cohort members..
  4. ncbi Characterization of Japanese-American men with a single neocortical AD lesion type
    Helen Petrovitch
    Pacific Health Research Institute, 846 South Hotel Street, Honolulu, HI 96813, USA
    Neurobiol Aging 29:1448-55. 2008
    ..The single neocortical AD lesion groups do not appear to represent early AD...
  5. ncbi AD lesions and infarcts in demented and non-demented Japanese-American men
    Helen Petrovitch
    Pacific Health Research Institute, Kuakini Medical Center, University of Hawaii, 846 South Hotel Street, Honolulu, HI 96813, USA
    Ann Neurol 57:98-103. 2005
    ..Prevention of cerebrovascular lesions may be critically important in preserving late-life cognitive function...
  6. ncbi Recent clinical-pathologic research on the causes of dementia in late life: update from the Honolulu-Asia Aging Study
    Lon White
    Honolulu Asia Aging Study, Kuakini Medical Center, Honolulu, HI, USA
    J Geriatr Psychiatry Neurol 18:224-7. 2005
    ..The results suggest that clinical diagnosis of dementia made during life may fail to reflect the pathogenic complexity of this condition in very elderly persons...
  7. ncbi Bowel movement frequency in late-life and substantia nigra neuron density at death
    Helen Petrovitch
    Pacific Health Research Institute, Honolulu, Hawaii, USA
    Mov Disord 24:371-6. 2009
    ..Constipation is associated with low SN neuron density independent of the presence of LB...
  8. ncbi Apolipoprotein E epsilon4 allele genotype and the effect of depressive symptoms on the risk of dementia in men: the Honolulu-Asia Aging Study
    Fumiko Irie
    Pacific Health Research Institute, Honolulu, Hawaii, USA
    Arch Gen Psychiatry 65:906-12. 2008
    ..Recently, depression has also become recognized as a risk factor for dementia. However, the possible effect of the APOE genotype on the association between depression and dementia is unexamined...
  9. ncbi White matter lesions on brain magnetic resonance imaging scan and 5-year cognitive decline: the Honolulu-Asia aging study
    Michiko Inaba
    Department of Geriatric Medicine, John A Hartford Center of Excellence in Geriatrics, John A Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, USA
    J Am Geriatr Soc 59:1484-9. 2011
    ..To study white matter lesions (WMLs) and 5-year cognitive decline in elderly Japanese-American men...
  10. ncbi Association of olfactory dysfunction with incidental Lewy bodies
    G Webster Ross
    Veterans Affairs Pacific Islands Health Care System, Honolulu, Hawaii, USA
    Mov Disord 21:2062-7. 2006
    ..0 (P = 0.02). Olfactory dysfunction is associated with ILB. If incidental Lewy bodies represent presymptomatic stage of PD, olfactory testing may be a useful screening tool to identify those at high risk for developing PD...
  11. ncbi Bowel movement frequency in late-life and incidental Lewy bodies
    Robert D Abbott
    Division of Biostatistics and Epidemiology, University of Virginia School of Medicine, Charlottesville, Virginia 22908 0717, and Veterans Affairs Pacific Islands Health Care System, Honolulu, HI, USA
    Mov Disord 22:1581-6. 2007
    ..Infrequent bowel movements are associated with ILB. Findings provide evidence that constipation can predate the extrapyramidal signs of PD. Constipation could be one of the earliest markers of the beginning of PD processes...
  12. ncbi Prospective association between low and high total and low-density lipoprotein cholesterol and coronary heart disease in elderly men
    J David Curb
    Honolulu Heart Program, Kuakini Medical Center, Honolulu, Hawaii, USA
    J Am Geriatr Soc 52:1975-80. 2004
    ..To examine the relationship between total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) and the incidence of coronary heart disease (CHD) in elderly men...
  13. ncbi Parkinsonian signs and substantia nigra neuron density in decendents elders without PD
    G Webster Ross
    Honolulu Department of Veteran's Affairs, Honolulu, HI, USA
    Ann Neurol 56:532-9. 2004
    ..There was a significant association of increasing number of signs present with decreasing neuron density in both quadrants (p = 0.001 for trend). Low SN neuron density may be the basis for parkinsonian signs in the elderly without PD...
  14. ncbi High density lipoprotein cholesterol and the risk of stroke in elderly men: the Honolulu heart program
    J David Curb
    Pacific Health Research Institute, Honolulu, HI 96817, USA
    Am J Epidemiol 160:150-7. 2004
    ..These findings suggest that HDL cholesterol level is inversely related to the risk of thromboembolic stroke in elderly men. Whether HDL cholesterol alters the effect of other factors on stroke risk in elderly men warrants further study...
