W Petroll

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. ncbi Quantitative 3-dimensional corneal imaging in vivo using a modified HRT-RCM confocal microscope
    W Matthew Petroll
    Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Cornea 32:e36-43. 2013
  2. ncbi Differential interference contrast and confocal reflectance imaging of collagen organization in three-dimensional matrices
    W Matthew Petroll
    Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9057, USA
    Scanning 28:305-10. 2006
  3. ncbi Direct, dynamic assessment of cell-matrix interactions inside fibrillar collagen lattices
    W Matthew Petroll
    Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9057, USA
    Cell Motil Cytoskeleton 55:254-64. 2003
  4. ncbi Direct correlation of collagen matrix deformation with focal adhesion dynamics in living corneal fibroblasts
    W Matthew Petroll
    Department of Ophthalmology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd Dallas, TX 75390 9057, USA
    J Cell Sci 116:1481-91. 2003
  5. ncbi Dynamic three-dimensional visualization of collagen matrix remodeling and cytoskeletal organization in living corneal fibroblasts
    W Matthew Petroll
    Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9057, USA
    Scanning 26:1-10. 2004
  6. ncbi Corneal fibroblasts respond rapidly to changes in local mechanical stress
    W Matthew Petroll
    Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9057, USA
    Invest Ophthalmol Vis Sci 45:3466-74. 2004
  7. ncbi Can postlens tear thickness be measured using three-dimensional in vivo confocal microscopy?
    W Matthew Petroll
    Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9057, USA
    Eye Contact Lens 29:S110-4; discussion S115-8, S192-4. 2003
  8. ncbi Analysis of the pattern of subcellular force generation by corneal fibroblasts after Rho activation
    W Matthew Petroll
    Department of Ophthalmology, The University of Texas Southwestern Medical Center, Dallas, TX 75390 9057, USA
    Eye Contact Lens 34:65-70. 2008
  9. ncbi Dynamic assessment of fibroblast mechanical activity during Rac-induced cell spreading in 3-D culture
    W Matthew Petroll
    Department of Ophthalmology, University of Texas, Southwestern Medical Center at Dallas, Texas 75390 9057, USA
    J Cell Physiol 217:162-71. 2008
  10. ncbi Localized application of mechanical and biochemical stimuli in 3-D culture
    W Matthew Petroll
    Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9057, USA
    Dev Dyn 237:2726-36. 2008

Collaborators

Detail Information

Publications69

  1. ncbi Quantitative 3-dimensional corneal imaging in vivo using a modified HRT-RCM confocal microscope
    W Matthew Petroll
    Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Cornea 32:e36-43. 2013
    ..The purpose of this study was to develop and test hardware and software modifications to allow quantitative full-thickness corneal imaging using the Heidelberg Retina Tomograph (HRT) Rostock Corneal Module...
  2. ncbi Differential interference contrast and confocal reflectance imaging of collagen organization in three-dimensional matrices
    W Matthew Petroll
    Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9057, USA
    Scanning 28:305-10. 2006
    ....
  3. ncbi Direct, dynamic assessment of cell-matrix interactions inside fibrillar collagen lattices
    W Matthew Petroll
    Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9057, USA
    Cell Motil Cytoskeleton 55:254-64. 2003
    ..The data suggest that adhesions organize along actin-based contractile elements that are much less complex than the network of actin filaments that mechanically links lamellar adhesions on 2-D substrates...
  4. ncbi Direct correlation of collagen matrix deformation with focal adhesion dynamics in living corneal fibroblasts
    W Matthew Petroll
    Department of Ophthalmology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd Dallas, TX 75390 9057, USA
    J Cell Sci 116:1481-91. 2003
    ..Our results are consistent with the previously described 'frontal towing' model of cell motility and demonstrate for the first time that this mechanism is employed by cells interacting with a fibrillar extracellular matrix...
  5. ncbi Dynamic three-dimensional visualization of collagen matrix remodeling and cytoskeletal organization in living corneal fibroblasts
    W Matthew Petroll
    Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9057, USA
    Scanning 26:1-10. 2004
    ..Overall, the continued development and application of this new approach should provide important insights into the basic underlying biochemical and biomechanical regulatory mechanisms controlling matrix remodeling by corneal fibroblasts...
