MARGARET PETROFF

Summary

Affiliation: University of Kansas Medical Center
Country: USA

Publications

  1. ncbi request reprint B7 family molecules: novel immunomodulators at the maternal-fetal interface
    M G Petroff
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Placenta 23:S95-101. 2002
  2. pmc B7 family molecules as regulators of the maternal immune system in pregnancy
    Margaret G Petroff
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, KS 66160, USA
    Am J Reprod Immunol 63:506-19. 2010
  3. pmc Review: Fetal antigens--identity, origins, and influences on the maternal immune system
    M G Petroff
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, KS 66160, USA
    Placenta 32:S176-81. 2011
  4. ncbi request reprint Immune interactions at the maternal-fetal interface
    Margaret G Petroff
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USA
    J Reprod Immunol 68:1-13. 2005
  5. pmc The immunomodulatory proteins B7-DC, B7-H2, and B7-H3 are differentially expressed across gestation in the human placenta
    Margaret G Petroff
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160 7400, USA
    Am J Pathol 167:465-73. 2005
  6. ncbi request reprint B7 family molecules are favorably positioned at the human maternal-fetal interface
    Margaret G Petroff
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City 66160, USA
    Biol Reprod 68:1496-504. 2003
  7. ncbi request reprint Recombinant HLA-G5 and -G6 drive U937 myelomonocytic cell production of TGF-beta1
    Ramsey H McIntire
    Departments of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    J Leukoc Biol 76:1220-8. 2004
  8. ncbi request reprint Trophoblast CD274 (B7-H1) is differentially expressed across gestation: influence of oxygen concentration
    Lesya M Holets
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Biol Reprod 74:352-8. 2006
  9. ncbi request reprint Decidual macrophages are potentially susceptible to inhibition by class Ia and class Ib HLA molecules
    Margaret G Petroff
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160 7400, USA
    J Reprod Immunol 56:3-17. 2002
  10. pmc Expression and function of PDCD1 at the human maternal-fetal interface
    Elizabeth S Taglauer
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Biol Reprod 79:562-9. 2008

Research Grants

  1. Maternal Tolerance to Fetal Alloantigens
    Margaret G Petroff; Fiscal Year: 2010
  2. Immunomodulatory B7 Family Proteins in the Placenta
    MARGARET PETROFF; Fiscal Year: 2004
  3. Immunomodulatory B7 Family Proteins in the Placenta
    MARGARET PETROFF; Fiscal Year: 2006
  4. Immunomodulatory B7 Family Proteins in the Placenta
    MARGARET PETROFF; Fiscal Year: 2005
  5. Immunomodulatory B7 Family Proteins in the Placenta
    MARGARET PETROFF; Fiscal Year: 2007