  15. ncbi Coffee intake in midlife and risk of dementia and its neuropathologic correlates
    Rebecca P Gelber
    Honolulu Asia Aging Study at Kuakini Medical Center, VA Pacific Islands Healthcare System, Honolulu, HI, USA
    J Alzheimers Dis 23:607-15. 2011
    ....
  16. ncbi Brain organochlorines and Lewy pathology: the Honolulu-Asia Aging Study
    G Webster Ross
    Veterans Affairs Pacific Islands Health Care System, Honolulu, Hawaii 96819, USA
    Mov Disord 27:1418-24. 2012
    ..013), the results were insignificant when correcting for multiple testing. Although consistent with earlier accounts of an association between organochlorines and clinical PD, associations with Lewy pathology warrant further study...
  17. ncbi Does cultural assimilation influence prevalence and presentation of depressive symptoms in older Japanese American men? The Honolulu-Asia aging study
    Nobuharu Harada
    John A Hartford Center of Excellence in Geriatrics, Department of Geriatric Medicine, John A Burns School of Medicine, University of Hawaii, Honolulu, HI 96817, USA
    Am J Geriatr Psychiatry 20:337-45. 2012
    ..We studied the influence of cultural assimilation on the prevalence and presentation of depressive symptoms in elderly Japanese American men...
  18. ncbi Pre-motor features of Parkinson's disease: the Honolulu-Asia Aging Study experience
    G Webster Ross
    Veterans Affairs Pacific Islands Health Care System, Honolulu, Hawaii 96819, USA
    Parkinsonism Relat Disord 18:S199-202. 2012
    ....
  19. ncbi Association of TTR polymorphisms with hippocampal atrophy in Alzheimer disease families
    Karen T Cuenco
    Department of Medicine, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Neurobiol Aging 32:249-56. 2011
    ..Results for the other MRI traits were unremarkable. This study highlights the potential value of neuroimaging endophenotypes as a tool for finding genes influencing AD pathogenesis...
  20. ncbi Effect of walking distance on 8-year incident depressive symptoms in elderly men with and without chronic disease: the Honolulu-Asia Aging Study
    Toby L Smith
    John A Hartford Center of Excellence in Geriatrics, Department of Geriatric Medicine, John A Burns School of Medicine, University of Hawaii, Honolulu, Hawaii 96817, USA
    J Am Geriatr Soc 58:1447-52. 2010
    ..To determine the effect of walking on incident depressive symptoms in elderly Japanese-American men with and without chronic disease...
  21. ncbi Cerebrovascular pathology and dementia in autopsied Honolulu-Asia Aging Study participants
    Lon White
    Kuakini Medical Center, 846 S Hotel Street, Honolulu, HI 96813, USA
    Ann N Y Acad Sci 977:9-23. 2002
    ..The cerebrovascular lesion type most essentially and inclusively related to dementia was multiple microinfarction...
  22. ncbi The American Diabetes Association and World Health Organization classifications for diabetes: their impact on diabetes prevalence and total and cardiovascular disease mortality in elderly Japanese-American men
    Beatriz L Rodriguez
    Division of Clinical Epidemiology and the Department of Geriatric Medicine, John A Burns School of Medicine, University of Hawaii at Manoa, Hawaii
    Diabetes Care 25:951-5. 2002
    ....
  23. ncbi Association of distinct variants in SORL1 with cerebrovascular and neurodegenerative changes related to Alzheimer disease
    Karen T Cuenco
    Genetics Program, Department of Medicine, Room L320, Boston University School of Medicine, 715 Albany St, Boston, MA 02118, USA
    Arch Neurol 65:1640-8. 2008
    ....
  24. ncbi Are depressive symptoms a risk factor for mortality in elderly Japanese American men?: the Honolulu-Asia Aging Study
    Junji Takeshita
    The Honolulu Asia Aging Study, Kuakini Medical Center, 4th Floor, 1356 Lusitana Street, Honolulu, HI 96813, USA
    Am J Psychiatry 159:1127-32. 2002
    ..This study determined the influence of depressive symptoms on subsequent mortality of all causes...