  6. ncbi Corneal fibroblasts respond rapidly to changes in local mechanical stress
    W Matthew Petroll
    Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9057, USA
    Invest Ophthalmol Vis Sci 45:3466-74. 2004
    ..To investigate the response of corneal fibroblasts to local changes in extracellular matrix (ECM) tension...
  7. ncbi Can postlens tear thickness be measured using three-dimensional in vivo confocal microscopy?
    W Matthew Petroll
    Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9057, USA
    Eye Contact Lens 29:S110-4; discussion S115-8, S192-4. 2003
    ..This study investigated the feasibility of using in vivo CMTF to measure postlens tear thickness (PLTT)...
  8. ncbi Analysis of the pattern of subcellular force generation by corneal fibroblasts after Rho activation
    W Matthew Petroll
    Department of Ophthalmology, The University of Texas Southwestern Medical Center, Dallas, TX 75390 9057, USA
    Eye Contact Lens 34:65-70. 2008
    ..To determine the structural and subcellular mechanical effects of Rho activation on corneal fibroblasts in three-dimensional collagen matrices...
  9. ncbi Dynamic assessment of fibroblast mechanical activity during Rac-induced cell spreading in 3-D culture
    W Matthew Petroll
    Department of Ophthalmology, University of Texas, Southwestern Medical Center at Dallas, Texas 75390 9057, USA
    J Cell Physiol 217:162-71. 2008
    ....
  10. ncbi Localized application of mechanical and biochemical stimuli in 3-D culture
    W Matthew Petroll
    Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9057, USA
    Dev Dyn 237:2726-36. 2008
    ..Injection of PDGF induced a similar cell spreading response. Cells in 3-D matrices showed remarkable plasticity, and extension of pseudopodia could be induced at both the leading and trailing edges of migrating cells...
  11. ncbi A prototype two-detector confocal microscope for in vivo corneal imaging
    W Matthew Petroll
    Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas 75390 9057, USA
    Scanning 24:163-70. 2002
    ..Thus, the instrument has the potential for improving corneal pachymetry and back-scattering measurements while still providing high-resolution corneal images...
  12. ncbi Assessment of keratocyte activation following LASIK with flap creation using the IntraLase FS60 laser
    W Matthew Petroll
    Dept of Ophthalmology, Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9057, USA
    J Refract Surg 24:847-9. 2008
    ..To assess the response of corneal keratocytes to the IntraLase FS60 femtosecond laser using attenuated steroids...
  13. ncbi Remote-controlled scanning and automated confocal microscopy through focusing using a modified HRT rostock corneal module
    W Matthew Petroll
    Departments of Ophthalmology, UT Southwestern Medical Center, Dallas, TX 75390 9057, USA
    Eye Contact Lens 35:302-8. 2009
    ..To modify the HRT-II Confocal Microscope with Rostock Corneal Module (HRT-RCM) to allow computerized control of the focal plane position (depth) within the cornea...
  14. ncbi Confocal assessment of the corneal response to intracorneal lens insertion and laser in situ keratomileusis with flap creation using IntraLase
    W Matthew Petroll
    Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9057, USA
    J Cataract Refract Surg 32:1119-28. 2006
    ..To assess the response of the cornea to hydrogel intracorneal lens (ICL) insertion or laser in situ keratomileusis (LASIK) with IntraLase (IntraLase Corp.) at the cellular level...
  15. ncbi Modulation of corneal fibroblast contractility within fibrillar collagen matrices
    Mridula Vishwanath
    Department of Ophthalmology, Southwestern Medical Center, Dallas, Texas 75390-9057, USA
    Invest Ophthalmol Vis Sci 44:4724-35. 2003
    ..Sarcomeric shortening of stress fibers in contracting corneal fibroblasts is also demonstrated for the first time...
  16. ncbi Growth factor regulation of corneal keratocyte differentiation and migration in compressed collagen matrices
    Areum Kim
    Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9057, USA
    Invest Ophthalmol Vis Sci 51:864-75. 2010
    ..To evaluate a novel 3D culture model of the corneal stroma and apply it to investigate how key wound-healing growth factors regulate the mechanics of corneal keratocyte migration...
  17. ncbi Regulation of corneal fibroblast morphology and collagen reorganization by extracellular matrix mechanical properties
    Dimitris Karamichos
    Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9057, USA
    Invest Ophthalmol Vis Sci 48:5030-7. 2007
    ..To investigate how extracellular matrix mechanical properties influence cell and matrix patterning in three-dimensional culture...