Detail Information

Publications18

  1. ncbi request reprint B7 family molecules: novel immunomodulators at the maternal-fetal interface
    M G Petroff
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Placenta 23:S95-101. 2002
    ..These studies document that the positioning of B7-H1 at the maternal-fetal interface is such that it could participate in suppression of activated maternal leukocytes...
  2. pmc B7 family molecules as regulators of the maternal immune system in pregnancy
    Margaret G Petroff
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, KS 66160, USA
    Am J Reprod Immunol 63:506-19. 2010
    ..Here, we review the known functions of the B7 family proteins in pregnancy...
  3. pmc Review: Fetal antigens--identity, origins, and influences on the maternal immune system
    M G Petroff
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, KS 66160, USA
    Placenta 32:S176-81. 2011
    ..Here, the current state of knowledge of fetal antigen-specific lymphocyte responses in pregnancy is reviewed...
  4. ncbi request reprint Immune interactions at the maternal-fetal interface
    Margaret G Petroff
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USA
    J Reprod Immunol 68:1-13. 2005
    ..Here, the current understanding of mechanisms of specific suppression of maternal lymphocytes is reviewed...
  5. pmc The immunomodulatory proteins B7-DC, B7-H2, and B7-H3 are differentially expressed across gestation in the human placenta
    Margaret G Petroff
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160 7400, USA
    Am J Pathol 167:465-73. 2005
    ..Thus, all three of these newly discovered B7 proteins are differentially positioned at the maternal-fetal interface such that they could steer maternal leukocytes away from a harmful immune response and toward a favorable one...
  6. ncbi request reprint B7 family molecules are favorably positioned at the human maternal-fetal interface
    Margaret G Petroff
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City 66160, USA
    Biol Reprod 68:1496-504. 2003
    ..Conversely, B7-2 was absent on trophoblasts and was appropriately localized to fetal and maternal macrophages, which may participate in antigen presentation...
  7. ncbi request reprint Recombinant HLA-G5 and -G6 drive U937 myelomonocytic cell production of TGF-beta1
    Ramsey H McIntire
    Departments of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    J Leukoc Biol 76:1220-8. 2004
    ..Collectively, the results are consistent with the postulate that environmental programming of decidual macrophages may be dictated in part by their proximity to soluble HLA-G-producing fetal cytotrophoblast cells...
  8. ncbi request reprint Trophoblast CD274 (B7-H1) is differentially expressed across gestation: influence of oxygen concentration
    Lesya M Holets
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Biol Reprod 74:352-8. 2006
    ..Further, the regulation of this immunomodulator by oxygen may implicate its alteration during and involvement in the pathogenesis of complications of pregnancy such as preeclampsia...
  9. ncbi request reprint Decidual macrophages are potentially susceptible to inhibition by class Ia and class Ib HLA molecules
    Margaret G Petroff
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160 7400, USA
    J Reprod Immunol 56:3-17. 2002
    ..These results reveal that inhibitory HLA receptors are expressed in decidual macrophages and suggest that HLA-G may deliver negative signals to maternal decidual macrophages through interaction with these receptors...
  10. pmc Expression and function of PDCD1 at the human maternal-fetal interface
    Elizabeth S Taglauer
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Biol Reprod 79:562-9. 2008
    ..These results suggest that the PDCD1:CD274 pathway functions in modification of maternal decidual lymphocyte cytokine secretion during pregnancy...
  11. ncbi request reprint HLA-G and immune tolerance in pregnancy
    Joan S Hunt
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, Kansas 66160 7400, USA
    FASEB J 19:681-93. 2005
    ....
  12. pmc The hidden maternal-fetal interface: events involving the lymphoid organs in maternal-fetal tolerance
    Elizabeth S Taglauer
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, KS, USA
    Int J Dev Biol 54:421-30. 2010
    ..Experimental data generated from human biological specimens as well as murine transgenic models are considered...
  13. pmc Maternal PD-1 regulates accumulation of fetal antigen-specific CD8+ T cells in pregnancy
    Elizabeth S Taglauer
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, KS 66160 7400, USA
    J Reprod Immunol 80:12-21. 2009
    ..These results suggest that PD-1 plays a previously unrecognized role in maternal-fetal tolerance by inducing apoptosis of paternal antigen-specific T cells during pregnancy, thereby controlling their abundance...
  14. ncbi request reprint In vitro models for studying human uterine and placental macrophages
    Ramsey H McIntire
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, KS, USA
    Methods Mol Med 122:123-48. 2006
    ....
  15. ncbi request reprint Isolation and culture of term human trophoblast cells
    Margaret G Petroff
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, USA
    Methods Mol Med 121:203-17. 2006
    ..The resulting cytotrophoblast cell populations have excellent viability and purity, and may be subjected to long-term culture...
  16. ncbi request reprint Dampening of IFN-gamma-inducible gene expression in human choriocarcinoma cells is due to phosphatase-mediated inhibition of the JAK/STAT-1 pathway
    Jason C Choi
    Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    J Immunol 178:1598-607. 2007
    ..We propose that phosphatase-mediated suppression of IFN-gamma signaling in TBCs contributes to fetal maintenance by inhibiting expression of genes that could be detrimental to successful pregnancy...
  17. ncbi request reprint Class II transactivator (CIITA) promoter methylation does not correlate with silencing of CIITA transcription in trophoblasts
    Renae Holtz
    Department of Immunology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Biol Reprod 69:915-24. 2003
    ..The fact that CIITA is expressed in the stable hybrids implies that trophoblasts may be missing a factor that regulates chromatin structure at the CIITA promoter...
  18. ncbi request reprint Effects of prostaglandin F2alpha and progesterone on the ability of bovine luteal cells to stimulate T lymphocyte proliferation
    Matthew J Cannon
    Department of Animal Sciences, The Ohio State University Ohio Agricultural Research and Development Center, Wooster, Ohio 44691, USA
    Biol Reprod 69:695-700. 2003
    ..These results also demonstrate that progesterone can suppress luteal cell-stimulated T lymphocyte proliferation...

Research Grants6

  1. Maternal Tolerance to Fetal Alloantigens
    Margaret G Petroff; Fiscal Year: 2010
    ..Understanding the events surrounding this unique physiological situation will yield insight on how infertility, cancer and autoimmune disease may be alleviated. ..
  2. Immunomodulatory B7 Family Proteins in the Placenta
    MARGARET PETROFF; Fiscal Year: 2004
    ..Further, these studies will advance our knowledge in developing therapies for infertility and a wide range of other ailments such as cancer and autoimmune disease. ..
  3. Immunomodulatory B7 Family Proteins in the Placenta
    MARGARET PETROFF; Fiscal Year: 2006
    ..Further, these studies will advance our knowledge in developing therapies for infertility and a wide range of other ailments such as cancer and autoimmune disease. ..
  4. Immunomodulatory B7 Family Proteins in the Placenta
    MARGARET PETROFF; Fiscal Year: 2005
    ..Further, these studies will advance our knowledge in developing therapies for infertility and a wide range of other ailments such as cancer and autoimmune disease. ..
  5. Immunomodulatory B7 Family Proteins in the Placenta
    MARGARET PETROFF; Fiscal Year: 2007
    ..Further, these studies will advance our knowledge in developing therapies for infertility and a wide range of other ailments such as cancer and autoimmune disease. ..