Research Topics

Genomes and Genes


Thomas M Petro


Affiliation: University of Nebraska Medical Center
Country: USA


  1. Petro T, Agarkova I, Zhou Y, Yolken R, Van Etten J, Dunigan D. Response of Mammalian Macrophages to Challenge with the Chlorovirus Acanthocystis turfacea Chlorella Virus 1. J Virol. 2015;89:12096-107 pubmed publisher
    ..Therefore, mammalian encounters with chloroviruses may contribute to chronic inflammatory responses from macrophages. ..
  2. Guinn Z, Petro T. IFN-γ synergism with poly I:C reduces growth of murine and human cancer cells with simultaneous changes in cell cycle and immune checkpoint proteins. Cancer Lett. 2018;438:1-9 pubmed publisher
    ..Thus IFN-γ plus poly I:C, and other PRR agonists, may well be effective adjuvants to cancer immunotherapy against several tumor cell types. ..
  3. Moore T, Kumm P, Brown D, Petro T. Interferon response factor 3 is crucial to poly-I:C induced NK cell activity and control of B16 melanoma growth. Cancer Lett. 2014;346:122-8 pubmed publisher
    ..Thus, IRF3 is a key factor controlling melanoma growth through NK-cell activities, especially during poly-I:C therapy. ..
  4. Guinn Z, Brown D, Petro T. Activation of IRF3 contributes to IFN-? and ISG54 expression during the immune responses to B16F10 tumor growth. Int Immunopharmacol. 2017;50:121-129 pubmed publisher
    ..Thus, it is likely that an IFN-?/IRF3/ISG54 nexus can significantly contribute to tumor cell control during anti-tumor immune responses. ..
  5. Guinn Z, Lampe A, Brown D, Petro T. Significant role for IRF3 in both T cell and APC effector functions during T cell responses. Cell Immunol. 2016;310:141-149 pubmed publisher
    ..Thus, IRF3 in APCs and T cells is required for optimal T-cell effector function and the ability of T cells to influence innate immune function of APCs. ..