  18. ncbi Prospective evaluation of PermaVision intracorneal implants using in vivo confocal microscopy
    Sara S Lindsey
    Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, USA
    J Refract Surg 23:410-3. 2007
    ..To report effects of the PermaVision intracorneal lens at the cellular level using in vivo confocal microscopy...
  19. ncbi Quantitative assessment of local collagen matrix remodeling in 3-D culture: the role of Rho kinase
    Areum Kim
    Graduate Program in Biomedical Engineering, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Exp Cell Res 312:3683-92. 2006
    ..Overall, the data suggests that Rho kinase-dependent contractile force generation leads to co-alignment of cells and collagen fibrils along the plane of greatest resistance, and that this process contributes to global matrix contraction...
  20. ncbi Characterization of corneal keratocyte morphology and mechanical activity within 3-D collagen matrices
    Neema Lakshman
    Department of Ophthalmology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9057, USA
    Exp Eye Res 90:350-9. 2010
    ..Overall, this experimental model provides a unique platform for quantitative investigation of the morphological, cytoskeletal and contractile behavior of corneal keratocytes (i.e. their mechanical phenotype) in a 3-D microenvironment...
  21. ncbi Adaptive effects of 30-night wear of hyper-O(2) transmissible contact lenses on bacterial binding and corneal epithelium: a 1-year clinical trial
    David H Ren
    Department of Ophthalmology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9057, USA
    Ophthalmology 109:27-39; discussion 39-40. 2002
    ....
  22. ncbi Postnatal corneal transparency, keratocyte cell cycle exit and expression of ALDH1A1
    James V Jester
    Department of Ophthalmology, University of California, Irvine, California, USA
    Invest Ophthalmol Vis Sci 48:4061-9. 2007
    ..The purpose of this study was to determine the relationship between the expression of these proteins and the development of postnatal corneal transparency...
  23. ncbi The role of contact lens type, oxygen transmission, and care-related solutions in mediating epithelial homeostasis and pseudomonas binding to corneal cells: an overview
    Danielle M Robertson
    Department of Ophthalmology, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9057, USA
    Eye Contact Lens 33:394-8; discussion 399-400. 2007
    ..Significantly, hyper-oxygen-transmissible lenses in any wearing mode with non-preserved care solutions appear to offer the safest potential clinical choice for contact lens wear...
  24. ncbi Effects of O2 transmissibility on corneal epithelium after daily and extended contact lens wear in rabbit and man
    Patrick M Ladage
    Department of Ophthalmology, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA
    Adv Exp Med Biol 506:885-93. 2002
  25. ncbi In vivo fluorescent labeling of corneal wound healing fibroblasts
    Joel Gatlin
    Division of Infectious Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390-9057, USA
    Exp Eye Res 76:361-71. 2003
    ..Our data further suggest that, in vivo, wound-healing fibroblasts have a defined life span within the wound...
  26. ncbi Vertical movement of epithelial basal cells toward the corneal surface during use of extended-wear contact lenses
    Patrick M Ladage
    Department of Ophthalmology, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75039-9057, USA
    Invest Ophthalmol Vis Sci 44:1056-63. 2003
    ..Overall, the data suggest that EW lenses significantly inhibit the normal homeostatic turnover rate of the corneal epithelium...
  27. ncbi Quantitative assessment of corneal wound healing following IntraLASIK using in vivo confocal microscopy
    James P McCulley
    Department of Ophthalmology, Southwestern Medical Center, Dallas, Texas, USA
    Trans Am Ophthalmol Soc 106:84-90; discussion 90-2. 2008
    ..To compare the response of the cornea to laser in situ keratomileusis (LASIK) with flap creation using the IntraLase FS15, FS30, and FS60 femtosecond lasers...
  28. ncbi Prolonged hypoxia induces lipid raft formation and increases Pseudomonas internalization in vivo after contact lens wear and lid closure
    Nobutaka Yamamoto
    Department of Ophthalmology, The University of Texas Southwestern Medical Center, Dallas, 75039-9057, USA
    Eye Contact Lens 32:114-20. 2006
    ..However, different distribution patterns of lipid raft-forming cells suggest physical effects of contact lens wear may direct localization of lipid raft-associated P. aeruginosa internalization on the corneal surface...
