Thomas M Petro
Affiliation: University of Nebraska Medical Center
Petro T, Agarkova I, Zhou Y, Yolken R, Van Etten J, Dunigan D. Response of Mammalian Macrophages to Challenge with the Chlorovirus Acanthocystis turfacea Chlorella Virus 1. J Virol. 2015;89:12096-107 pubmed publisher
..Therefore, mammalian encounters with chloroviruses may contribute to chronic inflammatory responses from macrophages. ..
Guinn Z, Petro T. IFN-γ synergism with poly I:C reduces growth of murine and human cancer cells with simultaneous changes in cell cycle and immune checkpoint proteins. Cancer Lett. 2018;438:1-9 pubmed publisher
..Thus IFN-γ plus poly I:C, and other PRR agonists, may well be effective adjuvants to cancer immunotherapy against several tumor cell types. ..
Moore T, Kumm P, Brown D, Petro T. Interferon response factor 3 is crucial to poly-I:C induced NK cell activity and control of B16 melanoma growth. Cancer Lett. 2014;346:122-8 pubmed publisher
..Thus, IRF3 is a key factor controlling melanoma growth through NK-cell activities, especially during poly-I:C therapy. ..
Guinn Z, Brown D, Petro T. Activation of IRF3 contributes to IFN-? and ISG54 expression during the immune responses to B16F10 tumor growth. Int Immunopharmacol. 2017;50:121-129 pubmed publisher
..Thus, it is likely that an IFN-?/IRF3/ISG54 nexus can significantly contribute to tumor cell control during anti-tumor immune responses. ..
Guinn Z, Lampe A, Brown D, Petro T. Significant role for IRF3 in both T cell and APC effector functions during T cell responses. Cell Immunol. 2016;310:141-149 pubmed publisher
..Thus, IRF3 in APCs and T cells is required for optimal T-cell effector function and the ability of T cells to influence innate immune function of APCs. ..