  25. ncbi Benefits of off-pump bypass on neurologic and clinical morbidity: a prospective randomized trial
    Jeffrey D Lee
    Department of Surgery, University of Hawaii School of Medicine, Honolulu, Hawaii 96813, USA
    Ann Thorac Surg 76:18-25; discussion 25-6. 2003
    ..Neurologic and clinical morbidity after coronary artery bypass grafting (CABG) can be significant. By avoiding cardiopulmonary bypass, off-pump CABG (OPCAB) may reduce morbidity...
  26. ncbi Midlife pulse pressure and incidence of dementia: the Honolulu-Asia Aging Study
    Michael H Freitag
    Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA
    Stroke 37:33-7. 2006
    ..CONCLUSIONS: Midlife PP is not independently associated with dementia incidence. Midlife SBP is the strongest BP component predicting incident dementia...
  27. ncbi Environmental, life-style, and physical precursors of clinical Parkinson's disease: recent findings from the Honolulu-Asia Aging Study
    Robert D Abbott
    University of Virginia Health System, Department of Health Evaluation Sciences, 800717, Charlottesville, Virginia 22908 0717, USA
    J Neurol 250:III30-9. 2003
    ..This report describes the relations between environmental, life-style, and physical attributes and the incidence of PD that have been observed in the Honolulu-Asia Aging Study...
  28. ncbi Physical activity, physical function, and incident dementia in elderly men: the Honolulu-Asia Aging Study
    Dennis R Taaffe
    School of Human Movement Studies, Faculty of Health Sciences, The University of Queensland, Brisbane, QLD 4072, Australia
    J Gerontol A Biol Sci Med Sci 63:529-35. 2008
    ..We examined the association of late life physical activity and the modifying effect of physical function with future risk of dementia in a well-characterized cohort of elderly men participating in the Honolulu-Asia Aging Study (HAAS)...
  29. ncbi Mid-life smoking and late-life dementia: the Honolulu-Asia Aging Study
    Suzanne L Tyas
    Sanders Brown Center on Aging, Kentucky School of Public Health, University of Kentucky, 203B Sanders Brown Building, Lexington, KY, USA
    Neurobiol Aging 24:589-96. 2003
    ..This study suggests that amount smoked is associated with an increasing risk of AD and Alzheimer-type neuropathology up to heavy smoking levels. The lack of association in very heavy smokers may be due to a hardy survivor effect...
  30. ncbi AD brain pathology: vascular origins? Results from the HAAS autopsy study
    Lenore J Launer
    Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, 7201 Wisconsin Ave, 3C 309 Bethesda, MD 20892, USA
    Neurobiol Aging 29:1587-90. 2008
    ..Our study suggests the burden of vascular and AD type lesions are independent of each other, and are consistent with an additive effect of the two types of lesions on cognitive impairment...
  31. ncbi A TGF-beta1 polymorphism association with dementia and neuropathologies: the HAAS
    Rita Peila
    Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, National Institutes of Health, 7201 Wisconsin Avenue, Suite 3C 309, Bethesda, MD 20892 9205, USA
    Neurobiol Aging 28:1367-73. 2007
    ..2-0.9). The CC genotype was associated with an increase risk of neocortical plaques (OR(CC)=4.34, CI: 1.6-11.8). These preliminary data suggest that the TGF genetic variability may be important in the risk of vascular related dementia...
  32. ncbi Endogenous sex hormones, cognitive decline, and future dementia in old men
    Mirjam I Geerlings
    University Medical Center Utrecht, Julius Center for Health Sciences and Primary Care, Utrecht, The Netherlands
    Ann Neurol 60:346-55. 2006
    ..To estimate the association of endogenous levels of bioavailable testosterone and estradiol with risk for cognitive decline and dementia in old men...
  33. ncbi Occupational exposures and movement abnormalities among Japanese-American men: the Honolulu-Asia Aging Study
    Luenda E Charles
    Biostatistics and Epidemiology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505 2888, USA
    Neuroepidemiology 26:130-9. 2006
    ....
  34. ncbi Dietary magnesium intake and the future risk of coronary heart disease (the Honolulu Heart Program)
    Robert D Abbott
    Division of Biostatistics and Epidemiology, Department of Health Evaluation Sciences, University of Virginia School of Medicine, PO Box 800717, Charlottesville, VA 22908 0717, USA
    Am J Cardiol 92:665-9. 2003
    ..We conclude that the intake of dietary Mg is associated with a reduced risk of CHD. Whether increases in dietary Mg intake can alter the future risk of disease warrants further study...