  29. ncbi Current concepts: contact lens related Pseudomonas keratitis
    Danielle M Robertson
    Department of Ophthalmology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390 9057, USA
    Cont Lens Anterior Eye 30:94-107. 2007
    ..Non-toxic blockade of raft formation in vitro or in vivo effectively abrogates PA internalization and may represent a unique, new strategy to prevent or ameliorate lens-related PA microbial keratitis...
  30. ncbi Evaluation of intrastromal lipid deposits after intacs implantation using in vivo confocal microscopy
    Linda T Ly
    University of Texas Southwestern Medical School, University of Texas Southwestern Medical Center, Dallas, TX 75390-9057, USA
    Eye Contact Lens 32:211-5. 2006
    ..By using in vivo confocal microscopy, the location and structure of these deposits can be determined...
  31. ncbi Role of oxygen in corneal epithelial homeostasis during extended contact lens wear
    Patrick M Ladage
    Department of Ophthalmology, The University of Texas Southwestern Medical Center, Dallas, TX 75390-9057, USA
    Eye Contact Lens 29:S2-6; discussion S26-9, S192-4. 2003
  32. ncbi Effects of contact lens care solutions on surface exfoliation and bacterial binding to corneal epithelial cells
    Susanna L Li
    Department of Ophthalmology, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390-9057, USA
    Eye Contact Lens 29:27-30. 2003
    ....
  33. ncbi Neonatal corneal stromal development in the normal and lumican-deficient mouse
    Julia Song
    Department of Ophthalmology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
    Invest Ophthalmol Vis Sci 44:548-57. 2003
    ..The purpose of this study was to characterize temporally stromal growth and transparency in lumican-deficient and normal neonatal mice...
  34. ncbi Effects of eyelid closure and disposable and silicone hydrogel extended contact lens wear on rabbit corneal epithelial proliferation
    Patrick M Ladage
    Department of Ophthalmology, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75039-9057, USA
    Invest Ophthalmol Vis Sci 44:1843-9. 2003
    ..The effects of lens wear and eyelid suturing on the cell proliferation rate in contralateral control eyes suggests a central mechanism that regulates corneal epithelial proliferation...
  35. ncbi Pseudomonas aeruginosa corneal binding after 24-hour orthokeratology lens wear
    Patrick M Ladage
    Department of Ophthalmology, University of Texas, Southwestern Medical Center at Dallas, Dallas, TX 75390-9057, USA
    Eye Contact Lens 30:173-8. 2004
    ..Future studies are needed to determine whether these results are similar in human wear and how P. aeruginosa binding during OKL wear compares with other lens-wearing modalities, such as daily or continuous soft lens wear...
  36. ncbi In vivo confocal microscopy through-focusing to measure corneal flap thickness after laser in situ keratomileusis
    Fusun Gokmen
    Department of Ophthalmology, University of Texas Southwestern Medical Center at Dallas, USA
    J Cataract Refract Surg 28:962-70. 2002
    ..The findings emphasize the importance of performing thickness measurements and the usefulness of in vivo CMTF in making these determinations to ensure the safety and effectiveness of LASIK...
  37. ncbi Insulin-like Growth Factor Binding Protein-3 expression in the human corneal epithelium
    Danielle M Robertson
    Department of Ophthalmology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9057, USA
    Exp Eye Res 85:492-501. 2007
    ..The differential localization and effect(s) on apoptosis suggest that the effects of IGFBP3 are likely tissue compartment and receptor specific and may be regulated by glycosylation...
  38. ncbi Castroviejo Lecture 2009: 40 years in search of the perfect contact lens
    H Dwight Cavanagh
    Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9057, USA
    Cornea 29:1075-85. 2010
    ....
  39. ncbi Effects of daily and overnight wear of a novel hyper oxygen-transmissible soft contact lens on bacterial binding and corneal epithelium: a 13-month clinical trial
    H Dwight Cavanagh
    Department of Ophthalmology, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
    Ophthalmology 109:1957-69. 2002
    ..To test prospectively a new biologic rationale for an advanced hyper oxygen-transmissible lens (HOTL) providing prospects for safer daily (DW) or extended (EW) contact lens wear...
  40. ncbi Recovery time of corneal epithelial proliferation in the rabbit following rigid gas-permeable extended contact-lens wear
    Patrick M Ladage
    Department of Opthalmology, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75039-9057, USA
    Eye Contact Lens 29:61-4. 2003
    ..Interestingly, hyperproliferation was noted within the limbal, peripheral, and mid-peripheral corneal epithelium 4 days after lens removal...