  35. ncbi Sex hormones and neuropathology in elderly men: the HAAS
    Dorothea Strozyk
    Laboratory of Epidemiology, Demography and Biometry, National Institutes on Aging, National Institutes of Health, Bethesda, MD 20892, USA
    Neurobiol Aging 28:62-8. 2007
    ..This community-based autopsy study suggests that peripheral levels of sex hormones are associated with neurofibrillary tangles and micro-infarcts, but not with other neuropathologic markers of brain disease in elderly men...
  36. ncbi Influence of estrogen plus progestin on breast cancer and mammography in healthy postmenopausal women: the Women's Health Initiative Randomized Trial
    Rowan T Chlebowski
    Harbor UCLA Research and Education Institute, Torrance 90502, USA
    JAMA 289:3243-53. 2003
    ..Outstanding issues not previously addressed include characteristics of breast cancers observed among women using hormones and whether diagnosis may be influenced by hormone effects on mammography...
  37. ncbi Age-related changes in risk factor effects on the incidence of coronary heart disease
    Robert D Abbott
    Division of Biostatistics and Epidemiology, University of Virginia School of Medicine, Charlottesville, VA, USA
    Ann Epidemiol 12:173-81. 2002
    ..The purpose of this report is to examine the potential for risk factor effects on the incidence of CHD to change over a broad range of ages from middle adulthood to late-life...
  38. ncbi Low LDL cholesterol and increased risk of Parkinson's disease: prospective results from Honolulu-Asia Aging Study
    Xuemei Huang
    Department of Neurology, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599 7025, USA
    Mov Disord 23:1013-8. 2008
    ..2, 0.9). This prospective study supports the hypothesis that low LDL-C is associated with an increased risk of PD. Although confirmation is required, the underlying mechanisms may be useful in understanding key aspects of PD...
  39. ncbi Walking and dementia in physically capable elderly men
    Robert D Abbott
    Division of Biostatistics and Epidemiology, University of Virginia School of Medicine, Charlottesville, USA
    JAMA 292:1447-53. 2004
    ..Evidence suggests that physical activity may be related to the clinical expression of dementia. Whether the association includes low-intensity activity such as walking is not known...
  40. ncbi Human serum albumin levels and cardiovascular risk factors in elderly Japanese-American men: the Honolulu Heart Program
    Chung Eun Ha
    Department of Native Hawaiian Health, John A Burns School of Medicine, University of Hawai i, Honolulu 96813, USA
    Hawaii Med J 66:148, 150-2. 2007
    ..However, the model R-square for all variables was only 0.10. In conclusion, HSA levels are significantly associated with several traditional cardiovascular risk factors, particularly serum lipid levels...
  41. ncbi A 32-year prospective study of change in body weight and incident dementia: the Honolulu-Asia Aging Study
    Robert Stewart
    Institute of Psychiatry, London, United Kingdom
    Arch Neurol 62:55-60. 2005
    ..The potential impact on prognosis should be considered in the case of elderly persons at risk for dementia...
  42. ncbi Associations of cortical astrogliosis with cognitive performance and dementia status
    Michael L Kashon
    Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Morgantown, WV 26505, USA
    J Alzheimers Dis 6:595-604; discussion 673-81. 2004
    ..Our findings underscore the need to look beyond standard neuropathological measures putatively linked to specific neuropathological conditions in efforts to identify common cellular and molecular processes that contribute to dementia...
  43. ncbi Cognitive deficits 3 to 6 years before dementia onset in a population sample: the Honolulu-Asia aging study
    Anthony F Jorm
    Centre for Mental Health Research, Australian National University, Canberra, Australia
    J Am Geriatr Soc 53:452-5. 2005
    ..To determine the type of cognitive deficits occurring 3 to 6 years before onset of dementia in a population sample...
  44. ncbi Reducing the risk of dementia: efficacy of long-term treatment of hypertension
    Rita Peila
    Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
    Stroke 37:1165-70. 2006
    ..We evaluated the risk of dementia and cognitive decline associated with duration of antihypertensive treatment...
  45. ncbi Exercise and cognitive function
    Helen Petrovitch
    Lancet Neurol 4:690-1. 2005
  46. ncbi Low-fat dietary pattern and risk of treated diabetes mellitus in postmenopausal women: the Women's Health Initiative randomized controlled dietary modification trial
    Lesley F Tinker
    Women s Health Initiative, Fred Hutchinson Cancer Research Center, PO Box 19024, Mail Stop M3 A410, Seattle, WA 98109, USA
    Arch Intern Med 168:1500-11. 2008
    ..This study was undertaken to assess the effects of a low-fat dietary pattern on incidence of treated diabetes among generally healthy postmenopausal women...