  41. ncbi Tandem scanning confocal microscopy of cornea after descemet stripping automated endothelial keratoplasty
    Pawan Prasher
    Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, 75390 9057, USA
    Eye Contact Lens 35:196-202. 2009
    ..To evaluate the changes in the corneal stroma after Descemet stripping automated endothelial keratoplasty (DSAEK) using tandem scanning confocal microscopy (CM)...
  42. ncbi TGFbeta induced myofibroblast differentiation of rabbit keratocytes requires synergistic TGFbeta, PDGF and integrin signaling
    James V Jester
    Department of Ophthalmology, University of Texas, Southwestern Medical Center at Dallas, Dallas, TX 75390 9057, USA
    Exp Eye Res 75:645-57. 2002
    ..Additionally, the similar TGFbeta1 temporal response of PDGF-stimulated compared to nai;ve keratocytes suggests that myofibroblast differentiation does not require transition through a fibroblast phenotype...
  43. ncbi Cell motility and mechanics in three-dimensional collagen matrices
    Frederick Grinnell
    Departments of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Annu Rev Cell Dev Biol 26:335-61. 2010
    ..Finally, we review the significance of these concepts for the physiology of wound repair...
  44. ncbi An experimental model for assessing fibroblast migration in 3-D collagen matrices
    Dimitris Karamichos
    Department of Ophthalmology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9057, USA
    Cell Motil Cytoskeleton 66:1-9. 2009
    ..These initial results demonstrate differences in cell and matrix patterning during migration in response to serum and PDGF...
  45. ncbi Outcomes of PermaVision intracorneal implants for the correction of hyperopia
    Steven M Verity
    Department of Ophthalmology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
    Am J Ophthalmol 147:973-7. 2009
    ..To report the clinical and visual outcomes of a series of patients implanted with the PermaVision intracorneal lens (ReVision Optics Inc, Lake Forest, California, USA) for correction of hyperopia...
  46. ncbi Quantitative assessment of ophthalmic viscosurgical device retention using in vivo confocal microscopy
    W Matthew Petroll
    Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9057, USA
    J Cataract Refract Surg 31:2363-8. 2005
    ..To develop and apply a new laboratory method for in vivo quantitative assessment of the retention of ophthalmic viscosurgical devices (OVDs) following phacoemulsification...
  47. ncbi The effect of nonpreserved care solutions on 12 months of daily and extended silicone hydrogel contact lens wear
    Danielle M Robertson
    Department of Ophthalmology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Invest Ophthalmol Vis Sci 49:7-15. 2008
    ..To determine the effects of nonpreserved care solutions on human corneal epithelium in long-term daily wear (DW) compared with overnight (extended) wear (EW) of hyper-oxygen-permeable silicone hydrogel contact lenses...
  48. ncbi Bcl-2 and Bax regulation of corneal homeostasis in genetically altered mice
    Danielle M Robertson
    Department of Ophthalmology, The University of Texas Southwestern Medical Center, Dallas, TX 75390 9057, USA
    Eye Contact Lens 32:3-7. 2006
    ....
  49. ncbi Central corneal thickness in patients with congenital aniridia
    Jess T Whitson
    Department of Ophthalmology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9057, USA
    Eye Contact Lens 31:221-4. 2005
    ..To compare the mean central corneal thickness (CCT) in patients with congenital aniridia to that of a group of age-matched control subjects. The findings of specular and confocal microscopy in a patient with aniridia are discussed...
  50. ncbi Effects of daily and overnight wear of hyper-oxygen transmissible rigid and silicone hydrogel lenses on bacterial binding to the corneal epithelium: 13-month clinical trials
    H Dwight Cavanagh
    Department of Ophthalmology, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    Eye Contact Lens 29:S14-6; discussion S26-9, S192-4. 2003
    ..Is this a great advance or another clinical triumph of hope over experience? What should the public know? What should patients do?..
  51. ncbi Evaluation of the corneal effects of topical ophthalmic fluoroquinolones using in vivo confocal microscopy
    Timmy A Kovoor
    University of Texas Southwestern Medical School, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Eye Contact Lens 30:90-4. 2004
    ..The results of this study suggest that Moxi induces less damage to the corneal epithelium than other antibiotic solutions, perhaps because it does not contain BAC...
  52. ncbi Comparative study of descemet stripping automated endothelial keratoplasty donor preparation by Moria CBm microkeratome, horizon microkeratome, and Intralase FS60
    V Vinod Mootha
    Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Cornea 30:320-4. 2011
    ..To evaluate the quality of stromal bed and the safety on endothelium in preparation of donor tissue for Descemet stripping automated endothelial keratoplasty in a masked fashion using 2 mechanical microkeratomes and a femtosecond laser...
  53. ncbi Tandem scanning confocal corneal microscopy in the diagnosis of suspected acanthamoeba keratitis
    Dipak N Parmar
    Division of Cornea, External Disease and Refractive Surgery, Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9057, USA
    Ophthalmology 113:538-47. 2006
    ..Mean follow-up was 14 months. CONCLUSION: In vivo corneal TSCM can establish the diagnosis of Acanthamoeba keratitis rapidly and noninvasively, particularly when conventional microbiology is inconclusive...
  54. ncbi Annexin V binding to rabbit corneal epithelial cells following overnight contact lens wear or eyelid closure
    Ling Li
    Department of Ophthalmology, The University of Texas Southwestern Medical Center at Dallas, 75390-9057, USA
    CLAO J 28:48-54. 2002
    ..However, under very low oxygen tensions combined with lens effect, such as in low Dk/t RGP lens wear, surface cell death may be accelerated...
  55. ncbi Dynamic assessment of cell-matrix mechanical interactions in three-dimensional culture
    W Matthew Petroll
    Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Methods Mol Biol 370:67-82. 2007
    ..Using this system, focal adhesion movement and reorganization in isolated cells can be directly correlated with collagen matrix deformation and changes in the mechanical behavior of fibroblasts can be assessed over time...
  56. ncbi Spherical indentations of human and rabbit corneal epithelium following extended contact lens wear
    Patrick M Ladage
    Department of Ophthalmology, The University of Texas Southwestern Medical Center at Dallas, Texas 75390-9057, USA
    CLAO J 28:177-80. 2002
    ..Surprisingly, stromal cells immediately beneath the holes were stimulated to proliferate, and there seemed to be an increase in localized cell density...
  57. ncbi Local thermal injury elicits immediate dynamic behavioural responses by corneal Langerhans cells
    Brant R Ward
    Department of Dermatology, University of Texas South Western Medical Center, Dallas, TX, USA
    Immunology 120:556-72. 2007
    ..Our results demonstrate rapid cytokine-mediated behavioural responses by LCs to local tissue injury, providing new insights into the biology of LCs...
  58. ncbi Intraocular pressure measurement after hyperopic LASIK
    Xiaohong Wang
    Department of Ophthalmology, The University of Texas Southwestern Medical Center at Dallas, 75390-9057, USA
    CLAO J 28:136-9. 2002
    ..There were no significant differences between central and peripheral IOP measurements using either method. CONCLUSION: The data demonstrate that GAT may underestimate IOP measurement, following hyperopic LASIK...
  59. ncbi Assessment of corneal epithelial integrity after acute exposure to ocular hypotensive agents preserved with and without benzalkonium chloride
    Jess T Whitson
    Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9057, USA
    Adv Ther 23:663-71. 2006
    ..004% preserved without BAK did not cause corneal epithelial toxicity; latanoprost 0.005% induced superficial cell loss, most likely caused by the presence of a relatively high concentration of BAK (0.02%)...
  60. ncbi Effect of eyelid closure and overnight contact lens wear on viability of surface epithelial cells in rabbit cornea
    Kazuaki Yamamoto
    Department of Ophthalmology, The University of Texas Southwestern Medical Center at Dallas, 75390-9057, USA
    Cornea 21:85-90. 2002
    ....
  61. ncbi Confocal assessment of the effects of fourth-generation fluoroquinolones on the cornea
    Linda T Ly
    University of Texas Southwestern Medical School, Dallas, TX, USA
    Eye Contact Lens 32:161-5. 2006
    ..Zymar induces a loss of superficial epithelial cells and breakdown of tight junctions under similar conditions...
  62. ncbi Risk factors for intraocular pressure elevation after descemet stripping automated endothelial keratoplasty
    Meredith B Allen
    Department of Ophthalmology, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9057, USA
    Eye Contact Lens 36:223-7. 2010
    ..To identify the incidence of and risk factors for intraocular pressure (IOP) elevation after Descemet stripping automated endothelial keratoplasty (DSAEK)...
  63. ncbi Updates in Acanthamoeba keratitis
    Shady T Awwad
    Department of Ophthalmology, The University of Texas Southwestern Medical Center, Dallas, TX 75390 9057, USA
    Eye Contact Lens 33:1-8. 2007
    ....
  64. ncbi Slit-lamp, confocal, and light microscopic findings of corneal siderosis
    S Robert Witherspoon
    Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9057, USA
    Cornea 26:1270-2. 2007
    ..To report the clinical, histopathologic, and confocal findings of corneal siderosis...
  65. ncbi Regulation of endotoxin-induced keratitis by PECAM-1, MIP-2, and toll-like receptor 4
    Saloni Khatri
    Department of Medicine, Case Western Reserve University, 2109 Adelbert Road, Cleveland, OH 44106-4983, USA
    Invest Ophthalmol Vis Sci 43:2278-84. 2002
    ....
  66. ncbi Effect of ophthalmic viscosurgical devices on lens epithelial cells: a morphological study
    Camille Budo
    Laboratory of Ultrastructural Morphology, Zoological Institute, University of Liege, Liege, Belgium
    J Cataract Refract Surg 29:2411-8. 2003
    ..To investigate the morphological effects of Viscoat (sodium hyaluronate 3.0%-chondroitin sulfate 4.0%) on lens epithelial cells (LECs)...
  67. ncbi Comparison of the corneal response to laser in situ keratomileusis with flap creation using the FS15 and FS30 femtosecond lasers: clinical and confocal microscopy findings
    Michael Y Hu
    University of Texas Southwestern Medical School, USA
    J Cataract Refract Surg 33:673-81. 2007
    ..To compare the response of the cornea to laser in situ keratomileusis (LASIK) with flap creation using the IntraLase FS15 or FS30 femtosecond laser (IntraLase Corp.)...
  68. ncbi Noninvasive corneal stromal collagen imaging using two-photon-generated second-harmonic signals
    Naoyuki Morishige
    The Eye Institute, University of California, Irvine Medical Center, Irvine, California, USA
    J Cataract Refract Surg 32:1784-91. 2006
    ..Human corneas had a unique organizational pattern with sutural lamellae to provide important biomechanical support that was not present in mouse or rabbit corneas...
  69. ncbi Development of a hyaluronan targeted contrast reagent for the demarcation of melanoma margins in vivo
    S R Rudrabhatla
    J Invest Dermatol 128:740-2. 2008

Research Grants14

  1. ASSESMENT OF CORNEAL FIBROBLAST BIOMECHANICAL BEHAVIOR
    W Matthew Petroll; Fiscal Year: 2010
    ..to use innovative 3-D culture models and quantitative imaging techniques to assess the mechanical response of keratocytes to biochemical and biophysical stimuli which have direct relevance to the process of corneal wound healing ..
  2. ASSESMENT OF CORNEAL FIBROBLAST BIOMECHANICAL BEHAVIOR
    W Petroll; Fiscal Year: 2009
    ..to use innovative 3-D culture models and quantitative imaging techniques to assess the mechanical response of keratocytes to biochemical and biophysical stimuli which have direct relevance to the process of corneal wound healing ..
  3. Assessment of Corneal Fibroblast Biomechanical Behavior
    W Petroll; Fiscal Year: 2007
    ..fields qfdevelopmental biology, wound healing and tissue engineering. ..
  4. Assessment of Corneal Fibroblast Biomechanical Behavior
    W Petroll; Fiscal Year: 2007
    ....
  5. Assessment of Corneal Fibroblast Biomechanical Behavior
    W Petroll; Fiscal Year: 2005
    ....
  6. ASSESMENT OF CORNEAL FIBROBLAST BIOMECHANICAL BEHAVIOR
    W Petroll; Fiscal Year: 2004
    ..This research should provide unique insights into the mechanical interactions between cells and ECM, and should serve as a critical foundation for future quantitative cell mechanics studies in this and other laboratories. ..
  7. ASSESMENT OF CORNEAL FIBROBLAST BIOMECHANICAL BEHAVIOR
    W Matthew Petroll; Fiscal Year: 2010
    ..propose to use innovative 3-D culture models and quantitative imaging techniques to assess the mechanical response of keratocytes to biochemical and biophysical stimuli which have direct relevance to the process of corneal wound healing ..